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Commentary

New insights into the role of vitamin D and calcium in osteoporosis management: an expert roundtable discussion

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Pages 1363-1370 | Accepted 20 Mar 2008, Published online: 02 Apr 2008

References

  • Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001;22:477–501
  • Chapuy MC, Pamphile R, Paris E, et al. Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporosis Int 2002;13:257–64
  • DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004;80(Suppl):1689–96S4. Heaney RP. Functional indices of vitamin D status and ramifications of vitamin D deficiency. Am J Clin Nutr 2004;80(Suppl):1706–9S
  • Heaney RP. Functional indices of vitamin D status and ramifications of vitamin D deficiency. Am J Clin Nutr 2004;80(Suppl):1706-9S
  • Bischoff-Ferrari HA, Giovannucci E, Willett WC, et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 2006;84: 18–28
  • Rizzoli R, Boonen S, Brandi ML, et al. The role of calcium and vitamin D in the management of osteoporosis. Bone 2008;42:246–9. Epub 2007 Oct 22
  • Dawson-Hughes B, Heaney RP, Holick MF, et al. Estimates of optimal vitamin D status. Osteoporosis Int 2005;16:713–16
  • Forman JP, Giovannucci E, Holmes MD, et al. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension 2007;49:1063–9
  • Giovannucci E, Liu Y, Willett WC. Cancer incidence and mortality and vitamin D in black and white male health professionals. Cancer Epidemiol Biomarkers Prev 2006;15:2467–72
  • Gorham ED, Garland CF, Garland FC, et al. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Am J Prev Med 2007;32:210–16
  • Munger KL, Levin LI, Hollis BW, et al. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006;296:2832–8
  • Mathieu C, Gysemans C, Giulietti A, Bouillon R. Vitamin D and diabetes. Diabetologia 2005;48:1247–57
  • Scragg R, Sowers M, Bell C. Third National Health and Nutrition Examination Survey. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care 2004;27: 2813–18
  • Bischoff-Ferrari HA, Borchers M, Gudat F, et al. Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res 2004;19:265–9
  • Bischoff-Ferrari HA, Dietrich T, Orav EJ, et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or = 60 y. Am J Clin Nutr 2004;80: 752–8
  • Visser M, Deeg DJ, Lips P. Longitudinal Aging Study Amsterdam. Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): Longitudinal Aging Study Amsterdam. J Clin Endocrinol Metab 2003;88:5766–72
  • Sambrook PN, Chen JS, March LM, et al. Serum parathyroid hormone predicts time to fall independent of vitamin D status in a frail elderly population. J Clin Endocrinol Metab 2004;89:1572–6
  • Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 2006;81:353–73
  • Weaver CM, Fleet JC. Vitamin D requirements: current and future. Am J Clin Nutr 2004;80(Suppl):1735–9S
  • Armas LAG, Hollis BW, Heaney RP. Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocinol Metab 2004;89: 5387–91
  • Holick MF, Biancuzzo RM, Chen TC, et al. Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab 2008;93:677–81 [Epub ahead of print]
  • Glendenning P, Taranto M, Noble JM, et al. Current assays overestimate 25-hydroxyvitamin D3 and underestimate 25-hydroxyvitamin D2 compared with HPLC: need for assayspecific decision limits and metabolite-specific assays. Ann Clin Biochem 2006;43(Pt 1):23–30
  • Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999;69:842–56
  • Institute of Medicine, Standing Committee on the Scientific Evaluation of Dietary Reference Intakes Food and Nutrition Board. Vitamin D. In: Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, vitamin D, and Fluoride. Washington, DC: National Academy Press, 1997:250–87
  • Department of Health Report on Health and Social Subjects No 41. Dietary Reference Values for Food, Energy and Nutrients for the United Kingdom. London: HMSO, 1991
  • FAO/WHO: Human vitamin and Mineral Requirements, 2002
  • National Osteoporosis Foundation, Osteoporosis Clinical Practice Guideline available at http://www.nof.org/professionals/clinical.htm (last accessed Jan, 2008)
  • Jackson RD, LaCroix AZ, Gass M, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006;354:669–83
  • Bischoff-Ferarri HA, Dawson-Hughes B, Baron JA, et al. Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials. Am J Clin Nutr 2007;86:1780–90
  • Owens G, Jackson R, Lewiecki EM. An integrated approach: bisphosphonate management for the treatment of osteoporosis. Am J Manage Care 2007;13(Suppl 11):S290–308
  • Devereaux PJ, Yusuf S. The evolution of the randomized controlled trial and its role in evidence-based decision making. J Intern Med 2003;254:105–13
  • Guyatt GH, Haynes RB, Jaeschke RZ, et al. Users’ guides to the medical literature: XXV. Evidence-based medicine: Principles for applying the users’ guides to patient care. JAMA 2000;284:1290–6
  • Simon R. Meta-analysis of clinical trials: opportunities and limitations. In: Stangle DK, Berry DA, eds. Meta-analysis in Medicine and Health Policy. New York, NY: Marcel Dekker Inc., 2000
  • Khoshdel A, Attia J, Carney SL. Basic concepts in meta-analysis: a primer for clinicians. Int J Clin Pract 2006;60:1287–94
  • Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions 4.2.5 [Updated May 2005] In: The Cochrane Library, Issue 3, 2005. Chichester, UK: John Wiley
  • Johnell O, Kanis JA, Odén A, et al. Mortality after osteoporotic fractures. Osteoporos Int 2004;15:38–42
  • Johnell O, Kanis JA. An estimate of the worldwide prevalence, mortality and disability associated with hip fracture. Osteoporos Int 2004;15:897–902
  • Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, et al. Effect of vitamin D on falls: a meta-analysis. JAMA 2004;291:1999–2006
  • Bischoff-Ferrari HA Orav EJ, Dawson-Hughes B. Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial. Arch Intern Med 2006;166:424–30
  • Broe KE Chen TC, Weinberg J, et al. A higher dose of vitamin D reduces the risk of falls in nursing home residents: a randomized, multiple-dose study. J Am Geriatr Soc 2007;55:234–9
  • Prince RL, Austin N, Devine A, et al. Effects of ergocalciferol added to calcium on the risk of falls in elderly high-risk women. Arch Intern Med 2008;168:103–8
  • Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005;293:2257–64
  • Boonen S, Lips P, Bouillon R, et al. Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endo Metab 2007;92:1415–23
  • Grant AM, Avenell A, Campbell MK, et al. RECORD Trial Group. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomized Evaluation of Calcium Or vitamin D, RECORD): a randomized placebocontrolled trial. Lancet 2005;365: 1621–8
  • Wortsman J, Matsuoka LY, Chen TC, et al. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000;72:690–3
  • Binkley N, Ringe JD, Reed JI, et al. Alendronate/vitamin D3 70mg/2800 IU with and without additional 2800 IU vitamin D3 for osteoporosis: Results from the 24-week extension of a 15-week randomized, controlled trial. Submitted to Bone, 2008
  • Heaney RP, Dowell MS, Hale CA, Bendich A. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr 2003;2:142–6
  • Norman AW, Bouillon R, Whiting SJ, et al. 13th workshop consensus for vitamin D nutritional guidelines. J Steroid Biochem Mol Biol 2007;103:204–5
  • Health & Consumer Protection Directorate-General. Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of vitamin D. European Commission, 2002. Brussels, Belgium. Available at: http://europa.eu.int/comm/food/fs/sc/scf/out157_en.pdf Accessed May 24, 2007
  • Hathcock JN, Shao A, Vieth R, et al. Risk assessment for vitamin D1,2. Am J Clin Nutr 2007;85:6–18
  • Bouillon R. Vitamin D: From photosynthesis, metabolism, and action to clinical applications. In: DeGroot LJ, Jameson JL, eds. Endocrinology. Philadelphia: Elsevier Saunders, 2005:1435–63
  • Urakawa I, Yamazaki Y, Shimada T, et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 2006;444:770–4 [Epub 2006 Oct 29]
  • Kuro-o, M. et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997;390:45–51
  • Shimada, T. et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J. Clin Invest 2004;113;561–8
  • Vieth R, Chan PC, MacFarlane GD. Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr 2001; 73:288–94
  • Heikinheimo RJ, Inkovaara JA, Harju EJ, et al. Annual injection of vitamin D and fractures of aged bones. Calcif Tissue Int 1992;51:105–10
  • Steingrimsdottir L, Gunnarsson O, Indridason OS, et al. Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. JAMA 2005;294:2336–41
  • Heaney RP, Nordin BE. Calcium effects on phosphorus absorption: implications for the prevention and co-therapy of osteoporosis. J Am Coll Nutr 2002;21:239–44
  • Tang BMP, Eslick GD, Nowson C, et al. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 2007;370:657–66
  • Freyschuss B, Ljunggren O, Saaf M, et al. Calcium and vitamin D for prevention of osteoporotic fractures. Comment on: Lancet 2007; 370:657–66; Lancet 2007;370:2098–9, author reply 2099
  • Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomized double blind controlled trial. BMJ 2003;326: 469
  • Bolland MJ, Barber PA, Doughty RN, et al. Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ 2008;336:262–6 [Epub 2008 Jan 15]
  • Resch H, Walliser J, Phillips S, et al. Physician and patient perceptions on the use of vitamin D and calcium in osteoporosis treatment: a European and Latin American perspective. Curr Med Res Opin 2007;23:1227–37

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