Genetically modified species in research: opportunities and challenges for the histology core laboratory

References

• Cardiff RD, Ward JM, Barthold SW. ‘One medicine—one pathology’: are veterinary and human pathology prepared? Lab Invest. 2008;88:18–26.
   PubMed Web of Science ®Google Scholar
• Rogers CS, Stoltz DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ, et al.. Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science. 2008;321:1837–41.
   PubMed Web of Science ®Google Scholar
• Sun X, Sui H, Fisher JT, Yan Z, Liu X, Cho HJ, et al.. Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis. J Clin Invest. 2010;120:3149–60.
   PubMed Web of Science ®Google Scholar
• Sasaki E, Suemizu H, Shimada A, Hanazawa K, Oiwa R, Kamioka M, et al.. Generation of transgenic non-human primates with germline transmission. Nature. 2009;459:523–7.
   PubMed Web of Science ®Google Scholar
• Stoltz DA, Meyerholz DK, Pezzulo AA, Ramachandran S, Rogan MP, Davis GJ, et al.. Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med. 2010;2:29ra31.
   PubMed Web of Science ®Google Scholar
• Ostedgaard LS, Meyerholz DK, Chen JH, Pezzulo AA, Karp PH, Rokhlina T, et al.. The DeltaF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. Sci Transl Med. 2011;3:74ra24.
   PubMed Web of Science ®Google Scholar
• Meyerholz DK, Stoltz DA, Namati E, Ramachandran S, Pezzulo AA, Smith AR, et al.. Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children. Am J Respir Crit Care Med. 2010;182:1251–61.
   PubMed Web of Science ®Google Scholar
• Meyerholz DK, Stoltz DA, Pezzulo AA, Welsh MJ. Pathology of gastrointestinal organs in a porcine model of cystic fibrosis. Am J Pathol. 2010;176:1377–89.
   PubMed Web of Science ®Google Scholar
• Renner S, Fehlings C, Herbach N, Hofmann A, von Waldthausen DC, Kessler B, et al.. Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function. Diabetes. 2010;59:1228–38.
   PubMed Web of Science ®Google Scholar
• Whyte JJ, Samuel M, Mahan E, Padilla J, Simmons GH, Arce-Esquivel AA, et al.. Vascular endothelium-specific overexpression of human catalase in cloned pigs. Transgenic Res. 2011;20:989–1001.
   PubMed Web of Science ®Google Scholar
• Schnieke AE, Kind AJ, Ritchie WA, Mycock K, Scott AR, Ritchie M, et al.. Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Science. 1997;278:2130–3.
   PubMed Web of Science ®Google Scholar
• Kondo M, Sakai T, Komeima K, Kurimoto Y, Ueno S, Nishizawa Y, et al.. Generation of a transgenic rabbit model of retinal degeneration. Invest Ophthalmol Vis Sci. 2009;50:1371–7.
   PubMed Web of Science ®Google Scholar
• Paquet D, Bhat R, Sydow A, Mandelkow EM, Berg S, Hellberg S, et al.. A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J Clin Invest. 2009;119:1382–95.
   PubMed Web of Science ®Google Scholar
• Tam BM, Moritz OL. Dark rearing rescues P23H rhodopsin-induced retinal degeneration in a transgenic Xenopus laevis model of retinitis pigmentosa: a chromophore-dependent mechanism characterized by production of N-terminally truncated mutant rhodopsin. J Neurosci. 2007;27:9043–53.
   PubMed Web of Science ®Google Scholar
• Feany MB, Bender WW. A Drosophila model of Parkinson’s disease. Nature. 2000;404:394–8.
   PubMed Web of Science ®Google Scholar
• Crowther DC, Kinghorn KJ, Miranda E, Page R, Curry JA, Duthie FA, et al.. Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer’s disease. Neuroscience. 2005;132:123–35.
   PubMed Web of Science ®Google Scholar
• Kiernan JA. Histological and histochemical methods: theory and practice. 4th ed. Bloxham: Scion; 2008.
   Google Scholar
• Drobysheva D, Ameel K, Welch B, Ellison E, Chaichana K, Hoang B, et al.. An optimized method for histological detection of dopaminergic neurons in Drosophila melanogaster. J Histochem Cytochem. 2008;56:1049–63.
   PubMed Web of Science ®Google Scholar
• Smucker JD, Bobst JA, Petersen EB, Nepola JV, Fredericks DC. B2A peptide on ceramic granules enhance posterolateral spinal fusion in rabbits compared with autograft. Spine. 2008;33:1324–9.
   PubMed Web of Science ®Google Scholar
• Meyerholz DK, Rodgers J, Castilow EM, Varga SM. Alcian Blue and Pyronine Y histochemical stains permit assessment of multiple parameters in pulmonary disease models. Vet Pathol. 2009;46:325–8.
   PubMed Web of Science ®Google Scholar
• Bonvin E, Rouzic LeP, Bernaudin JF, Cottart CH, Vandebrouck C, Crié A, et al.. Congenital tracheal malformation in cystic fibrosis transmembrane conductance regulator-deficient mice. J Physiol. 2008;586:3231–43.
   PubMed Web of Science ®Google Scholar
• Dabbs DJ, ScienceDirect (Online service).Diagnostic immunohistochemistry theranostic and genomic applications. 3rd ed. Philadelphia, PA: Saunders/Elsevier; 2010.
   Google Scholar
• Ramos-Vara JA, Beissenherz ME. Optimization of immunohistochemical methods using two different antigen retrieval methods on formalin-fixed paraffin-embedded tissues: experience with 63 markers. J Vet Diagn Invest. 2000;12:307–11.
   PubMed Web of Science ®Google Scholar
• Beckstead JH. A simple technique for preservation of fixation-sensitive antigens in paraffin-embedded tissues. J Histochem Cytochem. 1994;42:1127–34.
   PubMed Web of Science ®Google Scholar
• Daneshtalab N, Dore JJ, Smeda JS. Troubleshooting tissue specificity and antibody selection: Procedures in immunohistochemical studies. J Pharmacol Toxicol Methods. 2010;61:127–35.
   PubMed Web of Science ®Google Scholar