Controversies in dengue pathogenesis

References

• Rigau-Perez JG. Severe dengue: the need for new case definitions. Lancet Infect Dis. 2006;6:297–302.
   PubMed Web of Science ®Google Scholar
• Bandyopadhyay S, Lum LC, Kroeger A. Classifying dengue: a review of the difficulties in using the WHO case classification for dengue haemorrhagic fever. Trop Med Int Health. 2006;11:1238–55.
   PubMed Web of Science ®Google Scholar
• Deen JL, Harris E, Wills B, Balmaseda A, Hammond SN, Rocha C, et al.. The WHO dengue classification and case definitions: time for a reassessment. Lancet. 2006;368:170–3.
   PubMed Web of Science ®Google Scholar
• Balmaseda A, Hammond SN, Perez MA, Cuadra R, Solano S, Rocha J, et al.. Short report: assessment of the World Health Organization scheme for classification of dengue severity in Nicaragua. Am J Trop Med Hyg. 2005;73:1059–62.
   PubMed Web of Science ®Google Scholar
• Wills BA, Oragui EE, Dung NM, Loan HT, Chau NV, Farrar JJ, et al.. Size and charge characteristics of the protein leak in dengue shock syndrome. J Infect Dis. 2004;190:810–18.
   PubMed Web of Science ®Google Scholar
• Halstead SB. The dengue case definition dilemma: a commentary. Pediatr Infect Dis J. 2007;26:291–2.
   Web of Science ®Google Scholar
• Halstead SB. Con: The World Health Organization definition of dengue haemorrhagic fever is inadequate for clinical and epidemiological purposes. In: Halstead SB, ed. Dengue. London: Imperial College Press, 2008; 431–6.
   Google Scholar
• Rigau-Perez JG. Pro: The World Health Organization definition of dengue haemorrhagic fever is inadequate for clinical and epidemiological purposes. In: Halstead SB, ed. Dengue. London: Imperial College Press, 2008; 427–31.
   Google Scholar
• World Health Organization. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. Geneva, Switzerland: WHO, 2009.
   Google Scholar
• Srikiatkhachorn A, Rothman AL, Gibbons RV, Sittisombut N, Malasit P, Ennis FA, et al.. Dengue – how best to classify it? Clin Infect Dis. 2011;53:653–7.
   Web of Science ®Google Scholar
• Falconar AK, Martinez F. The NS1 glycoprotein can generate dramatic antibody-enhanced dengue viral replication in normal out-bred mice resulting in lethal multi-organ disease. PLoS ONE. 2011;6:e21024.
   PubMed Web of Science ®Google Scholar
• Rosen L. The emperor's new clothes revisited, or reflections on the pathogenesis of dengue hemorrhagic fever. Am J Trop Med Hyg. 1977;26:337–43.
   PubMed Web of Science ®Google Scholar
• Guzmán MG, Kouri G, Valdes L, Bravo J, Alvarez M, Vazques S, et al.. Epidemiologic studies on dengue in Santiago de Cuba, 1997. Am J Epidemiol. 2000;159:793–9.
   Google Scholar
• Guzman MG, Kouri GP, Bravo J, Soler M, Vazquez S, Morier L. Dengue hemorrhagic fever in Cuba, 1981: a retrospective seroepidemiologic study. Am J Trop Med Hyg. 1990;42:179–84.
   PubMed Web of Science ®Google Scholar
• Alvarez M, Rodriguez R, Bernardo L, Vasquez S, Morier L, Gonzalez D, et al.. Dengue hemorrhagic fever caused by sequential dengue 1–3 infections at a long interval: Havana epidemic, 2001–2002. Am J Trop Med Hyg. 2006;75:1113–17.
   PubMed Web of Science ®Google Scholar
• Anuradha S, Singh NP, Rizvi SN, Agarwal SK, Gur R, Mathur MD. The 1996 outbreak of dengue hemorrhagic fever in Delhi, India. Southeast Asian J Trop Med Public Health. 1998;29:503–6.
   PubMedGoogle Scholar
• Gubler DJ. Dengue and dengue hemorrhagic fever: its history and resurgence as a global public health problem. In: , Gubler D J, Kuno G, ed Dengue and Dengue Hemorrhagic Fever. New York: CAB International, 1997.
   Google Scholar
• Gubler DJ, Reed D, Rosen L, Hitchcock JC. Epidemiological, clinical, and virologic observations on dengue in The Kingdom of Tonga. Am J Trop Med Hyg. 1978;27:581–9.
   PubMed Web of Science ®Google Scholar
• Watts DM, Porter KR, Putvatana P, Vasquez B, Calampa C, Hayes CG, et al.. Failure of secondary infection with American genotype dengue 2 to cause dengue haemorrhagic fever. Lancet. 1999;354:1431–4.
   PubMed Web of Science ®Google Scholar
• Kouri GP, Guzman MG, Bravo JR, Triana C. Dengue haemorrhagic fever/dengue shock syndrome: lessons from the Cuban epidemic, 1981. Bull WHO. 1989;67:375–80.
   PubMed Web of Science ®Google Scholar
• Halstead SB, Streit TG, Lafontant JG, Putvatana R, Russell K, Sun W, et al.. Haiti: absence of dengue hemorrhagic fever despite hyperendemic dengue virus transmission. Am J Trop Med Hyg. 2001;65:180–3.
   PubMed Web of Science ®Google Scholar
• Guzman MG, Kouri G, Bravo J, Valdes L, Vazquez S, Halstead SB. Effect of age on outcome of secondary dengue 2 infections. Int J Infect Dis. 2002;6:118–24.
   PubMedGoogle Scholar
• Guzman MG, Kouri G, Valdes L, Bravo J, Vazquez S, Halstead SB. Enhanced severity of secondary dengue 2 infections occurring at an interval of 20 compared with 4 years after dengue 1 infection. PAHO J Epidemiol. 2002;81:223–7.
   Google Scholar
• Sabin AB. Research on dengue during World War II. Am J Trop Med Hyg. 1952;1:30–50.
   PubMedGoogle Scholar
• Kochel TJ, Watts DM, Halstead SB, Hayes CG, Espinosa A, Felices V, et al.. Effect of dengue-1 antibodies on American dengue-2 viral infection and dengue haemorrhagic fever. Lancet. 2002;360:310–12.
   PubMed Web of Science ®Google Scholar
• Kliks SC, Nisalak A, Brandt WE, Wahl L, Burke DS. Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever. Am J Trop Med Hyg. 1989;40:444–51.
   PubMed Web of Science ®Google Scholar
• Halstead SB. Antibodies determine virulence in dengue. Ann NY Acad Sci. 2009;1171 (suppl 1):E48–56.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Roche R, Sanchez L, Burgher Y, Rosario D, Alvarez M, Kouri G, et al.. Virus role during intraepidemic increase in dengue disease severity. Vector Borne Zoonotic Dis. 2011;11:675–81.
   PubMed Web of Science ®Google Scholar
• Mangada MM, Rothman AL. Altered cytokine responses of dengue-specific CD4+ T cells to heterologous serotypes. J Immunol. 2005;175:2676–83.
   PubMed Web of Science ®Google Scholar
• Mongkolsapaya J, Dejnirattisai W, Xu XN. Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. Nat Med. 2003;9:921–7.
   PubMed Web of Science ®Google Scholar
• Mongkolsapaya J, Duangchinda T, Dejnirattisai W, Vasanawathana S, Avirutnan P, Jairungsri A, et al.. T cell responses in dengue hemorrhagic fever: are cross-reactive T cells suboptimal? J Immunol. 2006;176:3821–9.
   PubMed Web of Science ®Google Scholar
• Midgley CM, Bajwa-Joseph M, Vasanawathana S, Limpitikul W, Wills B, Flanagan A, et al.. An in-depth analysis of original antigenic sin in dengue virus infection. J Virol. 2011;85:410–21.
   PubMed Web of Science ®Google Scholar
• Rothman AL. Immunology and immunopathogenesis of dengue disease. Adv Virus Res. 2003;60:397–419.
   PubMed Web of Science ®Google Scholar
• Rothman AL, Kanesa-thasan N, West K, Janus J, Saluzzo JF, Ennis FA. Induction of T lymphocyte responses to dengue virus by a candidate tetravalent live attenuated dengue virus vaccine. Vaccine. 2001;19:4694–9.
   PubMed Web of Science ®Google Scholar
• Hung NT, Lei HY, Lan NT, Lin YS, Huang KJ, Lien LB, et al.. Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles. J Infect Dis. 2004;189:221–32.
   PubMed Web of Science ®Google Scholar
• Kliks SC, Nimmannitya S, Nisalak A, Burke DS. Evidence that maternal dengue antibodies are important in the development of dengue hemorrhagic fever in infants. Am J Trop Med Hyg. 1988;38:411–19.
   PubMed Web of Science ®Google Scholar
• Halstead SB. Neutralization and antibody-dependent enhancement of dengue viruses. In: , Chambers T J, Monath T P, ed, eds. The Flaviviruses: Pathogenesis and Immunity. New York: Elsevier Academic Press, 2003.
   Google Scholar
• Halstead SB. Immunological parameters of Togavirus disease syndromes. In: Schlesinger RW, ed. Immunological Parameters of Togavirus Disease Syndromes. New York: Academic Press, 1980; 107–73.
   Google Scholar
• Halstead SB. In vivo enhancement of dengue virus infection in Rhesus monkeys by passively transferred antibody. J Infect Dis. 1979;140:527–33.
   PubMed Web of Science ®Google Scholar
• Goncalvez AP, Engle RE, Claire StM, Purcell RH, Lai CJ. Monoclonal antibody-mediated enhancement of dengue virus infection in vitro and in vivo and strategies for prevention. Proc Natl Acad Sci USA. 2007;104:9422–7.
   PubMed Web of Science ®Google Scholar
• Libraty DH, Endy TP, Houng HS, Green S, Kalayanarooj S, Suntayakorn S, et al.. Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections. J Infect Dis. 2002;185:1213–21.
   PubMed Web of Science ®Google Scholar
• Halstead SB. Immunological parameters of Togavirus disease syndromes. In: , Schlesinger R W, ed, ed. The Togaviruses, Biology, Structure, Replication. New York: Academic Press, 1980.
   Google Scholar
• Fujinami RS, von Herrath MG, Christen U. Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease. Clin Microbiol Rev. 2006;19:80–94.
   PubMed Web of Science ®Google Scholar
• Kim B, Kaistha SD, Rouse BT. Viruses and autoimmunity. Autoimmunity. 2006;39:71–7.
   PubMed Web of Science ®Google Scholar
• Rouse BT, Deshpande S. Viruses and autoimmunity: an affair but not a marriage contract. Rev Med Virol. 2002;12:107–13.
   PubMed Web of Science ®Google Scholar
• Markoff LJ, Innis BL, Houghten R, Henchal LS. Development of cross-reactive antibodies to plasminogen during the immune response to dengue virus infection. J Infect Dis. 1991;164:294–301.
   PubMed Web of Science ®Google Scholar
• Falconar AK. The dengue virus nonstructural-1 protein (NS1) generates antibodies to common epitopes on human blood clotting, integrin/adhesin proteins and binds to human endothelial cells: potential implications in haemorrhagic fever pathogenesis. Arch Virol. 1997;142:897–916.
   PubMed Web of Science ®Google Scholar
• Huang KJ, Li SY, Chen SC, Liu HS, Lin YS, Yeh TM, et al.. Manifestation of thrombocytopenia in dengue-2-virus-infected mice. J Gen Virol. 2000;81:2177–82.
   PubMed Web of Science ®Google Scholar
• Lin CF, Lei HY, Shiau AL, Liu CC, Liu HS, Yeh TM, et al.. Antibodies from dengue patient sera cross-react with endothelial cells and induce damage. J Med Virol. 2003;69:82–90.
   PubMed Web of Science ®Google Scholar
• Halstead SB. Con: Dengue hemorrhagic fever is caused by autoimmune phenomena triggered by a dengue viral infection. In: , Halstead S B, ed, ed. Dengue. London: Imperial College Press, 2008.
   Google Scholar
• Zaki SR, Greer PW, Coffield LM, Goldsmith CS, Nolte KB, Foucar K, et al.. Hantavirus pulmonary syndrome. Pathogenesis of an emerging infectious disease. Am J Pathol. 1995;146:552–79.
   PubMed Web of Science ®Google Scholar
• Jessie K, Fong MY, Devi S, Lam SK, Wong KT. Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in site hybridization. J Infect Dis. 2004;189:1411–18.
   PubMed Web of Science ®Google Scholar
• Balsitis SJ, Coloma J, Castro G, Alava A, Flores D, McKerrow JH, et al.. Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining. Am J Trop Med Hyg. 2009;80:416–24.
   PubMed Web of Science ®Google Scholar
• Halstead SB, Mahalingam S, Marovich MA, Ubol S, Mosser DM. Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes. Lancet Infect Dis. 2010;10:712–22.
   PubMed Web of Science ®Google Scholar
• World Health Organization. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control, 2nd edn. Geneva, Switzerland: WHO, 1997.
   Google Scholar