- 1) Sugimura, T. and Sato, S., Mutagens-carcinogens in foods. Cancer Res., 43, 2415-2421 (1983).
- 2) Weisburger, J. H., Heterocyclic amines in cooked foods: possible human carcinogens. Cancer Res., 53, 2422-2424 (1993).
- 3) Wakabayashi, K., Nagao, M., Esumi, H., and Sugimura, T., Food-derived mutagens and carcinogens. Cancer Res., 52, 2092-2098 (1992).
- 4) Sugimura, T., Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process. Mutat. Res., 150, 33-41 (1985).
- 5) Manabe, S., Suzuki, H., Wada, O., and Ueki, A., Detection of the carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in beer and wine. Carcinogenesis, 14, 899-901 (1993).
- 6) Ito, N., Hasegawa, R., Sano, M., Tamano, S., Esumi, H., Takayama, S., and Sugimura, T., A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis, 12, 1503-1506 (1991).
- 7) Ochiai, M., Ogawa, K., Wakabayashi, K., Sugimura, T., Nagase, S., Esumi, H., and Nagao, M., Induction of intestinal adenocarcinomas by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Nagase analbuminemic rats. Jap. J. Cancer Res., 82, 363-366 (1991).
- 8) Shirai, M., Sano, M., Tamano, S., Takahashi, S., Hirose, M., Futakuchi, M., Hasegawa, R., Imaida, K., Matsumoto, K., Wakabayashi, K., Sugimura, T., and Ito, N., The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods. Cancer Res., 57, 195-198 (1997).
- 9) Folch, L., Lees, M., and Sloane-Stanley, G. H., A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem., 226, 497-509 (1957).
- 10) Goto, T., Ohnomi, S., Khedara, A., Kato, N., Ogawa, H., and Yanagita, T., Feeding the nitric oxide synthase inhibitor L-Nω nitroarginine elevates serum very low density lipoprotein and hepatic triglyceride synthesis in rats. J. Nutr. Biochem., 10, 274-278 (1999).
- 11) Kawasaki, M., Funabiki, R., and Yagasaki, K., Effects of dietary methionine and cystine on lipid metabolism in hepatoma-bearing rats with hyperlipidemia. Lipids, 33, 905-911 (1998).
- 12) Wakabayashi, K., Ushijima, H., Takahashi, M., Nukaya, H., Kim, S.-B., Hirose, M., Ochiai, M., Sugimura, T., and Nagao, M., Exposure to heterocyclic amines. Environ. Health Perspect., 99, 129-133 (1993).
- 13) Takahashi, S., Imaida, K., Shirai, T., Wakabayashi, K., Nagao, M., Sugimura, T., and Ito, N., Chronic administration of the mutagenic heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces cardiac damage with characteristic mitochondrial changes in Fisher rats. Toxicol. Pathology, 24, 273-277 (1996).
- 14) Boring, C. C., Squires, T. S., Tong, T., and Montgomery, S., Cancer statistics 1994. C. A. Cancer J. Clin., 44, 7-25 (1979).
Full access
Hypertriglyceridemia in Rats Induced by Consumption of a Food-derived Carcinogen, 2-Amino-1-methyl-phenylimidazo[4,5b]pyridine (PhIP)
Reprints and Corporate Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
To request a reprint or corporate permissions for this article, please click on the relevant link below:
Academic Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
Obtain permissions instantly via Rightslink by clicking on the button below:
If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.