1,353
Views
30
CrossRef citations to date
0
Altmetric
Research Article

Native whey protein with high levels of leucine results in similar post-exercise muscular anabolic responses as regular whey protein: a randomized controlled trial

, , , , , , , , & show all

References

  • AretaJLBurkeLMRossMLCameraDMWestDWDBroadEMBroadEMJeacockeNAMooreDRStellingwerffTPhillipsSMHawleyJACoffeyVGTiming and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesisJ Physiol2013591 Pt 9 2319 2331 1:CAS:528:DC%2BC3sXos1Kgurg%3D 10.1113/jphysiol.2012.244897 23459753 3650697
  • Atherton, P.J., Etheridge, T., Watt, P.W., Wilkinson, D., Selby, A., Rankin, D., Smith, K., and Rennie, M.J. 2010a. Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling. The American journal of clinical nutrition 92(5): 1080–1088. American Society for Nutrition. doi:https://doi.org/https://doi.org/10.3945/ajcn.2010.29819.
  • Atherton PJ, Kumar V, Selby A, Rankin D, Hildebrandt W, Phillips B, Williams J, Hiscock N, Smith K. Enriching a protein drink with leucine augments muscle protein synthesis after resistance exercise in young and older men. Clinical Nutrition In press. 2016; https://doi.org/https://doi.org/10.1016/j.clnu.2016.04.025.
  • AthertonPJSmithKEtheridgeTRankinDRennieMJ Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells Amino Acids2010 Vienna Springer 1533 1539 5
  • BorsheimETiptonKDWolfSEWolfeRREssential amino acids and muscle protein recovery from resistance exerciseAm J Physiol Endocrinol Metab2002283 4 E648 E657 1:CAS:528:DC%2BD38XotV2rurg%3D 10.1152/ajpendo.00466.2001 12217881 American Physiological Society
  • BuckleyJDThomsonRLCoatesAMHowePRCDeNichiloMORowneyMKSupplementation with a whey protein hydrolysate enhances recovery of muscle force-generating capacity following eccentric exerciseJ Sci Med Sport201013 1 178 181 10.1016/j.jsams.2008.06.007 18768358
  • BurdNAWestDWWestDWRerecichTRerecichTPriorTPriorTBakerSKPhillipsSMValidation of a single biopsy approach and bolus protein feeding to determine myofibrillar protein synthesis in stable isotope tracer studies in humansNutr Metab (Lond)20118 1 15 1:CAS:528:DC%2BC3MXjslKnu7o%3D 10.1186/1743-7075-8-15 BioMed Central Ltd
  • BurdNAYangYMooreDRTangJETarnopolskyMAPhillipsSMGreater stimulation of myofibrillar protein synthesis with ingestion of whey protein isolate v. Micellar casein at rest and after resistance exercise in elderly menBr J Nutr2012108 6 958 962 1:CAS:528:DC%2BC38XhtlWiu7rJ 10.1017/S0007114511006271 22289570
  • Churchward-VenneTABreenLDi DonatoDMHectorAJMitchellCJMooreDRStellingwerffTBreuilleDOffordEABakerSKPhillipsSMLeucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men: a double-blind, randomized trialAm J Clin Nutr201499 2 276 286 1:CAS:528:DC%2BC2cXhs1WlsLk%3D 10.3945/ajcn.113.068775 24284442
  • Churchward-VenneTABurdNAMitchellCJWestDWDPhilpAMarcotteGRBakerSKBaarKPhillipsSMSupplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in menJ Physiol2012590 Pt 11 2751 2765 1:CAS:528:DC%2BC38XhtFGrsL%2FF 10.1113/jphysiol.2012.228833 22451437 3424729
  • CookeMBRybalkaEStathisCGCribbPJHayesAWhey protein isolate attenuates strength decline after eccentrically-induced muscle damage in healthy individualsJ Int Soc sports Nutr20107 1 30 10.1186/1550-2783-7-30 20860817 2955583 BioMed Central
  • DreyerHCDrummondMJPenningsBFujitaSGlynnELChinkesDLDhananiSVolpiERasmussenBBLeucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscleAm J Physiol Endocrinol Metab2008294 2 E392 E400 1:CAS:528:DC%2BD1cXit1yktbc%3D 10.1152/ajpendo.00582.2007 18056791
  • GlynnELFryCSDrummondMJDreyerHCDhananiSVolpiERasmussenBBMuscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exerciseAm J Physiol Regul Integr Comp Physiol2010299 2 R533 R540 1:CAS:528:DC%2BC3cXhtVOhu7fN 10.1152/ajpregu.00077.2010 20519362 2928613
  • GlynnELFryCSDrummondMJTimmermanKLDhananiSVolpiERasmussenBBExcess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and womenJournal of nutrition2010140 11 1970 1976 1:CAS:528:DC%2BC3cXhtl2nur%2FE 10.3945/jn.110.127647 20844186 2955876 American Society for Nutrition
  • GreenhaffPLKaragounisLGPeirceNSimpsonEJHazellMLayfieldRWackerhageHSmithKAthertonPSelbyARennieMJDisassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscleAm J Physiol Endocrinol Metab2008295 295 E595 E604 1:CAS:528:DC%2BD1cXhtFCgt7%2FM 10.1152/ajpendo.90411.2008 18577697 2536736
  • Hamarsland, H., Laahne, J.A.L., Paulsen, G., Cotter, M., Borsheim, E., and Raastad, T. 2017. Native whey induces higher and faster leucinemia than other whey protein supplements and milk: a randomized controlled trial. BMC Nutrition 2017 3:1 3(1): 10. BioMed Central. doi:https://doi.org/https://doi.org/10.1186/s40795-017-0131-9.
  • Helsedirektoratet Kostråd for å fremme folkehelsa og forebygge kroniske sykdommer2011 Helsedirektoratet
  • HulmiJJTannerstedtJSelänneHKainulainenHKovanenVMeroAAResistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in menJ Appl Physiol2009106 5 1720 1729 1:CAS:528:DC%2BD1MXlvFOgsb8%3D 10.1152/japplphysiol.00087.2009 19299575
  • KangSAPacoldMECervantesCLLimDLouHJOttinaKGrayNSTurkBEYaffeMBSabatiniDMmTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycinScience2013341 6144 1236566 1236566 10.1126/science.1236566 23888043 3771538 American Association for the Advancement of Science
  • Lactalis. ᅟ (n.d.). 2016. Pronativ.com. Available from http://pronativ.com/#home-research. Accessed 22 Aug 2017.
  • Mitchell, C.J., McGregor, R.A., D'Souza, R.F., Thorstensen, E.B., Markworth, J.F., Fanning, A.C., Poppitt, S.D., and Cameron-Smith, D. 2015a.a Consumption of milk protein or whey protein results in a similar increase in muscle protein synthesis in middle aged men. Nutrients 7(10): 8685–8699. Multidisciplinary Digital Publishing Institute. doi:https://doi.org/https://doi.org/10.3390/nu7105420.
  • MitchellWKPhillipsBEWilliamsJPRankinDLundJNSmithKAthertonPJA dose- rather than delivery profile-dependent mechanism regulates the “muscle-full” effect in response to oral essential amino acid intake in young menThe journal of nutrition2015145 2 207 214 1:CAS:528:DC%2BC2MXivFOis78%3D 10.3945/jn.114.199604 25644339 American Society for Nutrition
  • MooreDRAthertonPJRennieMJTarnopolskyMAPhillipsSMResistance exercise enhances mTOR and MAPK signalling in human muscle over that seen at rest after bolus protein ingestionActa Physiol (Oxf)2011201 3 365 372 1:CAS:528:DC%2BC3MXislGjtbo%3D 10.1111/j.1748-1716.2010.02187.x Blackwell Publishing Ltd
  • MooreDRMooreDRTangJETangJEBurdNABurdNARerecichTRerecichTTarnopolskyMAPhillipsSMDifferential stimulation of myofibrillar and sarcoplasmic protein synthesis with protein ingestion at rest and after resistance exerciseThe journal of physiology2009587 4 897 904 1:CAS:528:DC%2BD1MXjtFGqtL4%3D 10.1113/jphysiol.2008.164087 19124543 2669978 Blackwell Science Inc
  • Moore, D.R., Robinson, M.J., Fry, J.L., Tang, J.E., Glover, E.I., Wilkinson, S.B., Prior, T., Tarnopolsky, M.A., and Phillips, S.M. 2009bb. Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. The American journal of clinical nutrition 89(1): 161–168. American Society for Nutrition. doi:https://doi.org/https://doi.org/10.3945/ajcn.2008.26401.
  • PaulsenGHamarslandHCummingKTJohansenREHulmiJJBorsheimEWiigHGartheIRaastadTVitamin C and E supplementation alters protein signalling after a strength training session, but not muscle growth during 10 weeks of trainingJ Physiol2014592 24 5391 5408 1:CAS:528:DC%2BC2cXitVOhsLjE 10.1113/jphysiol.2014.279950 25384788 4270502
  • PaulsenGMikkelsenURRaastadTPeakeJMLeucocytes, cytokines and satellite cells: what role do they play in muscle damage and regeneration following eccentric exercise?Exerc Immunol Rev201218 42 97 22876722
  • PenningsBBoirieYSendenJMGGijsenAPKuipersHvan LoonLJCWhey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older menAm J Clin Nutr201193 5 997 1005 1:CAS:528:DC%2BC3MXltlCqsb8%3D 10.3945/ajcn.110.008102 21367943
  • PhillipsSMA brief review of critical processes in exercise-induced muscular hypertrophySports Med201444 Suppl 1 71 77 10.1007/s40279-014-0152-3 4008813
  • Phillips, S.M., Tipton, K.D., Aarsland, A., Wolf, S.E., and Wolfe, R.R. 1997. Mixed muscle protein synthesis and breakdown after resistance exercise in humans. 273(1): E99–E107. Available from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=mekentosj&SrcApp=Papers&DestLinkType=FullRecord&DestApp=WOS&KeyUT=A1997XK48800013.
  • ReidyPTRasmussenBBRole of ingested amino acids and protein in the promotion of resistance exercise-induced muscle protein anabolismJournal of nutrition2016146 155 183 1:CAS:528:DC%2BC28XhsFWrtbbO 10.3945/jn.114.203208 26764320 4725426 American Society for Nutrition
  • Reidy PT, Walker DK, Dickinson JM, Gundermann DM, Drummond MJ, Timmerman KL, Fry CS, Borack MS, Borack MS, Cope MB, Cope MB, Mukherjea R, Mukherjea R, Jennings K, Volpi E, Rasmussen BB. Protein blend ingestion following resistance exercise promotes human muscle protein synthesis. J Nutr. 2013; https://doi.org/https://doi.org/10.3945/jn.112.168021.
  • ReitelsederSAgergaardJDoessingSHelmarkICLundPKristensenNBFrystykJFlyvbjergASchjerlingPvan HallGKjaerMHolmLWhey and casein labeled with L-[1-13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestionAJP: Endocrinology and Metabolism2011300 1 E231 E242 1:CAS:528:DC%2BC3MXhvVSjsbs%3D
  • RennieMJEdwardsRHHallidayDMatthewsDEWolmanSLMillwardDJMuscle protein synthesis measured by stable isotope techniques in man: the effects of feeding and fastingClin Sci198263 6 519 523 1:CAS:528:DyaL3sXovVSqsQ%3D%3D 10.1042/cs0630519 6181926
  • SchiaffinoSDyarKACiciliotSBlaauwBSandriMMechanisms regulating skeletal muscle growth and atrophyFEBS J2013280 17 4294 4314 1:CAS:528:DC%2BC3sXht1ymu7nK 10.1111/febs.12253 23517348
  • TangJEMooreDRKujbidaGWTarnopolskyMAPhillipsSMIngestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young menJ Appl Physiol2009107 3 987 992 1:CAS:528:DC%2BD1MXhtFKnurvN 10.1152/japplphysiol.00076.2009 19589961
  • ThoreenCCKangSAChangJWLiuQZhangJGaoYReichlingLJSimTSabatiniDMGrayNSAn ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1J. Biol. Chem2009284 12 8023 8032 1:CAS:528:DC%2BD1MXjtVSmtLY%3D 10.1074/jbc.M900301200 19150980 2658096 American Society for Biochemistry and Molecular Biology
  • TiptonKDElliottTACreeMGWolfSESanfordAPWolfeRRIngestion of casein and whey proteins result in muscle anabolism after resistance exerciseMed Sci Sport Exer200436 12 2073 2081 1:CAS:528:DC%2BD2cXhtVals73F 10.1249/01.MSS.0000147582.99810.C5
  • VolpiEKobayashiHSheffield-MooreMMittendorferBWolfeRREssential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adultsAm J Clin Nutr200378 2 250 258 1:CAS:528:DC%2BD3sXlvF2is70%3D 12885705 3192452 Available from http://ajcn.nutrition.org/content/78/2/250.full
  • WestDWBurdNACoffeyVGBakerSKBurkeLMHawleyJAMooreDRStellingwerffTPhillipsSMRapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exerciseAm J Clin Nutr201194 3 795 803 1:CAS:528:DC%2BC3MXhtFSqu7vE 10.3945/ajcn.111.013722 21795443
  • WilkinsonSBTarnopolskyMAMacdonaldMJMacDonaldJRArmstrongDPhillipsSMConsumption of fluid skim milk promotes greater muscle protein accretion after resistance exercise than does consumption of an isonitrogenous and isoenergetic soy-protein beverageAm J Clin Nutr200785 4 1031 1040 1:CAS:528:DC%2BD2sXks1Ogs7o%3D 17413102 Available from http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=17413102&retmode=ref&cmd=prlinks
  • WitardOCJackmanSRBreenLSmithKSelbyATiptonKDMyofibrillar muscle protein synthesis rates subsequent to a meal in response to increasing doses of whey protein at rest and after resistance exerciseAm. J. Clin. Nutr201499 1 86 95 1:CAS:528:DC%2BC2cXislamtw%3D%3D 10.3945/ajcn.112.055517 24257722 American Society for Nutrition
  • Wolfe RR, Chinkes DL. Isotope tracers in metabolic research: John Wiley & Sons; 2005.