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Articles

Immunohistochemistry of Small Blue Round Cell Tumors

Pages 229-234 | Published online: 29 Nov 2013

References

  • Paulussen M, Frohlich B, Jurgens H: Ewing tumour: inci-dence, prognosis and treatment options. Paediatr Drugs 3: 899–913, 2001
  • Bisogno G, Roganovich J, Sotti G, Ninfo V, di Montezemolo LC, Donfrancesco A, et al: Desmoplastic small round cell tumour in children and adolescents. Med Pediatr Oncol 34: 338–342, 2000
  • Crist WM, Anderson JR, Meza JL, Fryer C, Raney RB, Ruy-mann FB, et al: Intergroup rhabdomyosarcoma study-IV: re-sults for patients with nonmetastatic disease. J Clin Oncol 19:3091–3102, 2001
  • Polin RS, Sheehan JP, Chenelle AG, Munoz E, Lamer J, Phil-lips CD, et al: The role of preoperative adjuvant treatment in the management of esthesioneuroblastoma: the University of Virginia experience. Neurosurgery 42:1029–1037, 1998
  • Stocker JT, Dehner LP: Pediatric Pathology (Second Edition). Lippincott Williams & Wilkins, Philadelphia, 2001
  • Newton WA, Jr, Gehan EA, Webber BL, Marsden HB, van Unnik AJ, Hamoudi AB, et al: Classification of rhabdomyo-sarcomas and related sarcomas. Pathologic aspects and pro-posal for a new classification—an Intergroup Rhabdomyosar-coma Study. Cancer 76:1073–1085, 1995
  • Qualman SJ, Coffin CM, Newton WA, Hojo H, Triche TJ, Parham DM, et al: Intergroup Rhabdomyosarcoma Study: up-date for pathologist. Pediatr Dev Pathol 1:550–561, 1998
  • Wang NP, Marx J, McNutt MA, Rutledge JC, Gown AM: Expression of myogenic regulatory proteins (myogenin and MyoD1) in small blue round cell tumors of childhood. Am J Pathol 147:1799–1810, 1995
  • Mukai K, Rosai J, Hallaway BE: Localization of myoglobin in normal and neoplastic human skeletal muscle cells using an immunoperoxidase method. Am J Surg Pathol 3:373–376, 1979
  • Brooks JJ: Immunohistochemistry of soft tissue tumors. Myo-globin as a tumor marker for rhabdomyosarcoma. Cancer 50: 1757–1763, 1982
  • Kindblom LG, Seidal T, Karlsson K: Immuno-histochemical localization of myoglobin in human muscle tissue and em-bryonal and alveolar rhabdomyosarcoma. Acta Pathol Micro-biol Immunol Scand 90:167–174, 1982
  • Parham DM, Dias P, Kelly DR, Rutledge JC, Houghton P: Desmin positivity in primitive neuroectodermal tumors of childhood. Am J Surg Pathol 16:483–492, 1992
  • Jong AS, van Vark M, Albus-Lutter CE, van Raamsdonk W, Voute PA: Myosin and myoglobin as tumor markers in the diagnosis of rhabdomyosarcoma. A comparative study. Am J Surg Pathol 8:521–528, 1984
  • Eusebi V, Bondi A, Rosai J: Immunohistochemical localiza-tion of myoglobin in nonmuscular cells. Am J Surg Pathol 8:51–55, 1984
  • Tsokos M: The role of immunocytochemistry in the diagnosis of rhabdomyosarcoma [editorial]. Arch Pathol Lab Med 110: 776–778, 1986
  • Altmannsberger M, Weber K, Droste R, Osborn M: Desmin is a specific marker for rhabdomyosarcomas of human and rat origin. Am J Pathol 118:85–95, 1985
  • Azumi N, Ben-Ezra J, Battifora H: Immunophenotypic diag-nosis of leiomyosarcomas and rhabdomy °sarcomas with monoclonal antibodies to muscle-specific actin and desmin in formalin-fixed tissue. Mod Pathol 1:469–474, 1988
  • Leader M, Collins M, Patel J, Henry K: Desmin: its value as a marker of muscle derived tumours using a commercial an-tibody. Virchows Arch A Pathol Anat Histopathol 411:345–349, 1987
  • Parham DM, Webber B, Holt H, Williams WK, Maurer H: Immunohistochemical study of childhood rhabdomyosarco-mas and related neoplasms. Results of an intergroup rhabdo-myosarcoma study project. Cancer 67:3072–3080, 1991
  • Folpe AL, Patterson K, Gown AM: Antibodies to desmin identify the blastemal component of nephroblastoma. Mod Pathol 10:895–900, 1997
  • Gerald WL, Miller HK, Battifora H, Miettinen M, Silva EG, Rosai J: Intra-abdominal desmoplastic small round-cell tumor. Report of 19 cases of a distinctive type of high-grade poly-phenotypic malignancy affecting young individuals [see com-ments]. Am J Surg Pathol 15:499–513, 1991
  • Tsukada T, McNutt MA, Ross R, Gown AM: HHF35, a muscle actin-specific monoclonal antibody. II. Reactivity in normal, reactive, and neoplastic human tissues. Am J Pathol 127:389–402, 1987
  • Tsukada T, Tippens D, Gordon D, Ross R, Gown AM: HHF35, a muscle-actin-specific monoclonal antibody. I. Im-munocytochemical and biochemical characterization. Ant J Pathol 126:51–60, 1987
  • Skalli O, Ropraz P, Trzeciak A, Benzonana G, Gillessen D, Gabbiani G: A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 103 (6 Pt 2):2787–2796, 1986
  • Schurch W, Skalli 0, Seemayer TA, Gabbiani G: Intermediate filament proteins and actin isoforms as markers for soft tissue tumor differentiation and origin I. Smooth muscle tumors. Am J Pathol 128:91–103, 1987
  • Skalli O, Gabbiani G, Babai F, Seemayer TA, Pizzolato G, Schurch W: Intermediate filament proteins and actin isoforms as markers for soft tissue tumor differentiation and origin. II. Rhabdomyosarcomas. Am J Pathol 130:515–531, 1988
  • Schmidt RA, Cone R, Haas JE, Gown AM: Diagnosis of rhab-domyosarcomas with HHF35, a monoclonal antibody directed against muscle actins. Am J Pathol 131:19–28, 1988
  • Rangdaeng S, Truong LD: Comparative immunohistochemi-cal staining for desmin and muscle-specific actin. A study of 576 cases [see comments]. Am J Clin Pathol 96:32–45, 1991
  • Davis RL, Weintraub H, Lassar AB: Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 51: 987–1000, 1987
  • Tapscott SJ, Davis RL, Thayer MJ, Cheng PF, Weintraub H, Lassar AB: MyoD 1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts. Science 242:405–411, 1988
  • Aurad'e F, Pinset C, Chafey P, Gros F, Montanas D. Myf5, MyoD, myogenin and MRF4 myogenic derivatives of the em-bryonic mesenchymal cell line C3H10T1/2 exhibit the same adult muscle phenotype. Differentiation 55:185–192, 1994
  • Dias P, Dilling M, Houghton P: The molecular basis of skel-etal muscle differentiation. Semi,' Diagn Pathol 11:3–14, 1994
  • Weintraub H, Davis R, Tapscott S, Thayer M, Krause M, Benezra R, et al: The myoD gene family: nodal point during specification of the muscle cell lineage. Science 251:761–766, 1991
  • Wright WE, Binder M, Funk W: Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site. Mol Cell Biol 11:4104–4110, 1991
  • Dias P, Parham DM, Shapiro DN, Tapscott SJ, Houghton PJ: Monoclonal antibodies to the myogenic regulatory protein MyoDI: epitope mapping and diagnostic utility. Cancer Res 52:6431–6439, 1992
  • Dias P, Chen B, Dilday B, Palmer H, Hosoi H, Singh S, et al: Strong immunostaining for myogenin in rhabdomyosarcoma is significantly associated with tumors of the alveolar sub-class. Am J Pathol 156:399–408, 2000
  • Kumar S, Perlman E, Harris CA, et al: A recent study has confirmed the very high specificity and sensitivity of antibod-ies to myogenin for all forms of rhabdomyosarcoma. Modern Pathol 2000;13:988–993.
  • Downing JR, Head DR, Parham DM, Douglass EC, Hulshof MG, Link MP, et al: Detection of the (11;22)(q24;q12) trans-location of Ewing's sarcoma and peripheral neuroectodermal tumor by reverse transcription polymerase chain reaction. Am J Pathol 143:1294–1300, 1993.
  • Delattre O, Zucman J, Melot T, Garau XS, Zucker JM, Lenoir GM, et al: The Ewing family of tumors—a subgroup of small-round-cell tumors defined by specific chimeric transcripts [see comments]. N Engl J Med 331:294–299, 1994
  • Melot T, Gruel N, Doubeikovski A, Sevenet N, Teillaud IL, Delattre O: Production and characterization of mouse mono-clonal antibodies to wild-type and oncogenic FLT-1 proteins. Hybridonta 16(5):457–464, 1997
  • Folpe AL, Hill CE, Parham DM, O'Shea PA, Weiss SW: Immunohistochemical detection of FLI-1 protein expression: a study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing's sarcoma/primitive neuroectoder-mal tumor. Am J Surg Pathol 24:1657–1662, 2000
  • Llombart-Bosch A, Navarro S: Immunohistochemical detec-tion of EWS and FLI-1 proteins in Ewing sarcoma and primi-tive neuroectodermal tumors: comparative analysis with CD99 (MIC-2) expression. Appl Immunohistochem Mol Mor-phol 9:255–260, 2001
  • Folpe AL, Chand EM, Goldblum JR, Weiss SW: Expression of flu-I, a nuclear transcription factor, distinguishes vascular neoplasms from potential mimics. Am J Surg Pathol 25:1061–1066, 2001
  • Fellinger EJ, Garin-Chesa P, Triche Ti, Huvos AG, Rettig WJ: Immunohistochemical analysis of Ewing's sarcoma cell sur-face antigen p30/32MIC2. Am J Pathol 139:317–325, 1991
  • Fellinger EJ, Garin-Chesa P, Glasser DB, Huvos AG, Rettig WJ: Comparison of cell surface antigen HBA71 (p30/32MIC2), neuron-specific enolase, and vimentin in the immu-nohistochemical analysis of Ewing's sarcoma of bone. Am J Surg Pathol 16:746–755, 1992
  • Perlman EJ, Dickman PS, Askin FB, Grier HE, Miser JS, Link MP: Ewing's sarcoma—routine diagnostic utilization of MIC2 analysis: a Pediatric Oncology Group/Children's Can-cer Group Intergroup Study. H1,1171 Pathol 25: 304-307, 1994
  • Ramani P, Rampling D, Link M: Immunocytochemical study of 12E7 in small round-cell tumours of childhood: an assess-ment of its sensitivity and specificity. Histopathology 23:557–561, 1993
  • Riopel M, Dickman PS, Link MP, Perlman EJ: MIC2 analysis in pediatric lymphomas and leukemias. Hum Pathol 25:396—399, 1994
  • Weidner N, Tjoe J: Immunohistochemical profile of monoclo-nal antibody 013: antibody that recognizes glycoprotein p30/ 32MIC2 and is useful in diagnosing Ewing's sarcoma and peripheral neuroepithelioma. Am J Surg Pathol 18:486–494, 1994
  • Renshaw AA: 013 (CD99) in spindle cell tumors. Appl 1171-munohistochem 3: 250-256, 1995
  • Folpe AL, Schmidt RA, Chapman D, Gown AM: Poorly differentiated synovial sarcoma: immunohistochemical distinc-tion from primitive neuroectodermal tumors and high-grade malignant peripheral nerve sheath tumors. Am J Surg Pathol 22:673–682, 1998.
  • Franks LM, Bollen A, Seeger RC, Stram DO, Matthay KK: Neuroblastoma in adults and adolescents: an indolent course with poor survival. Cancer 79:2028–2035,1997
  • Ambros IM, Zellner A, Roald B, Amann G, Ladenstein R, Printz D, et al: Role of ploidy, chromosome lp, and Schwann cells in the maturation of neuroblastoma. N Engl J Med 334: 1505–1511, 1996
  • Wick MR: Immunohistology of neuroendocrine and neuroectodermal tumors. Semin Diagn Pathol 17:194–203, 2000
  • Franquemont DW, Mills SE, Lack EE: Immunohistochemical detection of neuroblastomatous foci in composite adrenal pheochromocytoma-neuroblastoma. Am J Clin Pathol 102: 163–170, 1994
  • Hicks MJ, Mackay B: Comparison of ultrastructural features among neuroblastic tumors: maturation from neuroblastoma to ganglioneuroma. Ultrastruct Pathol 19:311–322, 1995
  • Romansky SG, Crocker DW, Shaw KN: Ultrastructural stud-ies on neuroblastoma: evaluation of cytodifferentiation and correlation of morphology and biochemical and survival data. Cancer 42:2392–2398, 1978.
  • Osborn M, Weber K: Tumor diagnosis by intermediate fila-ment typing. Lab Invest 48:372–394, 1983
  • Mukai M, Torikata C, In H, Morikawa Y, Shimizu K, Shi-moda T, et al: Expression of neurofilament triplet proteins in human neural tumors. An immunohistochemical study of paraganglioma, ganglioneuroma, ganglioneuroblastoma, and neuroblastoma. Am J Pathol 122:28–35, 1986
  • Gould VE, Wiedenmann B, Lee I, Schwechheimer K, Dock-horn-Dworniczak B, Radosevich JA, et al: Synaptophysin ex-pression in neuroendocrine neoplasms as determined by im-munocytochemistry. Am J Pathol 126:243–257, 1987
  • Gould YE, Lee I, Wiedenmann B, Moll R, Chejfec G, Franke WW. Synaptophysin: a novel marker for neurons, certain neu-roendocrine cells, and their neoplasms. Hum Pathol 17:979–983, 1986
  • Molenaar WM, Baker DL, Pleasure D, Lee VM, Trojanowski JQ: The neuroendocrine and neural profiles of neuroblasto-mas, ganglioneuroblastomas, and ganglioneuromas. Am J Pathol 136:375–382, 1990
  • Shanfeld RL, Edelman J, Willis JE, Tuason L, Goldblum JR: Immunohistochemical analysis of neural markers in peripheral primitive neuroectodermal tumors (pPNET) without light mi-croscopic evidence of neural differentiation. App Imnutnohis-tochem 5:78–86, 1997
  • Garin-Chesa P, Fellinger EJ, Huvos AG, Beresford HR, Melamed MR, Triche Ti, et al: Immunohistochemical analysis of neural cell adhesion molecules. Differential expression in small round cell tumors of childhood and adolescence. Am J Pathol 139:275–286, 1991
  • Folpe AL, Patterson K, Gown AM: Antineuroblastoma anti-body NB-84 also identifies a significant subset of other small blue round cell tumors. App Immunohistochem 5:239–245, 1997
  • Miettinen M, Chatten J, Paetau A, Stevenson A. Monoclonal antibody NB84 in the differential diagnosis of neuroblastoma and other small round cell tumors. Am J Surg Pathol 22:327–332, 1998
  • Venkateswaran L, Jenkins .1.1, Kaste SC, Shurtleff SA, Down-ing JR, Pappo AS: Disseminated intrathoracic desmoplastic small round-cell tumor: a case report. J Pediatr Hematol On-col 19:172–175, 1997
  • Ordonez NG: Desmoplastic small round cell tumor: II: an ultrastructural and immunohistochemical study with emphasis on new immunohistochemical markers. Am J Surg Pathol 1998;22:1314–1327
  • Ordonez NG: Desmoplastic small round cell tumor: I: a his-topathologic study of 39 cases with emphasis on unusual his-tological patterns. Am J Surg Pathol 22:1303–1313, 1998
  • Coindre JM, de Mascarel A, Trojani M, de Mascarel I, Pages A: Immunohistochemical study of rhabdomyosarcoma. Unex-pected staining with S100 protein and cytokeratin. J Pathol 155:127–132, 1988
  • Gerald WL, Ladanyi M, de Alava E, Cuatrecasas M, Kushner BH, LaQuaglia MP, et al: Clinical, pathologic, and molecular spectrum of tumors associated with t(11;22)(p13;q12): des-moplastic small round-cell tumor and its variants. J Clin On-col 6:3028–3036, 1998
  • Barnoud R, Delattre 0, Peoc'h M, Pasquier D, Plantaz D, Leroux D, et al: Desmoplastic small round cell tumor: RT-PCR analysis and immunohistochemical detection of the Wilm's tumor gene WTI. Pathol Res Pract 194:693–700, 1998
  • Charles AK, Moore IE, Berry PJ: Immunohistochemical de-tection of the Wilms' tumour gene WTI in desmoplastic small round cell tumour. Histopathology 30:312–314, 1997

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