Advanced search
Publication Cover
Bioscience, Biotechnology, and Biochemistry Volume 67, 2003 - Issue 9
Journal homepage
118
Views
20
CrossRef citations to date
0
Altmetric
Original Articles

Structural Effects of Phenolic Acids on the Transepithelial Transport of Fluorescein in Caco-2 Cell Monolayers

Yutaka KONISHIApplied Bioresearch Center, Research & Development Department3 Miyaharacho, Takasaki-shi, Gunma 370-1295, Japan
,
Kazuo KUBOPharmaceutical Research Laboratories, Pharmaceutical Division, Kirin Brewery Co., Ltd.3 Miyaharacho, Takasaki-shi, Gunma 370-1295, Japan
&
Makoto SHIMIZUDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
Pages 2014-2017 | Received 12 Mar 2003, Accepted 13 May 2003, Published online: 22 May 2014

  • 1) Steinmetz, K. A., and Potter, J. D., Vegetables, fruit, and cancer prevention. J. Am. Diet. Assoc., 96, 1027-1039 (1996).
  • 2) Criqui, M. H., and Ringel, B. L., Does diet or alcohol explain the French paradox? Lancet, 344, 1719-1723 (1994).
  • 3) Adlercreutz, H., and Mazur, W., Phyto-oestrogens and Western diseases. Ann. Med., 29, 95-120 (1997).
  • 4) Scalbert, A., and Williamson, G., Dietary intake and bioavailability of polyphenols. J. Nutr., 130, 2073S-2085S (2000).
  • 5) Hidalgo, I. J., Raub, T. J., and Borchardt, R. T., Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96, 736-749 (1989).
  • 6) Hilgers, A. R., Conradi, R. A., and Burton, P. S., Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa. Pharm. Res., 7, 902-910 (1990).
  • 7) Artursson, P., and Karlsson, J., Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Commun., 175, 880-885 (1991).
  • 8) Hidalgo, I. J., and Borchardt, R. T., Transport of a large neutral amino acid (phenylalanine) in a human intestinal epithelial cell line, Caco-2. Biochim. Biophys. Acta, 1028, 25-30 (1990).
  • 9) Hidalgo, I. J., and Borchardt, R. T., Transport of bile acids in a human intestinal epithelial cell line, Caco-2. Biochim. Biophys. Acta, 1035, 97-103 (1990).
  • 10) Dantzig, A. H., and Bergin, L., Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2. Biochim. Biophys. Acta, 1027, 211-217 (1990).
  • 12) Rahman, B., Schneider, H. P., Broer, A., Deitmer, J. W., and Broer, S., Helix 8 and Helix 10 are involved in substrate recognition in the rat monocarboxylate transporter MCT1. Biochemistry, 38, 11577-11584 (1999).
  • 13) Ogihara, T., Tamai, I., and Tsuji, A., Structural characterization of substrates for the anion exchange transporter in Caco-2 cells. J. Pharm. Sci., 88, 1217-1221 (1999).
  • 11) Konishi, Y., Hagiwara, K., and Shimizu, M., Transepithelial transport of fluorescein in Caco-2 cell monolayers and its use in in vitro evaluation of phenolic acids availability. Biosci. Biotechnol. Biochem., 66, 2449-2457 (2002).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.