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Original Articles

A Positive Screening for Drugs that Specifically Inhibit the Ca2+-Signaling Activity on the Basis of the Growth Promoting Effect on a Yeast Mutant with a Peculiar Phenotype

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Pages 1942-1946 | Received 27 Mar 2000, Accepted 01 May 2000, Published online: 22 May 2014

  • 1) Banuett, F., Signalling in the yeasts: An informational cascade with links to the filamentous fungi. Microbiol. Mol. Biol., 62, 249-274 (1998).
  • 2) Mager, W. H. and Kruijff, A. J. J., Stress induced transcriptional activation. Microbiol. Rev., 59, 506-531 (1995).
  • 3) Mizunuma, M., Hirata, D., Miyahara, K., Tsuchiya, E., and Miyakawa, T., Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast. Nature, 392, 303-306 (1998).
  • 4) Booher, R. N., Deshaies, R. J., and Kirschner, M. W., Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. EMBO J., 12, 3417-3426 (1993).
  • 5) Ma, X. J., and Grunstein, M., A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae. Genes Dev., 10,1327-1340 (1996).
  • 6) Tanaka, S. and Nojima, H., Nik1, a Nim1-like protein kinase of S. cerevisiae interacts with the Cdc28 complex and regulates cell-cycle progression. Genes Cells, 1, 905-921 (1996).
  • 7) Nakamura, T., Ohmoto, T., Hirata, D., Tsuchiya, E., and Miyakawa, T., Genetic evidence for the functional redundancy of the calcineurin- and Mpk1-mediated pathways in the regulation of cellular events important for growth in Saccharomyces cerevisiae. Mol. Gen. Genet., 251, 211-219 (1996).
  • 8) Foor, F., Parent, S. A., Morin, N., Dahl, A. M., Ramadan, N., Chrebet, G., Bostian, K.A., and Nielsen, J. B., Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from α-factor arrest in yeast. Nature, 360, 682-684 (1992).
  • 9) Nakamura, T., Liu, Y., Hirata, D., Namba, H., Harada, S., Hirokawa, T., and Miyakawa, T., Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions. EMBO J., 12, 4063-4071 (1993).
  • 10) Nitiss, J. and Wang, J. C., DNA topoisomerase targeting antitumor drugs can be studied in yeast. Proc. Natl. Acad. Sci. U.S.A., 85, 7501-7505 (1988).
  • 11) Hemmi, K., Julmanop, C., Hirata, D., Tsuchiya, E., Takemoto, J., and Miyakawa, T., The physiological role of membrane ergosterol as revealed by the phenotypes of syr1/erg3 null mutant of Saccharomyces cerevisiae. Biosci. Biotechnol. Biochem., 59, 482-486 (1995).
  • 12) Clapham, D. E., Calcium signaling. Cell, 80, 259-268 (1995).

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