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Review

Nutritional and other types of oedema, albumin, complex carbohydrates and the interstitium – a response to Malcolm Coulthard's hypothesis: Oedema in kwashiorkor is caused by hypo-albuminaemia

References

  • Diskin CJ, Stokes TJ, Dansby LM, Carter TB, Radcliff L, Thomas SG. Towards an understanding of oedema. Br Med J. 1999;318:1610.
  • The Bible. Nehemiah, ch 9, v 21.
  • The Bible. Deuteronomy, ch 8, v 4.
  • The Bible. Lamentations, ch 5, v 10.
  • Hinojosa F. Apuntes sobre una enfermedad del pueblo de la Magdalena. Gac Med Mex. 1865;1:137–9.
  • Autret M, Behar M. Sindrome policarencial infantil (kwashiorkor) and its prevention in Central America. 13 edn. Rome, Italy: Food and Agriculture Organisation; 1954.
  • Bloch CE. Diseases of infants due to prolonged feeding with excess carbohydrates. Br Med J. 1921;1:293.
  • Normet L. La Bouffissure d'Annam. Bull Soc Pathol Exotique. 1926;3:207–13.
  • Procter RAW. Medical work in a native reserve. Kenya Med J. 1926;3:284–9.
  • Williams CD. Kwashiorkor: a nutritional disease of children associated with a maize diet. Lancet. 1935;2:1151–2.
  • Coulthard M. Hypothesis: oedema in kwashiorkor is caused by hypo-albuminaemia. Paediatr Int Child Health. 2015;35:in press.
  • Golden MH, Golden BE, Jackson AA. Albumin and nutritional oedema. Lancet. 1980;1:114–6.
  • Jackson AA. Albumin in nephrotic syndrome and kwashiorkor. Paediatr Int Child Health. 2015;35:in press.
  • Starling EH. On the absorption of fluids from the connective tissue spaces. J Physiol. 1896;19:312–26.
  • Bayliss WM, Starling EH. Observations on venous pressures and their relationship to capillary pressures. J Physiol. 1894;16:159.
  • Anonymous. Cause of nutritional oedema. Lancet. 1946;248:914.
  • Fisher M. Oedema, a Study of the Physiology and the Pathology of Water Absorption by the Living Organism. New York: John Wiley; 1910.
  • Keys A. The edema problem. In: Keys A, Brozek J, Henschel A, Mickelsen O, Taylor HL, editors. The Biology of Human Starvation. Minneapolis: University of Minnesota; 1950; p. 921–65.
  • Michel CC. Microvascular permeability, ultrafiltration, and restricted diffusion. Am J Physiol Heart Circ Physiol. 2004;287:H1887–8.
  • Pappenheimer JR, Renkin EM, Borrero LM. Filtration, diffusion and molecular sieving through peripheral capillary membranes; a contribution to the pore theory of capillary permeability. Am J Physiol. 1951;167:13–46.
  • Pappenheimer JR, Soto-Rivera A. Effective osmotic pressure of the plasma proteins and other quantities associated with the capillary circulation in the hindlimbs of cats and dogs. Am J Physiol. 1948;152:471–91.
  • Canaan-Kuhl S, Venkatraman ES, Ernst SI, Olshen RA, Myers BD. Relationships among protein and albumin concentrations and oncotic pressure in nephrotic plasma. Am J Physiol. 1993;264:F1052–9.
  • Michel CC, Phillips ME, Turner MR. The effects of native and modified bovine serum albumin on the permeability of frog mesenteric capillaries. J Physiol. 1985;360:333–46.
  • Michel CC, Phillips ME. The effects of bovine serum albumin and a form of cationised ferritin upon the molecular selectivity of the walls of single frog capillaries. Microvasc Res. 1985;29:190–203.
  • Curry FE, Michel CC, Phillips ME. Effect of albumin on the osmotic pressure exerted by myoglobin across capillary walls in frog mesentery. J Physiol. 1987;387:69–82.
  • Guardia JA, Ortiz-Butcher C, Bourgoignie JJ. Oncotic pressure and edema formation in hypoalbuminemic HIV-infected patients with proteinuria. Am J Kidney Dis. 1997;30:822–8.
  • DeFronzo RA. Insulin and renal sodium handling: clinical implications. Int J Obes. 1981;5(suppl 1):93–104.
  • Kolanowski J. On the mechanisms of fasting natriuresis and of carbohydrate-induced sodium retention. Diabete Metab. 1977;3:131–43.
  • Garnett ES, Cohen H, Nahmias C, Viol G. The roles of carbohydrate, renin, and aldosterone in sodium retention during and after total starvation. Metabolism. 1973;22:867–74.
  • Levick JR. Revision of the Starling principle: new views of tissue fluid balance. J Physiol. 2004;557:704.
  • Michel CC, Phillips ME. Steady-state fluid filtration at different capillary pressures in perfused frog mesenteric capillaries. J Physiol. 1987;388:421–35.
  • Levick JR. Capillary filtration-absorption balance reconsidered in light of dynamic extravascular factors. Exp Physiol. 1991;76:825–57.
  • Michel CC. Fluid exchange in the microcirculation. J Physiol. 2004;557:701–2.
  • Hu X, Adamson RH, Liu B, Curry FE, Weinbaum S. Starling forces that oppose filtration after tissue oncotic pressure is increased. Am J Physiol Heart Circ Physiol. 2000;279:H1724–36.
  • Adamson RH, Lenz JF, Zhang X, Adamson GN, Weinbaum S, Curry FE. Oncotic pressures opposing filtration across non–fenestrated rat microvessels. J Physiol. 2004;557:889–907.
  • Arkill KP, Knupp C, Michel CC, Neal CR, Qvortrup K, Rostgaard J. Similar endothelial glycocalyx structures in microvessels from a range of mammalian tissues: evidence for a common filtering mechanism? Biophys J. 2011;101:1046–56.
  • Arkill KP, Qvortrup K, Starborg T, Mantell JM, Knupp C, Michel CC. Resolution of the three dimensional structure of components of the glomerular filtration barrier. BMC Nephrol. 2014;15:24.
  • Curry FR, Rygh CB, Karlsen T, Wiig H, Adamson RH, Clark JF. Atrial natriuretic peptide modulation of albumin clearance and contrast agent permeability in mouse skeletal muscle and skin: role in regulation of plasma volume. J Physiol. 2010;588:325–39.
  • Waschke J, Curry FE, Adamson RH, Drenckhahn D. Regulation of actin dynamics is critical for endothelial barrier functions. Am J Physiol Heart Circ Physiol. 2005;288:H1296–305.
  • Zeng Y, Adamson RH, Curry FR, Tarbell JM. Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding. Am J Physiol Heart Circ Physiol. 2014;306:H363–72.
  • Curry FE, Clark JF, Adamson RH. Erythrocyte-derived sphingosine-1-phosphate stabilizes basal hydraulic conductivity and solute permeability in rat microvessels. Am J Physiol Heart Circ Physiol. 2012;303:H825–34.
  • Adamson RH, Clark JF, Radeva M, Kheirolomoom A, Ferrara KW, Curry FE. Albumin modulates S1P delivery from red blood cells in perfused microvessels: mechanism of the protein effect. Am J Physiol Heart Circ Physiol. 2014;306:H1011–7.
  • Lin YC, Adamson RH, Clark JF, Reed RK, Curry FR. Phosphodiesterase 4 inhibition attenuates plasma volume loss and transvascular exchange in volume-expanded mice. J Physiol. 2012;590:309–22.
  • Levick JR, Michel CC. Microvascular fluid exchange and the revised Starling principle. Cardiovas Res. 2010;87:198–210.
  • Woodcock TE, Woodcock TM. Revised Starling equation and the glycocalyx model of transvascular fluid exchange: an improved paradigm for prescribing intravenous fluid therapy. Br J Anaesth. 2012;108:384–94.
  • Morlese JF, Forrester TE, Badaloo AV, Del Rosario M, Frazer M, Jahoor PF. Albumin kinetics in edematous and nonedematous protein-energy malnourished children. Am J Clin Nutr. 1996;64:952–9.
  • Richardson BD, du Plessis JP, Rose EF. Serum albumin and protein energy malnutrition in black preschool children in Transkei. S Afr Med J. 1979;55:113–4.
  • Steyl C, Van Zyl-Smit R. Mechanisms of oedema formation: the minor role of hypoalbuminaemia. S Afr Med J. 2009;99:57–9.
  • Purves LR, Hansen JD. The nature of the hypoalbuminaemia of kwashiorkor. S Afr Med J. 1962;36:1047–50.
  • Purves LR, Hansen JDL. The rate of synthesis of albumin before and after treatment in cases with kwashiorkor. Proc Nutr Soc S Afr. 1962;3:24–5.
  • James WP, Hay AM. Albumin metabolism: effect of the nutritional state and the dietary protein intake. J Clin Invest. 1968;47:1958–72.
  • Stahl AM, Gillen CM, Takamata A, Nadel ER, Mack GW. Reduced blood-to-tissue albumin movement after plasmapheresis. Shock. 2003;19:440–7.
  • Joles JA, Koomans HA, Kortlandt W, Boer P, Dorhout Mees EJ. Hypoproteinemia and recovery from edema in dogs. Am J Physiol. 1988;254:F887–94.
  • Coward WA. Serum colloidal osmotic pressure in the development of kwashiorkor and in recovery: its relationship to albumin and globulin concentrations and oedema. Br J Nutr. 1975;34:459–67.
  • Golden MH. Protein deficiency, energy deficiency, and the oedema of malnutrition. Lancet. 1982;1:1261–5.
  • Kritzinger EE, Kanengoni E, Jones JJ. Plasma renin activity in children with protein energy malnutrition (kwashiorkor). S Afr Med J. 1974;48:499–501.
  • Van Der Westhuysen JM, Kanengoni E, Jones JJ, Van Niekerk CH. Plasma renin activity in oedematous and marasmic children with protein energy malnutrition. S Afr Med J. 1975;49:1729–31.
  • Van Der Westhuysen JM, Kanengoni E, Mbizvo M, Jones JJ. The effect of protein energy malnutrition on plasma renin and oedema in the pig. S Afr Med J. 1977;51:18–20.
  • Saieh C, Acuna L, Maddaleno M, Lopez G, Idalzoaga V. Plasma renin activity in normal and malnourished children. Rev Chil Pediatr. 1983;54:158–61.
  • Lurie AO, Jackson WPU. Aldosteronuria and the edema of kwashiorkor. Am J Clin Nutr. 1962;11:115–26.
  • Lurie AO, Jackson WPU. Aldosteronuria and oedema of infant malnutrition. Proc Nutr Soc S Afr. 1962;3:20–4.
  • Zhang W, Chen L, Zhang L, Xiao M, Ding J, Goltzman D, . Administration of exogenous 1,25(OH)D normalizes overactivation of the central renin-angiotensin system in 1alpha(OH)ase knockout mice. Neurosci Lett. 2015;588C:184–9.
  • Lucisano S, Buemi M, Passantino A, Aloisi C, Cernaro V, Santoro D. New insights on the role of vitamin D in the progression of renal damage. Kidney Blood Press Res. 2013;37:667–78.
  • Bahr V, Mobius K, Redmann A, Oelkers W. Ascorbate and alpha-tocopherol depletion inhibit aldosterone stimulation by sodium deficiency in the guinea pig. Endocr Res. 1996;22:595–600.
  • Mobius K, Redmann A, Hiller HH, Oelkers W, Bahr V. Permissive role of alpha-tocopherol in the stimulation of aldosterone by sodium depletion in the guinea pig. Eur J Endocrinol. 1996;134:758–63.
  • Redmann A, Mobius K, Hiller HH, Oelkers W, Bahr V. Ascorbate depletion prevents aldosterone stimulation by sodium deficiency in the guinea pig. Eur J Endocrinol. 1995;133:499–506.
  • DeLorme CB, Lupien PJ, Despointes RH. Influence of vitamin B-6 on the renin-angiotensin system in rats. J Nutr. 1975;105:1192–8.
  • Makani H, Bangalore S, Romero J, Wever-Pinzon O, Messerli FH. Effect of renin-angiotensin system blockade on calcium channel blocker-associated peripheral edema. Am J Med. 2011;124:128–35.
  • Jansen WH. Die Odemkrankheit: Studien über die Physiologie der Unterernährung und über die Ödempathogenese. Deutsch Arch Klin Med. 1920;144–200:330–77.
  • Kostyal L. Beitrage zur Physiologie und Pathologie des Wasserhaushaltes II Von dem Hungerodem. Z Ges Exp Med. 1935;96:672–84.
  • Youmans JB. Nutritional edema. Int Clin. 1936;4:120–45.
  • Youmans JB, Bell A, Donley D, Frank H. Endemic nutritional edema: 1. Clinical findings and dietary studies. Arch Int Med. 1932;50:843–54.
  • Youmans JB, Bell A, Donley D, Frank H. Endemic nutritional edema: 2. Serum proteins and nitrogen balance. Arch Int Med. 1933;51:45–61.
  • Dodd K, Minot AS. Edema in infancy and childhood as an expression of chronic dietary insufficiency. J Pediatr. 1936;8:442–51.
  • Dodd K, Minot AS. The occurrence of moderately reduced serum albumin in five hundred children in a southern clinic. J Pediatr. 1936;8:452–8.
  • Klahr S, Alleyne GAO. Effects of chronic protein-calorie malnutrition on the kidney. Kidney Int. 1973;3:129–41.
  • Keys A, Brozeck J, Henschell A, Mickelsen O, Taylor HL. The Biology of Human Starvation. London: Oxford University Press; 1950.
  • McCance RA. The history, significance and aetiology of hunger oedema. In: McCance RA, editor. Studies of Undernutrition: Wuppertal 1946–9. London: HMSO; 1951; p. 21–82.
  • McCance RA, Widdowson EM. The osmotic pressure of the serum proteins. In: McCance RA, editor. Studies of Undernutrition: Wuppertal 1946–9. MRC Special Report Series No. 275. London: HMSO; 1951; p. 204–6.
  • Sinclair HM. Nutritional oedema. Proc R Soc Med. 1948;41:541.
  • Sinclair HM. Pathogenesis of nutritional oedema. VIIe Congr Chim Biologique. Liège. 1946;:75–95.
  • Stapleton T. Oedema in recovered prisoners-of-war. Lancet. 1946;1:850–1.
  • Rigaud D, Boulier A, Tallonneau I, Brindisi MC, Rozen R. Body fluid retention and body weight change in anorexia nervosa patients during refeeding. Clin Nutr. 2010;29:749–55.
  • Derman O, Kilic EZ. Edema can be a handicap in treatment of anorexia nervosa. Turkish J Pediatr. 2009;51:593–7.
  • Mascolo M, Chu ES, Mehler PS. Abuse and clinical value of diuretics in eating disorders therapeutic applications. Int J Eat Disord. 2011;44:200–2.
  • Kishibe M, Sakai H, Iizuka H. Acute edema/cutaneous distention syndrome associated with refeeding in a patient with anorexia nervosa. Arch Dermatol. 2009;145:1202–3.
  • Vincent RP, Aylwin SJ, le Roux CW. When the brakes came off: re-feeding oedema after deflation of a gastric band: a case report. Obes Surg. 2009;19:1468–70.
  • Korbonits M, Blaine D, Elia M, Powell-Tuck J. Metabolic and hormonal changes during the refeeding period of prolonged fasting. Eur J Endocrinol. 2007;157:157–66.
  • Ehrlich S, Querfeld U, Pfeiffer E. Refeeding oedema: an important complication in the treatment of anorexia nervosa. Eur Child Adolesc Psychiatr. 2006;15:241–3.
  • Tey HL, Lim SC, Snodgrass AM. Refeeding oedema in anorexia nervosa. Singapore Med J. 2005;46:308–10.
  • Yucel B, Ozbey N, Polat A, Yager J. Weight fluctuations during early refeeding period in anorexia nervosa: case reports. Int J Eat Disord. 2005;37:175–7.
  • Sullam PM, Falk RH. Cardiac tamponade with refeeding in malnutrition. Am Heart J. 1983;106:422–3.
  • Hendrikx A, De MP. Metabolic changes in obese patients during fasting and refeeding. Acta Clin Belg. 1969;24:1–16.
  • Gelfand M. Kwashiorkor in a breast-fed infant. Trans R Soc Trop Med Hyg. 1951;45:393–6.
  • Oyelami OA, Maxwell SM, Aladekomo TA, Adelusola KA. Two unusual cases of kwashiorkor: can protein deficiency explain the mystery? Ann Trop Paediatr. 1995;15:217–9.
  • Chaudhuri RN, Bhattacharyya AK, Mandal JN. An aetiological study of kwashiorkor in relation to maternal health. Bull Calcutta Sch Trop Med. 1963;11:45.
  • Markoska V. http://files.ennonline.net/attachments/1012/markoska–vesna.pdf Antioxidant Capacity of Breast-milk Taken by Patients with Kwashiorkor. : University of Aberdeen; 2000.
  • Hassan H, Hashim SA, Van Itallie TB. Sebrell WH. Syndrome in premature infants associated with low plasma vitamin E levels and high polyunsaturated fatty acid diet. Am J Clin Nutr. 1966;19:147–57.
  • Keith NM, Binger MW. Diuretic action of potassium salts. J Am Med Assoc. 1935;105:1584–91.
  • Blum L. Recherches sur le rôle des sels alcalins dans la pathogénie des oedèmes, l'action diurétique du chlorure de potassium. Presse Med. 1920;28:685–8.
  • Falta W. Ueber das diabetische Oedem. Wien Arch Finn Med. 1923;5:581.
  • Gibson RB, Larimer RN. Generalized edema immediately following insulin control in diabetes mellitus. J Am Med Assoc. 1925;84:491–2.
  • Shelburne SA, Egloff WC. Experimental edema. Arch Int Med. 1931;48:51–69.
  • Schwartz WB, Relman AS. Metabolic and renal studies in chronic potassium depletion resulting from overuse of laxatives. J Clin Invest. 1953;32:258.
  • Schlesinger B. Hypokalemia and paralytic ileus in gastroenteritis. Arch Franc Pediatr. 1952;10:178–85.
  • Garrow JS. Total body potassium in kwashiorkor and marasmus. Lancet. 1965;2:455–8.
  • Alleyne GAO, Hay RW, Picou DIM, Stanfield JP, Whitehead RG. Protein Energy Malnutrition. London: Edward Arnold; 1977.
  • Hansen JDL, Brock JF. Potassium deficiency in the pathogenesis of nutritional oedema in infants. Lancet. 1954;2:477.
  • Thompson MD. Potassium deficiency and kwashiorkor. Lancet. 1955;1:1181.
  • Black DAK, Milne MD. Experimental potassium depletion in man. Clin Sci. 1952;11:397–415.
  • Fourman P. Depletion of potassium induced in man with an exchange resin. Clin Sci. 1954;13:93–110.
  • Fourman P, Hervey GR. An experimental study of oedema in potassium deficiency. Clin Sci. 1955;14:75–9.
  • Patrick J, Golden MH. Leukocyte electrolytes and sodium transport in protein energy malnutrition. Am J Clin Nutr. 1977;30:1478–81.
  • Patrick J. Relationship between intracellular and extracellular potassium in normal and malnourished subjects as studied in leucocytes. Pediatr Res. 1978;12:767–70.
  • Laragh JH. The effect of potassium chloride on hyponatremia. J Clin Invest. 1954;33:807.
  • Patrick J. Death during recovery from severe malnutrition and its possible relationship to sodium pump activity in the leucocyte. Br Med J. 1977;1:1051–4.
  • Grellety Y. The Management of Severe Malnutrition in Africa. PhD thesis, : University of Aberdeen; http://ethos.bl.uk/OrderDetails.do?uin = uk.bl.ethos.324139 and at http://www.ennonline.net/managementsamafrica 2000.
  • Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO. Mortality after fluid bolus in African children with severe infection. N Engl J Med. 2011;364:2483–95.
  • Maitland K, George EC, Evans JA, Kiguli S, Olupot-Olupot P, Akech SO, . Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial. BMC Med. 2013;11:68.
  • Das M, Khanna SK. Epidemic dropsy. Natl Med J India. 1998;11:207–8.
  • Babu CK, Ansari KM, Mehrotra S, Khanna R, Khanna SK, Das M. Alterations in redox potential of glutathione/glutathione disulfide and cysteine/cysteine disulfide couples in plasma of dropsy patients with argemone oil poisoning. Food Chem Toxicol. 2008;46:2409–14.
  • Das M, Babu K, Reddy NP, Srivastava LM. Oxidative damage of plasma proteins and lipids in epidemic dropsy patients: alterations in antioxidant status. Biochem Biophys Acta. 2005;1722:209–17.
  • Babu CK, Khanna SK, Das M. Antioxidant status of erythrocytes and their response to oxidative challenge in humans with argemone oil poisoning. Toxicol Appl Pharmacol. 2008;230:304–11.
  • Banerjee BD, Seth V, Koner BC, Ahmed RS, Sharma M, Grover SS. Evaluation of oxidative stress in some cases of argimone oil poisoning during a recent outbreak of epidemic dropsy in India. Int J Environ Health Res. 2000;10:341–6.
  • Tripathi AM, Agrawal KK, Agarwal KN. Oedema fluid composition in childhood disorders. Acta Paediatr Scand. 1983;72:741–5.
  • Kumar A, Husain F, Das M, Khanna SK. An out-break of epidemic dropsy in the Barabanki District of Uttar Pradesh, India: a limited trial for the scope of antioxidants in the management of symptoms. Biomed Environ Sci. 1992;5:251–6.
  • Graz B, Willcox ML, Diakite C, Falquet J, Dackuo F, Sidibe O, . Argemone mexicana decoction versus artesunate–amodiaquine for the management of malaria in Mali: policy and public-health implications. Trans R Soc Trop Med Hyg. 2010;104:33–41.
  • Willcox ML, Graz B, Falquet J, Sidibe O, Forster M, Diallo D. Argemone mexicana decoction for the treatment of uncomplicated falciparum malaria. Trans R Soc Trop Med Hyg. 2007;101:1190–8.
  • Thorn GW. Cyclical edema. Am J Med. 1957;23:507–9.
  • Thorn GW. Approach to the patient with “idiopathic edema” or “periodic swelling”. J Am Med Assoc. 1968;206:333–8.
  • Mach RS, Favre H. Is idiopathic oedema idiopathic? Lancet. 1979;313:826–7.
  • Macgregor GA, Tasker PR, De Wardener HE. Diuretic-induced oedema. Lancet. 1975;1:489–92.
  • Macgregor GA, Markandu ND, Roulston JE, Jones JC, De Wardener HE. Is “idiopathic” edema idiopathic? Lancet. 1979;1:397–400.
  • Missouris CG, Cappuccio FP, Markandu ND, Macgregor GA. Diuretics and oedema: how to avoid rebound sodium retention. Lancet. 1992;339:1546.
  • Brod JA, Fejar ZD. The origin of oedema in heart failure. QJM. 1950;19:187–220.
  • Breidthardt T, Irfan A, Klima T, Drexler B, Balmelli C, Arenja N. Pathophysiology of lower extremity edema in acute heart failure revisited. Am J Med. 2012;125:1124.
  • Jacob M, Saller T, Chappell D, Rehm M, Welsch U, Becker BF. Physiological levels of A-, B- and C-type natriuretic peptide shed the endothelial glycocalyx and enhance vascular permeability. Basic Res Cardiol. 2013;108:347.
  • Dull RO, Cluff M, Kingston J, Hill D, Chen H, Hoehne S, . Lung heparan sulfates modulate K(fc) during increased vascular pressure: evidence for glycocalyx-mediated mechanotransduction. Am J Physiol Lung Cell Mol Physiol. 2012;302:L816–28.
  • Tainsh AR. Beriberi: an historical perspective. Int J Environ Stud. 1998;55:141–59.
  • Datta SC, Ghosh JJ. Production and purification of penicillium citreoviride toxin and its effect on tpp-dependent liver transketolase. Folia Microbiol. 1981;26:408–12.
  • Yonezawa W, Aoki F, Ota M, Nishio K, Matsumoto K. Trichosporon aneurinolyticum, a new thiamine-destroying fungus. Proc Japan Acad. 1957;33:59–61.
  • Golden MH, Connon JJ. Beriberi heart disease. J Irish Med Assoc. 1972;65:193.
  • Watson JT, El BH, Lebo EJ, Bwire G, Kiyengo J, Emukule G, . Outbreak of beriberi among African Union troops in Mogadishu, Somalia. PLoS ONE. 2011;6:e28345.
  • Cerroni MP, Barrado JC, Nobrega AA, Lins AB, da Silva IP, Mangueira RR, . Outbreak of beriberi in an Indian population of the upper Amazon region, Roraima State, Brazil, 2008. Am J Trop Med Hyg. 2010;83:1093–7.
  • Fozi K, Azmi H, Kamariah H, Azwa MS. Prevalence of thiamine deficiency at a drug rehabilitation centre in Malaysia. Med J Malaysia. 2006;61:519–25.
  • Ikram H, Maslowski AH, Smith BL, Nicholls MG. The haemodynamic, histopathological and hormonal features of alcoholic cardiac beriberi. QJM. 1981;50:359–75.
  • Hailemariam B, Landman JP, Jackson AA. Thiamin status in normal and malnourished children in Jamaica. Br J Nutr. 1985;53:477–83.
  • Laditan AA, Ette SI. Erythrocyte transketolase activity in protein-energy malnutrition. J Trop Med Hyg. 1983;86:85–7.
  • Caridi G, Dagnino M, Lugani F, Shalev SA, Campagnoli M, Galliano M, . A novel mutation in the albumin gene (c.1A>C) resulting in analbuminemia. Eur J Clin Invest. 2013;43:72–8.
  • Russi E, Weigand K. Analbuminemia. Klin Woch. 1983;61:541–5.
  • Neuhaus TJ, Stallmach T, Genewein A. A boy with congenital analbuminemia and steroid-sensitive idiopathic nephrotic syndrome: an experiment of nature. Eur J Pediatr. 2008;167:1073–7.
  • Becker-Cohen R, Belostotsky R, Ben-Shalom E, Feinstein S, Rinat C, Frishberg Y. Congenital analbuminemia with acute glomerulonephritis: a diagnostic challenge. Pediatr Nephrol. 2009;24:403–6.
  • Joles JA, Willekesl-Koolschijn N, Braam B, Kortlandt W, Koomans HA, Dorhout Mees EJ. Colloid osmotic pressure in young analbuminemic rats. Am J Physiol. 1989;257:F23–8.
  • Yaschuk DM, Sanker JM, Zhou J, Wilson N, Keeler R. Abnormal renal response to twenty-four-hour dehydration and fasting in Nagase analbuminemic rats. Lab Anim Sci. 1991;41:577–80.
  • Fujihara CK, Arcos-Fajardo M, Brandao De Almeida PE. Jose Brandao De Almeida Prado M, Sesso A, Zatz R. Enhanced glomerular permeability to macromolecules in the Nagase analbuminemic rat. Am J Physiol Renal Physiol. 2002;282:F45–F50.
  • Shearer GC, Stevenson FT, Atkinson DN, Jones H, Staprans I, Kaysen GA. Hypoalbuminemia and proteinuria contribute separately to reduced lipoprotein catabolism in the nephrotic syndrome. Kidney Int. 2001;59:179–89.
  • Figueira TR, Vercesi AE, Oliveira HC. Lack of plasma albumin impairs intravascular lipolysis and explains the associated free fatty acids deficiency and hypertriglyceridemia. Lipids Health Dis. 2010;9:146.
  • Hua L, Aoki T, Jin Z, Nishino N, Yasuda D, Izumida Y, . Elevation of serum albumin levels in nagase analbuminemic rats by allogeneic bone marrow cell transplantation. Eur Surg Res. 2005;37:111–4.
  • Ross MG, Hayashi R, Murad S, Leake RD, Ervin MG, Fisher DF. Water excretion in preeclampsia: behavior as nephrotic syndrome. Am J Perinatol. 1985;2:283–7.
  • Al Ghazali B, Al-Taie AA-H, Hameed RJ. Study of the clinical significance of serum albumin level in preeclampsia and in the detection of its severity. Am J BioMed. 2014;2:964–74.
  • Seong WJ, Chong GO, Hong DG, Lee TH, Lee YS, Cho YL, . Clinical significance of serum albumin level in pregnancy related hypertension. J Obstet Gynaecol Res. 2010;36:1165–73.
  • Cheek DB, Petrucco OM, Gillespie A, Green RC, Ness D, Dalton M. Muscle cell potassium, RNA and hydration in pregnancy and pre-eclampsia. Early Hum Dev. 1989;19:191–8.
  • Lam GK, Hopoate-Sitake M, Adair CD, Buckalew VM, Johnson DD, Lewis DF. Digoxin antibody fragment, antigen binding (Fab), treatment of preeclampsia in women with endogenous digitalis-like factor: a secondary analysis of the DEEP Trial. Am J Obstet Gynecol. 2013;209:119–16.
  • Adair CD, Haupert GT Jr, Koh HP, Wang Y, Veille JC, Buckalew V. Erythrocyte sodium/potassium ATPase activity in severe preeclampsia. J Perinatol. 2009;29:280–3.
  • Graves SW. Sodium regulation, sodium pump function and sodium pump inhibitors in uncomplicated pregnancy and preeclampsia. Front Biosci. 2007;12:2438–46.
  • Lopatin DA, Ailamazian EK, Dmitrieva RI, Shpen VM, Fedorova OV, Doris PA. Circulating bufodienolide and cardenolide sodium pump inhibitors in preeclampsia. J Hypertens. 1999;17:1179–87.
  • Maxwell CV, Tao QF, Seely EW, Repke JT, Graves SW. Regulation of the sodium pump in pregnancy-related tissues in preeclampsia. Am J Obstet Gynecol. 1998;179:28–34.
  • Forrester TE, Alleyne GAO. Leucocyte electrolytes and sodium efflux rate constants in the hypertension of pre-eclampsia. Clin Sci. 1980;59:199–201s.
  • Patrick J. Oedema in protein energy malnutrition: the role of the sodium pump. Proc Nutr Soc. 1979;38:61–8.
  • Linder GC, Lundsgaard C, Van Slyke DD. The concentration of the plasma proteins in nephritis. J Exp Med. 1924;39:887–920.
  • Linder GC, Lundsgaard C, Van Slyke DD. The globulin and albumin content of the plasma in nephritis. Exp Biol Med. 1923;20:320.
  • Gilbertsen AS, Bashour F. Use of malaria therapy in the nephrotic syndrome. J Am Med Assoc. 1956;160:25–30.
  • Byrne EAJ. Malarial therapy in lipoid nephrosis. Lancet. 1952;259:844–5.
  • Gairdner D. Nephrosis treated by malaria. Lancet. 1952;259:842–4.
  • Hutchins G, Janeway CA. Observations on the relationship of measles and remissions in the nephrotic syndrome. Am J Dis Child. 1947;73:242.
  • Keng GK, Kuipers F. Inoculation with measles virus in therapy of nephrotic syndrome. Ned Tijdschr Geneeskd. 1951;95:1806–14.
  • Lin CY, Hsu HC. Histopathological and immunological studies in spontaneous remission of nephrotic syndrome after intercurrent measles infection. Nephron. 1986;42:110–5.
  • Strauss J, Freundlich M, Zilleruelo G. Nephrotic edema: etiopathogenic and therapeutic considerations. Nephron. 1984;38:73–5.
  • Palmer BF, Alpern RJ. Pathogenesis of edema formation in the nephrotic syndrome. Kidney Int Suppl. 1997;59:S21–7.
  • Bockenhauer D. Over- or underfill: not all nephrotic states are created equal. Pediatr Nephrol. 2013;28:1153–6.
  • Dorhout EJ, Roos JC, Boer P, Yoe OH, Simatupang TA. Observations on edema formation in the nephrotic syndrome in adults with minimal lesions. Am J Med. 1979;67:378–84.
  • Ichikawa I, Rennke HG, Hoyer JR, Badr KF, Schor N, Troy JL. Role for intrarenal mechanisms in the impaired salt excretion of experimental nephrotic syndrome. J Clin Invest. 1983;71:91–103.
  • Doucet A, Favre G, Deschenes G. Molecular mechanism of edema formation in nephrotic syndrome: therapeutic implications. Pediatr Nephrol. 2007;22:1983–90.
  • Valentin JP, Qiu C, Muldowney WP, Ying WZ, Gardner DG, Humphreys MH. Cellular basis for blunted volume expansion natriuresis in experimental nephrotic syndrome. J Clin Invest. 1992;90:1302–12.
  • Deschenes G, Doucet A. Collecting duct (Na+/K+)-ATPase activity is correlated with urinary sodium excretion in rat nephrotic syndromes. J Am Soc Nephrol. 2000;11:604–15.
  • Deschenes G, Wittner M, Stefano A, Jounier S, Doucet A. Collecting duct is a site of sodium retention in PAN nephrosis: a rationale for amiloride therapy. J Am Soc Nephrol. 2001;12:598–601.
  • Juncos LI. Intrarenal mechanisms of salt and water retention in the nephritic syndrome. Kidney Int. 2002;61:1182–95.
  • Besse-Eschmann V, Klisic J, Nief V, Le HM, Kaissling B, Ambuhl PM. Regulation of the proximal tubular sodium/proton exchanger NHE3 in rats with puromycin aminonucleoside (PAN)-induced nephrotic syndrome. J Am Soc Nephrol. 2002;13:2199–206.
  • Feraille E, Vogt B, Rousselot M, Barlet-Bas C, Cheval L, Doucet A, . Mechanism of enhanced Na-K-ATPase activity in cortical collecting duct from rats with nephrotic syndrome. J Clin Invest. 1993;91:1295–300.
  • Deschenes G, Feraille E, Doucet A. Mechanisms of oedema in nephrotic syndrome: old theories and new ideas. Nephrol Dial Transplant. 2003;18:454–6.
  • Klisic J, Zhang J, Nief V, Reyes L, Moe OW, Ambuhl PM. Albumin regulates the Na+/H+ exchanger 3 in OKP cells. J Am Soc Nephrol. 2003;14:3008–16.
  • Besse-Eschmann V, Klisic J, Nief V, Le HM, Kaissling B, Ambuhl PM. Regulation of the proximal tubular sodium/proton exchanger NHE3 in rats with puromycin aminonucleoside (PAN)-induced nephrotic syndrome. J Am Soc Nephrol. 2002;13:2199–206.
  • Klisic J, Hu MC, Nief V, Reyes L, Fuster D, Moe OW. Insulin activates Na(+)/H(+) exchanger 3: biphasic response and glucocorticoid dependence. Am J Physiol Renal Physiol. 2002;283:F532–9.
  • Gekle M, Drumm K, Mildenberger S, Freudinger R, Gassner B, Silbernagl S. Inhibition of Na+-H+ exchange impairs receptor-mediated albumin endocytosis in renal proximal tubule-derived epithelial cells from opossum. J Physiol. 1999;520 Pt 3:709–21.
  • Gekle M. Renal tubule albumin transport. Ann Rev Physiol. 2005;67:573–94.
  • Andersen RF, Buhl KB, Jensen BL, Svenningsen P, Friis UG, Jespersen B. Remission of nephrotic syndrome diminishes urinary plasmin content and abolishes activation of ENaC. Pediatr Nephrol. 2013;28:1227–34.
  • Svenningsen P, Friis UG, Versland JB, Buhl KB, Moller FB, Andersen H, . Mechanisms of renal NaCl retention in proteinuric disease. Acta Physiol. 2013;207:536–45.
  • Svenningsen P, Uhrenholt TR, Palarasah Y, Skjodt K, Jensen BL, Skott O. Prostasin-dependent activation of epithelial Na+ channels by low plasmin concentrations. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1733–41.
  • Svenningsen P, Bistrup C, Friis UG, Bertog M, Haerteis S, Krueger B, . Plasmin in nephrotic urine activates the epithelial sodium channel. J Am Soc Nephrol. 2009;20:299–310.
  • Dane MJ, van den Berg Berg, Avramut MC, Faas FG, van der Vlag J,, . Glomerular endothelial surface layer acts as a barrier against albumin filtration. Am J Pathol. 2013;182:1532–40.
  • Dane MJ, Khairoun M, Lee DH, van den Berg BM, Boels MG, . Association of kidney function with changes in the endothelial surface layer. Clin J Am Soc Nephrol. 2014;9:698–704.
  • Dane MJ, van den Berg BM, Avramut MC, Faas FG, van der Vlag J, Rops A, . Glomerular endothelial surface layer acts as a barrier against albumin filtration. Am J Pathol. 2013;182:1532–40.
  • Foster RR, Armstrong L, Baker S, Wong DW, Wylie EC, Ramnath R, . Glycosaminoglycan regulation by VEGFA and VEGFC of the glomerular microvascular endothelial cell glycocalyx in-vitro. Am J Pathol. 2013;183:604–16.
  • Obeidat M, Obeidat M, Ballermann BJ. Glomerular endothelium: a porous sieve and formidable barrier. Exp Cell Res. 2012;318:964–72.
  • Mathew JL, Kabi BC, Rath B. Anti-oxidant vitamins and steroid responsive nephrotic syndrome in Indian children. J Paediatr Child Health. 2002;38:450–37.
  • Ece A, Atamer Y, Gurkan F, Bilici M, Kocyigit Y. Anti-oxidant status in relation to lipoproteins, leptin and pro-inflammatory cytokines in children with steroid-sensitive nephrotic syndrome. Nephrology. 2004;9:366–73.
  • Ece A, Atamer Y, Gurkan F, Davutoglu M, Kocyigit Y, Tutanc M. Paraoxonase, total antioxidant response, and peroxide levels in children with steroid-sensitive nephrotic syndrome. Pediatr Nephrol. 2005;20:1279–84.
  • Pawluczyk IZ, Ghaderi NM, Patel S, Desai P, Vashi D, Saleem MA. Sialic acid attenuates puromycin aminonucleoside-induced desialylation and oxidative stress in human podocytes. Exp Cell Res. 2014;320:258–68.
  • Gopalan C. Kwashiorkor and marasmus: evolution and distinguishing features. In: McCance RA, Widdowson EM, editors. Calorie Deficiencies and Protein Deficiencies. London: Churchill; 1968; p. 48–58.
  • Kismul H, Van Den Broeck J. Lunde TM. Diet and kwashiorkor: a prospective study from rural DR Congo. PeerJ. 2014;2:e350.
  • Sullivan J, Ndekha M, Maker D, Hotz C, Manary MJ. The quality of the diet in Malawian children with kwashiorkor and marasmus. Matern Child Nutr. 2006;2:114–22.
  • Fawzi W, Herrera MG, Nestel P. Tomato intake in relation to mortality and morbidity among Sudanese children. J Nutr. 2000;130:2537–42.
  • Golden MH. The nature of nutritional deficiency in relation to growth failure and poverty. Acta Paediatr Scand Suppl. 1991;374:95–110.
  • Sive AA, Dempster WS, Malan H, Rosseau S, Heese HD. Plasma free iron: a possible cause of oedema in kwashiorkor. Arch Dis Child. 1997;76:54–6.
  • Hudson MA, Ramdath DD, Golden MH. Iron in malnutrition. West Indian Med J. 1988;37(suppl 1):26–7.
  • Miles J, Golden MH, Ramdath DD, Golden BE. Hepatic trace elements in kwashiorkor. In: Hurley LS, Keen CL, Lonnerdal B, Rucker RB, editors. Trace Element Metabolism in Man and Animals – 6. New York: Plenum Press; 1988; p. 497–8.
  • Ramdath DD, Golden MH. Non-haematological aspects of iron nutrition. Nutr Res Rev. 1989;2:29–49.
  • Golden MH, Ramdath DD, Golden BE. Free radicals and malnutrition. In: Dreosti IE, editor. Trace Elements, Micronutrients and Free Radicals. 1st edn. Totowa, NJ: Humana Press; 1991; p. 199–222.
  • Golden MH, Ramdath D. Free radicals in the pathogenesis of kwashiorkor. Proc Nutr Soc. 1987;46:53–68.
  • Becker K, Pons-Kuhnemann J, Fechner A, Funk M, Gromer S, Gross HJ, . Effects of antioxidants on glutathione levels and clinical recovery from the malnutrition syndrome kwashiorkor – a pilot study. Redox Rep. 2005;10:215–26.
  • Shaaban SY, Nassar MF, Ibrahim SA, Mahmoud SE. Impact of nutritional rehabilitation on enzymatic antioxidant levels in protein energy malnutrition. East Mediterr Health J. 2002;8:290–7.
  • Fechner A, Bohme C, Gromer S, Funk M, Schirmer R, Becker K. Antioxidant status and nitric oxide in the malnutrition syndrome kwashiorkor. Pediatr Res. 2001;49:237–43.
  • Ashour MN, Salem SI, El-Gadban HM, Elwan NM, Basu TK. Antioxidant status in children with protein-energy malnutrition (PEM) living in Cairo. Egypt. Eur J Clin Nutr. 1999;53:669–73.
  • Etukudo MH, Agbedana EO, Akinyinka OO, Osifo BO. Plasma electrolytes, total cholesterol, liver enzymes, and selected antioxidant status in protein energy malnutrition. Afr J Med Sci. 1999;28:81–5.
  • Becker K, Botticher D, Leichsenring M. Antioxidant vitamins in malnourished Nigerian children. Int J Vit Nutr Res. 1994;64:306–10.
  • Berhe N, Halvorsen BL, Gundersen TE, Myrvang B, Gundersen SG, Blomhoff R. Reduced serum concentrations of retinol and alpha-tocopherol and high concentrations of hydroperoxides are associated with community levels of S. mansoni infection and schistosomal periportal fibrosis in Ethiopian school children. Am J Trop Med Hyg. 2007;76:943–9.
  • Ece A, Gurkan F, Celik F, Bosnak M, Yel S, Balik H. Paraoxonase, total antioxidant activity and peroxide levels in marasmic children: relationships with leptin. Clin Biochem. 2007;40:634–9.
  • Reddy YN, Murthy SV, Krishna DR, Prabhakar MC. Oxidative stress and anti-oxidant status in leprosy patients. Indian J Lepr. 2003;75:307–16.
  • Tatli MM, Vural H, Koc A, Kosecik M, Atas A. Altered anti-oxidant status and increased lipid peroxidation in marasmic children. Pediatr Int. 2000;42:289–92.
  • Adelekan DA, Adeodu OO, Thurnham DI. Comparative effects of malaria and malnutrition on plasma concentrations of antioxidant micronutrients in children. Ann Trop Paediatr. 1997;17:223–7.
  • Houssaini FZS, Arnaud J, Richard MJ, Renversez JC, Favier A. Evaluation of oxidative stress and antioxidant protective factors in malnourished, Moroccan children. Ann Nutr Metabol. 1997;41:149–59.
  • Michelis R, Kristal B, Snitkovsky T, Sela S. Oxidative modifications impair albumin quantification. Biochem Biophys Res Com. 2010;401:137–42.
  • Ciliberto H, Ciliberto M, Briend A, Ashorn P, Bier D, Manary M. Antioxidant supplementation for the prevention of kwashiorkor in Malawian children: randomised, double blind, placebo controlled trial. Br Med J. 2005;330:1109–14.
  • Siega-Riz AM, Estrada Del CY, Kinlaw A, Reinhart GA, Allen LH, Shahab-Ferdows S, . Effect of supplementation with a lipid-based nutrient supplement on the micronutrient status of children aged 6–18 months living in the rural region of Intibuca, Honduras. Paediatr Perinat Epidemiol. 2014;28:245–54.
  • Grellety E, Shepherd S, Roederer T, Manzo ML, Doyon S, Ategbo EA, . Effect of mass supplementation with ready-to-use supplementary food during an anticipated nutritional emergency. PLoS ONE. 2012;7:e44549.
  • Abbeddou S, Hess SY, Yakes Jimenez E, Somé JW, Vosti SA, Guissou RM, . Comparison of methods to assess adherence to small-quantity lipid-based nutrient supplements (SQ-LNS) and dispersible tablets among young Burkinabé children participating in a community-based intervention trial. Matern Child Nutr. 2015;., http://dx.doi.org/10.1111/mcn.12162:n/a.
  • Kehoe SH, Chheda PS, Sahariah SA, Baird J, Fall CH. Reporting of participant compliance in randomized controlled trials of nutrition supplements during pregnancy. Matern Child Nutr. 2009;5:97–103.
  • Matilsky DK, Maleta K, Castleman T, Manary MJ. Supplementary feeding with fortified spreads results in higher recovery rates than with a corn/soy blend in moderately wasted children. J Nutr. 2009;139:773–8.
  • Leichsenring M, Sutterlin N, Less S, Baumann K, Anninos A, Becker K. Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein-energy malnutrition. Acta Paediatr. 1995;84:516–20.
  • Lenhartz H, Ndasi R, Anninos A, Botticher D, Mayatepek E, Tetanye E, . The clinical manifestation of the kwashiorkor syndrome is related to increased lipid peroxidation. J Pediatr. 1998;132:879–81.
  • Singh A, Ramnath RD, Foster RR, Wylie EC, Friden V, Dasgupta I, . Reactive oxygen species modulate the barrier function of the human glomerular endothelial glycocalyx. PLoS One. 2013;8:e55852.
  • Rubio-Gayosso I, Platts SH, Duling BR. Reactive oxygen species mediate modification of glycocalyx during ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2006;290:H2247–56.
  • Vink H, Constantinescu AA, Spaan JA. Oxidized lipoproteins degrade the endothelial surface layer implications for platelet-endothelial cell adhesion. Circulation. 2000;101:1500–2.
  • Abrahamsson T, Brandt U, Marklund SL, Sjoqvist PO. Vascular bound recombinant extracellular superoxide dismutase type C protects against the detrimental effects of superoxide radicals on endothelium-dependent arterial relaxation. Circulation Res. 1992;70:264–71.
  • Winick M. Hunger Disease: Physicians of the Warsaw Ghetto. New York: Wiley; 1979.
  • Wiig H, Gyenge C, Iversen PO, Gullberg D, Tenstad O. The role of the extracellular matrix in tissue distribution of macromolecules in normal and pathological tissues: potential therapeutic consequences. Microcirculation. 2008;15:283–96.
  • Gyenge CC, Tenstad O, Wiig H. In vivo determination of steric and electrostatic exclusion of albumin in rat skin and skeletal muscle. J Physiol. 2003;552:907–16.
  • Watson PD, Bell DR, Renkin EM. Early kinetics of large molecule transport between plasma and lymph in dogs. Am J Physiol. 1980;239:H525–31.
  • Comper WD, Williams RP, Zamparo O. Water transport in extracellular matrices. Connective Tissue Res. 1990;25:89–102.
  • Edmond E, Ogston AG. Phase separation in an aqueous quaternary system. Biochem J. 1970;117:85–9.
  • Ogston AG, Silpananta P. The thermodynamics of interaction between Sephadex and penetrating solutes. Biochem J. 1970;116:171–5.
  • Wiggins PM, van Ryn RT. Changes in ionic selectivity with changes in density of water in gels and cells. Biophys J. 1990;58:585–96.
  • Wells JD. Salt activity and osmotic pressure in connective tissue. I. A study of solutions of dextran sulphate as a model system. Proc R Soc Lond Series B Biol Sci. 1973;183:399–419.
  • Maroudas A, Weinberg PD, Parker KH, Winlove CP. The distributions and diffusivities of small ions in chondroitin sulphate, hyaluronate and some proteoglycan solutions. Biophys Chem. 1988;32:257–70.
  • Katz MA, Schaeffer RC Jr, Gratrix M, Mucha D, Cárbajal J. The glomerular barrier fits a two-pore-and-fiber-matrix model: derivation and physiologic test. Microvasc Res. 1999;57:227–43.
  • Zheng Q, Durben DJ, Wolf GH, Angell CA. Liquids at large negative pressures: water at the homogeneous nucleation limit. Science. 1991;254:829–32.
  • Lampinen MJ, Noponen T. Thermodynamic analysis of the interaction of the xylem water and phloem sugar solution and its significance for the cohesion theory. J Theoret Biol. 2003;224:285–98.
  • Golden MH. Oedematous malnutrition. Br Med Bull. 1998;54:433–44.
  • Golden MH, Brooks SE, Ramdath DD, Taylor E. Effacement of glomerular foot processes in kwashiorkor. Lancet. 1990;336:1472–4.
  • Amadi B, Fagbemi AO, Kelly P, Mwiya M, Torrente F, Salvestrini C. Reduced production of sulfated glycosaminoglycans occurs in Zambian children with kwashiorkor but not marasmus. Am J Clin Nutr. 2009;89:592–600.
  • Chandrasekaran EV, Mukherjee KL, Bachhawat BK. Isolation and characterization of glycosaminoglycans from brain of children with protein-calorie malnutrition. J Neurochem. 1971;18:1913–20.
  • Mohanram M, Reddy V. Urinary excretion of acid mucopolysaccharides in kwashiorkor and vitamin A-deficient children. Clin Chim Acta. 1971;34:93–6.
  • Latif KA, Amla I, Rama Rao PB. Studies on skin and urinary mucopolysaccharides in malnourished/vitamin A deficient children. Clin Chim Acta. 1982;122:317–25.
  • Brown RE, Jelliffe DB. Decreased elasticity of the auricular cartilage in Ugandan children with kwashiorkor. Am J Clin Nutr. 1967;20:1230–3.
  • Katta J, Stapleton T, Ingham E, Jin ZM, Fisher J. The effect of glycosaminoglycan depletion on the friction and deformation of articular cartilage. Proc Inst Mech Eng H. 2008;222:1–11.
  • Vernier RL, Klein DJ, Sisson SP. Heparan sulfate-rich anionic sites in the human glomerular basement membrane: decreased concentration in congenital nephrotic syndrome. N Engl J Med. 1983;309:1001–9.
  • Michael AF, Blau E, Vernier RL. Glomerular polyanion: alteration in aminonucleoside nephrosis. Lab Invest. 1970;23:649–57.
  • Bellini C, Hennekam R. Non-immune hydrops fetalis: a short review of etiology and pathophysiology. Am J Med Genet Part A. 2012;158:597–605.
  • Collins SR, Blank RS, Deatherage LS, Dull RO. Special article: the endothelial glycocalyx: emerging concepts in pulmonary edema and acute lung injury. Anesth Analg. 2013;117:664–74.
  • Gotloib L, Shostak A, Galdi P, Jaichenko J, Fudin R. Loss of microvascular negative charges accompanied by interstitial edema in septic rats' heart. Circ Shock. 1992;36:45–56.
  • Strunden MS, Bornscheuer A, Schuster A, Kiefmann R, Goetz AE, Heckel K. Glycocalyx degradation causes microvascular perfusion failure in the ex vivo perfused mouse lung: hydroxyethyl starch 130/0.4 pretreatment attenuates this response. Shock. 2012;38:559–66.
  • van den Berg BM, Vink H, Spaan JA. The endothelial glycocalyx protects against myocardial edema. Circulation Res. 2003;92:592–4.
  • Vanteeffelen JW. How to prevent leaky vessels during reperfusion? Just keep that glycocalyx sealant in place. Crit Care. 2008;12:167.
  • Yang Y, Schmidt EP. The endothelial glycocalyx: an important regulator of the pulmonary vascular barrier. Tissue Barriers. 2013;1:pii23494.
  • Zausig YA, Chappell D, Becker BF, Potschka D, Busse H, Nixdorf K, . The impact of crystalloidal and colloidal infusion preparations on coronary vascular integrity, interstitial oedema and cardiac performance in isolated hearts. Crit Care. 2013;17:R203.
  • Constantinescu AA, Vink H, Spaan JA. Elevated capillary tube hematocrit reflects degradation of endothelial cell glycocalyx by oxidized LDL. Am J Physiol. 2001;280:H1051–7.
  • Lipowsky HH, Lescanic A. The effect of doxycycline on shedding of the glycocalyx due to reactive oxygen species. Microvasc Res. 2013;90:80–5.
  • Gouverneur M, Broekhuizen L, Meuwese M, Mooij H, Stroes E, Vink H. Sulfated glycosaminoglycans restore glycocalyx barrier properties of cultured endothelial cells in hyperglycemia. FASEB J. 2008;22, (Meeting Abstract supplement 83).
  • Josephine A, Amudha G, Veena CK, Preetha SP, Rajeswari A, Varalakshmi P. Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by cyclosporine A in rat kidney. Mol Nutr Food Res. 2007;51:1413–22.
  • Suter A, Bommer S, Rechner J. Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: a review of 5 clinical studies. Adv Ther. 2006;23:179–90.
  • Chappell D, Bruegger D, Potzel J, Jacob M, Brettner F, Vogeser M, . Hypervolemia increases release of atrial natriuretic peptide and shedding of the endothelial glycocalyx. Crit Care. 2014;18:538.
  • Maitland K, Babiker A, Kiguli S, Molyneux E. The FEAST trial of fluid bolus in African children with severe infection. Lancet. 2012;379:613–4.
  • Jackson AA. Blood glutathione in severe malnutrition in childhood. Trans R Soc Trop Med Hyg. 1986;80:911–3.
  • Reid M, Badaloo A, Forrester T, Morlese JF, Frazer M, Heird WC, . In vivo rates of erythrocyte glutathione synthesis in children with severe protein–energy malnutrition. Am J Physiol. 2000;278:E405–12.
  • Badaloo A, Reid M, Forrester T, Heird WC, Jahoor F. Cysteine supplementation improves the erythrocyte glutathione synthesis rate in children with severe edematous malnutrition. Am J Clin Nutr. 2002;76:646–52.
  • Badaloo A, Hsu JW, Taylor-Bryan C, Green C, Reid M, Forrester T. Dietary cysteine is used more efficiently by children with severe acute malnutrition with edema compared with those without edema. Am J Clin Nutr. 2012;95:84–90.
  • Luckner H. Über das Ernährungsödem und seine Entstehung. Tierexperimentelle Untersuchungen. Z Ges Exp Med. 1938;103:563–85.
  • Waterlow JC, Alleyne GAO. Protein Malnutrition in Children: Advances in Knowledge in the Last Ten Years. Adv Prot Chem. 1971;25:117–241, http://www.sciencedirect.com/science/article/pii/S0065323308602806.
  • Waterlow JC. Protein-Energy Malnutrition. London: Edward Arnold; 1992.
  • Forrester T, Golden MH, Brand S, Swales J. Reduction in vitro of red cell glutathione reproduces defects of cellular sodium transport seen in oedematous malnutrition. Eur J Clin Nutr. 1990;44:363–9.
  • Liu SH, Chu HI, Wang SH, Chung HL. Nutritional edema: 1. The effects of the level and quality of protein intake on nitrogen balance, plasma proteins and edema. Chinese J Physiol. 1932;VI:73–94.
  • Petrides EP. Hunger edema in children. J Pediatr. 1948;32:333–50.
  • Wharton BA, Howells GR, McCance RA. Cardiac failure in kwashiorkor. Lancet. 1967;ii:384–7.

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