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Bioscience, Biotechnology, and Biochemistry Volume 67, 2003 - Issue 6
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Original Articles

Insulin Stimulates Expression of the Pyruvate Kinase M Gene in 3T3-L1 Adipocytes

Yuuki ASAIDepartment of Applied Molecular Biosciences, Nagoya University Graduate School of Bioagricultural SciencesChikusa-ku, Nagoya 464-8601, Japan
,
Kazuya YAMADADepartment of Biochemistry, Fukui Medical University and CREST, Japan Science and TechnologyMatsuoka, Fukui 910-1193, Japan
,
Toyoaki WATANABEDepartment of Applied Molecular Biosciences, Nagoya University Graduate School of Bioagricultural SciencesChikusa-ku, Nagoya 464-8601, Japan
,
Vincent W. KENGDepartment of Applied Molecular Biosciences, Nagoya University Graduate School of Bioagricultural SciencesChikusa-ku, Nagoya 464-8601, Japan
&
Tamio NOGUCHIDepartment of Applied Molecular Biosciences, Nagoya University Graduate School of Bioagricultural SciencesChikusa-ku, Nagoya 464-8601, Japan
Pages 1272-1277 | Received 29 Nov 2002, Accepted 22 Feb 2003, Published online: 22 May 2014

  • 1) Imamura, K., and Tanaka, T., Pyruvate kinase isozymes from rat. Methods Enzymol., 90, 150-165 (1982).
  • 2) Yamada, K., and Noguchi, T., Nutrient and hormonal regulation of pyruvate kinase gene expression. Biochem. J., 337, 1-11 (1999).
  • 3) Noguchi, T., Yamada, K., Inoue, H., Matsuda, T., and Tanaka, T., The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters. J. Biol. Chem., 262, 14366-14371 (1987).
  • 4) Noguchi, T., Inoue, H., and Tanaka, T., The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. J. Biol. Chem., 261, 13807-13812 (1986).
  • 5) Takenaka, M., Noguchi, T., Inoue, H., Yamada, K., Matsuda, T., and Tanaka, T., Rat pyruvate kinase M gene. Its complete structure and characterization of the 5′-flanking region. J. Biol. Chem., 264, 2363-2367 (1989).
  • 6) Takenaka, M., Noguchi, T., Sadahiro, S., Hirai, H., Yamada, K., Matsuda, T., Imai, E., and Tanaka, T., Isolation and characterization of the human pyruvate kinase M gene. Eur. J. Biochem., 198, 101-106 (1991).
  • 7) Yamada, K., and Noguchi, T., Regulation of pyruvate kinase M gene expression. Biochem. Biophys. Res. Commun., 256, 257-262 (1999).
  • 8) Noguchi, T., Inoue, H., and Tanaka, T., Transcriptional and post-transcriptional regulation of L-type pyruvate kinase in diabetic rat liver by insulin and dietary fructose. J. Biol. Chem., 260, 14393-14397 (1985).
  • 9) Munnch, A., Lyonnet, S., Chauvet, D., Van Schaftinge, E., and Kahn, A., Differential effects of glucose and fructose on liver L-type pyruvate kinase gene expression in vivo. J. Biol. Chem., 262, 17065-17071 (1987).
  • 10) Decaux, J.-F., Antoine, B., and Kahn, A., Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture. J. Biol. Chem., 264, 11584-11590 (1989).
  • 11) Matsuda, T., Noguchi, T., Yamada, K., Takenaka, M., and Tanaka, T., Regulation of the gene expression of glucokinase and L-type pyruvate kinase in primary cultures of rat hepatocytes by hormones and carbohydrates. J. Biochem., 108, 778-784 (1990).
  • 12) Noguchi, T., Okabe, M., Wang, Z., Yamada, K., Imai, E., and Tanaka, T., An enhancer unit of L-type pyruvate kinase gene is responsible for transcriptional stimulation by dietary fructose as well as glucose in transgenic mice. FEBS Lett., 318, 269-272 (1993).
  • 13) Liimatta, M., Towle, H. C., Clarke, S., and Jump, D. B., Dietary polyunsaturated fatty acids interfere with the insulin/glucose activation of L-type pyruvate kinase gene transcription. Mol. Endocrinol., 8, 1147-1153 (1994).
  • 14) Foefelle, F., and Ferre, P., New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem. J., 366, 377-391 (2002).
  • 15) Traxinger, R. R., and Marshall, S., Insulin regulation of pyruvate kinase activity in isolated adipocytes. Crucial role of glucose and the hexosamine biosynthesis pathway in the expression of insulin action. J. Biol. Chem., 267, 9718-9723 (1992).
  • 16) Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., and Kliewer, S. A., An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem., 270, 12953-12956 (1995).
  • 17) Chomczynski, P., and Sacchi, N., Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159 (1987).
  • 18) Matsuda, T., Noguchi, T., Takenaka, M., Yamada, K., and Tanaka, T., Regulation of L-type pyruvate kinase gene expression by dietary fructose in normal and diabetic rats. J. Biochem., 107, 655-660 (1990).
  • 19) Hotta, K., Nakajima, H., Yamasaki, T., Hamaguchi, T., Kuwajima, M., Noguchi, T., Tanaka, T., Kono, N., and Tarui, S., Rat-liver-type phosphofructokinase mRNA. Structure, tissue distribution and regulation. Eur. J. Biochem., 202, 293-298 (1991).
  • 20) Foufelle, F., Gouhot, B., Pegorier, J.-P., Perdereau, D., Girard, J., and Ferre, P., Glucose stimulation of lipogenic enzyme gene expression in cultured white adipose tissue. A role for glucose 6-phosphate. J. Biol. Chem., 267, 20543-20546 (1992).
  • 21) Jones, B. H., Standridge, M. K., Claycombe, K. J., Smith, P. J., and Moustaid-Moussa, N., Glucose induces expression of stearoyl-CoA desaturase in 3T3-L1 adipocytes. Biochem. J., 335, 405-408 (1998).
  • 22) Schafer, D., Hamm-Kunzelmann, B., and Brand, K., Glucose regulates the promoter activity of aldolase A and pyruvate kinase M2 via dephosphorylation of Sp1. FEBS Lett., 417, 325-328 (1997).
  • 23) Proud, C. G., and Denton, R. M., Molecular mechanisms for the control of translation by insulin. Biochem. J., 328, 329-341 (1997).
  • 24) Saltiel, A., and Kahn, C. R., Insulin signaling and the regulation of glucose and lipid metabolism. Nature, 414, 799-806 (2001).
  • 25) Shepherd, P. R., Nave, B. T., and Siddle, K., Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase. Biochem. J., 305, 25-28 (1995).
  • 26) Fasshauer, M., Klein, J., Neumann, S., Eszlinger, M., and Paschke, R., Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun., 290, 1084-1089 (2002).
  • 27) Gronning, L. M., Cederberg, A., Miura, N., Enerback, S., and Tasken, K., Insulin and TNFα induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK 1/2-dependent pathways. Mol. Endocrinol., 16, 873-883 (2002).
  • 28) Netzker, R., Weigert, C., and Brand, K., Role of the stimulatory proteins Sp1 and Sp3 in the regulation of transcription of the rat pyruvate kinase M gene. Eur. J. Biochem., 245, 174-181 (1997).
  • 29) Yamada, K., Tanaka, T., Miyamoto, K., and Noguchi, T., Sp family members and nuclear factor-Y cooperatively stimulate transcription from the rat pyruvate kinase M gene distal promoter region via their direct interactions. J. Biol. Chem., 275, 18129-18137 (2000).
  • 30) Daniel, S., Zhang, S., DePaoli-Roach, A. A., and Kim, K.-H., Dephosphorylation of Sp1 by protein phosphatase 1 is involved in the glucose-mediated activation of the acetyl-CoA carboxylase gene. J. Biol. Chem., 271, 14692-14697 (1996).
  • 31) Keembiyehetty, C. N., Candelaria, R. P., Majumdar, Raghow, R., Martinez-Hernandez, and Solomon, S. S., Paradoxical regulation of Sp1 transcription factor by glucagon. Endocrinology, 143, 1512-1520 (2002).
  • 32) Garcia, A., Cereghini, S., and Sontag, E., Protein phosphatase 2A and phosphatidylinositol 3-kinase regulate the activity of Sp1-responsive promoters. J. Biol. Chem., 275, 9385-9389 (2000).
  • 33) Reisinger, K., Kaufmann, R., and Gille, J., Increased Sp1 phosphorylation as a mechanism of hepatocyte growth factor (HGF/SF)-induced vascular endothelial growth factor (VEGF/VPF) transcription. J. Cell Sci., 116, 225-238 (2003).
  • 34) O'Brien, R. M., and Granner, D. K., Regulation of gene expression by insulin. Physiol. Rev., 76, 1109-1161 (1996).
  • 35) Moncion, A., Truong, N. T., Garrone, A., Beaune, P., Barouki, R., and de Waziers, I., Identification of a 16-nucleotide sequence that mediates post-transcriptional regulation of rat CYP2E1 by insulin. J. Biol. Chem., 277, 45904-45910 (2002).

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