275
Views
30
CrossRef citations to date
0
Altmetric
Original Articles

Elevated Body Fat in Rats by the Dietary Nitric Oxide Synthase Inhibitor, L-Nω Nitroarginine

, , , &
Pages 698-702 | Received 19 Oct 1998, Accepted 12 Dec 1998, Published online: 22 May 2014

  • 1) Moncada, S., Palmer, R. M., and Higgs, E. A., Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43, 109-142 (1991).
  • 2) Bredt, D. S. and Snyder, S. H. Nitric oxide: a physiologic messenger molecule. Ann. Rev. Biochem., 63, 175-195 (1994).
  • 3) Wink, D. A., Hanbauer, I., Krishna, M. C., DeGraff, W., Gamson, J., and Mitchell, J., Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species. Proc. Natl. Acad. Sci. USA, 90, 9813-9817 (1993).
  • 4) Hayashi, T., Yamada, K., Esaki, T., Kuzuya, M., Satake, S., Ishikawa, T., Hidaka, H., and Iguchi, A., Estrogen increases endothelial nitric oxide by a receptor-mediated system. Biochim. Biophys. Res. Commun., 214, 847-855 (1995).
  • 5) Stadler, J., Stefanovic-Racic, M., Billiar, T. R., Curran, R. D., McIntyre, L. A., Greorgescu, H. I., Simmons, R. L., and Evans, C. H., Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J. Immunol., 147, 3915-3920 (1991).
  • 6) Bernstein, R. D., Ochoa, F. Y., Xu, X., Forfia, P., Shen, W., Thompson, C. I., and Hintze, T. H., Function and production of nitric oxide in the coronary circulation of the conscious dog during exercise. Circ. Res., 79, 840-848 (1996).
  • 7) Koizumi, T., Hermo, C. I., Bjertnaes, L. J., Banerjee, M., Newman, J. H., and Kubo, K., Nitric oxide and nitroglycerin reversal of pulmonary vasoconstriction induced by alpha-activation during exercise. Am. J. Physiol., 270, H875-880 (1996).
  • 8) Umans, J. G. and Levi, R., Nitric oxide in the regulation of blood flow and arterial pressure. Ann. Rev. Physiol., 57, 771-790 (1995).
  • 9) Taddei, S., Virdis, A., Ghiadoni, L., Magagna, A., and Salvetti, A., Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation, 97, 2222-2229 (1998).
  • 10) Shimokawa, H., Lam, J. Y. T., Chesebro, J. H., Bowie, E. J. W., and Vanhoutte, P. M., Effects of dietary supplementation with cod-liver oil on endothelium-dependent responses in porcine coronary arteries. Circulation, 76, 898-905 (1987).
  • 11) Boulanger, C., Schini, V. B., Hendrickson, H., and Vauhoutte, P. M., Chronic exposure of cultured endothelial cells to eicosapentaenic acid potentiates the release of endothelium-derived relaxating factor(s). Br. J. Pharmacol., 99, 176-180 (1990).
  • 12) Shimokawa, H., and Vanhoutte, P. M., Dietary cod-liver oil improves endothelium-dependent responses in hypercholesterolemic and atherosclerotic porcine coronary arteries. Circulation, 78, 1421-1430 (1988).
  • 13) Khedara, A., Kawai, Y., Kayashita, J., and Kato, N., Feeding rats the nitric oxide synthase inhibitor, L-Nω nitroarginine, elevates serum triglyceride and cholesterol and lowers hepatic fatty acid oxidation. J. Nutr., 126, 2563-2567 (1996).
  • 14) Khedara, A., Goto, T., Kayashita, J., and Kato, N., Hypercholesterolemic effect in rats of a dietary addition of the nitric oxide synthase inhibitor, L-Nwnitroarginine, by less synthesis of bile acids. Biosci. Biotechnol. Biochem., 62, 773-777 (1998).
  • 15) Azuma, H., Ishikawa, M., and Sekizaki, S., Endothelium-dependent inhibition of platelet aggregation. Br. J. Pharmacol., 88, 411-415 (1986).
  • 16) Radomski, M. W., Palmer, R. M. J., and Moncada, S., The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochim. Biophys. Res. Commun., 148, 1482-1489 (1987).
  • 17) Kurowska, E. M., and Carroll, K. K., Hypocholesterolemic properties of nitric oxide. In vivo and in vitro studies using nitric oxide donors. Biochim. Biophys. Acta, 1392, 41-50 (1998).
  • 19) Albert, P. R., Insulin resistance, obesity and hypertension. J. Nutr., 125, 1718-1724 (1995).
  • 18) Huang, P. L., Huang, Z., Mashimo, H., Bloch, K. D., Moskowitz, M. A., Bevan, J. A., and Fishman, M. C., Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature, 377, 239-242 (1995).
  • 19) Albert, P. R., Insulin resistance, obesity and hypertension. J. Nutr., 125, 1718-1724 (1995).
  • 20) Kaplan, N. M., The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch. Intern. Med., 149, 1514-1520 (1989).
  • 21) Rocchini, A. P., Insulin resistance and blood pressure regulation in obese and non-obese subjects. Hypertension, 17, 837-842 (1991).
  • 22) American Institute of Nutrition, Report of the American Institute of Nutrition and ad hoc committee on standards for nutritional studies. J. Nutr., 107, 1340-1348 (1977).
  • 23) Folch, J., Lees, M., and Sloane-Stanley, G. H., A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem., 226, 497-509 (1957).
  • 24) Freedland, R. A., Effect of progressive starvation on rat liver enzyme activities. J. Nutr., 91, 489-495 (1967).
  • 25) Martin, D. B., Horning, M. G., and Vagelos, P. R., Fatty acid synthesis in adipose tissue, I. Purification and properties of a long chain fatty acid-synthesizing system. J. Biol. Chem., 236, 663-668 (1961).
  • 26) Bieber, L. L. and Fiol, C., Purification and assay of carnitine acyltransferases. Methods in Enzymol., 12, 276-284 (1985).
  • 27) Shimomura, Y., Tamura, T., and Suzuki, M., Less body fat accumulation in rats fed a safflower oil diet than in rats fed a beef tallow diet. J. Nutr., 120, 1291-1296 (1990).
  • 28) Nilsson-Ehle, P. and Schotz, M. C., A stable, radioactive substrate emulsion for assay of lipoprotein lipase. J. Lipid Res., 17, 536 (1976).
  • 29) Garfinkel, A. S., Nilsson-Ehle, P., and Schotz, M. C., Regulation of lipoprotein lipase: Induction by insulin. Biochim. Biophys. Acta, 424, 264-273 (1976).
  • 30) Nilsson-Ehle, P., Tornquist, H., and Belfrage. P., Rapid determination of lipoprotein lipase activity in human adipose tissue. Clin. Chim. Acta, 42, 338-390 (1972).
  • 31) Duncan, D. B., Multiple range test for correlated and heteroscedatic means. Biometrics, 13, 164-176 (1957).
  • 32) Morley, J. E. and Flood, J. F., Competitive antagonism of nitric oxide synthase causes weight loss in mice. Life Sci., 51, 1285-1289 (1992).
  • 33) Squadrito, F., Calapai, G., Altavilla, D., Cucinotta, D., Zingarelli, B., Arcoraci, V., Campo, G. M., and Caputi, A. P., Central serotoninergic system involvement in the anorexia induced by NG-nitro-L-arginine, an inhibitor of nitric oxide synthase. Eur. J. Pharmacol., 255, 51-55 (1994).
  • 34) Ikeda, K., Gutierrez, Jr., O. G., and Yamori, Y., Dietary NG-nitro-L-arginine induces sustained hypertension in normotensive Wistar-Kyoto rats. Clin. Exp. Pharmacol. Physiol., 19, 583-586 (1992).
  • 35) Michael, W. B., John, E. H., Bruce, N. V. V., Magdalena, A. G., Guillermo, A. H., and Dion, Z., Obesity and hypertension: roles of hyperinsulinemia, sympathetic nervous system and intrarenal mechanisms. J. Nutr., 125, 1725S-1731S (1995).
  • 36) Harano, Y., Kashiwagi, A., Kojima, H., Suzuki, M., Hashimoto, T., and Shigeta, Y., Phosphorylation of carnitine palmitoyltransferase and activation by glucagon in isolated rat hepatocytes. FEBS Lett., 188, 267-272 (1985).
  • 37) Baldo, A., Sniderman, A. D., Luce, S. St., Zhang, X.-J., and Cianflone, K. K., Single transduction pathway of acylation stimulating protein: involvement of protein kinase C. J. Lipid Res., 36, 1415-1426 (1995).
  • 38) Gopalakrishna, R., Chen, Z. H., and Gundimela, U., Nitric oxide and nitric oxide-generating agents induce a reversible inactivation of protein kinase C activity and phorbol ester binding. J. Biol. Chem., 268, 27180-27185 (1993).
  • 39) Gaudiot, N., Jaubert, A. M., Charbonnier, E., Sabouraut, D., Lacasa, D., Giudicelli, Y., and Ribiere, C., Modulation of white adipose tissue lipolysis by nitric oxide. J. Biol. Chem., 273, 13475-13481 (1998).
  • 40) Friedman, J. M., Leptin, Leptin receptors, and the control of body weight. Nutrition Reviews, 56, S38-S46 (1998).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.