Decision support software-guided medication reviews in elderly patients with polypharmacy: a prospective analysis of routine data from community pharmacies (OPtiMed study protocol)

References

• Medication safety in polypharmacy: technical report. World Health Organization. 2019. https://apps.who.int/iris/bitstream/handle/10665/325454/WHO-UHC-SDS-2019.11-eng.pdf?sequence=1&isAllowed=y. Accessed 17 June 2022.
   Google Scholar
• Payne RA, Avery AJ. Polypharmacy: one of the greatest prescribing challenges in general practice. Br J Gen Pract. 2011;61:83–84.
   PubMed Web of Science ®Google Scholar
• Pazan F, Wehling M. Polypharmacy in older adults: a narrative review of definitions, epidemiology and consequences. Eur Geriatr Med. 2021;12:443–452.
   PubMed Web of Science ®Google Scholar
• Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatr. 2017;17:1–10.
   PubMed Web of Science ®Google Scholar
• Hovstadius B, Hovstadius K, Åstrand B, Petersson G. Increasing polypharmacy—an individual-based study of the Swedish population 2005–2008. BMC Clin Pharmacol. 2010;10:16.
   PubMedGoogle Scholar
• Midão L, Giardini A, Menditto E, Kardas P, Costa E. Polypharmacy prevalence among older adults based on the survey of health, ageing and retirement in Europe. Arch Gerontol Geriatr. 2018;78:213–220.
   PubMed Web of Science ®Google Scholar
• Steinman MA, Seth Landefeld C, Rosenthal GE, Berthenthal D, Sen S, Kaboli PJ. Polypharmacy and prescribing quality in older people. J Am Geriatr Soc. 2006;54:1516–1523.
   PubMed Web of Science ®Google Scholar
• Zelko E, Klemenc-Ketis Z, Tusek-Bunc K. Medication adherence in elderly living at home: a systematic review of existing studies. Mater Sociomed. 2016;28:129.
   PubMedGoogle Scholar
• Ahmed B, Nanji K, Mujeeb R, Patel MJ. Effects of polypharmacy on adverse drug reactions among geriatric outpatients at a tertiary care Hospital in Karachi: a prospective cohort study. PLoS ONE. 2014;9:e112133.
   PubMed Web of Science ®Google Scholar
• Griese-Mammen N, Hersberger KE, Messerli M, Leikola S, Horvat N, van Mil JWF, et al. PCNE definition of medication review: reaching agreement. Int J Clin Pharm. 2018;40:1199–1208.
   PubMed Web of Science ®Google Scholar
• Rankin A, Cadogan CA, Patterson SM, Kerse N, Cardwell CR, Bradley MC, et al. Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev. 2018;9:CD008165.
   PubMedGoogle Scholar
• Huiskes VJB, Burger DM, van den Ende CHM, van den Bemt BJF. Effectiveness of medication review: a systematic review and meta-analysis of randomized controlled trials. BMC Fam Pract. 2017;18:5.
   PubMed Web of Science ®Google Scholar
• De Smet PAGM, Denneboom W, Kramers C, Grol R. A composite screening tool for medication reviews of outpatients: general issues with specific examples. Drugs Aging. 2007;24:733–760.
   PubMed Web of Science ®Google Scholar
• Haefeli WE, Seidling HM. Elektronische Entscheidungsunterstützung zur Annäherung an eine sichere Arzneimitteltherapie. Bundesgesundheitsblatt - Gesundheitsforsch - Gesundheitsschutz. 2018;61:271–277.
   PubMedGoogle Scholar
• Catwell L, Sheikh A. Evaluating eHealth interventions: the need for continuous systemic evaluation. PLoS Med. 2009;6:e1000126.
   PubMed Web of Science ®Google Scholar
• Jolly R. The e health revolution—easier said than done. Parliament of Australia. 2011. https://parlinfo.aph.gov.au/parlInfo/download/library/prspub/1232345/upload_binary/1232345.pdf;fileType=application/pdf#search=%222010s%20jolly,%20rhonda%22. Accessed 16 June 2022.
   Google Scholar
• Sutton RT, Pincock D, Baumgart DC, Sadowski DC, Fedorak RN, Kroeker KI. An overview of clinical decision support systems: benefits, risks, and strategies for success. Npj Digit Med. 2020;3:1–10.
   PubMed Web of Science ®Google Scholar
• Jia P, Zhang L, Chen J, Zhao P, Zhang M. The effects of clinical decision support systems on medication safety: an overview. PLoS ONE. 2016;11:e016768.
   Web of Science ®Google Scholar
• Rieckert A, Reeves D, Altiner A, Drewelow E, Esmail A, Flamm M, et al. Use of an electronic decision support tool to reduce polypharmacy in elderly people with chronic diseases: cluster randomised controlled trial. BMJ. 2020;369:m1822.
   PubMedGoogle Scholar
• Muth C, Uhlmann L, Haefeli WE, Rochon J, Van Den Akker M, Perera R, et al. Effectiveness of a complex intervention on Prioritising Multimedication in Multimorbidity (PRIMUM) in primary care: results of a pragmatic cluster randomised controlled trial. BMJ Open. 2018;8:1–16.
   Web of Science ®Google Scholar
• Medinspector—Medikations-Manager 2.0. https://www.medinspector.de/. Accessed 16 June 2022.
   Google Scholar
• ATHINA—Apothekerkammer Westfalen-Lippe. https://www.akwl.de/inhalt.php?id=703. Accessed 16 June 2022.
   Google Scholar
• Hanlon JT, Schmader KE, Samsa GP, Weinberger M, Uttech KM, Lewis IK, et al. A method for assessing drug therapy appropriateness. J Clin Epidemiol. 1992;45:1045–1051.
   PubMed Web of Science ®Google Scholar
• Hanlon JT, Schmader KE. The medication appropriateness index at 20: where it started, where it has been, and where it may be going. Drugs Aging. 2013;30:893–900.
   PubMed Web of Science ®Google Scholar
• Samsa GP, Hanlon JT, Schmader KE, Weinberger M, Clipp EC, Uttech KM, et al. A summated score for the medication appropriateness index: development and assessment of clinimetric properties including content validity. J Clin Epidemiol. 1994;47:891–896.
   PubMed Web of Science ®Google Scholar
• Nachtigall A, Heppner HJ, Thürmann PA. Influence of pharmacist intervention on drug safety of geriatric inpatients: a prospective, controlled trial. Ther Adv Drug Saf. 2019;10:204209861984336.
   Web of Science ®Google Scholar
• Joks G. Evaluation und Optimierung der Arzneimitteltherapiesicherheit in einer Einrichtung der Altenpflege. Dissertation, Universität Witten/Herdecke, Germany. 2014. https://scholar.google.com/scholar_lookup?hl=en&publication_year=2014&author=G.+Joks&title=Evaluation+und+Optimierung+der+Arzneimitteltherapiesicherheit+in+einer+Einrichtung+der+Altenpflege. Accessed 16 June 2022.
   Google Scholar
• Seidling HM, Wien K, Fabricius J, John C, Hauser J, Renner K, et al. Short and mid-term impact of community pharmacy-based medication reviews on medication- and patient-related outcomes in Germany. Int J Clin Pharmacol Ther. 2021;59:188–197.
   PubMed Web of Science ®Google Scholar
• Hilmer SN, Mager DE, Simonsick EM, Cao Y, Ling SM, Windham BG, et al. A drug burden index to define the functional burden of medications in older people. Arch Intern Med. 2007;167:781–787.
   PubMed Web of Science ®Google Scholar
• Jeffrey S, Ruby CM, Twersky J, Hanlon J. Effect of an interdisciplinary team on suboptimal prescribing in a long-term care facility. Consult Pharm. 1999;14:1386–1391.
   Google Scholar
• Lu M, Safren SA, Skolnik PR, Rogers WH, Coady W, Hardy H, et al. Optimal recall period and response task for self-reported HIV medication adherence. AIDS Behav. 2008;12:86–94.
   PubMed Web of Science ®Google Scholar
• Feldman BJ, Fredericksen RJ, Crane PK, Safren SA, Mugavero MJ, Willig JH, et al. Evaluation of the single-item self-rating adherence scale for use in routine clinical care of people living with HIV. AIDS Behav. 2013;17:307–318.
   PubMed Web of Science ®Google Scholar
• Wild D, Grove A, Martin M, Eremenco S, McElroy S, Verjee-Lorenz A, et al. Principles of good practice for the translation and cultural adaptation process for patient-reported outcomes (PRO) measures: report of the ISPOR Task Force for Translation and Cultural Adaptation. Value Health. 2005;8:94–104.
   PubMed Web of Science ®Google Scholar
• Hons A. Arzneimitteltherapiesicherheit bei älteren Patienten in öffentlichen Apotheken. Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, Germany. 2013. https://bonndoc.ulb.uni-bonn.de/xmlui/bitstream/handle/20.500.11811/6079/3575.pdf?sequence=1&isAllowed=y. Accessed 16 June 2022.
   Google Scholar
• Hedström M, Lidström B, Åsberg KH. PHASE-20: Ett nytt instrument för skattning av möjliga läkemedelsrelaterade symtom hos äldre personer i äldreboende. Nord J Nurs Res. 2009;29:9–14.
   Google Scholar
• Verdoorn S, Kwint HF, Blom JW, Gussekloo J, Bouvy ML. Effects of a clinical medication review focused on personal goals, quality of life, and health problems in older persons with polypharmacy: a randomised controlled trial (DREAMeR-study). PLoS Med. 2019;16:e1002798.
   PubMed Web of Science ®Google Scholar
• Köberlein-Neu J, Mennemann H, Hamacher S, Waltering I, Jaehde U, Schaffert C, et al. Interprofessional medication management in patients with multiple morbidities—a cluster-randomized trial (the WestGem study). Dtsch Arztebl Int. 2016;113:731–740.
   Web of Science ®Google Scholar
• Krisch L, Mahlknecht A, Bauer U, Nestler N, Hempel G, Osterbrink J, et al. The challenge to define a relevant change in medication appropriateness index score in older adults—an approach. Br J Clin Pharmacol. 2020;86:398–399.
   PubMed Web of Science ®Google Scholar
• Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39:175–191.
   PubMed Web of Science ®Google Scholar
• Rose O, Mennemann H, John C, Lautenschläger M, Mertens-Keller D, Richling K, et al. Priority setting and influential factors on acceptance of pharmaceutical recommendations in collaborative medication reviews in an ambulatory care setting—analysis of a cluster randomized controlled trial (WestGem-study). PLoS ONE. 2016;11:e0156304.
   PubMed Web of Science ®Google Scholar
• Aktionsplan AMTS 2021–2024 des Bundesministeriums für Gesundheit zur Verbesserung der Arzneimitteltherapiesicherheit in Deutschland. 2021. https://www.bundesgesundheitsministerium.de/fileadmin/Dateien/5_Publikationen/Gesundheit/Berichte/Aktionsplan_2021-2024_BMG_AMTS.pdf. Accessed 16 June 2022.
   Google Scholar
• Waltering I, Schwalbe O, Hempel G. Identification of factors for a successful implementation of medication reviews in community pharmacies: using positive deviance in pharmaceutical care. Int J Clin Pharm. 2022;44:79–89.
   PubMed Web of Science ®Google Scholar
• Beuscart J-B, Knol W, Cullinan S, Schneider C, Dalleur O, Boland B, et al. International core outcome set for clinical trials of medication review in multi-morbid older patients with polypharmacy. BMC Med. 2018;16:21.
   PubMed Web of Science ®Google Scholar