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Bioscience, Biotechnology, and Biochemistry Volume 67, 2003 - Issue 12
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Original Articles

Enhancing Effect of Lipids and Emulsifiers on the Accumulation of Quercetin Metabolites in Blood Plasma after the Short-term Ingestion of Onion by Rats

Keiko AZUMANational Institute of Vegetable and Tea Science, National Agricultural Research OrganizationAno, Mie 514-2392, Japan
,
Katsunari IPPOUSHINational Institute of Vegetable and Tea Science, National Agricultural Research OrganizationAno, Mie 514-2392, Japan
,
Hidekazu ITONational Institute of Vegetable and Tea Science, National Agricultural Research OrganizationAno, Mie 514-2392, Japan
,
Hideki HORIENational Institute of Vegetable and Tea Science, National Agricultural Research OrganizationAno, Mie 514-2392, Japan
&
Junji TERAODepartment of Nutrition, School of Medicine, The University of TokushimaKuramoto-cho 3, Tokushima 770-8503, Japan
Pages 2548-2555 | Received 23 May 2003, Accepted 08 Aug 2003, Published online: 22 May 2014

  • 1) de Whalley, C. V., Rankin, S. M., Hoult, J. R., Jessup, W., and Leake, D., Flavonoids inhibit the oxidative modification of low density lipoproteins by macropharges. Biochem. Pharmacol., 39, 1743-1750 (1990).
  • 2) Mangiapane, H., Thomson, J., Salter, A., Brown, S., Bell, G. P., and White, D. A., The inhibition of the oxidation of low density lipoprotein by (+)-catechin, a naturally occurring flavonoid. Biochem. Pharmacol., 43, 445-450 (1992).
  • 3) Miura, S., Watanabe, J., Sano, M., Tomita, T., Osawa, T., Hara, Y., and Tomita, I., Effects of various natural antioxidants on the Cu2+-mediated oxidative modification of low-density lipoprotein. Biol. Pharm. Bull., 18, 1-4 (1995).
  • 4) da Silva, E. L., Tsushida, T., and Terao, J., Inhibition of mammalian 15-lipoxygenase-dependent lipid peroxidation in low-density lipoprotein by quercetin and quercetin monoglucosides. Arch. Biochem. Biophys., 349, 313-320 (1998).
  • 5) Hertog, M. G. L., Feskens, E. J. M., Hollman, P. C. H., Katan, M. B., and Kromhout, D., Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen elderly study. Lancet, 342, 1007-1011 (1993).
  • 6) Hertog, M. G. L., Kromhout, D., Aravanis, C., Blackburn, H., Buzina, R., Fidanza, F., Giampaoli, S., Jansen, A., Menotti, A., Nedelijkovic, S., Pekkarinen, M., Simic, B. S., Toshoma, H., Feskens, E. J. M., Hollman, P. C. H., and Katan, M., Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch. Intern. Med., 155, 381-386 (1995).
  • 7) Knekt, P., Jarvinen, R., Reunanen, A., and Maatela, J., Flavonoid intake and coronary mortality in Finland: a cohort study. Br. Med. J., 312, 478-481 (1996).
  • 8) Yochum, L., Kushi, L., Meyer, K., and Folsom, A., Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women. Am. J. Epidemiol., 149, 943-949 (1999).
  • 9) Hertog, M. G. L., Hollman, P. C. H., and Katan, M. B., Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J. Agric. Food Chem., 40, 2379-2383 (1992).
  • 10) Sakakibara, H., Honda, Y., Nakagawa, S., Ashida, H., and Kanazawa, K., Simultaneous determination of all polyphenols in vegetables, fruits, and teas. J. Agric. Food Chem., 51, 571-581 (2003).
  • 11) Azuma, K., Nakayama, M., Koshioka, M., Ippoushi, K., Yamaguchi, Y., Kohata, K., Yamauchi, Y., Ito, H., and Higashio, H., Phenolic antioxidants from the leaves of Corchorus olitorius L. J. Agric. Food Chem., 47, 3963-3966 (1999).
  • 12) Terao, J., Piskula, M., and Yao, Q., Protective effect of epicatechin, epicatechin gallate, and quercetin on lipid peroxidation in phospholipid bilayers. Arch. Biochem. Biophys., 308, 278-284 (1994).
  • 13) Rice-Evans, C. A., Miller, N. J., and Paganga, G., Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Rad. Biol. Med., 20, 933-956 (1996).
  • 14) Rice-Evans, C. A., Miller, N. J., and Paganga, G., Antioxidant properties of phenolic compouns. Trends in Plant Sci., 2, 152-159 (1997).
  • 15) Pulido, R., Bravo, L., and Saura-Calixto, F., Antioxidant activity of dietary polyphenols as determined by a modified ferric reducing/antioxidant power assay. J. Agric. Food Chem., 48, 3396-3402 (2000).
  • 16) Ueno, I., Nakano, N., and Hirono, I., Metabolic fate of [14C]quercetin in the ACI rat. J. Exp. Med., 53, 41-50 (1983).
  • 17) Manach, C., Texier, O., Regerat, F., Agullo, G., Demigne, C., and Remesy, C., Dietary quercetin is recovered in rat plasma as conjugated derivatives of isorhamnetin and quercetin. Nutr. Biochem., 7, 375-380 (1996).
  • 18) Manach, C., Morand, C., Crespy, B., Demigne, C., Texier, O., Regerat, F., and Remesy, C., Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. FEBS Lett., 426, 331-336 (1998).
  • 19) da Silva, E. L., Piskula, M. K., Yamamoto, N., Moon, J.-H., and Terao, J., Quercetin metabolites inhibit copper ion-induced lipid peroxidation in rat plasma. FEBS Lett., 430, 405-408 (1998).
  • 20) Day, A. J., Dupont, M. S., Ridley, S., Rhodes, M., Rhodes, M. J. C., Morgan, M. R. A., and Williamson, G., Deglycosidation of flavonoid and isoflavonoid glycosides by human small intestine and liver β-glucosidase activity. FEBS Lett., 436, 71-75 (1998).
  • 21) Ioku, K., Pongpiriyadacha, Y., Konishi, Y., Takei, Y., Nakatani, N., and Terao, J., β-Glucuronidase activity in the rat small intestine toward quercetin monoglucosides. Biosci. Biotechnol. Biochem., 63, 1428-1431 (1998).
  • 22) Morand, C., Crespy, V., Manach, C., Besson, C., Demigne, C., and Remesy, C., Plasma metabolites of quercetin and their antioxidant properties. Am. J. Physiol., 275, R212-R219 (1998).
  • 23) Moon, J.-H., Nakata, R., Oshima, S., Inafuku, T., and Terao, J., Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women. Am. J. Physiol. Regulatory Integrative Comp. Phys., 279, R461-R467 (2000).
  • 24) Moon, J.-H., Tsushida, T., Nakahara, K., and Terao, J., Identification of quercetin 3-o-β-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin. Free Rad. Biol. Med., 30, 1274-1285 (2001).
  • 25) Walle, T., Otake, Y., Walle, U. K., and Wilson, F. A., Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption. J. Nutr., 130, 2658-2661 (2000).
  • 26) Shirai, M., Moon, J.-H., Tsushida, T., and Terao, J., Inhibitory effect of a quercetin metabolite, quercetin 3-o-β-D-glucuronide, on lipid peroxidation in liposomal membranes. J. Agric. Food Chem., 49, 5602-5608 (2001).
  • 27) Murota, K., and Terao, J., Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. Arch. Biochem. Biophys., 417, 12-17 (2003).
  • 28) Yamamoto, N., Moon, J.-H., Tsushida, T. , Nagao, A., and Terao, J., Inhibitory effect of quercetin metabolites and their related derivatives on copper ion-induced lipid peroxidation in human low-density lipoprotein. Arch. Biochem. Biophys., 372, 347-354 (1999).
  • 29) Piskula, M., and Terao, J., Quercetin's solubility affects its accumulation in rat plasma after oral administration. J. Agric. Food Chem., 46, 4313-4317 (1998).
  • 30) Azuma, K., Ippoushi, K., Ito, H., Higashio, H., and Terao, J., Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats. J. Agric. Food Chem., 50, 1706-1712 (2002).
  • 31) Helen, A., Rajasree, C. R., Krishnakumar, K., Augusti, K. T., and Vijayammal, P. L., Antioxidant role of oils isolated from garlic (Allium sativum Linn) and onion (Allium cepa Linn) on nicotine-induced lipid peroxidation. Vet. Human Toxicol., 41, 316-319 (1999).
  • 32) Helen, A., Krishnakumar, K., Vijayammal, P. L., and Augusti, K. T., Antioxidant effect of onion (Allium cepa Linn) on the damages induced by nicotine in rats as compared to alpha-tocopherol. Toxicol. Lett., 116, 61-68 (2000).
  • 33) Boyle, S. P., Dobson, V. L., Duthie, S. J., Kyle, J. A. M., and Collins, A. R., Absorption and DNA protective effects of flavonoid glycosides from an onion meal. Eur. J. Nutr., 39, 213-223 (2000).
  • 34) Carson, J. F., Chemistry and biological properties of onion and garlic. Food Res. Internat., 3, 71-103 (1987).
  • 35) Suresh, Babu, P., and Srinivasan, K., Influence of dietary capsaicin and onion on the metabolic abnormalities associated with streptozotocin induced diabetes mellitus. Mol. Cell. Biochem., 175, 49-57 (1997).
  • 36) Suresh, Babu, P., and Srinivasan, K., Renal lesions in streptozotocin-induced diabetic rats maintained on onion and capsaicin containing diets. J. Nutr. Biochem., 10, 477-483 (1999).
  • 37) Tsushida, T., and Suzuki, M., Content of flavonol glucosides and some properties of enzymes metabolizing the glucosides in onion. Nippon Shokuhin Kagaku Kogaku Kaishi, 43, 642-649 (1996).
  • 38) Price, K. R., Bacon, J. R., and Rhodes, J. C., Effect of storage and domestic processing on the content and composition of flavonol glucosides in onion (Allium cepa L.). J. Agric. Food Chem., 45, 938-942 (1997).
  • 39) Patil, B. S., Pike, L. M., and Yoo, K. S., Variation in the quercetin content in different colored onions (Allium cepa L.). J. Amer. Soc. Hort. Sci., 120, 909-913 (1995).
  • 40) Ioku, K., Aoyama, Y., Tokuno, A., Terao, J., Nakatani, N., and Takei, Y., Various cooking methods and the flavonoid content in onion. J. Nutr. Sci. Vitaminol., 47, 78-83 (2001).

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