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Acta Clinica Belgica
International Journal of Clinical and Laboratory Medicine
Volume 64, 2009 - Issue 1
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Original Articles

METFORMIN AND LACTIC ACIDOSIS IN PATIENTS WITH TYPE 2 DIABETES – FROM PRIDE AND PREJUDICE TO SENSE AND SENSIBILITY

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Pages 42-48 | Published online: 09 Jan 2014

References

  • Fantus IG. Metformin's contraindications: needed for now. CMAJ 2005; 173: 505–7.
  • Misbin RI. The phantom of Lactic acidosis due to metformin inpatients with diabetes. Diabetes Care 2004; 27: 1791–3.
  • UK Prospective Diabetes Study (UKPDS) Group. Effect of inten-sive bLood-gLucose controL with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998; 352: 854–65.
  • HoLstein A, StumvoLL M. Contraindications can damage your heaLth - is metformin a case in point? Diabetologia 2005; 48: 2454–9.
  • McCormack J, Johns K, TiLdesLey H. Metformin's contraindications shou Ed be contraindicated. CMAJ 2005; 173: 502–4.
  • EmsLie-Smith AM, BoyEe DI, Evans JM, Sullivan F, Morris AD. Contraindications to metformin therapy in patients with Type 2 diabetes - a popuLation-based study of adherence to prescrib-ing guidelines. Diabet Med 2001; 18:483–8.
  • HoLstein A, Egberts E-H. TraditionaL contraindications to the use of metformin - more harmfuL than beneficiaL?Dtsch Med Wschr 2006; 131: 105–10.
  • StacpooLe PW. Metformin and Lactic acidosis: gat by association (Ed itoria L). Diabetes Care 1998; 21: 1587–8.
  • Stades AM, Heikens JT, ErkeLens DW, Haeman F, Hoekstra JB. Metformin and Lactic acidosis: cause or coincidence? A review of case reports. J Intern Med 2004; 255: 179–87.
  • Stades AME, Heikens JT, Haeman F, Hoekstra JBL. Metformin - current restrictions shouLd be alieviated. J Intern Med 2004; 256: 358.
  • Chang CT, Chen YC, Fang JT, Huang CC. Metformin-associated Lactic acidosis: case reports and Literature review.' Nephrol 2002; 15: 398–402.
  • Chu CK, Chang YT, Lee BJ, Hu SY, Hu WH, Yang DY. Metformin-associated Lactic acidosis and acute renaE faiLure in a type 2 diabetic patient. J Chin Med Assoc 2003; 66: 505–8.
  • Orban JC, Giunti C, Levraut J, Grimaud D, Ichai C. Metformin-associated Lactic acidosis remains a serious complication of metformin therapy. Ann Fr Anesth Reanim 2003; 22: 461–5.
  • Moerer O, Barwing J, Neumann P. Lactic acidosis and acute abdomen from biguanide intoxication. Anaesthesist 2004; 53: 153–6.
  • Becker C, LuginbühL A, PittE U, SchLienger R. Metformin-associ-ated Lactic acidosis in a patient with pre-existing risk factors. Schweiz Rundsch Med Prax 2005; 94: 1402–7.
  • Brassoe R, ELkmann T, HempeL M, GravhoLt CH. FuLminant Lactic acidosis in two patients with Type 2 diabetes treated with metformin. Diabet Med 2005; 22: 1451–3.
  • DePaLo VA, MaiLer K, Yoburn D, Crausman RS. Lactic acidosis as-sociated with metformin use in treatment of type 2 diabetes meLLitus. Geriatrics 2005; 60: 36–41.
  • Fox GN. Metformin in type 2 diabetes. J Fam Pract 2004; 53: 900.
  • Nyirenda MJ, Sandeep T, Grant I, Price G, McKnight JA. Severe acidosis in patients taking metformin--rapid reversaL and sur-vivaL despite high APACHE score. Diabet Med 2006; 23:432–5.
  • Friesecke S, AbeL P, Kraft M, Gerner A, Runge S. Combined renaE repLacement therapy for severe metformin-induced Lactic aci-dosis. Nephrol Dial Transplant 2006; 21: 2038–9.
  • Shenoy C. Metformin-associated Lactic acidosis precipitated by acute renaE fah re. Am J Med Sci 2006; 331: 55–7.
  • EL-Hennawy AS, Jacob S, Mahmood AK. Metformin-associated Lactic acidosis precipitated by diarrhea. Arn J Ther 2007; 14:403–5.
  • Ortega Carnicer J, Ambrps Checa A, Martin Rodriguez C, Ruiz Lorenzo F, Portilla BoteLho M, Górnez Grande L. Metformin secondary to acute renaE insufficiency:a report of six cases. Med lntensiva 2007; 31: 521–5.
  • ALivanis P, Giannikouris I, PaLiuras C, Arvanitis A, VoLanaki M, Zervos A. Metformin-associated Lactic acidosis treated with continuous renaE repLacement therapy. Clin Ther 2006; 28:396–400.
  • Berner B, HummeL KM, Strutz F, et al Metformin-associated Lactic acidosis with acute renaE faiLure in type 2 diabetes meL-Litus. Med Klin (Munich) 2002; 97: 99–103.
  • Pertek JP, VidaL S, Mariot J, GaLy-FLoc'h M, AzouLay E. Metformin-associated Lactic acidosis precipitated by acute renaE faiLure. Ann Fr Anasth Réanim 2003; 22:457–60.
  • Chan NN, Brain HP, Feher MD. Metformin-associated Lactic acidosis: a rare or very rare cLinicaL entity? DiabetMed 1999; 16: 273–81.
  • LaEau J, Race J. Metformin and Lactic acidosis in diabetic humans. Diabetes Obes Metab 2000; 2:131–7.
  • Stang M, Wysowski DK, ButLer-Jones D. Incidence of Lactic aci-dosis in metformin users. Diabetes Care 1999; 22: 925–7.
  • Misbin RI, Green L, StadeL BV, Gueriguian JL, Gubbi A, FLeming GA. Lactic acidosis in patients with diabetes treated with met-formin. New EngIJ Med 1998; 338: 265–6.
  • SaLpeter SR, Greyber E, Pasternak G, SaLpeter E. Risk of fataE and non-fataL Lactic acidosis with metformin use in type 2 diabetes meLLitus. Cochrane Database Syst Rev 2006; 1 CD002967.
  • Kamber N, Davis WA, Bruce DG, Davis TM. Metformin and Lactic acidosis in an Australian community setting: the FremantLe Diabetes Study. Med J Aust 2008; 188:446–9.
  • BaiLey CJ, Turner RC. Metformin. New Engl J Med 1996; 334: 574–9.
  • BaiLey CJ, HowLett HC. Defining the risk of Lactic acidosis. In: BaiLey CJ, CampbeLL IW, Chan JC (Eds). Metformin: the goLd standard. Chichester, UK: WiLey, 2007: 185–192.
  • Runge S, MayerLe J, Warnke C, et al Metformin-associated Lactic acidosis in patients with renaE impairment soLeLy due to drug accu mu Lation? Diabetes Obes Metabolism 2008; 10:91–3.
  • Shaw JS, WiLmot RL, KiLpatrick ES. Establishing pragmatic esti-mated GFR threshoLds to guide metformin prescribing. Diabet Med 2007; 24:1160–3.
  • SeEby JV, Ettinger B, Swain BE, Brown JB. First 20 months' expe-rience with use of metformin for type 2 diabetes in a Large heaLth maintenance organization. Diabetes Care 1999 22: 38–44.
  • Gregorio F, Ambrosi F, FiLipponi P, Manfrini S, Testa I. Is met-formin safe enough for ageing type 2 diabetic patients? Diabe-tes Metab 1996; 22: 43–50.
  • HoLstein A, NahrwoLd D, Hinze S, Egberts E-H. Contra-indications to metformin are LargeLy disregarded. Diabet Med 1999; 16: 692–6.
  • Luft D, DeichseL G, Schmuffing RM, Stein N, Eggstein M. Defini-tion of clinicaRy reLevant Lactic acidosis in patients with internaL diseases. Am J Clin Pathol 1983; 80:484–9.
  • Davis TM, Jackson D, Davis WA, Bruce DG, Chubb P. The reLation-ship between metformin therapy and the fasting pLasma Lactate in type 2 diabetes: the FremantLe Diabetes Study. BrJ Clin Phar-macol 2001; 52: 137–44.
  • Franzetti I, Pack) D, Marco G, EmanueLa M, Elisabetta Z, Renato U. Possible synergistic effect of metformin and enaLapriL on the deveLopment of hyperka Liemic Lactic acidosis. Diabetes Res Clin Pract 1997; 38: 173–6.
  • Chan NN, FauveL NJ, Feher MD. Non-steroidaL anti-inflamma-tory drugs and metformin: a cause for concern? Lancet 1998; 352: 201.
  • Lim VCC, Sum CF, Chan ESY, Yeoh LY, Lee YM, Lim SC. Lactate LeveLs in Asian patients with type 2 diabetes meLLitus on met-formin and its association with dose of metformin and renaE function. Int J Clin Pract 2007; 61: 1829–33.
  • Kennedy L, Herman WH. Renal status among patients using metformin in a primary care setting. Diabetes Care 2005; 28: 922–4.
  • Gras V, Bouffandeau B, Montravers PH, Lalau JD. Effect of met-formin on survival rate in experimental sepsis. Diabetes Metab 2006; 32: 147–50.
  • Johnson JA, Simpson SH, Toth EL, Majumdar SR. Reduced car-diovascular morbidity and mortality associated with met-formin use in subjects with Type 2 diabetes. Diabet Med 2005; 22: 497–502.
  • Simpson SH, Majumdar SR, Tsuyuki RT, Eurich DT, Johnson JA. Dose-response relation between sulfonylurea drugs and mortal-ity in type 2 diabetes mellitus:a population-based cohort study. CMAJ 2006; 174: 169–74.

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