Advanced search
Publication Cover
Bioscience, Biotechnology, and Biochemistry Volume 66, 2002 - Issue 5
Journal homepage
185
Views
13
CrossRef citations to date
0
Altmetric
Original Articles

Antigen Presentation by Peyer's Patch Cells Can Induce both Th1- and Th2-type Responses Depending on Antigen Dosage, but a Different Cytokine Response Pattern from That of Spleen Cells

Tadashi YOSHIDADepartment of Applied Biological Chemistry, University of Tokyo Tokyo 113-8657, Japan;Present address: Department of Applied Biological Science, Tokyo University of Agriculture and Technology Fuchu 183-8509, Japan
,
Satoshi HACHIMURADepartment of Applied Biological Chemistry, University of Tokyo Tokyo 113-8657, Japan
,
Mina ISHIMORIDepartment of Applied Biological Chemistry, University of Tokyo Tokyo 113-8657, Japan
,
Fumitaka KINUGASADepartment of Applied Biological Chemistry, University of Tokyo Tokyo 113-8657, Japan
,
Wataru ISEDepartment of Applied Biological Chemistry, University of Tokyo Tokyo 113-8657, Japan
,
Mamoru TOTSUKADepartment of Applied Biological Chemistry, University of Tokyo Tokyo 113-8657, Japan
,
Akio AMETANIDepartment of Applied Biological Chemistry, University of Tokyo Tokyo 113-8657, Japan;Division of Immune Regulation, La Jolla Institute for Allergy and Immunology San Diego, CA 92121, U.S.A.)
&
Shuichi KAMINOGAWADepartment of Applied Biological Chemistry, University of Tokyo Tokyo 113-8657, Japan
 show all
Pages 963-969 | Received 16 Oct 2001, Accepted 28 Dec 2001, Published online: 22 May 2014

  • 1) Constant, S., Pfeiffer, C., Pasqualini, T., and Bottomly, K., Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. J. Exp. Med., 182, 1591-1596 (1995).
  • 2) Hosken, N. A., Shibuya, K., Heath, A. W., Murphy, K. M., and O'Garra, A. O., The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-αβ-transgenic model. J. Exp. Med., 182, 1579-1584 (1995).
  • 3) Schweitzer, A. N., Borriello, F., Wong, R. C. K., Abbas, A. K., and Sharpe, A. H., Role of costimulators in T cell differentiation; studies using antigen-presenting cells lacking expression of CD80 or CD86. J. Immunol., 158, 2713-2722 (1997).
  • 4) Ranger, A. M., Das, M. P., Kuchroo, V. K., and Glimcher, L. H., B7-2 (CD86) is essential for the development of IL-4-producing T cells. Int. Immunol., 8, 1549-1560 (1996).
  • 5) Hsieh, C.-S., Heimberger, A. B., Gold, J. S., O'Garra, A., and Murphy, K. M., Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell-receptor transgenic system. Proc. Natl. Acad. Sci. USA, 89, 6065-6069 (1992).
  • 6) Rogers, P. R., and Croft, M., CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen. J. Immunol., 164, 2955-2963 (2000).
  • 7) Ruedl, C., Bachmann, M. F., and Kopf, M., The antigen dose determines T helper subset development by regulation of CD40 ligand. Eur. J. Immunol., 30, 2056-2064 (2000).
  • 8) Yoshida, T., Hachimura, S., and Kaminogawa, S., The oral administration of low-dose antigen induces activation followed by tolerization, while high-dose antigen induces tolerance without activation. Clin. Immunol. Immunopathol., 82, 207-215 (1997).
  • 9) Everson, M. P., Lemak, D. G., McDuffie, D. S., Koopman, W. J., McGhee, J. R., and Beagkey, K. W., Dendritic cells from Peyer's patch and spleen induce different T helper cell responses. J. Interferon Cytokine Res., 18, 103-115 (1998).
  • 10) Iwasaki, A., and Kelsall, B. L., Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J. Exp. Med., 190, 229-239 (1999).
  • 11) Nagata, S., Mckenzie, C., Pender, S. L. F., Bajaj- Elliott, M., Fairclough, P. D., Walker-Smith, J. A., Monteleone, G., and Macdonald, T. T., Human Peyer's patch T cells are sensitized to dietary antigen and display a Th cell type 1 cytokine profile. J. Immunol., 165, 5315-5321 (2000).
  • 12) Marth, T., Strober, W., and Kelsall, B. L., High dose oral tolerance in ovalbumin TCR-transgenic mice: Systemic neutralization of IL-12 augments TGF-β secretion and T cell apoptosis. J. Immunol., 157, 2348-2357 (1996).
  • 13) Sato, T., Sasahara, T., Nakamura, Y., Osaki, T., Hasegawa, T., Tadakura, T., Arata, Y., Kumagai, Y., Katsuki, M., and Habu, S., Naive T cells can mediate delayed-type hypersensitivity response in T cell receptor transgenic mice. Eur. J. Immunol., 24, 1512-1516 (1994).
  • 14) Santos, L. M. B., Al-Sabbagh, A., Londono, A., and Weiner, H. L., Oral tolerance to myelin basic protein induces regulatory TGF-β-secreting T cells in Peyer's patches of SJL mice. Cell. Immunol., 157, 439-447 (1994).
  • 15) Xu-Amano, J., Aicher, W. K., Taguchi, T., Kiyono, H., and McGhee, J. R., Selective induction of Th2 cells in murine Peyer's patch by oral immunization. Int. Immunol., 4, 433-445 (1992).
  • 16) Robertson, J. M., Jensen, P. E., and Evavold, B. D., DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323-339 epitope. J. Immunol., 164, 4706-4712 (2000).
  • 17) Kellermann, S. A., and McEvoy, L. M., The Peyer's patch microenvironment suppresses T cell responses to chemokines and other stimuli. J. Immunol., 167, 682-690 (2001).
  • 18) Bruce, M. G., and Ferguson, A., Oral tolerance to ovalbumin in mice: studies of chemically modified and ‘biologically filtered’ antigen. Immunology, 57, 627-630 (1986).
  • 19) Furrie, E., Turner, M. W., and Strobel, S., Partial characterization of a circulating tolerogenic moiety which, after a feed of ovalbumin, suppresses delayed-type hypersensitivity in recipient mice. Immunology, 86, 480-486 (1995).
  • 20) Peng, H., Turner, M., and Ferguson, A., The generation of a tolerogen after a feed of ovalbumin is time-dependent and unrelated to the serum level of immunoreactive protein. Clin. Exp. Immunol., 81, 510-515 (1990).
  • 21) Tsuji, N. M., Mizumachi, K., and Kurisaki, J., Interleukin-10-secreting Peyer's patch cells are responsible for active suppression in low-dose oral tolerance. Immunology, 103, 458-464 (2001).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.