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Editorial

IARC and the DEHP Quagmire

Pages 402-404 | Published online: 19 Jul 2013

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  • Kluwe WM, Haseman JK, Douglas JF, HuffJE. The carcinogenicity of dietary di(2-ethylhexyl) phthalate (DEHP) in Fischer 344 rats and B6C3F1 mice. J Toxicol Environ Health. 1982; 10: 797–815.
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  • Tomaszewski KE, Heindel SW, Jenkins WL, Melnick RI,. Induction of peroxi-somal acyl CoA oxidase activity and lipid peroxi.dation in primary rat hepa-tocyte cultures. Toxicology. 1990; 65: 49–60.
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  • Melnick RL. Is peroxisome prolifera-tion an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl) phthalate (DEHP)? Environ Health Perspect. 2001; 109:43742.
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  • Soffritti M, Belpoggi F, Minardi F, Mal-toni C. Ramazzini Foundation cancer program: history and major projects, life-span carcinogenicity bioassay design, chemicals studied, and results. Ann NYAcad Sci. 2002; 982: 26–45.
  • Huff J. Chemicals studied and evalu-ated in long-term carcinogenesis bioas-says by both the Ramazzini Foundation and the National Toxicology Program: in tribute to Cesare Maltoni and David Rall. Ann NY Acad Sci. 2002; 982: 208–30.
  • Melnick RL, Kamel F, Huff J. Declaring chemicals “not carcinogenic to humans” requires validation, not spec-ulation. Environ Health Perspect. 2003; 111: A204–5.
  • Huff J, Melnick RL. Chemical carcino-genesis bioassays: critical for the sensi-ble application of the precautionary principle for protecting public health. In memory: Cesare Maltoni, Norton Nelson, David Rail, Irving Selikoff. Eur J Oncol, in press.

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