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Journal of the International Society of Sports Nutrition Volume 12, 2015 - Issue 1

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Review

International society of sports nutrition position stand: Beta-Alanine

Eric T. Trexler1 Applied Physiology Laboratory, Department of Exercise and Sport ScienceUniversity of North CarolinaChapel HillNCUSA

Abbie E. Smith-Ryan1 Applied Physiology Laboratory, Department of Exercise and Sport ScienceUniversity of North CarolinaChapel HillNCUSACorrespondence[email protected]

Jeffrey R. Stout2 Department of Sport and Exercise ScienceUniversity of Central FloridaOrlandoFLUSA

Jay R. Hoffman2 Department of Sport and Exercise ScienceUniversity of Central FloridaOrlandoFLUSA

Colin D. Wilborn3 Human Performance Laboratory, Department of Exercise ScienceUniversity of Mary Hardin-BaylorBeltonTXUSA

Craig Sale4 Health and Performance Enhancement Research Centre, Department of Sport ScienceNottingham Trent UniversityNottinghamUK

Richard B. Kreider5 Exercise & Sport Nutrition Lab, Department of Health & KinesiologyTexas A&M UniversityCollege StationTXUSA

Ralf Jäger6 Increnovo LLC2138 E Lafayette PlMilwaukeeWIUSA

Conrad P. Earnest5 Exercise & Sport Nutrition Lab, Department of Health & KinesiologyTexas A&M UniversityCollege StationTXUSA;7 Nutrabolt InternationalBryanTXUSA

Laurent Bannock8 Guru Performance LTDLondonUK

Bill Campbell9 Performance & Physique Enhancement LaboratoryUniversity of South FloridaTampaFLUSA

Douglas Kalman10 Department of Nutrition & EndocrinologyMiami Research Associates, QPS-MRAMiamiFLUSA

Tim N. Ziegenfuss11 The Center for Applied Health Sciences4302 Allen RdSTE 120StowOHUSA

Jose Antonio12 Exercise and Sports ScienceNova Southeastern UniversityDavieFLUSA

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Article: 30 | Published online: 01 Apr 2022

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https://doi.org/10.1186/s12970-015-0090-y
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References

HarrisRCTallonMJDunnettMBoobisLCoakleyJKimHJ et al The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralisAmino Acids200630 3 279 89 1:CAS:528:DC%2BD28Xktlaksrk%3D 16554972 https://doi.org/10.1007/s00726-006-0299-9
PubMed Web of Science ®Google Scholar
DunnettMHarrisRCInfluence of oral beta-alanine and L-histidine supplementation on the carnosine content of the gluteus mediusEquine Vet J Suppl199930 499 504 10659307
PubMedGoogle Scholar
HillCAHarrisRCKimHJHarrisBDSaleCBoobisLH et al Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacityAmino Acids200732 2 225 33 1:CAS:528:DC%2BD2sXhtFyhtbo%3D 16868650 https://doi.org/10.1007/s00726-006-0364-4
PubMed Web of Science ®Google Scholar
BaguetAReyngoudtHPottierAEveraertICallensSAchtenE et al Carnosine loading and washout in human skeletal musclesJ Appl Physiol2009106 3 837 42 1:CAS:528:DC%2BD1MXjvFWmtrg%3D 19131472 https://doi.org/10.1152/japplphysiol.91357.2008 doi:10.1152/japplphysiol.91357.2008
PubMed Web of Science ®Google Scholar
HarrisRCJonesGHillCHKendrickIPBoobisLKimCK et al The carnosine content of vastus lateralis in vegetarians and omnivoresFASEB J200721 76.20 https://doi.org/10.1096/fj.06-6925com 1:CAS:528:DC%2BD2sXhslGqsbs%3D
Web of Science ®Google Scholar
TallonMJHarrisRCBoobisLHFallowfieldJLWiseJAThe carnosine content of vastus lateralis is elevated in resistance-trained bodybuildersJ Strength Cond Res200519 4 725 9 16287364
PubMed Web of Science ®Google Scholar
BaguetAEveraertIHespelPPetrovicMAchtenEDeraveWA new method for non-invasive estimation of human muscle fiber type compositionPLoS One20116 7 3131401 1:CAS:528:DC%2BC3MXpsFCgu70%3D 21760934 https://doi.org/10.1371/journal.pone.0021956
PubMedGoogle Scholar
KendrickIPHarrisRCKimHJKimCKDangVHLamTQ et al The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body compositionAmino Acids200834 4 547 54 1:CAS:528:DC%2BD1cXlsVOgsb0%3D 18175046 https://doi.org/10.1007/s00726-007-0008-3
PubMed Web of Science ®Google Scholar
KendrickIPKimHJHarrisRCKimCKDangVHLamTQ et al The effect of 4 weeks beta-alanine supplementation and isokinetic training on carnosine concentrations in type I and II human skeletal muscle fibresEur J Appl Physiol2009106 1 131 8 1:CAS:528:DC%2BD1MXkvValtLk%3D 19214556 https://doi.org/10.1007/s00421-009-0998-5
PubMedGoogle Scholar
MannionAFJakemanPMWillanPLEffects of isokinetic training of the knee extensors on high-intensity exercise performance and skeletal muscle bufferingEur J Appl Physiol Occup Physiol199468 4 356 61 1:STN:280:DyaK2czjtleitg%3D%3D 8055896 https://doi.org/10.1007/BF00571457
PubMedGoogle Scholar
SuzukiYItoOTakahashiHTakamatsuKThe effect of sprint training on skeletal muscle carnosine in humansInt J Sport Health Sci20042 105 10 https://doi.org/10.5432/ijshs.2.105
Google Scholar
BoldyrevAAAldiniGDeraveWPhysiology and pathophysiology of carnosinePhysiol Rev201393 4 1803 45 1:CAS:528:DC%2BC3sXhvVShtrvM 24137022 https://doi.org/10.1152/physrev.00039.2012
PubMed Web of Science ®Google Scholar
DeraveWEveraertIBeeckmanSBaguetAMuscle carnosine metabolism and beta-alanine supplementation in relation to exercise and trainingSports Med201040 3 247 63 20199122 https://doi.org/10.2165/11530310-000000000-00000
PubMed Web of Science ®Google Scholar
EveraertIMooyaartABaguetAZutinicABaeldeHAchtenE et al Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humansAmino Acids201140 4 1221 9 1:CAS:528:DC%2BC3MXjsFGjur4%3D 20865290 https://doi.org/10.1007/s00726-010-0749-2
PubMed Web of Science ®Google Scholar
MannionAFJakemanPMDunnettMHarrisRCWillanPLCarnosine and anserine concentrations in the quadriceps femoris muscle of healthy humansEur J Appl Physiol Occup Physiol199264 1 47 50 1:STN:280:DyaK387jslajtw%3D%3D 1735411 https://doi.org/10.1007/BF00376439
PubMedGoogle Scholar
AbeHRole of histidine-related compounds as intracellular proton buffering constituents in vertebrate muscleBiochemistry (Mosc)200065 7 757 65 1:CAS:528:DC%2BD3cXlvFOlsb4%3D
PubMed Web of Science ®Google Scholar
HarrisRCDunnettMGreenhaffPLCarnosine and taurine contents in individual fibres of human vastus lateralis muscleJ Sports Sci199816 7 639 43 https://doi.org/10.1080/026404198366443
Web of Science ®Google Scholar
DunnettMHarrisRCHigh-performance liquid chromatographic determination of imidazole dipeptides, histidine, 1-methylhistidine and 3-methylhistidine in equine and camel muscle and individual muscle fibresJ Chromatogr B Biomed Sci Appl1997688 1 47 55 1:CAS:528:DyaK2sXksVSitQ%3D%3D 9029312 https://doi.org/10.1016/S0378-4347(97)88054-1
PubMedGoogle Scholar
StellingwerffTAnwanderHEggerABuehlerTKreisRDecombazJ et al Effect of two beta-alanine dosing protocols on muscle carnosine synthesis and washoutAmino Acids201242 6 2461 72 1:CAS:528:DC%2BC38XmvFGksLk%3D 21847611 https://doi.org/10.1007/s00726-011-1054-4
PubMed Web of Science ®Google Scholar
DeraveWOzdemirMSHarrisRCPottierAReyngoudtHKoppoK et al beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprintersJ Appl Physiol (1985)2007103 5 1736 43 1:CAS:528:DC%2BD2sXhtlyrtrzK https://doi.org/10.1152/japplphysiol.00397.2007 doi:10.1152/japplphysiol.00397.2007
Web of Science ®Google Scholar
BexTChungWBaguetAStegenSStautemasJAchtenE et al Muscle carnosine loading by beta-alanine supplementation is more pronounced in trained vs. untrained musclesJ Appl Physiol (1985)2014116 2 204 9 1:CAS:528:DC%2BC2cXksFSitb0%3D https://doi.org/10.1152/japplphysiol.01033.2013 doi:10.1152/japplphysiol.01033.2013
Web of Science ®Google Scholar
StoutJRCramerJTZoellerRFTorokDCostaPHoffmanJR et al Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in womenAmino Acids200732 3 381 6 1:CAS:528:DC%2BD2sXjvFanu7c%3D 17136505 https://doi.org/10.1007/s00726-006-0474-z
PubMed Web of Science ®Google Scholar
StegenSBexTVervaetCVanheeLAchtenEDeraveWbeta-Alanine dose for maintaining moderately elevated muscle carnosine levelsMed Sci Sports Exerc201446 7 1426 32 1:CAS:528:DC%2BC2cXpvV2ksLs%3D 24389513 https://doi.org/10.1249/MSS.0000000000000248
PubMed Web of Science ®Google Scholar
StoutJRGravesBSSmithAEHartmanMJCramerJTBeckTW et al The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55–92 Years): a double-blind randomized studyJ Int Soc Sports Nutr20085 21 2585553 18992136 https://doi.org/10.1186/1550-2783-5-21 1:CAS:528:DC%2BC3cXksVKitLg%3D
PubMed Web of Science ®Google Scholar
SaleCSaundersBHarrisRCEffect of beta-alanine supplementation on muscle carnosine concentrations and exercise performanceAmino Acids201039 2 321 33 1:CAS:528:DC%2BC3cXotVaisL4%3D 20091069 https://doi.org/10.1007/s00726-009-0443-4
PubMed Web of Science ®Google Scholar
JacksonMCKuceraCMLenneyJFPurification and properties of human serum carnosinaseClin Chim Acta1991196 2–3 193 205 1:CAS:528:DyaK3MXhsF2murc%3D 1903095 https://doi.org/10.1016/0009-8981(91)90073-L
PubMedGoogle Scholar
GardnerMLIllingworthKMKelleherJWoodDIntestinal absorption of the intact peptide carnosine in man, and comparison with intestinal permeability to lactuloseJ Physiol1991439 1 411 22 1180115 1:CAS:528:DyaK3MXksVKmtb0%3D 1910085 https://doi.org/10.1113/jphysiol.1991.sp018673
PubMedGoogle Scholar
SeverinSEKirzonMVKaftanovaTM[Effect of carnosine and anserine on action of isolated frog muscles]Dokl Akad Nauk SSSR195391 3 691 4 1:CAS:528:DyaG2cXnvFyr 13095299
PubMedGoogle Scholar
TanokuraMTasumiMMiyazawaT1H nuclear magnetic resonance studies of histidine-containing di- and tripeptides. Estimation of the effects of charged groups on the pKa value of the imidazole ringBiopolymers197615 2 393 401 1:CAS:528:DyaE28Xht1agsL0%3D 2351 https://doi.org/10.1002/bip.1976.360150215
PubMedGoogle Scholar
SuzukiYNakaoTMaemuraHSatoMKamaharaKMorimatsuF et al Carnosine and anserine ingestion enhances contribution of nonbicarbonate bufferingMed Sci Sports Exerc200638 2 334 8 1:CAS:528:DC%2BD28Xit1GqtLY%3D 16531904
PubMed Web of Science ®Google Scholar
DaveyCLThe significance of carnosine and anserine in striated skeletal muscleArch Biochem Biophys196089 303 8 1:CAS:528:DyaF3cXht12mt7k%3D 13814256 https://doi.org/10.1016/0003-9861(60)90059-X
PubMed Web of Science ®Google Scholar
BaguetAKoppoKPottierADeraveWBeta-alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exerciseEur J Appl Physiol2010108 3 495 503 1:CAS:528:DC%2BC3cXmsVGku7s%3D 19841932 https://doi.org/10.1007/s00421-009-1225-0
PubMed Web of Science ®Google Scholar
PowersSKJacksonMJExercise-induced oxidative stress: cellular mechanisms and impact on muscle force productionPhysiol Rev200888 4 1243 76 2909187 1:CAS:528:DC%2BD1cXhtlGgtbnP 18923182 https://doi.org/10.1152/physrev.00031.2007
PubMed Web of Science ®Google Scholar
BaileyDMDaviesBYoungISHullinDASeddonPSA potential role for free radical-mediated skeletal muscle soreness in the pathophysiology of acute mountain sicknessAviat Space Environ Med200172 6 513 21 1:CAS:528:DC%2BD3MXks1aisrc%3D 11396556
PubMedGoogle Scholar
VendittiPDi MeoSEffect of training on antioxidant capacity, tissue damage, and endurance of adult male ratsInt J Sports Med199718 7 497 502 1:CAS:528:DyaK2sXntlKjtLg%3D 9414071 https://doi.org/10.1055/s-2007-972671
PubMed Web of Science ®Google Scholar
KlebanovGITeselkin YuOBabenkovaIVLyubitskyOBRebrovaOBoldyrevAA et al Effect of carnosine and its components on free-radical reactionsMembr Cell Biol199812 1 89 99 1:STN:280:DyaK1M%2Fks1OjsA%3D%3D 9829262
PubMedGoogle Scholar
KohenRYamamotoYCundyKCAmesBNAntioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brainProc Natl Acad Sci U S A198885 9 3175 9 280166 1:CAS:528:DyaL1cXitF2ns7w%3D 3362866 https://doi.org/10.1073/pnas.85.9.3175
PubMed Web of Science ®Google Scholar
HoffmanJRatamessNARossRKangJMagrelliJNeeseK et al Beta-alanine and the hormonal response to exerciseInt J Sports Med200829 12 952 8 1:CAS:528:DC%2BD1MXmvFSrtQ%3D%3D 18548362 https://doi.org/10.1055/s-2008-1038678
PubMedGoogle Scholar
HarrisRCJonesGAKimHJKimCKPriceKAWiseJAChanges in muscle carnosine of subjects with 4 weeks of supplementation with a controlled relase formulation of beta-alanine (CarnoSyn), and for 6 weeks post (Abstract)FASEB J200923 599.4
Web of Science ®Google Scholar
StellingwerffTDecombazJHarrisRCBoeschCOptimizing human in vivo dosing and delivery of beta-alanine supplements for muscle carnosine synthesisAmino Acids201243 1 57 65 1:CAS:528:DC%2BC38XotlOhtro%3D 22358258 https://doi.org/10.1007/s00726-012-1245-7
PubMed Web of Science ®Google Scholar
StegenSBlancquaertLEveraertIBexTTaesYCaldersP et al Meal and beta-alanine coingestion enhances muscle carnosine loadingMed Sci Sports Exerc201345 8 1478 85 1:CAS:528:DC%2BC3sXhtFeqsr%2FL 23439427 https://doi.org/10.1249/MSS.0b013e31828ab073
PubMedGoogle Scholar
HobsonRMSaundersBBallGHarrisRCSaleCEffects of beta-alanine supplementation on exercise performance: a meta-analysisAmino Acids201243 1 25 37 3374095 1:CAS:528:DC%2BC38XotlOhtrY%3D 22270875 https://doi.org/10.1007/s00726-011-1200-z
PubMed Web of Science ®Google Scholar
ShinoharaTHaradaMOgiKMaruyamaMFujiiRTanakaH et al Identification of a G protein-coupled receptor specifically responsive to beta-alanineJ Biol Chem2004279 22 23559 64 1:CAS:528:DC%2BD2cXkt1Gitb0%3D 15037633 https://doi.org/10.1074/jbc.M314240200
PubMed Web of Science ®Google Scholar
CrozierRAAjitSKKaftanEJPauschMHMrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitabilityJ Neurosci200727 16 4492 6 1:CAS:528:DC%2BD2sXkvFCjt7c%3D 17442834 https://doi.org/10.1523/JNEUROSCI.4932-06.2007
PubMedGoogle Scholar
MacpheeSWeaverINWeaverDFAn Evaluation of Interindividual Responses to the Orally Administered Neurotransmitter beta-AlanineJ Amino Acids20132013 429847 3705897 23864937 https://doi.org/10.1155/2013/429847 1:CAS:528:DC%2BC3sXhtVGqurzM
PubMedGoogle Scholar
MurakamiTFuruseMThe impact of taurine- and beta-alanine-supplemented diets on behavioral and neurochemical parameters in mice: antidepressant versus anxiolytic-like effectsAmino Acids201039 2 427 34 1:CAS:528:DC%2BC3cXotVaisL0%3D 20099004 https://doi.org/10.1007/s00726-009-0458-x
PubMed Web of Science ®Google Scholar
DawsonRJrBiasettiMMessinaSDominyJThe cytoprotective role of taurine in exercise-induced muscle injuryAmino Acids200222 4 309 24 1:CAS:528:DC%2BD38XmvFCqt74%3D 12107759 https://doi.org/10.1007/s007260200017
PubMed Web of Science ®Google Scholar
Cramer JT. Creatine Supplementation in Endurance Sports. In: Stout JR, Antonio J, Kalman D, editors. Essentials of Creatine in Sports and Health. Totowa, New Jersey: Humana Press; 2008. p. 45–99.
Google Scholar
ShrierIDoes stretching improve performance? A systematic and critical review of the literatureClin J Sport Med200414 5 267 73 15377965 https://doi.org/10.1097/00042752-200409000-00004
PubMed Web of Science ®Google Scholar
CulbertsonJYKreiderRBGreenwoodMCookeMEffects of beta-alanine on muscle carnosine and exercise performance: a review of the current literatureNutrients20102 1 75 98 3257613 1:CAS:528:DC%2BC3cXhsV2mtbo%3D 22253993 https://doi.org/10.3390/nu2010075
PubMed Web of Science ®Google Scholar
SkulachevVPBiological role of carnosine in the functioning of excitable tissues. Centenary of Gulewitsch's discoveryBiochemistry (Mosc)200065 7 749 50 1:CAS:528:DC%2BD3cXlvFOlsLY%3D
Google Scholar
BeaverWLWassermanKWhippBJBicarbonate buffering of lactic acid generated during exerciseJ Appl Physiol (1985)198660 2 472 8 1:STN:280:DyaL287jvFKnsg%3D%3D
PubMed Web of Science ®Google Scholar
SweeneyKMWrightGAGlenn BriceADobersteinSTThe effect of beta-alanine supplementation on power performance during repeated sprint activityJ Strength Cond Res201024 1 79 87 19935102 https://doi.org/10.1519/JSC.0b013e3181c63bd5
PubMedGoogle Scholar
GhiasvandRAskariGMalekzadehJHajishafieeMDaneshvarPAkbariF et al Effects of Six Weeks of beta-alanine Administration on VO(2) max, Time to Exhaustion and Lactate Concentrations in Physical Education StudentsInt J Prev Med20123 8 559 63 3429803 22973486
PubMedGoogle Scholar
JagimARWrightGABriceAGDobersteinSTEffects of beta-alanine supplementation on sprint enduranceJ Strength Cond Res201327 2 526 32 22476168 https://doi.org/10.1519/JSC.0b013e318256bedc
PubMedGoogle Scholar
Smith-RyanAEFukudaDHStoutJRKendallKLHigh-velocity intermittent running: effects of beta-alanine supplementationJ Strength Cond Res201226 10 2798 805 22797003 https://doi.org/10.1519/JSC.0b013e318267922b
PubMedGoogle Scholar
Van ThienenRVan ProeyenKVanden EyndeBPuypeJLefereTHespelPBeta-alanine improves sprint performance in endurance cyclingMed Sci Sports Exerc200941 4 898 903 19276843 https://doi.org/10.1249/MSS.0b013e31818db708 1:CAS:528:DC%2BD1MXjtlOhtbo%3D
PubMedGoogle Scholar
ZoellerRFStoutJRO'KroyJATorokDJMielkeMEffects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustionAmino Acids200733 3 505 10 1:CAS:528:DC%2BD2sXpvVahu74%3D 16953366 https://doi.org/10.1007/s00726-006-0399-6
PubMedGoogle Scholar
SmithAEWalterAAGraefJLKendallKLMoonJRLockwoodCM et al Effects of beta-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trialJ Int Soc Sports Nutr20096 5 2649036 19210788 https://doi.org/10.1186/1550-2783-6-5 1:CAS:528:DC%2BC3cXksVKitbo%3D
PubMed Web of Science ®Google Scholar
Smith-RyanAEWoessnerMNMelvinMNWingfieldHLHackneyACThe effects of beta-alanine supplementation on physical working capacity at heart rate thresholdClin Physiol Funct Imaging201434 5 397 404 1:CAS:528:DC%2BC2cXhsVGhtLzI 24308676 https://doi.org/10.1111/cpf.12111
PubMedGoogle Scholar
BaguetABourgoisJVanheeLAchtenEDeraveWImportant role of muscle carnosine in rowing performanceJ Appl Physiol (1985)2010109 4 1096 101 https://doi.org/10.1152/japplphysiol.00141.2010 doi:10.1152/japplphysiol.00141.2010
Web of Science ®Google Scholar
de SallesPVRoschelHde JesusFSaleCHarrisRCSolisMY et al The ergogenic effect of beta-alanine combined with sodium bicarbonate on high-intensity swimming performanceAppl Physiol Nutr Metab201338 5 525 32 https://doi.org/10.1139/apnm-2012-0286 1:CAS:528:DC%2BC3sXms1Wmsbg%3D
Web of Science ®Google Scholar
DuckerKJDawsonBWallmanKEEffect of beta-alanine supplementation on 800-m running performanceInt J Sport Nutr Exerc Metab201323 6 554 61 1:CAS:528:DC%2BC2cXltFKis78%3D 23630039
PubMed Web of Science ®Google Scholar
DuckerKJDawsonBWallmanKEEffect of beta-alanine supplementation on 2000-m rowing-ergometer performanceInt J Sport Nutr Exerc Metab201323 4 336 43 1:CAS:528:DC%2BC3sXhs1SmsbjJ 23239676
PubMed Web of Science ®Google Scholar
HobsonRMHarrisRCMartinDSmithPMacklinBGualanoB et al Effect of Beta-Alanine With and Without Sodium Bicarbonate on 2,000-m Rowing PerformanceInt J Sport Nutr Exerc Metab201323 5 480 7 1:CAS:528:DC%2BC3sXhvFWksb3I 23535873
PubMed Web of Science ®Google Scholar
KernBDRobinsonTLEffects of beta-alanine supplementation on performance and body composition in collegiate wrestlers and football playersJ Strength Cond Res201125 7 1804 15 21659893 https://doi.org/10.1519/JSC.0b013e3181e741cf
PubMed Web of Science ®Google Scholar
ChungWShawGAndersonMEPyneDBSaundersPUBishopDJ et al Effect of 10 week beta-alanine supplementation on competition and training performance in elite swimmersNutrients20124 10 1441 53 3497003 1:CAS:528:DC%2BC38XhvVagsr7L 23201763 https://doi.org/10.3390/nu4101441
PubMed Web of Science ®Google Scholar
SaleCSaundersBHudsonSWiseJAHarrisRCSunderlandCDEffect of beta-alanine plus sodium bicarbonate on high-intensity cycling capacityMed Sci Sports Exerc201143 10 1972 8 1:CAS:528:DC%2BC3MXhtF2jtrzP 21407127
PubMed Web of Science ®Google Scholar
DanaherJGerberTWellardRMStathisCGThe effect of beta-alanine and NaHCO3 co-ingestion on buffering capacity and exercise performance with high-intensity exercise in healthy malesEur J Appl Physiol2014114 8 1715 24 4097338 1:CAS:528:DC%2BC2cXotFWls7s%3D 24832191 https://doi.org/10.1007/s00421-014-2895-9
PubMed Web of Science ®Google Scholar
ChungWBaguetABexTBishopDJDeraveWDoubling of muscle carnosine concentration does not improve laboratory 1-h cycling time-trial performanceInt J Sport Nutr Exerc Metab201424 3 315 24 1:CAS:528:DC%2BC2cXhsVChsLrF 24457999 https://doi.org/10.1123/ijsnem.2013-0125
PubMedGoogle Scholar
StoutJRCramerJTMielkeMO'KroyJTorokDJZoellerRFEffects of twenty-eight days of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue thresholdJ Strength Cond Res200620 4 928 31 17194255
PubMed Web of Science ®Google Scholar
SmithAEMoonJRKendallKLGraefJLLockwoodCMWalterAA et al The effects of beta-alanine supplementation and high-intensity interval training on neuromuscular fatigue and muscle functionEur J Appl Physiol2009105 3 357 63 1:CAS:528:DC%2BD1MXotVGlsg%3D%3D 18989693 https://doi.org/10.1007/s00421-008-0911-7
PubMed Web of Science ®Google Scholar
McCormackWPStoutJREmersonNSScanlonTCWarrenAMWellsAJ et al Oral nutritional supplement fortified with beta-alanine improves physical working capacity in older adults: a randomized, placebo-controlled studyExp Gerontol201348 9 933 9 1:CAS:528:DC%2BC3sXhtlSitbbE 23832078 https://doi.org/10.1016/j.exger.2013.06.003
PubMedGoogle Scholar
HoffmanJRRatamessNAFaigenbaumADRossRKangJStoutJR et al Short-duration beta-alanine supplementation increases training volume and reduces subjective feelings of fatigue in college football playersNutr Res200828 1 31 5 1:CAS:528:DC%2BD1cXptlahtg%3D%3D 19083385 https://doi.org/10.1016/j.nutres.2007.11.004 doi:S0271-5317(07)00277-1
PubMed Web of Science ®Google Scholar
SaleCHillCAPonteJHarrisRCbeta-alanine supplementation improves isometric endurance of the knee extensor musclesJ Int Soc Sports Nutr20129 1 26 3420321 1:CAS:528:DC%2BC38XhvVSiurzF 22697405 https://doi.org/10.1186/1550-2783-9-26
PubMedGoogle Scholar
HoffmanJRatamessNKangJMangineGFaigenbaumAStoutJEffect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletesInt J Sport Nutr Exerc Metab200616 4 430 46 1:CAS:528:DC%2BD2sXlvFylsbo%3D 17136944
PubMed Web of Science ®Google Scholar
HoffmanJRLandauGStoutJRDaboraMMoranDSSharvitN et al beta-alanine supplementation improves tactical performance but not cognitive function in combat soldiersJ Int Soc Sports Nutr201411 1 15 3983672 24716994 https://doi.org/10.1186/1550-2783-11-15 1:CAS:528:DC%2BC2MXivVahsrk%3D doi:10.1186/1550-2783-11-15
PubMedGoogle Scholar
KoRLow DogTGoreckiDKCantilenaLRCostelloRBEvansWJ et al Evidence-based evaluation of potential benefits and safety of beta-alanine supplementation for military personnelNutr Rev201472 3 217 25 24697258 https://doi.org/10.1111/nure.12087
PubMedGoogle Scholar
HoffmanJRLandauGStoutJRHoffmanMWShavitNRosenP et al beta-Alanine ingestion increases muscle carnosine content and combat specific performance in soldiersAmino Acids201547 3 627 36 4326648 1:CAS:528:DC%2BC2cXitFCrtbjE 25510839 https://doi.org/10.1007/s00726-014-1896-7 doi:10.1007/s00726-014-1896-7
PubMed Web of Science ®Google Scholar
SolisMYCooperSHobsonRMArtioliGGOtaduyMCRoschelH et al Effects of Beta-alanine supplementation on brain homocarnosine/carnosine signal and cognitive function: an exploratory studyPLoS One201510 4 4397072 25875297 https://doi.org/10.1371/journal.pone.0123857
PubMedGoogle Scholar
PeartDJSieglerJCVinceRVPractical recommendations for coaches and athletes: a meta-analysis of sodium bicarbonate use for athletic performanceJ Strength Cond Res201226 7 1975 83 22505127 https://doi.org/10.1519/JSC.0b013e3182576f3d
PubMed Web of Science ®Google Scholar
TobiasGBenattiFBde SallesPVRoschelHGualanoBSaleC et al Additive effects of beta-alanine and sodium bicarbonate on upper-body intermittent performanceAmino Acids201345 2 309 17 3714561 1:CAS:528:DC%2BC3sXhtFelsbvO 23595205 https://doi.org/10.1007/s00726-013-1495-z
PubMed Web of Science ®Google Scholar
MeroAAHirvonenPSaarelaJHulmiJJHoffmanJRStoutJREffect of sodium bicarbonate and beta-alanine supplementation on maximal sprint swimmingJ Int Soc Sports Nutr201310 1 52 4176133 24215679 https://doi.org/10.1186/1550-2783-10-52 1:CAS:528:DC%2BC2cXislOqsbo%3D
PubMedGoogle Scholar
DuckerKJDawsonBWallmanKEEffect of Beta alanine and sodium bicarbonate supplementation on repeated-sprint performanceJ Strength Cond Res201327 12 3450 60 23524361 https://doi.org/10.1519/JSC.0b013e31828fd310
PubMed Web of Science ®Google Scholar
SaundersBSaleCHarrisRCSunderlandCEffect of sodium bicarbonate and Beta-alanine on repeated sprints during intermittent exercise performed in hypoxiaInt J Sport Nutr Exerc Metab201424 2 196 205 1:CAS:528:DC%2BC2cXhtVyiurnE 24225816 https://doi.org/10.1123/ijsnem.2013-0102
PubMed Web of Science ®Google Scholar
BellingerPMHoweSTShingCMFellJWEffect of combined beta-alanine and sodium bicarbonate supplementation on cycling performanceMed Sci Sports Exerc201244 8 1545 51 1:CAS:528:DC%2BC38XhtVCrsrbK 22330016 https://doi.org/10.1249/MSS.0b013e31824cc08d
PubMed Web of Science ®Google Scholar
CarrAJSlaterGJGoreCJDawsonBBurkeLMEffect of sodium bicarbonate on [HCO3-], pH, and gastrointestinal symptomsInt J Sport Nutr Exerc Metab201121 3 189 94 1:CAS:528:DC%2BC3MXos1SnsLw%3D 21719899
PubMed Web of Science ®Google Scholar
BranchJDEffect of creatine supplementation on body composition and performance: a meta-analysisInt J Sport Nutr Exerc Metab200313 2 198 226 1:CAS:528:DC%2BD3sXlsVemtrc%3D 12945830
PubMed Web of Science ®Google Scholar
HarrisRCHillCWiseJAEffect of combined beta-alanine and creatine monohydrate supplementation on exercise performance (Abstract)Med Sci Sports Exerc200335 5 S218 https://doi.org/10.1097/00005768-200305001-01206
Google Scholar
KrestaJYOliverJMJagimARFluckeyJRiechmanSKellyK et al Effects of 28 days of beta-alanine and creatine supplementation on muscle carnosine, body composition and exercise performance in recreationally active femalesJ Int Soc Sports Nutr201411 1 55 4263036 25505854 https://doi.org/10.1186/s12970-014-0055-6 1:CAS:528:DC%2BC2MXitlCit7w%3D
PubMedGoogle Scholar
WalshALGonzalezAMRatamessNAKangJHoffmanJRImproved time to exhaustion following ingestion of the energy drink Amino ImpactJ Int Soc Sports Nutr20107 14 2861014 20398312 https://doi.org/10.1186/1550-2783-7-14 1:CAS:528:DC%2BC3cXlsVyrtrc%3D
PubMed Web of Science ®Google Scholar
SpradleyBDCrowleyKRTaiCYKendallKLFukudaDHEspositoEN et al Ingesting a pre-workout supplement containing caffeine, B-vitamins, amino acids, creatine, and beta-alanine before exercise delays fatigue while improving reaction time and muscular enduranceNutr Metab (Lond)20129 28 1:CAS:528:DC%2BC38XotlCqt7w%3D https://doi.org/10.1186/1743-7075-9-28 doi:10.1186/1743-7075-9-28
PubMed Web of Science ®Google Scholar
SpillaneMSchwarzNLeddySCorreaTMinterMLongoriaV et al Effects of 28 days of resistance exercise while consuming commercially available pre- and post-workout supplements, NO-Shotgun(R) and NO-Synthesize(R) on body composition, muscle strength and mass, markers of protein synthesis, and clinical safety markers in malesNutr Metab (Lond)20118 78 1:CAS:528:DC%2BC38XhsFWluw%3D%3D https://doi.org/10.1186/1743-7075-8-78 doi:10.1186/1743-7075-8-78
Web of Science ®Google Scholar
ShelmadineBCookeMBufordTHudsonGReddLLeutholtzB et al Effects of 28 days of resistance exercise and consuming a commercially available pre-workout supplement, NO-Shotgun(R), on body composition, muscle strength and mass, markers of satellite cell activation, and clinical safety markers in malesJ Int Soc Sports Nutr20096 16 2731073 19656392 https://doi.org/10.1186/1550-2783-6-16 1:CAS:528:DC%2BC3cXksVKiuro%3D
PubMedGoogle Scholar
OrmsbeeMJThomasDDMandlerWKWardEGKinseyAWPantonLB et al The effects of pre- and post-exercise consumption of multi-ingredient performance supplements on cardiovascular health and body fat in trained men after six weeks of resistance training: a stratified, randomized, double-blind studyNutr Metab (Lond)201310 1 39 1:CAS:528:DC%2BC3sXptFygsLg%3D https://doi.org/10.1186/1743-7075-10-39
Web of Science ®Google Scholar
OrmsbeeMJMandlerWKThomasDDWardEGKinseyAWSimonaviceE et al The effects of six weeks of supplementation with multi-ingredient performance supplements and resistance training on anabolic hormones, body composition, strength, and power in resistance-trained menJ Int Soc Sports Nutr20129 1 49 3542109 1:CAS:528:DC%2BC3sXhvVOku74%3D 23153110 https://doi.org/10.1186/1550-2783-9-49
PubMedGoogle Scholar
KendallKLMoonJRFairmanCMSpradleyBDTaiCYFalconePH et al Ingesting a preworkout supplement containing caffeine, creatine, beta-alanine, amino acids, and B vitamins for 28 days is both safe and efficacious in recreationally active menNutr Res201434 5 442 9 1:CAS:528:DC%2BC2cXotFynur4%3D 24916558 https://doi.org/10.1016/j.nutres.2014.04.003
PubMedGoogle Scholar
GonzalezAMWalshALRatamessNAKangJHoffmanJREffect of a pre-workout energy supplement on acute multi-joint resistance exerciseJ Sports Sci Med201110 2 261 6 3761845 24149870
PubMed Web of Science ®Google Scholar
OutlawJJWilbornCDSmith-RyanAEHaywardSEUrbinaSLTaylorLW et al Acute effects of a commercially-available pre-workout supplement on markers of training: a double-blind studyJ Int Soc Sports Nutr201411 40 4190923 25302053 https://doi.org/10.1186/s12970-014-0040-0 1:CAS:528:DC%2BC2cXhvFKgsr7P
PubMed Web of Science ®Google Scholar
HipkissARGlycation, ageing and carnosine: are carnivorous diets beneficial?Mech Ageing Dev2005126 10 1034 9 1:CAS:528:DC%2BD2MXpvFeisbk%3D 15955546 https://doi.org/10.1016/j.mad.2005.05.002
PubMedGoogle Scholar
HipkissARCartwrightSPBromleyCGrossSRBillRMCarnosine: can understanding its actions on energy metabolism and protein homeostasis inform its therapeutic potential?Chem Cent J20137 1 38 3602167 23442334 https://doi.org/10.1186/1752-153X-7-38 1:CAS:528:DC%2BC3sXpvVKmtLc%3D
PubMedGoogle Scholar
HipkissARBrownsonCCarrierMJCarnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groupsMech Ageing Dev2001122 13 1431 45 1:CAS:528:DC%2BD3MXltFyqsr8%3D 11470131 https://doi.org/10.1016/S0047-6374(01)00272-X
PubMed Web of Science ®Google Scholar
HipkissARMichaelisJSyrrisPNon-enzymatic glycosylation of the dipeptide L-carnosine, a potential anti-protein-cross-linking agentFEBS Lett1995371 1 81 5 1:CAS:528:DyaK2MXotFCltrw%3D 7664889 https://doi.org/10.1016/0014-5793(95)00849-5
PubMed Web of Science ®Google Scholar
DeckerEACrumADCalvertJTDifferences in the antioxidant mechanism of carnosine in the presence of copper and ironJ Agric Food Chem199240 756 9 1:CAS:528:DyaK38XitlCjurw%3D https://doi.org/10.1021/jf00017a009
Web of Science ®Google Scholar
DeckerEAIvanovVZhuBZFreiBInhibition of low-density lipoprotein oxidation by carnosine histidineJ Agric Food Chem200149 1 511 6 1:CAS:528:DC%2BD3cXos1Kmt7w%3D 11305256 https://doi.org/10.1021/jf0010533
PubMedGoogle Scholar
GariballaSESinclairAJCarnosine: physiological properties and therapeutic potentialAge Ageing200029 3 207 10 1:STN:280:DC%2BD3M%2FhtF2htQ%3D%3D 10855900 https://doi.org/10.1093/ageing/29.3.207
PubMed Web of Science ®Google Scholar
SmithAEStoutJRKendallKLFukudaDHCramerJTExercise-induced oxidative stress: the effects of beta-alanine supplementation in womenAmino Acids201243 1 77 90 1:CAS:528:DC%2BC38XotlOht7o%3D 22102056 https://doi.org/10.1007/s00726-011-1158-x
PubMed Web of Science ®Google Scholar
Smith-RyanAEFukudaDHStoutJRKendallKLThe influence of beta-alanine supplementation on markers of exercise-induced oxidative stressAppl Physiol Nutr Metab201439 1 38 46 1:CAS:528:DC%2BC3sXhs1yhsb3O 24383505 https://doi.org/10.1139/apnm-2013-0229
PubMedGoogle Scholar
BoldyrevAKurellaEStvolinskiSBiological role of carnosine metabolism in excitable tissues: speculations and factsPathophysiology19941 215 9 1:CAS:528:DyaK2MXltlCjt7w%3D https://doi.org/10.1016/0928-4680(94)90040-X
Google Scholar
HoffmanJROstfeldIStoutJRHarrisRCKaplanZCohenHbeta-Alanine supplemented diets enhance behavioral resilience to stress exposure in an animal model of PTSDAmino Acids2015
Web of Science ®Google Scholar
DutkaTLLambGDEffect of carnosine on excitation-contraction coupling in mechanically-skinned rat skeletal muscleJ Muscle Res Cell Motil200425 3 203 13 1:CAS:528:DC%2BD2cXmslWgt7s%3D 15467383 https://doi.org/10.1023/B:JURE.0000038265.37022.c5
PubMedGoogle Scholar
LamontCMillerDJCalcium sensitizing action of carnosine and other endogenous imidazoles in chemically skinned striated muscleJ Physiol1992454 421 34 1175612 1:CAS:528:DyaK38Xks1Ogu7w%3D 1474497 https://doi.org/10.1113/jphysiol.1992.sp019271
PubMed Web of Science ®Google Scholar
HannahRStannardRLMinshullCArtioliGGHarrisRCSaleCbeta-Alanine supplementation enhances human skeletal muscle relaxation speed but not force production capacityJ Appl Physiol (1985)2015118 5 604 12 1:CAS:528:DC%2BC2MXmtlShtrk%3D https://doi.org/10.1152/japplphysiol.00991.2014 doi:10.1152/japplphysiol.00991.2014
Web of Science ®Google Scholar

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