- 1) Jaattela, M., Biologic activities and mechanisms of action of tumor necrosis factor-α/cachectin. Lab. Invest., 64, 724-742 (1991).
- 2) Sherry, B. and Cerami, A., Cachectin/tumor necrosis factor exerts endocrine, paracrine, and autocrine control of inflammatory responses. J. Cell Bio., 107, 1269-1277 (1988).
- 3) Beutler, B., Krochin, N., Milsark, I. W., Luedke, C., and Cerami, A., Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science, 232, 977-980 (1986).
- 4) Zuckerman, S. H., Evans, G. F., and Butler, L. D., Endotoxin tolerance: independent regulation of interleukin-1 and tumor necrosis factor expression. Infect. Immun., 59, 2774-2780 (1991).
- 5) Targan, S. R. and Murphy, L. K., Clarifying the causes of Crohn’s. Nature Medicine, 1, 1241-1243 (1995).
- 6) Dullemen, H. M. V., Deventer, S. J. H. V., Hommes, D. W., Bijl, H. A., Jansen, J., Tytgat, G. N. J., and Woody, J., Treatment of Crohn’s disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology, 109, 129-135 (1995).
- 7) Arend, W. P. and Dayer, J. M., Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis. Arthritis Rheumatism, 33, 305-315 (1990).
- 8) Elliott, M. J., Maini, R. N., Feldmann, M., Long-Fox, A., Charles, P., Katsikis, P., Brennan, F. M., Walker, J., Bijl, H., Ghrayeb, J., and Woody, J. N., Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α. Arthritis Rheumatism, 36, 1681-1690 (1993).
- 9) Young, P., McDonnell, P., Dunnington, D., Hand, A., Laydon, J., and Lee, J., Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level. Agents Actions, 39, C67-C69 (1993).
- 10) Smith III, E. F., Slivjak, M. J., Bartus, J. O., and Esser, K. M., SK&F 86002 inhibits tumor necrosis factor formation and improves survival in endotoximic rats. J. Cardiovasc. Pharmacol., 18, 721-728 (1991).
- 11) Olivera, D. L., Esser, K. M., Lee, J. C., Greig, R. G., and Badger, A. M., Beneficial effects of SK&F 105809, a novel cytokine-suppressive agent, in murine models of endotoxin shock. Circ. Shock, 37, 301-306 (1992).
- 12) Ochalski, S. J., Hartman, D. A., Belfast, M. T., Walter, T. L., Glaser, K. B., and Carlson, R. P., Inhibition of endotoxin-induced hypothermia and serum TNF-α levels in CD-1 mice by various pharmacological agents. Agents Actions, 39, C52-C54 (1993).
- 13) Mohler, K. M., Sleath, P. R., Fitzner, J. N., Cerretti, D. P., Alderson, M., Kerwar, S. S., Torrance, D. S., Otten-Evans, C., Greenstreet, T., Weerawarna, K., Kronheim, S. R., Petersen, M., Gerhart, M., Kozlosky, C. J., March, C. J., and Black, R. A., Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing. Nature, 370, 218-220 (1994).
- 14) Gearing, A. J. H., Beckett, P., Christodoulou, M., Churchill, M., Clements, J., Davidson, A. H., Drummond, A. H., Galloway, W. A., Gilbert, R., Gordon, J. L., Leber, T. M., Mangan, M., Miller, K., Nayee, P., Owen, K., Patel, S., Thomas, W., Wells, G., Wood, L. M., and Woolley, K., Processing of tumour necrosis factor-α precursor by metalloproteinases. Nature, 370, 555-557 (1994).
- 15) McGeehan, G. M., Becherer, J. D., Bast, Jr., R. C., Boyer, C. M., Champion, B., Connolly, K. M., Conway, J. G., Furdon, P., Karp, S., Kidao, S., McElroy, A. B., Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor. Nature, 370, 558-561 (1994).
- 16) Olivera, D. L., Laydon, J. T., Hillegass, L., Badger, A. M., and Lee, J. C., Effects of pyridinyl imidazole compounds on murine TNF-α production. Agents Actions, 39, C55-C57 (1993).
- 17) Elliott, M. J., Maini, R. N., Feldmann, M., Kalden, J. R., Antoni, C., Smolen, J. S., Leeb, B., Breedveld, F. C., Macfarlene, J. D., Biji H., and Woody, J. N., Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis. Lancet, 344, 1105-1110 (1994).
- 18) Elliott, M. J., Maini, R. N., Feldmann, M., Long-Fox, A., Charles, P., Biji, H., and Woody, J. N., Repeated therapy with monoclonal antibody to tumour necrosis factor α (cA2) in patients with rheumatoid arthritis. Lancet, 344, 1125-1127 (1994).
- 19) Yamamura, M., Uyemura, K., Deans, R. J., Weinberg, K., Rea, T., Bloom, B. R., and Modlin, R. L., Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science, 254, 277-279 (1991).
- 20) Griending, K. K., Minieri, C. A., Ollerenshaw, J. D., and Alexander R. W., Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ. Res., 74, 1141-1148 (1994).
- 21) Folliard, F., Bousseau, A., and Terlain, B., RP 54745, a potential antirheumatic compound. I. inhibitor of macrophage stimulation and interleukin-1 production. Agents Actions, 36, 119-126 (1992).
- 22) Cordle, S. R., Donald, R., Read, M. A., and Hawiger, J., Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-κB proteins in human monocytic THP-1 cells. J. Biol. Chem., 268, 11803-11810 (1993).
- 23) Colasanti, M., Persichini, T., Menegazzi, M., Mariotto, S., Giordano, E., Caldarera, C. M., Sogos, V., Lauro, G. M., and Suzuki, H., Induction of nitric oxide synthase mRNA expression. J. Biol. Chem., 270, 26731-26733 (1995).
- 24) Reimann, T., Buscher, D., Hipskind, R. A., Krautwald, S., Lohmann-Matthes, M., and Baccarini, M., Lipopolysaccharide induces activation of the Raf-1/MAP kinase pathway. J. Immunol., 153, 5740-5749 (1994).
- 25) Beutler, B., Milsark, I. W., and Cerami, A., Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science, 229, 869-871 (1985).
- 26) Mathison, J. C., Wolfson, E., and Ulevitch, R. J., Participation of tumor necrosis factor in the mediation of Gram negative bacterial lipopolysaccharide-induced injury in rabbits. J. Clin. Invest., 81, 1925-1937 (1988).
Full access
N2733, 1-[3-(3-Pyridyl)-acryloyl]-2-pyrrolidinone Hydrochloride Inhibits LPS-induced TNF-α Production and Improves Survival in Endotoxemic Mice
Reprints and Corporate Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
To request a reprint or corporate permissions for this article, please click on the relevant link below:
Academic Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
Obtain permissions instantly via Rightslink by clicking on the button below:
If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.