Publication Cover
Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 35, 2013 - Issue 6
146
Views
9
CrossRef citations to date
0
Altmetric
Review

Association of angiotensin-converting enzyme insertion/deletion polymorphism (rs4646994) with the risk of primary intracerebral hemorrhage

, , &
Pages 545-552 | Received 27 Oct 2012, Accepted 01 Feb 2013, Published online: 18 Feb 2014

References

  • Shi FL, Hart RG, Sherman DG, Tegeler CH. Stroke in the People’s Republic of China. Stroke. 1989;20:1581–5.
  • Hajat C, Dundas R, Stewart JA, Lawrence E, Rudd AG, Howard R, et al.. Cerebrovascular risk factors and stroke subtypes: differences between ethnic groups. Stroke. 2001;32:37–42.
  • Labovitz DL, Halim A, Boden-Albala B, Hauser WA, Sacco RL. The incidence of deep and lobar intracerebral hemorrhage in whites, blacks, and hispanics. Neurology. 2005;65:518–22.
  • Ariesen MJ, Claus SP, Rinkel GJ, Algra A. Risk factors for intracerebral hemorrhage in the general population: a systematic review. Stroke. 2003;34:2060–5.
  • Van Stavern RB. Primary intracerebral hemorrhage: natural history, prognosis, and outcomes. Semin Cerebrovasc Dis Stroke. 2005;5:163–7.
  • Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H, Hanley DF. Spontaneous intracerebral hemorrhage. N Engl J Med. 2001;344:1450–60.
  • Sessa M. Intracerebral hemorrhage and hypertension. Neurol Sci. 2008;29 (Suppl.2):S258–9.
  • Kalita J, Misra UK, Bindu IS, Kumar B, Mittal B. Angiotensin-converting enzyme (rs4646994) and alpha ADDUCIN (rs4961) gene polymorphisms’ study in primary spontaneous intracerebral hemorrhage. Neurol India. 2011;59:41–6.
  • Domingues-Montanari S, Hernandez-Guillamon M, Fernandez-Cadenas I, Mendioroz M, Boada M, Munuera J, et al.. ACE variants and risk of intracerebral hemorrhage recurrence in amyloid angiopathy. Neurobiol Aging. 2011;32:551.e13–22.
  • Crisan D, Carr J. Angiotensin I-converting enzyme: genotype and disease associations. J Mol Diagn. 2000;2:105–15.
  • Duprez DA. Role of the renin-angiotensin-aldosterone system in vascular remodeling and inflammation: a clinical review. J Hypertens. 2006;24:983–91.
  • Chen CM, Chen YC, Wu YR, Hu FJ, Lyu RK, Chang HS, et al.. Angiotensin-converting enzyme polymorphisms and risk of spontaneous deep intracranial hemorrhage in Taiwan. Eur J Neurol. 2008;15:1206–11.
  • Miners JS, Ashby E, Van Helmond Z, Chalmers KA, Palmer LE, Love S, et al.. Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer’s disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy. Neuropathol Appl Neurobiol. 2008;34:181–93.
  • Xu X, Wang Z, Zeng Q, Wen F. Gene polymorphism and serum levels of the angiotensin-converting enzyme (ACE) in relation to cerebral hemorrhage in hypertensives. Stroke Nerv Dis. 2001;8:84–7.
  • Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990;86:1343–6.
  • Tiret L, Rigat B, Visvikis S, Breda C, Corvol P, Cambien F, et al.. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet. 1992;51:197–205.
  • Cambien F. The angiotensin-converting enzyme (ACE) genetic polymorphism: its relationship with plasma ACE level and myocardial infarction. Clin Genet. 1994;46:94–101.
  • Huang S, Chen XH, Payne JR, Pennell DJ, Gohlke P, Smith MJ, et al.. Haplotype of growth hormone and angiotensin I-converting enzyme genes, serum angiotensin I-converting enzyme and ventricular growth: pathway inference in pharmacogenetics. Pharmacogenet Genomics. 2007;17:291–4.
  • Lang XF. Association of ACE gene polymorphism with hypertensive cerebral hemorrhage. Chin Pract Med. 2011;6:80–2.
  • Thakkinstian A, McElduff P, D’Este C, Duffy D, Attia J. A method for meta-analysis of molecular association studies. Stat Med. 2005;24:1291–306.
  • Catto A, Carter AM, Barrett JH, Stickland M, Bamford J, Davies JA, et al.. Angiotensin-converting enzyme insertion/deletion polymorphism and cerebrovascular disease. Stroke. 1996;27:435–40.
  • Nakata Y, Katsuya T, Rakugi H, Takami S, Sato N, Kamide K, et al.. Polymorphism of angiotensin converting enzyme, angiotensinogen, and apolipoprotein E genes in a Japanese population with cerebrovascular disease. Am J Hypertens. 1997;10:1391–5.
  • Zhang J, Lu S, Sun X, Wu P, Weng Q, Xiang K. Angiotensin I converting enzyme gene and acute cerebrovascular disease. Chin J Gerontol. 1997;17:137–9.
  • Xu Y, Wang X, Zhu J, Wang Y, Dai L. Angiotensin converting enzyme gene polymorphism and cerebrovascular disease. Chin J Neurol. 1998;31:152–5.
  • He YS, Yao JL, Le YL. A study on relationship between insertion/deletion polymorphism of angiotensin-converting enzyme gene and cerebrovascular disease. Chin J Clin Neurosci. 1999;7:78–82.
  • Lin JJ, Yueh KC, Lin GY, Chang DC, Chang CY, Shieh HL, et al.. Lack of association between angiotensin I-converting enzyme gene deletion polymorphism and cerebrovascular disease in Taiwanese. J Formos Med Assoc. 2000;99:895–901.
  • Nie YX, Li L, Chen Y, Wang J, Wang MY. Study of the relationship between the angiotensin converting enzyme gene polymorphism and cerebral hemorrhage. J Apopl Nerv Dis. 2000;17:41–3.
  • Qiu XL, Zhang XL, Tang YJ, Huang JJ, Wang XB. Study of ACE gene and hypertension on mechanism of CVD. Mod Rehabil. 2000;4:1504–5.
  • Zhou C, Zhang C, Luo B. Preliminary study on ACE gene deletion polymorphism in patients with cerebrovascular disease. J Clin Neurol. 2000;13:143–5.
  • Yang Z, Yu M, Xie R, Xiao W, Song H, Zhang X, et al.. Association of angiotension-converting enzyme gene polymorphism with cerebral hemorrhage. Chin J Pract Int Med. 2001;21:608–9.
  • Yao L, Liu L, Xu H, Gao H. Study on the role and mechanism of angiotensin-converting enzyme gene polymorphism in cerebrovascular diseases. Chin J Crit Care Med. 2002;22:585–6.
  • Slowik A, Turaj W, Dziedzic T, Haefele A, Pera J, Malecki MT, et al.. DD genotype of ACE gene is a risk factor for intracerebral hemorrhage. Neurology. 2004;63:359–61.
  • He JL, Wang YF, Wang YH, Wang XL, Chen P, Yang GA, et al.. Relationship between I/D polymorphism of ACE gene and cerebrovascular diseases. J Clin Neurol. 2004;17:406–7.
  • Pan QY, Sun XF, Liao BP, Li SY, Kong S. Analysis of relation between angiotensin coverting enzyme (ACE) gene polymorphism and cerebral infarct, cerebral hemorrhage. Chin J Mod Med. 2004;14:50–2.
  • Shang W, Dou XF, Zhang HY, Huang XH, Liu XN, Ju ZN, et al.. Relationship between angiotensin converting enzyme gene insertion/deletion polymorphism and intracerebral hemorrhage in Chinese. J Apopl Nerv Dis. 2004;21:388–90.
  • Zhang Y, Qian M, Shi J, Liu Y, Fang Q. A study on the relationship of angiotensin converting enzyme gene QTLs polymorphism to cerebrovascular diseases. J Brain Nerv Dis. 2004;12:323–5.
  • Li X, Bu TX, Wang JH, Zhu XD. The analysis of angiotensin converting enzyme gene insertion/deletion polymorphism in cerebral stroke. Chin J Lab Med. 2005;28:825–7.
  • Dikmen M, Gunes HV, Degirmenci I, Ozdemir G, Basaran A. Are the angiotensin-converting enzyme gene and activity risk factors for stroke? Arq Neuropsiquiatr. 2006;64:211–6.
  • Zhao WX, Ji HZ, Zhu WS, Li H, Xu GL, Ren SH, et al.. Relationship between polymorphism of angiotensin converting enzyme gene and risk for stroke in elderly. Chin J Geriatr Heart Brain Vessel Dis. 2007;9:826–8.
  • Sun HY, He JL, Yang YM, Yuan LH, Cheng JL. Analysis of ApoE and ACE gene polymorphisms in patients with intracerebral hemorrhage. Chin J Cerebrovasc Dis. 2008;5:150–3.
  • Gao BF, Zhao Y, Liu XD. Association of ACE insertion/deletion polymorphism with hypertension and hypertensive cerebral hemorrhage. Shandong Med J. 2010;50:39–40.
  • Li F, Dou H, Xiao Z, Zhao R, Chen K, Tao X, et al.. Association between angiotension-converting enzyme and stroke. J Med Res. 2010;39:37–9.
  • Xu H, Fan XJ, Guo C, Nie L, Chang LH, Nie Z, et al.. The relationship between insertion/deletion polymorphism of angiotensin-converting enzyme gene and cerebrovascular diseases in Yunnan Bai ethnic groups. J Apopl Nerv Dis. 2010;27:211–4.
  • Kalita J, Somarajan BI, Kumar B, Mittal B, Misra UK. A study of ACE and ADD1 polymorphism in ischemic and hemorrhagic stroke. Clin Chim Acta. 2011;412:642–6.
  • Guo X, Shi XM, Zhao XY, Zhou XM, Xing HY, Song GY. The relationship between PAI-1 promoter region 4G/5G gene polymorphism,ACE I/D gene polymorphism and cerebral stroke. Bas Clin Med. 2011;31:1238–41.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.