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Original Articles

Construction of a Bacillus subtilis (natto) with High Productivity of Vitamin K2 (Menaquinone-7) by Analog Resistance

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Pages 2007-2015 | Received 05 Feb 2001, Accepted 13 Apr 2001, Published online: 22 May 2014

  • 1) Boukaert, H.J., and Said, A.H., Fracture healing by vitamin K. Nature (London), 19, 849 (1960).
  • 2) Hauschka, P.V., Lian, J.B., and Gallop, P.M., Direct identification of the calcium-binding amino acid, γ-carboxylglutamate, in mineral tissue. Proc. Natl. Acad. Sci. USA, 72, 925-3929 (1975).
  • 3) Price, P.A., Willamson, M.K., Lothringer, M.K., and Lothringer, J.W., Origin of the vitamin K-dependent bone protein found in plasma and its clearance by kidney and bone. J. Biol. Chem., 256, 12760-12766 (1981).
  • 4) Hauschka, P.V., and Carr, S.A., Calcium-dependent α-helical structure in osteocalcin. Biochemistry, 21, 2538-2547 (1982).
  • 5) Price, P.A., Vitamin K-dependent formation of bone gla protein (osteocalcin) and its function. Vitam. Horm., 42, 65-108 (1985).
  • 6) Koshihara, Y., Hoshi, K., and Shiraki, M., Enhancement of mineralization of human osteoblasts by vitamin K2 (menaquinone). J. Clin. Exp. Med., 161, 439-444 (1992).
  • 7) Akiyama, Y., Hara, K., Ohkawa, I., and Tajima, T., Effects of menaterenone on bone loss induced by ovariectomy in rats. Jpn J. Pharmacol., 62, 145-153 (1993).
  • 8) Kishi, S., Segawa, Y., and Yamaguchi, M., Histomorphological confirmation of preventive effect of β-alanyl-1-histidinate zinc on bone loss in ovariectomized rats. Biol. Pharm. Bull., 17, 862-865 (1994).
  • 9) Hara, K., Akiyama, Y., Ohkawa, I., and Tajima, T., Effects of menaterenone on prednisolone-induced bone loss in rats. Bone, 14, 813-818 (1993).
  • 10) Hara, K., Akiyama, Y., Nakamura, T., Murota, S., and Morita, I., The inhibitory effect of vitamin K2 (menaquinone) on bone resorption may be related to its side chain. Bone (NY), 16, 179-184 (1995).
  • 11) Ehara, Y., Takahashi, H., Hanashita, T., and Yamaguchi, M., Effect of vitamin K2 (menaquinone) on bone metabolism in the femoral metaphyseal tissues of normal and skeletal-unloaded rats: Enhancement with zinc. Res. Exp. Med., 196, 171-178 (1996).
  • 12) Sato, T., Isobe, Y., Ehara, Y., and Yamaguchi, M., Effect of menaquinone-7 purified from the fermented soybean (natto) in the femoral metaphysis from rat femur. Vitamins, 70, 312-322 (1996).
  • 13) Kaneki, M., Serum concentration of vitamin K in elderly women with involutional osteoporosis. Clin. Calcium (in Japanese), 6, 41-44 (1996).
  • 14) Hosoi, T., Recent progress in treatment of osteoporosis. Nippon Ronnen Igakkai Zasshi (in Japanese), 33, 24-244 (1996).
  • 15) Sakano, T., Notsumoto, S., Nagaoka, T., Morimoto, A., Fujimoto, K., Masuda, S., Suzuki, Y., and Hirauchi, K., Measurement of K vitamins in food by high-performance liquid chromatography with fluorometric detection. Vitamins (Japan), 62, 393-398 (1988).
  • 16) Kaneki, M., Vitamin K and bone metabolism turnover. Clinical Calcium (in Japanese), 6, 1041-1044 (1996).
  • 17) Sumi, H., Determination of the vitamin K (menaquinone-7) content in fermented soybean natto and in the plasma of natto ingesting subjects. Food Sci. Technol. Res. (in Japanese), 15, 48-50 (1999).
  • 18) Onishi, R., Abe, K., Honma, S., and Aida, K., Studies on a viscous substance of the natto. Nihon Kasei Gakkaishi (in Japanese), 38, 871-876 (1987).
  • 19) Iizuka, M., Tanaka, T., Ohmachi, T., and Asada, Y., Synthesis of fructan and oligosaccharides by microbial and plant fructosyltransferases. Denpun Kagaku (in Japanese), 38, 217-222 (1991).
  • 20) Ito, H., Sato, K., Matusi, K., Sano, K., Nakamori, S., Tanaka, T., and Enei, H., Cloning and characterization of gene resposible for m-fluoro-D,L-phenylalanine resistance in Brevibacterium lactofermentum. Agric. Biol. Chem., 54, 707-713 (1990).
  • 21) Hara, T., Nagamoto, S., Ogata, S., and Ueda, S., The DNA sequence of γ-glutamyltranspeptidase gene of B. subtilis (natto) plasmid pUH1. Appl. Microbiol. Biotechnol., 37, 211-215 (1992).
  • 22) Nagami, Y., and Tanaka, T., Cloning and sequencing of the prtR gene from B. natto that enhances production of extracellular protease and levasucrase in B. subtilis. Mitsubishi Chem. Res. Dev. Rev., 1, 35-43 (1987).
  • 23) Nagai, T., Koguchi, K., and Ito, Y., Chemical analysis of poly-γ-glutamic acid produced by plasmid-free B. subtilis (natto): Evidence that plasmids are not involved in poly-γ-glutamic acid production. J. Gen. Appl. Microbiol., 43, 139-143 (1997).
  • 24) Ashiuchi, M., Tani, K., Misono, H., and Soda, K., Properties of glutamate racemase from B. subtilis IFO 3336 producing poly-γ-glutamate. J. Biochem., 123, 1156-1163 (1998).
  • 25) Ashiuchi, M., Soda, K., and Misono, H., A poly-γ-glutamate synthetic system of B. subtilis IFO 3336: Gene cloning and biochemical analysis of poly-γ-glutamate production by E. coli clone cells. Biochem. Biophys. Res. Commun., 263, 6-12 (1999).
  • 26) Ito, Y., Molecular regulation and genetic instability of γ-polyglutamic acid production in B. subtilis (natto). Bioscience and industry (in Japanese), 57, 247-250 (1999).
  • 27) Nagai, T., Tran, L. -S., Inatsu, Y., and Ito, Y., A new IS4 family insertion sequence. IS4Bsul, responsible for genetic instability of poly-γ-glutamic acid production in B. subtilis. J. Bacteriol., 182, 2387-2392 (2000).
  • 28) Yamaguchi, M., Taguchi, T., Gao, Y.H., Igarashi, A., and Tsukamoto, Y., Effect of vitamin K2 (menaquinone-7) in fermented soybean (natto) on bone loss in ovariectomized rats. J. Bone Miner. Metab., 17, 23-29 (1999).
  • 29) Yamaguchi, M., Kakuda, H., Gao, Y.H., and Tsukamoto, Y., Prolonged intake of fermented soybean (natto) diets containing vitamin K2 (menaquinone-7) prevents bone loss in ovariectomized rats. J. Bone Miner. Metab., 18, 71-76 (2000).
  • 30) Tsukamoto, Y., Ichise, H., Kakuda, H., and Yamaguchi, M., Intake of fermented soybean (natto) increases circulating vitamin K2 (menaquinone-7) and y-carboxylated osteocalcin concentrations in normal individuals. J. Bone Miner. Metab., 18, 216-222 (2000).
  • 31) Tsukamoto, Y., Ichise, H., and Yamaguchi, M., Prolonged intake of dietary fermented soybeans (natto) with the reinforced vitamin K2 (menaquinone-7) enhances circulating γ-carboxylated osteocalcin concentration in normal individuals. J. Health Sci., 46, 317-321 (2000).

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