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Journal of the International Society of Sports Nutrition Volume 16, 2019 - Issue 1

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Dietary Aronia melanocarpa extract enhances mTORC1 signaling, but has no effect on protein synthesis and protein breakdown-related signaling, in response to resistance exercise in rat skeletal muscle

Yuhei Makanae1 Department of Physical EducationNational Defense AcademyYokosukaKanagawaJapan;2 Ritsumeikan Global Innovation Research OrganizationRitsumeikan UniversityKusatsuShigaJapan;3 Faculty of Sports and Health ScienceRitsumeikan UniversityKusatsuShigaJapan

Satoru Ato3 Faculty of Sports and Health ScienceRitsumeikan UniversityKusatsuShigaJapan;4 Department of Life Science and Applied ChemistryNagoya Institute of TechnologyNagoyaJapan

Kohei Kido3 Faculty of Sports and Health ScienceRitsumeikan UniversityKusatsuShigaJapan;5 Laboratory of Sports and Exercise Medicine, Graduate School of Human and Envionmental StudiesKyoto UniversityKyotoJapan

Satoshi Fujita2 Ritsumeikan Global Innovation Research OrganizationRitsumeikan UniversityKusatsuShigaJapan;3 Faculty of Sports and Health ScienceRitsumeikan UniversityKusatsuShigaJapanCorrespondence[email protected]

https://orcid.org/0000-0002-2297-1647

Article: 60 | Published online: 01 Apr 2022

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https://doi.org/10.1186/s12970-019-0328-1
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WangZMYingZBosy-WestphalAZhangJLaterWHeymsfieldSB et al Specific metabolic rates of major organs and tissues across adulthood evaluation by mechanistic model of resting energy expenditureAm J Clin Nutr201092 1396 1377 https://doi.org/10.3945/ajcn.2010.29885 1:CAS:528:DC%2BC3cXhsFGgtLfJ
Google Scholar
BodineSCStittTNGonzalezMKlineWOStoverGLBauerleinR et al Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivoNat Cell Biol20013 1014 1019 1:CAS:528:DC%2BD3MXosVCjsrk%3D 11715023 https://doi.org/10.1038/ncb1101-1014
PubMed Web of Science ®Google Scholar
GoodmanCAFreyJWMabreyDMJacobsBLLincolnHCYouJS et al The role of skeletal muscle mTOR in the regulation of mechanical load-induced growthJ Physiol2011589 5485 5501 1:CAS:528:DC%2BC3MXhsFyhu7vE 21946849 3240886 https://doi.org/10.1113/jphysiol.2011.218255
PubMed Web of Science ®Google Scholar
BaarKEsserKPhosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exerciseAm J Phys1999276 C120 C127 1:CAS:528:DyaK1MXnt12qtw%3D%3D https://doi.org/10.1152/ajpcell.1999.276.1.C120
PubMed Web of Science ®Google Scholar
MitchellCJChurchward-VenneTABellamyLPariseGBakerSKPhillipsSMMuscular and systemic correlates of resistance training-induced muscle hypertrophyPLoS One20138 e78636 1:CAS:528:DC%2BC3sXhs1egs7jN 24130904 3793973 https://doi.org/10.1371/journal.pone.0078636
PubMed Web of Science ®Google Scholar
OgasawaraRFujitaSHornbergerTAKitaokaYMakanaeYNakazatoK et al The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exerciseSci Rep20166 31142 1:CAS:528:DC%2BC28XhtlCisbvM 27502839 4977552 https://doi.org/10.1038/srep31142
PubMed Web of Science ®Google Scholar
BondPRegulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glanceJ Int Soc Sports Nutr201613 s12970 016-0118-y https://doi.org/10.1186/s12970-016-0118-y 1:CAS:528:DC%2BC2sXis1ejt7g%3D
Google Scholar
NakashimaKYakabeYAMPK activation stimulates myofibrillar protein degradation and expression of atrophy-related ubiquitin ligases by increasing FOXO transcription factors in C2C12 myotubesBiosci Biotechnol Biochem200771 1650 1656 1:CAS:528:DC%2BD2sXovFakt7w%3D 17617726 https://doi.org/10.1271/bbb.70057
PubMed Web of Science ®Google Scholar
RussellRCYuanHXGuanKLAutophagy regulation by nutrient signalingCell Res201424 42 57 1:CAS:528:DC%2BC3sXhvFCru77L 24343578 https://doi.org/10.1038/cr.2013.166
PubMed Web of Science ®Google Scholar
BodineSCBaehrLMSkeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1Am J Physiol Endocrinol Metab2014307 E469 E484 1:CAS:528:DC%2BC2cXhslChurzP 25096180 4166716 https://doi.org/10.1152/ajpendo.00204.2014
PubMed Web of Science ®Google Scholar
ZachariMGanleyIGThe mammalian ULK1 complex and autophagy initiationEssays Biochem201761 585 596 29233870 5869855 https://doi.org/10.1042/EBC20170021
PubMed Web of Science ®Google Scholar
BurdNAHolwerdaAMSelbyKCWestDWStaplesAWCainNE et al Resistance exercise volume affects myofibrillar protein synthesis and anabolic signalling molecule phosphorylation in young menJ Physiol2010588 3119 3130 1:CAS:528:DC%2BC3cXhtFWmsrjJ 20581041 2956949 https://doi.org/10.1113/jphysiol.2010.192856
PubMed Web of Science ®Google Scholar
FujitaSDreyerHCDrummondMJGlynnELCadenasJGYoshizawaF et al Nutrient signalling in the regulation of human muscle protein synthesisJ Physiol2007582 813 823 1:CAS:528:DC%2BD2sXosFCisbs%3D 17478528 2075348 https://doi.org/10.1113/jphysiol.2007.134593
PubMedGoogle Scholar
KunkelSDSunejaMEbertSMBongersKSFoxDKMalmbergSE et al mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle massCell Metab201113 627 638 1:CAS:528:DC%2BC3MXntFSltL0%3D 21641545 3120768 https://doi.org/10.1016/j.cmet.2011.03.020
PubMed Web of Science ®Google Scholar
OgasawaraRSatoKHigashidaKNakazatoKFujitaSUrsolic acid stimulates mTORC1 signaling after resistance exercise in rat skeletal muscleAm J Physiol Endocrinol Metab2013305 E760 E765 1:CAS:528:DC%2BC3sXhs1Sqsb%2FF 23900420 https://doi.org/10.1152/ajpendo.00302.2013 23900420
PubMed Web of Science ®Google Scholar
OgasawaraRSuginoharaTRapamycin-insensitive mechanistic target of rapamycin regulates basal and resistance exercise-induced muscle protein synthesisFASEB J201832 5824 5834 1:CAS:528:DC%2BC1cXisVeiurvN https://doi.org/10.1096/fj.201701422R
Google Scholar
IkedaYMurakamiAOhigashiHUrsolic acid: an anti- and pro-inflammatory triterpenoidMol Nutr Food Res200852 26 42 1:CAS:528:DC%2BD1cXhsFSjtb4%3D 18203131 https://doi.org/10.1002/mnfr.200700389 18203131
PubMed Web of Science ®Google Scholar
KullingSERawelHMChokeberry (aronia melanocarpa) - a review on the characteristic components and potential health effectsPlanta Med200874 1625 1634 1:CAS:528:DC%2BD1cXhtl2hsb3F 18937167 https://doi.org/10.1055/s-0028-1088306
PubMed Web of Science ®Google Scholar
Zapolska-DownarDBrykDMaleckiMHajdukiewiczKSitkiewiczDAronia melanocarpa fruit extract exhibits anti-inflammatory activity in human aortic endothelial cellsEur J Nutr201251 563 572 1:CAS:528:DC%2BC38XhtVGhsLbI 21863241 https://doi.org/10.1007/s00394-011-0240-1
PubMed Web of Science ®Google Scholar
BlomstrandEEliassonJKarlssonHKKöhnkeRBranched-chain amino acids activate key enzymes in protein synthesis after physical exerciseJ Nutr2006136 269S 273S 1:CAS:528:DC%2BD28XivFSitg%3D%3D 16365096 https://doi.org/10.1093/jn/136.1.269S 16365096
PubMed Web of Science ®Google Scholar
DreyerHCDrummondMJPenningsBFujitaSGlynnELChinkesDL et al Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscleAm J Physiol Endocrinol Metab2008294 E392 E400 1:CAS:528:DC%2BD1cXit1yktbc%3D 18056791 https://doi.org/10.1152/ajpendo.00582.2007 18056791
PubMed Web of Science ®Google Scholar
KarlssonHKNilssonPANilssonJChibalinAVZierathJRBlomstrandEBranched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exerciseAm J Physiol Endocrinol Metab2004287 E1 E7 1:CAS:528:DC%2BD2cXlvFOhtLc%3D 14998784 https://doi.org/10.1152/ajpendo.00430.2003 14998784
PubMed Web of Science ®Google Scholar
BorgenvikMAproWBlomstrandEIntake of branched-chain amino acids influences the levels of MAFbx mRNA and MuRF-1 total protein in resting and exercising human muscleAm J Physiol Endocrinol Metab2012302 E510 E521 1:CAS:528:DC%2BC38XkslSrt7g%3D 22127230 https://doi.org/10.1152/ajpendo.00353.2011 22127230
PubMed Web of Science ®Google Scholar
WilloughbyDSStoutJRWilbornCDEffects of resistance training and protein plus amino acid supplementation on muscle anabolism, mass, and strengthAmino Acids200732 467 477 1:CAS:528:DC%2BD2sXlsVGnsLk%3D 16988909 https://doi.org/10.1007/s00726-006-0398-7 16988909
PubMed Web of Science ®Google Scholar
YouJSMcNallyRMJacobsBLPrivettREGundermannDMLinKH et al The role of raptor in the mechanical load-induced regulation of mTOR signaling, protein synthesis, and skeletal muscle hypertrophyFASEB J201933 4021 4034 1:CAS:528:DC%2BC1MXptl2htrY%3D 30509128 https://doi.org/10.1096/fj.201801653RR 30509128
PubMedGoogle Scholar
JungCHRoSHCaoJOttoNMKimDHmTOR regulation of autophagyFEBS Lett2010584 1287 1295 1:CAS:528:DC%2BC3cXjs12nu74%3D 20083114 2846630 https://doi.org/10.1016/j.febslet.2010.01.017
PubMed Web of Science ®Google Scholar
ZhaoJZhaiBGygiSPGoldbergALmTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagyProc Natl Acad Sci U S A2015112 15790 15797 1:CAS:528:DC%2BC2MXitVWjtLjI 26669439 4703015 https://doi.org/10.1073/pnas.1521919112
PubMed Web of Science ®Google Scholar
NakazatoKOchiEWagaTDietary apple polyphenols have preventive effects against lengthening contraction-induced muscle injuriesMol Nutr Food Res201054 364 372 1:CAS:528:DC%2BC3cXjtFKhs7w%3D 19866470 https://doi.org/10.1002/mnfr.200900145 19866470
PubMedGoogle Scholar
MakanaeYOgasawaraRSatoKTakamuraYMatsutaniKKidoK et al Acute bout of resistance exercise increases vitamin D receptor protein expression in rat skeletal muscleExp Physiol2015100 1168 1176 1:CAS:528:DC%2BC2MXhs1GhtL3F 26347486 https://doi.org/10.1113/EP085207 26347486
PubMed Web of Science ®Google Scholar
GoodmanCAMabreyDMFreyJWMiuMHSchmidtEKPierreP et al Novel insights into the regulation of skeletal muscle synthesis as revealed by a new nonradioactive in vivo techniqueFASEB J201125 1028 1039 1:CAS:528:DC%2BC3MXivF2ltr0%3D 21148113 3042844 https://doi.org/10.1096/fj.10-168799
PubMed Web of Science ®Google Scholar
AtoSMakanaeYKidoKFujitaSContraction mode itself does not determine the level of mTORC1 activity in rat skeletal musclePhysiol Rep20164 e12976 27688433 5064134 https://doi.org/10.14814/phy2.12976 1:CAS:528:DC%2BC28Xhs1KrsLvK
PubMedGoogle Scholar
KidoKSatoKMakanaeYAtoSHayashiTFujitaSHerbal supplement Kamishimotsuto augments resistance exercise-induced mTORC1 signaling in rat skeletal muscleNutrition201632 108 113 1:CAS:528:DC%2BC2MXhsFyhurjF 26423232 https://doi.org/10.1016/j.nut.2015.06.015
PubMedGoogle Scholar
KimJKunduMViolletBGuanKLAMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1Nat Cell Biol201113 132 141 1:CAS:528:DC%2BC3MXhtlamtb0%3D 21258367 3987946 https://doi.org/10.1038/ncb2152
PubMed Web of Science ®Google Scholar
MizushimaNThe role of the Atg1/ULK1 complex in autophagy regulationCurr Opin Cell Biol201022 132 139 1:CAS:528:DC%2BC3cXks1SrtL0%3D 20056399 https://doi.org/10.1016/j.ceb.2009.12.004
PubMed Web of Science ®Google Scholar
KabeyaYMizushimaNUenoTYamamotoAKirisakoTNodaTLC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingEMBO J200019 5720 5728 1:CAS:528:DC%2BD3cXovFaiurk%3D 11060023 305793 https://doi.org/10.1093/emboj/19.21.5720
PubMed Web of Science ®Google Scholar
LeeJGiordanoSZhangJAutophagy, mitochondria and oxidative stress: cross-talk and redox signallingBiochem J2012441 523 540 1:CAS:528:DC%2BC38Xmt1Wksw%3D%3D 22187934 https://doi.org/10.1042/BJ20111451 22187934
PubMed Web of Science ®Google Scholar
InokiKLiYZhuTWuJGuanKLTSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signallingNat Cell Biol20024 648 657 1:CAS:528:DC%2BD38Xms1ahtL4%3D 12172553 https://doi.org/10.1038/ncb839
PubMed Web of Science ®Google Scholar
MiyazakiMMcCarthyJJFedeleMJEsserKAEarly activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signallingJ Physiol2011589 1831 1846 1:CAS:528:DC%2BC3MXlt1ShsLw%3D 21300751 3099033 https://doi.org/10.1113/jphysiol.2011.205658
PubMed Web of Science ®Google Scholar
YouJSFreyJWHornbergerTAMechanical stimulation induces mTOR signaling via an ERK-independent mechanism: implications for a direct activation of mTOR by phosphatidic acidPLoS One20127 e47258 1:CAS:528:DC%2BC38Xhs1SitLnI 23077579 3471816 https://doi.org/10.1371/journal.pone.0047258
PubMedGoogle Scholar
KimJHAugerCKuritaIAnselmERivoarilalaLOLeeHJ et al Aronia melanocarpa juice, a rich source of polyphenols, induces endothelium-dependent relaxations in porcine coronary arteries via the redox-sensitive activation of endothelial nitric oxide synthaseNitric Oxide201335 54 64 1:CAS:528:DC%2BC2cXksFOhsQ%3D%3D 23973200 https://doi.org/10.1016/j.niox.2013.08.002
PubMedGoogle Scholar
GoodmanCAMayhewDLHornbergerTARecent progress toward understanding the molecular mechanisms that regulate skeletal muscle massCell Signal201123 1896 1906 1:CAS:528:DC%2BC3MXht1Kku77F 21821120 3744211 https://doi.org/10.1016/j.cellsig.2011.07.013
PubMed Web of Science ®Google Scholar
PhillipsSMA brief review of critical processes in exercise-induced muscular hypertrophySports Med201444 S71 S77 24791918 https://doi.org/10.1007/s40279-014-0152-3
PubMed Web of Science ®Google Scholar
MitchellCJChurchward-VenneTAPariseGBellamyLSmithK et al Acute post-exercise myofibrillar protein synthesis is not correlated with resistance training-induced muscle hypertrophy in young menPLoS One20149 e89431 24586775 3933567 https://doi.org/10.1371/journal.pone.0089431 1:CAS:528:DC%2BC2cXhsVGrsrvJ
PubMed Web of Science ®Google Scholar
BangHSSeoDYChangYMOhKMParkJJArturoF et al Ursolic acid-induced elevation of serum irisin augments muscle strength during resistance training in menKorean J Physiol Phamacol201418 441 446 1:CAS:528:DC%2BC2cXitVGmtbnO https://doi.org/10.4196/kjpp.2014.18.5.441
PubMed Web of Science ®Google Scholar
ChenJWongHSLeongPKLeungHYChanWMKoKMUrsolic acid induces mitochondrial biogenesis through the activation of AMPK and PGC-1 in C2C12 myotubes: a possible mechanism underlying its beneficial effect on exercise enduranceFood Funct20178 2425 2436 1:CAS:528:DC%2BC2sXpvFymt70%3D 28675237 https://doi.org/10.1039/C7FO00127D
PubMedGoogle Scholar
ChuXHeXShiZLiCGuoFLiS et al Ursolic acid increases energy expenditure through enhancing free fatty acid uptake and beta-oxidation via an UCP3/AMPK-dependent pathway in skeletal muscleMol Nutr Food Res201559 1491 1503 1:CAS:528:DC%2BC2MXptFSiu7g%3D 25944715 https://doi.org/10.1002/mnfr.201400670 25944715
PubMed Web of Science ®Google Scholar
LeeYKLeeWSKimGSParkOJAnthocyanins are novel AMPKalpha1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylationOncol Rep201024 1471 1477 21042741
PubMed Web of Science ®Google Scholar
OngKWHsuATanBKChlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetesPLoS One20127 e32718 1:CAS:528:DC%2BC38XktF2gt7Y%3D 22412912 3296733 https://doi.org/10.1371/journal.pone.0032718
PubMed Web of Science ®Google Scholar
TalagavadiVRapisardaPGalvanoFPelicciPGiorgioMCyanidin-3-O-β-glucoside and protocatechuic acid activate AMPK/mTOR/S6K pathway and improve glucose homeostasis in miceJ Funct Foods201621 338 348 1:CAS:528:DC%2BC2MXitV2ksbzN https://doi.org/10.1016/j.jff.2015.12.007
Web of Science ®Google Scholar
AtoSMakanaeYKidoKSaseKYoshiiNFujitaSThe effect of different muscle contraction regimens on the expression of muscle proteolytic signaling proteins and genesPhysiol Rep20175 e13364 28778992 5555890 https://doi.org/10.14814/phy2.13364 1:CAS:528:DC%2BC2sXhtlemt7bF
PubMedGoogle Scholar
AthertonPJEtheridgeTWattPJWilkinsonDSelbyARandkinD et al Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signalingAm J Clin Nutr201092 1080 1088 1:CAS:528:DC%2BC3cXhsVWgt7bO 20844073 https://doi.org/10.3945/ajcn.2010.29819 20844073
PubMed Web of Science ®Google Scholar

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Dietary Aronia melanocarpa extract enhances mTORC1 signaling, but has no effect on protein synthesis and protein breakdown-related signaling, in response to resistance exercise in rat skeletal muscle

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Dietary Aronia melanocarpa extract enhances mTORC1 signaling, but has no effect on protein synthesis and protein breakdown-related signaling, in response to resistance exercise in rat skeletal muscle

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