Publication Cover
Redox Report
Communications in Free Radical Research
Volume 15, 2010 - Issue 2
454
Views
14
CrossRef citations to date
0
Altmetric
Research article

Contribution of hexose-6-phosphate dehydrogenase to NADPH content and redox environment in the endoplasmic reticulum

, , &
Pages 64-70 | Published online: 19 Jul 2013

References

  • Salvemini F, Franze A, Iervolino A, Filosa S, Salzano S, Ursini MV. Enhanced glutathione levels and oxidoresistance mediated by increased glucose-6-phosphate dehydrogenase expression. J Biol Chem 1999; 274: 2750–2757.
  • Filosa S, Fico A, Paglialunga F et al. Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxidative stress. Biochem J 2003; 370: 935–943.
  • Fico A, Paglialunga F, Cigliano L et al. Glucose-6-phosphate dehydrogenase plays a crucial role in protection from redox-stress-induced apoptosis. Cell Death Differ 2004; 11: 823–831.
  • Atanasov AG, Nashev LG, Gelman L et al. Direct protein-protein interaction of 1 lbetahydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the endoplasmic reticulum lumen. Biochim Biophys Acta 2008; 1783: 1536–1543.
  • McCormick KL, Wang X, Mick GJ. Evidence that the 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1) is regulated by pentose pathway flux. Studies in rat adipocytes and microsomes. J Biol Chem 2006; 281: 341–347.
  • Mason PJ, Stevens D, Diez A, Knight SW, Scopes DA, Vulliamy TJ. Human hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) encoded at 1p36: coding sequence and expression. Blood Cells Mol Dis 1999; 25: 30–37.
  • Ozols J. Isolation and the complete amino acid sequence of lumenal endoplasmic reticulum glucose-6-phosphate dehydrogenase. Proc Natl Acad Sci USA 1993; 90: 5302–5306.
  • Lavery GG, Walker EA, Turan N et al. Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy. J Biol Chem 2008; 283: 8453–8461.
  • Rogoff D, Ryder JW, Black K et al. Abnormalities of glucose homeostasis and the hypothalamic-pituitary-adrenal axis in mice lacking hexose-6-phosphate dehydrogenase. Endocrinology 2007; 148: 5072–5080.
  • Kardon T, Senesi S, Marcolongo P et al. Maintenance of luminal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytes. FEBS Lett 2008; 582: 1809–1815.
  • Leuzzi R, Banhegyi G, Kardon T et al. Inhibition of microsomal glucose-6-phosphate transport in human neutrophils results in apoptosis: a potential explanation for neutrophil dysfunction in glycogen storage disease type lb. Blood 2003; 101: 2381–2387.
  • Cheung YY, Kim SY, Yiu WH et al. Impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking glucose-6-phosphatase-beta. J Clin Invest 2007; 117: 784–793.
  • Heuson-Stiennon JA, Wanson JC, Drochmans P. Isolation and characterization of the sarcoplasmic reticulum of skeletal muscle. J Cell Biol 1972; 55: 471–488.
  • Hori H, Nembai T, Miyata Y, Hayashi T, Ueno K, Koide T. Isolation and characterization of two 20S proteasomes from the endoplasmic reticulum of rat liver microsomes. J Biochem 1999; 126: 722–730.
  • Zhang Z, Yu J, Stanton RC. A method for determination of pyridine nucleotides using a single extract. Anal Biochem 2000; 285: 163–167.
  • Ellman G, Lysko H. A precise method for the determination of whole blood and plasma sulfhydryl groups. Anal Biochem 1979; 93: 98–102.
  • Rahman I, Kode A, Biswas SK. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat Protoc 2006; 1: 3159–3165.
  • Griffith OW Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 1980; 106: 207–212.
  • Piccirella S, Czegle I, Lizak B et al. Uncoupled redox systems in the lumen of the endoplasmic reticulum. Pyridine nucleotides stay reduced in an oxidative environment. J Biol Chem 2006; 281: 4671–4677.
  • Schafer FQ, Buettner GR. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 2001; 30: 1191–1212.
  • Margittai E, Banhegyi G. Isocitrate dehydrogenase: a NADPH-generating enzyme in the lumen of the endoplasmic reticulum. Arch Biochem Biophys 2008; 471: 184–190.
  • Chakravarthi S, Bulleid NJ. Glutathione is required to regulate the formation of native disulfide bonds within proteins entering the secretory pathway. J Biol Chem 2004; 279: 39872–39879.
  • Molteni SN, Fassio A, Ciriolo MR et al. Glutathione limits Erol - dependent oxidation in the endoplasmic reticulum. J Biol Chem 2004; 279: 32667–32673.
  • Banhegyi G, Benedetti A, Fulceri R, Senesi S. Cooperativity between llbeta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the lumen of the endoplasmic reticulum. J Biol Chem 2004; 279: 27017–27021.
  • Hwang C, Sinskey AJ, Lodish HE Oxidized redox state of glutathione in the endoplasmic reticulum. Science 1992; 257: 1496–1502.
  • Dixon BM, Heath SH, Kim R, Suh JH, Hagen TM. Assessment of endoplasmic reticulum glutathione redox status is confounded by extensive ex vivo oxidation. Antioxid Redox Signal 2008; 10: 963–972.
  • Vishwasrao HD, Heikal AA, Kasischke KA, Webb WW. Conformational dependence of intracellular NADH on metabolic state revealed by associated fluorescence anisotropy. J Biol Chem 2005; 280: 25119–25126.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.