- Tomatis L. The IARC monographs pro-gram: changing attitudes towards public health. Int J Occup Environ Health. 2002; 8: 144–52.
- Huff J. IARC monographs, industry influence, and upgrading, downgrad-ing, and under-grading chemicals: a personal point of view. International Agency for Research on Cancer. Int J Occup Environ Health. 2002; 8: 249–70.
- Brody C, DiGangi J, Easthope T, Rossi M, Schetder T. IARC downgrading of DEHP. Health Care Without Harm letter. Int J Occup Environ Health. 2003; 9:399400.
- Kleihues P. IARC response letter to Brody C et al. Unpublished.
- Melnick RL, Brody C, DiGangi J, Huff J. The IARC evaluation lof DEHP excludes key papers demonstrating car-cinogenic effects. Int J Occup Environ Health. 2003; 9: 400–2.
- Melnick RL. The IARC evaluation of di (2-ethylhexyl) phthalate (DEHP): a flawed decision based on an untested hypothesis. Int J Occup Environ Health. 2002; 8: 284–6.
- Melnick RL. Suppression of crucial information in the IARC evaluation of DEHP. Int J Occup Environ Health. 2003; 9: 84–5.
- Mirer FE. Comment from the union participant in the IARC Working Group that downgraded DEHP. Int J Occup Environ Health. 2003; 9: 85–7.
- Capen CC, Dybing E, Rice JM, Wilbourn JD (eds). Species differ-ences in thyroid, kidney and urinary bladder carcinogenesis. IARC Sci Publ. 1999; (147): 1-225.
- Rice JM, Baan RA, Blearier M, et al. Rodent tumors of urinary bladder, renal cortex, and thyroid gland in IARC Monographs evaluations of car-cinogenic risk to humans. Toxicol Sci. 1999; 49: 166–71.
- Tomatis L, Aitio A, Wilbourn J, Shuker L. Human carcinogens so far identi-fied. Jpn J Cancer Res. 1989; 80: 795–807.
- Huff J. Chemicals causally associated with cancers in humans and in labora-tory animals: a perfect concordance. Chapter 2: 25-37. In: Waalkes MP, Ward JM ( eds). Carcinogenesis. New York, Raven Press.
- Huff J. Value, validity, and historical development of carcinogenesis studies for predicting and confirming carcino-genic risks to humans. Chapter 2: 21-123. In: Kitchin KT ( ed). Carcino-genicity Testing, Predicting, 8c Interpreting Chemical Effects. New York, Marcel Dekker, 1999.
- Tomatis L. The predictive value of rodent carcinogenicity tests in the eval-uation of human risks. Annu Rev Phar-rnacol Toxicol. 1979; 19: 511–30.
- Huff J. Chemicals and cancer in humans: first evidence in experimental animals. Environ Health Perspect. 1993; 100: 201–10.
- Moure-Eraso R. Primary prevention and precaution in hazard identification in the NIEHS/NTP: body in the morgue approach. Public Health Rep. 2002; 117: 564–73.
- Baan RA, Rice JM. Carcinogenicity of EBDCs: response (letter). Environ Health Perspect. 2003; 111: A266–7.
- NTP. Toxicology and Carcinogenesis Studies of Ethylene Thiourea (CAS: 96-45-7) in F344 Rats and B6C3F1 Mice (Feed Studies). NTP TR 388. National Toxicology Program, Research Trian-gle Park, NC, 1992.
- Chhabra RS, Eustis S, Haseman JK, Kurtz PJ, Carlton BD. Comparative car-cinogenicity of ethylene thiourea with or without perinatal exposure in rats and mice. Fundam Appl Toxicol. 1992; 18: 405–17.
- Steenland K, Cedillo L, Tucker J, et al.Thyroid hormones and cytogenetic outcomes in backpack sprayers using ethylenebis(dithiocarbamate) (EBDC) fungicides in Mexico. Environ Health Perspect. 1997; 105: 1126–30.
- Steenland K. Carcinogenicity of EBDCs. Environ Health Perspect. 2003; 111:A266.
- Huff J, Ward J, Melnick R. IARC ignores valid thyroid gland cancer find-ings citing modes-of-action specula-tions. Submitted.
- IARC. DEHP. In: Some industrial chemicals. IARC Monogr Eval Car-cinog Risks Hum. 2000; 77: 41–148.
- NTP. Carcinogenesis Bioassay of Di(2-ethylhexyl)phthalate (CAS No. 117-81-7) in F344 Rats and B6C3F1 Mice (Feed Studies). NTP TR 217. National Toxicology Program, Research Trian-gle Park, NC, 1982.
- Kluwe WM, Haseman JK, Douglas JF, HuffJE. The carcinogenicity of dietary di(2-ethylhexyl) phthalate (DEHP) in Fischer 344 rats and B6C3F1 mice. J Toxicol Environ Health. 1982; 10: 797–815.
- Kluwe WM, Haseman JK, Huff JE. The carcinogenicity of di(2-ethylhexyl) phthalate (DEHP) in perspective. J Toxicol Environ Health. 1983; 12: 159–69.
- Huff JE, Kluwe WM. Phthalate esters carcinogenicity in F344/N rats and B6C3F1 mice. Progr Clin Biol Res. 1984; 141: 137–54.
- Melnick RL, Schiller CM. Effect of phthalate esters on energy coupling and succinate oxidation in rat liver mitochondria. Toxicology. 1985; 34: 13–27.
- Kluwe WM, Huff JE, Matthews HB, Irwin R, Haseman JK. Comparative chronic toxicities and carcinogenic potentials of 2-ethylhexyl-containing compounds in rats and mice. Carcino-genesis. 1985; 6: 1577-83.
- Kluwe WM. Carcinogenic potential of phthalic acid esters and related com-pounds: structure-activity relationships. Environ Health Perspect. 1986; 65: 271–8.
- Tomaszewski KE, Agarwal DK, Melnick RL. In vitro steady-state levels of hydro-gen peroxide after exposure of male F344 rats and female B6C3F1 mice to hepatic peroxisome proliferators. Car-cinogenesis. 1986; 7: 1871–6.
- Melnick RL, Morrissey RE, Tomaszew-ski KE. Studies by the National Toxi-cology Program on di(2-ethylhexyl) phthalate. Toxicol Ind Health. 1987; 3: 99–118.
- Tomaszewski KE, Derks MC, Melnick RL. Acyl CoA oxidase is the most suit-able marker for hepatic peroxisomal changes caused by treatment of F344 rats with di(2-ethylhexyl)phthalate. Toxicol Lett. 1987; 37: 203–12.
- Tomaszewski KE, Heindel SW, Jenkins WL, Melnick RI,. Induction of peroxi-somal acyl CoA oxidase activity and lipid peroxi.dation in primary rat hepa-tocyte cultures. Toxicology. 1990; 65: 49–60.
- Tomaszewski KE, Montgomery CA, Melnick RL. Modulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in F344 rats by di(2-ethylhexyl)phthalate. Chem Biol Interact. 1988; 65: 205–22.
- Melnick RL. Is peroxisome prolifera-tion an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl) phthalate (DEHP)? Environ Health Perspect. 2001; 109:43742.
- Huff J. Issues and controversies sur-rounding qualitative strategies for identifying and forecasting cancer causing agents in the human environ-ment. Pharmacol Toxicol. 1993;72 suppl 1: 12-27.
- Maltoni C. The contribution of experi-mental [animal] studies to the control of industrial carcinogenesis. Appl Occup Environ Hyg. 1995; 10: 749–60.
- Haseman J, Melnick R, Tomatis L, Huff J. Carcinogenesis bioassays: study dura-tion and biological relevance. Food Chem Toxicol. 2001; 39:73944.
- Soffritti M, Belpoggi F, Minardi F, Mal-toni C. Ramazzini Foundation cancer program: history and major projects, life-span carcinogenicity bioassay design, chemicals studied, and results. Ann NYAcad Sci. 2002; 982: 26–45.
- Huff J. Chemicals studied and evalu-ated in long-term carcinogenesis bioas-says by both the Ramazzini Foundation and the National Toxicology Program: in tribute to Cesare Maltoni and David Rall. Ann NY Acad Sci. 2002; 982: 208–30.
- Melnick RL, Kamel F, Huff J. Declaring chemicals “not carcinogenic to humans” requires validation, not spec-ulation. Environ Health Perspect. 2003; 111: A204–5.
- Huff J, Melnick RL. Chemical carcino-genesis bioassays: critical for the sensi-ble application of the precautionary principle for protecting public health. In memory: Cesare Maltoni, Norton Nelson, David Rail, Irving Selikoff. Eur J Oncol, in press.
Free access
Reprints and Corporate Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
To request a reprint or corporate permissions for this article, please click on the relevant link below:
Academic Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
Obtain permissions instantly via Rightslink by clicking on the button below:
If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.