Prescription opioid dispensing in Canada: an update on recent developments to 2018

References

• Murphy Y, Goldner E, Fischer B. Prescription opioid use, harms and interventions in Canada: a review update of new developments and findings since 2010. Pain Physician. 2015;18:E605–E14.
   PubMed Web of Science ®Google Scholar
• Belzak L, Halverson J. Evidence synthesis-the opioid crisis in Canada: a national perspective. Health promotion and chronic disease prevention in Canada: Research, Policy and Practice. 2018;38(6):224.
   PubMed Web of Science ®Google Scholar
• Kolodny A, Courtwright DT, Hwang CS, Kreiner P, Eadie JL, Clark TW, et al. The prescription opioid and heroin crisis: a public health approach to an epidemic of addiction. Annu Rev Public Health. 2015;36:559–74.
   PubMed Web of Science ®Google Scholar
• Scholl L, Seth P, Kariisa M, Wilson N, Baldwin G. Drug and opioid-involved overdose deaths - United States, 2013-2017. Morbidity Mortality Weekly Report.2019;67(5152):1419.
   Google Scholar
• International Narcotics Control Board. Availability of internationally controlled drugs: ensuring adequate access for medical and scientific purposes. New York: International Narcotics Control Board (INCB), 2016 April 29, 2019.
   Google Scholar
• Case A, Deaton A. Rising morbidity and mortality in midlife among white non-Hispanic Americans in the 21st century. Proc Natl Acad Sci. 2015;112(49):15078–83.
   PubMed Web of Science ®Google Scholar
• Sauber-Schatz EK, Mack KA, Kiekman ST, Paulozzi L. Associations between pain clinic density and distributions of opioid pain relievers, drug-related deaths, hospitalizations, emergency department visits, and neonatal abstinence syndrome in Florida. Drug Alcohol Depend. 2013;133(1):161–6.
   PubMed Web of Science ®Google Scholar
• Fischer B, Jones W, Urbanoski K, Skinner R, Rehm J. Correlations between prescription opioid analgesic dispensing levels and related mortality and morbidity in Ontario, Canada, 2005-2011. Drug and Alcohol Review. 2014;33(1):19–26.
   PubMed Web of Science ®Google Scholar
• Gladstone EJ, Smolina K, Weymann KR, Morgan SG. Geographic variations in prescription opioid dispensations and deaths among women and men in British Columbia, Canada. Med Care. 2015;53(11):954–9.
   PubMed Web of Science ®Google Scholar
• Fischer B, Rehm J, Tyndall M. Effective Canadian policy to reduce harms from prescription opioids: learning from past failures. CMAJ. 2016;188(17-18):1240–4.
   PubMed Web of Science ®Google Scholar
• Rutkow L, Chang HY, Daubresse M, Webster DW, Stuart EA, Alexander GC. Effect of Florida’s prescription drug monitoring program and pill mill laws on opioid prescribing and use. JAMA Intern Med. 2015;174(10):1642–9.
   Google Scholar
• Volkow N, McLellan TA. Curtailing diversion and abuse of opioid analgesics without jeopardizing pain treatment. JAMA.2011;305(13):1346–7.
   PubMed Web of Science ®Google Scholar
• Meyer R, Patel MA, Rattana SK, Quock TP, Mody SH. Prescription opioid abuse: a literature review of the clinical and econimic burden in the United States. Population Health Management. 2014;17(6):372–87.
   PubMed Web of Science ®Google Scholar
• Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain—United States, 2016. JAMA.2016;315(15):1624–45.
   PubMed Web of Science ®Google Scholar
• Busse JW, Craigie S, Juurlink DN, Buckley DN, Wang L, Couban RJ, et al. Guideline for opioid therapy and chronic noncancer pain. Can Med Assoc J. 2017;189(18):E659–E66.
   PubMed Web of Science ®Google Scholar
• Health Canada. Federal action on opioids Ottawa, ON: Government of Canada; 2019. Available from: https://www.canada.ca/en/health-canada/services/substance-use/problematic-prescription-drug-use/opioids/federal-actions.html. Retrieved: April 10, 2019.
   Google Scholar
• The Globe and Mail. More than 10,000 Canadians have died from opioid-related overdoses since 2016, public health data show. Retrieved: April 10 2019.
   Google Scholar
• Guy GPJr, Zhand K, Bohm MK, Losby J, Lewis B, Young R, et al. Vital signs: changes in opioid prescribing in the United States, 2006-2015. Morbidity Mortality Weekly Report. 2017;66(26):697.
   PubMed Web of Science ®Google Scholar
• Levy B, Paulozzi L, Mack KA, Jones CM. Trends in opioid analgesic-prescribing rates by specialty, US, 2007-2012. Am J Prev Med. 2015;49(3):409–13.
   PubMed Web of Science ®Google Scholar
• International Narcotics Control Board. Narcotic drugs 2018. New York: International Narcotics Control Board (INCB); 2018.
   Google Scholar
• Fischer B, Jones W, Vojtila L, Kurdyak P. Patterns, changes, and trends in prescription opioid dispensing in Canada, 2005-2016. Pain Physician. 2018;21(3):219–28.
   PubMed Web of Science ®Google Scholar
• Fischer B, Jones W, Rehm J. Trends and changes in prescription opioid analgesic dispensing in Canada 2005-2012: an update with a focus on recent interventions. BMC Health Serv Res. 2014;14(1):90.
   PubMedGoogle Scholar
• Canadian Institutes for Health Information. Pan-Canadian trends in the prescribing of opioids, 2012 to 2016. Ottawa, ON: Canadian Institute for Health Information (CIHI), 2017.
   Google Scholar
• Frank RG, Pollack HA. Addressing the fentanyl threat to public health. N Engl J Med. 2017;376(7):605–7.
   PubMed Web of Science ®Google Scholar
• Fischer B, Vojtila L, Rehm J. The ‘fentanyl epidemic’in Canada–some cautionary observations focusing on opioid-related mortality. Prev Med. 2018;107:109–13.
   PubMed Web of Science ®Google Scholar
• Gomes T, Khuu W, Martins D, Tadrous M, Mamdani MM, Paterson JM, et al. Contributions of prescribed and non-prescribed opioids to opioid related deaths: population based cohort study in Ontario, Canada. BMJ. 2018;362:k3207.
   PubMedGoogle Scholar
• National Institute on Drug Abuse. Overdose Death Rates (Revised 2019) North Bethesda, MD, USA: National Institute on Drug Abuse (NIDA); 2019. Available from: https://www.drugabuse.gov/related-topics/trends-statistics/overdose-death-rates.
   Google Scholar
• IMS Brogan (IMSB). IMSB Canadian compuscript audit. Available from: http://www.imsbrogancapabilities.com/.
   Google Scholar
• Fischer B, Jones W, Krahn M, Rehm J. Differences and over-time changes in levels of prescription opioid analgesic dispensing from retail pharmacies in Canada, 2005-2010. Pharmacoepidemiol Drug Saf. 2011;20(12):1269–77.
   PubMed Web of Science ®Google Scholar
• IQVIA. Retail Prescriptions Dispensed in Canada, 2013-2017. Pharmaceutical trrends 2018. IQVIA; 2018. Available from: https://www.iqvia.com/-/media/iqvia/pdfs/canada-location-site/retailprescriptionscanada_en_17.pdf?la=en&hash=F4B8ABE5F640247F99D9CF104E79BC3A18DD4158.
   Google Scholar
• CIHI. Pan-Canadian trends in the prescribing of opioids and benzodiazepines, 2012 to 2017, vol. 2018. Ottawa, ON: Canadian Institute for Health Information (CIHI).
   Google Scholar
• Fischer B, Kurdyak P, Goldner E, Tyndall M, Rehm J. Treatment of prescription opioid disorder in Canda: looking at the ‘other epidemic’?Substance abuse treatment, prevention, and policy. 2016;11(1):12.
   PubMedGoogle Scholar
• Fischer B, Kurdyak P, Jones W. Tramadol dispensing patterns and trends in Canada, 2007-2016. Pharmacoepidemiol Drug Saf. 2019;28(3):396–400.
   PubMed Web of Science ®Google Scholar
• WHO Collaborating Centre for Drug Statistics Methodology. Methodology: definition and general considerations. World Health Organization (WHO). Available from: http://www.whocc.no/ddd/definition_and_general_considera/.
   Google Scholar
• WHO Collaborating Centre for Drug Statistics Methodology. ATC/DDD index. World Health Organization (WHO). Available from: http://www.whocc.no/atc_ddd_index/. Retrieved: April 9, 2019.
   Google Scholar
• Statistics Canada. Population estimates, quarterly, Table: 17-10-0009-01 [cited 2020 August 19] Ottawa, ON: Government of Canada; 2020. Available: https://www150.statcan.gc.ca/t1/tbl1/en/tv.action?pid=1710000901. Retrieved: August 19, 2020.
   Google Scholar
• World Health Organization. WHO’s Pain Ladder. Available from: http://www.who.int/cancer/palliative/painladder/en/. Retrieved: April 10, 2020.
   Google Scholar
• IMSB. Canadian Compuscript audit [computer program]. IMS Brogan: Montreal; 2013.
   Google Scholar
• Drug & Alcohol Testing Association of Canada. Cough syrups with codeine to become controlled medications 2019. Available: https://datac.ca/cough-syrups-with-codeine-to-become-controlled-medications/. Retrieved: April 10, 2020.
   Google Scholar
• MacKinnon J. Tighter regulations needed for over-the-counter codeine in Canada. Canadian Pharmacists Journal/Revue des Pharmaciens du Canada. 2016;149(6):322–4.
   Google Scholar
• Nielsen S, Gisev N, Bruno R, Hall W, Cohen M, Larance B, et al. Defined daily doses (DDD) do not accurately reflect opioid doses used in contemporary chronic pain treatment. Pharmacoepidemiol Drug Saf. 2017;26(5):587–91.
   PubMed Web of Science ®Google Scholar
• McDonald DC, Carlson K, Izreal D. Geographic variation in opioid prescribing in the US. J Pain. 2012;13(10):988–96.
   PubMed Web of Science ®Google Scholar
• Ontario Drug Policy Research Network. Behind the prescriptions: a snapshop of opioid use across all Ontarians. Toronto, ON: Ontario Drug Policy Research Network (ODPRN); 2017 April 29 2019.
   Google Scholar
• Jovey RD, Ennis J, Gardner-Nix J, Goldman B, Hays H, Lynch M, et al. Use of opioid analgesics for the treatment of chronic noncancer pain - a consensus statement and guidelines from the Canadian Pain Society, 2002. Pain Research and Management.2003;8:3A–14A.
   PubMedGoogle Scholar
• Moulin DE, Clark AJ, Speechley M, Morley-Forster PK. Chronic pain in Canada-prevalence, treatment, impact and the role of opioid analgesia. Pain Research and Management.2002;7(4):179–84.
   PubMedGoogle Scholar
• Mularksi RA, White-Chu F, Overbay D, Miller L, Asch SM, Ganzini L. Measuring pain as the 5th vital sign does not improve quality of pain management. J Gen Internal Medicine. 2006;21(6):607–12.
   PubMed Web of Science ®Google Scholar
• Schopflocher D, Taenzer P, Jovey R. The prevalence of chronic pain in Canada. Pain Research and Management. 2011;16(6):445–50.
   PubMed Web of Science ®Google Scholar
• Boulanger A, Clark AJ, Squire P, Cui E, Horbay GL. Chronic pain in Canada: have we improved our management of chronic noncancer pain?Pain Research and Management.2007;12(1):39–47.
   PubMed Web of Science ®Google Scholar
• Busse J, Jurrlink D, Guyatt GH. Addressing the limitations of the CDC guideline for prescribing opioids for chronic noncancer pain. CMAJ.2016;188(17-18):1210–1.
   PubMed Web of Science ®Google Scholar
• MacDonald N, MacLeod SM. Has the time come to phase out codeine?CMAJ.2010;182(17):1825.
   PubMed Web of Science ®Google Scholar
• Furlan AD, MacDougall P, Pellerin D, Shaw K, Spitzig D, Wilson G, et al. Overview of four prescription monitoring/review programs in Canada. Pain Research Management. 2014;19(2):102–6.
   PubMed Web of Science ®Google Scholar
• Gomes T, Juurlink D, Yao Z, Camacho X, Paterson JM, Singh S, et al. Impact of legislation and a prescription monitoring program on the prevalence of potentially inappropriate prescriptions for monitored drugs in Ontario: a time series analysis. CMAJ Open. 2014;2(4):E256.
   PubMedGoogle Scholar
• Fischer B, Vojtila L, Kurdyak P. ‘Delisting’OxyContin® to reduce prescription opioid-related harms in Ontario (Canada)—gauging effects 5 years later. Pharmacoepidemiol Drug Saf. 2017;26(9):1040–3.
   PubMed Web of Science ®Google Scholar
• Ansari B, Tote KM, Rosenberg ES, Martin EG. A rapid review of the impact of systems-level policies and interventions on population-level outcomes related to the opioid epidemic, United States and Canada, 2014-2018. Public Health Rep. 2020;135(1_suppl):100S–27S.
   PubMed Web of Science ®Google Scholar
• Clarke H, Bao J, Weinrib A, Dubin RE, Kahan M. Canada’s hidden opioid crisis: the health care system’s inability to manage high-dose opioid patients: fallout from the 2017 Canadian opioid guidelines. Can Fam Physician. 2019;65(9):612–4.
   PubMed Web of Science ®Google Scholar
• Canadian Institute for Health Information. Opioid-related harms in Canada. Ottawa, ON: Canadian Institute for Health Information (CIHI); 2018.
   Google Scholar
• Public Health Agency of Canada. National report: apparent opioid-related deaths in Canada. Ottawa, ON: Government of Canada; 2019.
   Google Scholar
• Gomes T, Greaves S, Tadrous M, Mamdani MM, Paterson JM, Juurlink DN. Measuring the burden of opioid-related mortality in Ontario, Canada. J Addict Med. 2018;12(5):418.
   PubMed Web of Science ®Google Scholar
• Baldwin N, Gray R, Goel A, Wood E, Buxton JA, Rieb LM. Fentanyl and heroin contained in seized illicit drugs and overdose-related deaths in British Columbia, Canada: an observational analysis. Drug Alcohol Depend. 2018;185:322–7.
   PubMed Web of Science ®Google Scholar
• Fischer B, Pang M, Tyndall M. The opioid death crisis in Canada: crucial lessons for public health. Lancet Public Health. 2019;4(2):81–2.
   Web of Science ®Google Scholar
• Unick GJ, Rosenblum D, Mars S, Ciccarone D. Intertwined epidemics: national demographic trends in hospitalizations for heroin-and opioid-related overdoses, 1993-2009. PLoS One. 2013;8(2):e54496..
   PubMed Web of Science ®Google Scholar