64
Views
1
CrossRef citations to date
0
Altmetric
Anticancer Chemotherapy

Heparin and Suramin Alter Plitidepsin Uptake Via Inhibition of GPCR Coupled Signaling

Pages 550-557 | Published online: 18 Jul 2013

REFERENCES

  • Maroun JA, Belanger K, Seymour L, Matthews S, Roach J, Dionne J, et al. Phase I study of Aplidine in a daily x5 one-hour infusion every 3 weeks in patients with solid tumors refractory to standard therapy. A National Cancer Institute of Canada Clinical Trials Group study: NCIC CTG IND 115. Ann Oncol 2006; 17: 1371–1378.
  • Faivre S, Chieze S, Delbaldo C, Ady-vago N, Guzman C, Lopez-Lazaro L, et al. Phase I and pharmacokinetic study of ap-lidine, a new marine cyclodepsipeptide, in patients with advanced malignancies. J Clin Oncol. 2005; 23: 7780–2.
  • Erba E, Bassano L, Di Liberti G, Muradore I, Chiorino G, Ubezio P, et al. Cell cycle phase perturbations and apoptosis in tumour cells induced by plitidepsine. Br J Cancer. 2002; 86 (9): 1510–7.
  • Broggini M, Marchini SV, Galliera E, Borsotti P, Taraboletti G, Erba E, et al. Plitidepsin, a new anticancer agent of marine ori-gin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (fit-1) autocrine loop in human leukemia cells MOLT-4. Leukemia 2003; 17 (1): 52–9
  • Erba E, Serafini M, Gaipa G, Tognon G, Marchini S, Celli N, et al. Effect of plitidepsin in acute lymphoblastic leukaemia cells. Br J Cancer. 2003; 89 (4): 763–73.
  • Biscardi M, Caporale R, Balestri F, Gavazzi S, Jimeno J, Grossi A. VEGF inhibition and cytotoxic effect of plitidepsin in leukemia cell lines and cells from acute myeloid leukemia. Ann Oncol. 2005; 16 (10): 1667–74.
  • Taraboletti G, Poli M, Dossi R, Manenti L, Borsotti P, Fair-cloth GT, et al. Antiangiogenic activity of plitidepsin, a new agent of marine origin. Br J Cancer. 2004; 90 (12): 2418–24.
  • Straight AM, Oakley K, Moores R, Bauer AJ, Patel A, Tuttle RM, et al. Plitidepsin reduces growth of anaplastic thyroid can-cer xenografts and the expression of several angiogenic genes. Cancer Chemother Pharmacol. 2006; 57 (1): 7–14.
  • Gajate C, An F, Mollinedo F. Rapid and selective apopto-sis in human leukemic cells induced by plitidepsin through a fas/CD95- and mitochondrial-mediated mechanism. Clin Can-cer Res. 2003; 9 (4): 1535–45.
  • Gajate C, Mollinedo F. Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J Biol Chem. 2005;280 (12): 11641–7.
  • Cuadrado A, Garcia-Fernandez LF, Gonzalez L, Suarez Y, Losada A, Alcaide V, et al. Plitidepsin induces apoptosis in human cancer cells via glutathione depletion and sustained acti-vation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK. J Biol Chem. 2003; 278 (1): 241–50.
  • Gonzalez-Santiago L, Suarez Y, Zarich N, Munoz-Alonso MJ, Cuadrado A, Martinez T, et al. Plitidepsin induces JNK-de-pendent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Racl GTPase activation, and MKP-1 phosphatase downregulation. Cell Death Differ. 2006; 13 (11): 1968–81.
  • Suarez Y, Gonzalez-Santiago L, Zarich N, Davalos A, Aranda JF, Alonso MA, et al. Plitidepsin cellular binding and Racl/JNK pathway activation depend on membrane cholesterol content. Mol Pharmacol. 2006; 70(5)4654-63.
  • Humeniuk R, Menon LG, Saydam G, Longo-Sorbello GSA, Elisseyeff Y, Lewis LD et al. Plitidepsin synergizes with cy-tosine arabinoside: function'al relevance of mitochondria in pli-tidepsin induced cytotoxicity. Leukemia. 2007;21.2399-2405.
  • Huang M, Wang Y, Collins M, Gu JJ, Mitchell BS, Graves LM. Inhibition of nucleoside transport by p38 MAPK inhibitors. J Biol Chem. 2002; 277 (32): 28364–7
  • Zhang XD, Deslandes E, Villedieu P, Poulain L, Duval M, Gauduchon P, et al. Effect of 2-deoxy-glucose on various malig-nant cell lines in vitro. Anticancer Res. 2006; 26( 5A)3561-6.
  • Smolen JE, Kuczynski B, Koh EK, Balazovich KJ, Woronoff A. ‘Depletion’ of ATP by 2-deoxyglucose: secretion by electroporated human neutrophils is not restored by readdition of ATP. Neurosignals 1992; 1: 23–33.
  • Martens JR, Sakamoto N, Sullivan SA, Grobaski TD, Tamkun MM. Isoform-specific localization of voltage-gated K+ channels to distinct lipid raft populations. J Biol Chem 2001; 276 (11): 8409–14.
  • Conti M. Targeting K+ channels for cancer therapy. J Exp Ther Oncol. 2004; 4 (2): 161–6.
  • Vink SR, van der Luit AH, Klarenbeek JB, Verheij M, van Blitterswijk WJ. Lipid rafts and metabolic energy differentially de-termine uptake of anti-cancer alkylphospholipids in lymphoma versus carcinoma cells. Biocheml Pharmacol 2007; 74: 145 6–1465.
  • Cristillo AD, Xiao X, Campbell-Malone R, Dimitrov DS Bierer BE. Differences between CEM and human peripheral blood T lymphocytes in cAMP-dependent HIV viral fusion and CXCR4 expression. Exp Mol Pathol 2002; 73: 9–18.
  • Lefkowitz RJ.G protein-coupled receptor kinases. Cell. 1993; 74 (3): 409–412.
  • Vila-Coro AJ, Rodriguez-Frade JM, Martin De Ana A, Moreno-Ortiz MC, Martinez-AC, Mellado M. The chemokine SDF-lalpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. FASEB J 1999; 13 (13): 1699-710.
  • Chung WC, Kermode JC. Suramin disrupts receptor-G protein coupling by blocking association of Gprotein alpha and betagamma subunits. J Pharmacol Exp Ther 2005; 313 (1): 191-8. Epub 2004 Dec 30.
  • Ferrand A, Kowalski-Chauvel A, Bertrand C, Escrieut C, Mathieu A, Portolan G, et al. A novel mechanism for JAK2 ac-tivation by a G protein-coupled receptor, the CCK2R:implica-tion of this signaling pathway in pancreatic tumor models. J Biol Chem 2005; 280 (11): 10710–5.)
  • Freissmuth M, Boehm S, Beindl W, Nickel P, Ijzerman AP, Hohenegger M, et al. Suramin analogues as subtype-selective G protein inhibitors. Mol Pharmacol. 1996; 49 (4): 602–11.
  • Hensey CE, Boscoboinik D, Azzi A. Suramin, an anti-can-cer drug, inhibits protein kinase C and induces differentiation in neuroblastoma cell clone NB2A. FESS Lett. 1989; 258 (1): 156–8.
  • Ju H, Venema VJ, Liang H, Harris MB, Zou R, Venema RC. Bradykinin activates the Janus-activated kinase/signal trans-ducers and activators of transcription (JAK/STAT) pathway in vascular endothelial cells: localization of JAK/STAT signaling proteins in plasmalemmal caveolae. Biochem J 2000; 351(Pt 1): 257–64.
  • Kassack MU, Hogger P, Gschwend DA, Kameyama K, Haga T, Graul RC, et al. Molecular modeling of G-protein cou-pled receptor kinase 2: docking and biochemical evaluation of inhibitors. AAPS PharmSci. 2000;2(1):E2.
  • Moriyama Y, Nelson N. Inhibition of vacuolar H+-AT-Pases by fusidic acid and suramin. FESS Lett. 1988; 234 (2): 383–6.
  • Ono K, Nakane H, Fukushima M. Differential inhibition of various deoxyribonucleic and ribonucleic acid polymerases by suramin. Eur J Biochem 1988; 172 (2): 349–53.
  • Jindal HK, Anderson CW, Davis RG, Vishwanatha JK. Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases. Cancer Res. 1990; 50 (24): 7754–7.
  • von Kugelgen I. Pharmacological profiles of cloned mam-malian P2Y-receptor subtypes. Pharmacol Ther. 2006; 110 (3): 415–32.
  • Lineweaver H, Burk D. The determination of enzyme dissociation constants. J Am Chem Soc 1934; 56: 658–666.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.