377
Views
11
CrossRef citations to date
0
Altmetric
Review

Is 1H NMR metabolomics becoming the promising early biomarker for neonatal sepsis and for monitoring the antibiotic toxicity?

, &

References

  • Mussap M, Fanos V. Neonatal nephrology and laboratory medicine: an effective interdisciplinary model to improve the outcome in neonatal intensive care unit. J Matern Fetal Neonatal Med. 2011;24(Suppl 2):1–2.
  • Mussap M, Degrandi R, Cataldi L, Fanos V, Plebani M. Biochemical markers for the early assessment of neonatal sepsis: the role of procalcitonin. J Chemother. 2007;19(Suppl 2):35–8.
  • Mussap M, Cataldi L, Plebani M, Fanos V. Laboratory investigation for the early diagnosis and monitoring of neonatal urinary tract infections: the present situation and future perspectives. J Chemother. 2006;18(Spec no 3):9–13.
  • Fanos V, Barberini L, Antonucci R, Atzori L. Metabolomics in neonatology and pediatrics. Clin Biochem. 2011;44:452–4.
  • Nicholson JK, Lindon JC. Systems biology: metabonomics. Nature. 2008;455:1054–6.
  • Lindon JC, Nicholson JK, Holmes E, Everett JR. Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts Magn Reson. 2000;12:289–20.
  • Fiehn O. Metabolomics–the link between genotypes and phenotypes. Plant Mol Biol. 2002;48(1–2):155–71.
  • Dunn WB, Broadhurst DI, Atherton HJ, Goodacre R, Griffin JL. Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy. Chem Soc Rev. 2011;40(1):387–426.
  • Atzori L, Antonucci R, Barberini L, Griffin JL, Fanos V. Metabolomics: a new tool for the neonatologist. J Matern Fetal Neonatal Med. 2009;22(Suppl 3):50–3.
  • Fanos V, Barberini L, Antonucci R, Atzori L. Pharma-metabolomics in neonatology: is it a dream or a fact? Curr Pharm Des. 2012;21:2996–3006.
  • Liu X-R, Zheng X-F, Ji S-Z, Lv Y-H, Zheng D-Y, Xia Z-F, et al. Metabolomic analysis of thermally injured and/or septic rats. Burns. 2010;36(7):992–8.
  • Stringer KA, Serkova NJ, Karnovsky A, Guire K, Paine R, Standiford TJ. Metabolic consequences of sepsis-induced acute lung injury revealed by plasma 1H-nuclear magnetic resonance quantitative metabolomics and computational analysis. Am J Physiol Lung Cell Mol Physiol. 2011;300(1):L4–11.
  • Izquierdo-García JL, Nin N, Ruíz-Cabello J, Rojas Y, de Paula M, López-Cuenca S, et al. A metabolomic approach for diagnosis of experimental sepsis. Intensive Care Med. 2011;37:2023–32.
  • Atzei A, Atzori L, Moretti C, Barberini L, Noto A, Ottonello G, et al. Metabolomics in paediatric respiratory diseases and bronchiolitis. J Matern Fetal Neonatal Med. 2011;(24 (Suppl 2):59–62.
  • Slupsky CM, Rankin KN, Fu H, Chang D, Rowe BH, Charles PGP, et al. Pneumococcal pneumonia: potential for diagnosis through a urinary metabolic profile. J Proteome Res. 2009;8(12):5550–8.
  • Lindon JC, Holmes E, Nicholson JK. Metabonomics techniques and applications to pharmaceutical research & development. Pharm Res. 2006;23(6):1075–88.
  • Atzori L, Griffin JL, Noto A, Fanos V. Metabolomics: a new approach to drug delivery in perinatology. Curr Med Chem. 2012;19(27):4654–61.
  • Antonucci R, Atzori L, Barberini L, Fanos V. Metabolomics: the ‘new clinical chemistry’ for personalized neonatal medicine. Minerva Pediatr. 2010;62:145–8.
  • Hanna MH, Segar JL, Teesch LM, Kasper DC, Schaefer FS, Brophy PD. Urinary metabolomic markers of aminoglycoside nephrotoxicity in newborn rats. Pediatr Res. 2013;73(5):585–91.
  • Bonventre JV, Vaidya VS, Schmouder R, Feig P, Dieterle F. Next-generation biomarkers for detecting kidney toxicity. Nat Biotechnol. 2010;28(5):436–40.
  • Atzori L, Antonucci R, Barberini L, Locci E, Cesare Marincola F, Scano P, et al. 1H NMR-based metabolic profiling of urine from children with nephrouropathies. Front Biosci (Elite Ed). 2010;2:725–32.
  • Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez-Hernandez FJ. New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view. Kidney Int. 2011;79(1):33–45.
  • Boudonck KJ, Mitchell MW, Német L, Keresztes L, Nyska A, Shinar D, et al. Discovery of metabolomics biomarkers for early detection of nephrotoxicity. Toxicol Pathol. 2009;37(3):280–92.
  • Tzovaras V, Tsimihodimos V, Kostara C, Mitrogianni Z, Elisaf M. Aminoglycoside-induced nephrotoxicity studied by proton magnetic resonance spectroscopy of urine. Nephrol Dial Transplant. 2011;26(10):3219–24.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.