Advanced search
Publication Cover
Bioscience, Biotechnology, and Biochemistry Volume 68, 2004 - Issue 6
Journal homepage
246
Views
12
CrossRef citations to date
0
Altmetric
Original Articles

Potent Hypocholesterolemic Activity of the Yeast Kluyveromyces marxianus YIT 8292 in Rats Fed a High Cholesterol Diet

Yasuto YOSHIDAYakult Central Institute for Microbiological Research
,
Wakae YOKOIYakult Central Institute for Microbiological Research
,
Yasue WADAYakult Central Institute for Microbiological Research
,
Kenji OHISHIYakult Central Institute for Microbiological Research
,
Masahiko ITOYakult Central Institute for Microbiological Research
&
Haruji SAWADAYakult Central Institute for Microbiological Research
Pages 1185-1192 | Received 24 Sep 2003, Accepted 29 Feb 2004, Published online: 22 May 2014

  • 1) Kannel, W. B., Castelli, W. P., Gordon, T., and McNamara, P. M., Serum cholesterol, lipoproteins and the risk of coronary heart disease: the Framingham study. Ann. Intern. Med., 74, 1–12 (1971).
  • 2) Martin, M. J., Hulley, S. B., Browner, W. S., Kuller, L. H., and Wentworth, D., Serum cholesterol, blood pressure and mortality: implications from a cohort of 361,662 men. Lancet, 2, 933–936 (1986).
  • 3) Badimon, J. J., Fuster, V., Chesebro, J. H., and Badimon, L., Coronary atherosclerosis: A multifactorial disease. Circulation, 87 (Suppl. II), 3–16 (1993).
  • 4) McCarthy, P. A., New approaches to atherosclerosis: an overview. Med. Res. Rev., 13, 139–159 (1993).
  • 5) Anderson, J. W., Dietary fiber, lipids and atherosclerosis. Am. J. Cardiol., 60, 17G–22G (1987).
  • 6) Thurnham, D. I., Functional foods: cholesterol-lowering benefits of plant sterols. Br. J. Nutr., 82, 255–256 (1999).
  • 7) Rajendran, S., Deepalakshmi, P. D., Parasakthy, K., Devaraj, H., and Devaraj, S. N., Effect of tincture of Crataegus on the LDL-receptor activity of hepatic plasma membrane of rats fed an atherogenic diet. Atherosclerosis, 123, 235–241 (1996).
  • 8) Robbins, E. A., and Seeley, R. D., Cholesterol lowering effect of dietary yeast and yeast fractions. J. Food Sci., 42, 694–698 (1977).
  • 9) Robbins, E. A., and Seeley, R. D., U. S. Patent 4251519 (Jul. 30, 1979).
  • 10) Ebihara, K., and Kiriyama, S., Plasma cholesterol-normalizing activity of brewer’s yeast and its various components in rats. Nutr. Rep. Int., 28, 861–871 (1983).
  • 11) Offenbacher, E. G., and Pi-Sunyer, F. X., Beneficial effect of chromium-rich yeast on glucose tolerance and blood lipids in elderly subjects. Diabetes, 29, 919–925 (1980).
  • 12) Elwood, J. C., Nash, D. T., and Streeten, D. H., Effect of high-chromium brewer’s yeast on human serum lipids. J. Am. Coll. Nutr., 1, 263–274 (1982).
  • 13) Wang, M. M., Fox, E. A., Stoeker, B. J., Menendez, C. E., and Chan, S. B., Serum cholesterol of adults supplemented with brewer’s yeast or chromium chloride. Nutr. Res., 9, 989–998 (1989).
  • 14) Dziekak, J. D., Yeast and yeast derivatives; definitions, characteristics and processing. Food Technol., 2, 104–120 (1987).
  • 15) Nicolosi, R., Bell, S. J., Bistrian, B. R., Greenberg, I., Forse, R. A., and Blackburn, G. L., Plasma lipid changes after supplementation with β-glucan fiber from yeast. Am. J. Clin. Nutr., 70, 208–212 (1999).
  • 16) Mifuchi, I., Hosoi, M., and Yokokura, T., Promotion of resistance to Ehrlich ascites carcinoma cells by injection of tumor cells mixed with yeast cell wall. Gann, 60, 655–656 (1969).
  • 17) Williams, D. L., Pretus, H. A., McNamee, R. B., Jones, E. L., Ensley, H. E., and Browder, I. W., Development of a water-soluble, sulfated (1→3)-β-D-glucan biological response modifier derived from S. cerevisiae. Carbohydr. Res., 235, 247–257 (1992).
  • 18) Nakamura, T., Agata, K., Mizutani, M., and Iino, H., Effects of brewer’s yeast cell wall on constipation and defecation in experimentally constipated rats. Biosci. Biotechnol. Biochem., 65, 774–780 (2001).
  • 19) Rabinowitz, M. B., Gonick, H. C., Levin, S. R., and Davidson, M. B., Effects of chromium and yeast supplements on carbohydrate and lipid metabolism in diabetic men. Diabetes Care, 6, 319–327 (1983).
  • 20) Offenbacher, E. G., Rinko, C. J., and Pi-Sunyer, F. X., The effects of inorganic chromium and brewer’s yeast on glucose tolerance, plasma lipids, and plasma chromium in elderly subjects. Am. J. Clin. Nutr., 42, 454–461 (1985).
  • 21) Li, Y. C., Effects of brewer’s yeast on glucose tolerance and serum lipids in Chinese adults. Biol. Trace. Elem. Res., 41, 341–347 (1994).
  • 22) Trow, L. G., Lewis, J., Greenwood, R. H., Sampson, M. J., Self, K. A., Crews, H. M., and Fairweather-Tait, S. J., Lack of effect of dietary chromium supplementation on glucose tolerance, plasma insulin and lipoprotein levels in patients with type 2 diabetes. Int. J. Vitam. Nutr. Res., 70, 14–18 (2000).
  • 23) Association of Official Analytical Chemists Official Methods of Analysis, 15th ed., AOAC, Arlington, VA (1990).
  • 24) Allain, C. C., Poon, L. S., Chan, C. S., Richmond, W., and Fu, P. C., Enzymatic determination of total serum cholesterol. Clin. Chem., 20, 470–475 (1974).
  • 25) Finley, P. R., Schifman, R. B., Williams, R. J., and Lichti, D. A., Cholesterol in high-density lipoprotein: use of Mg2+/dextran sulfate in its enzymic measurement. Clin. Chem., 24, 931–933 (1978).
  • 26) Spayd, R. W., Bruschi, B., Burdick, B. A., Dappen, G. M., Eikenberry, J. N., Esders, T. W., Figueras, J., Goodhue, C. T., LaRossa, D. D., Nelson, R. W., Rand, R. N., and Wu, T. W., Multilayer film elements for clinical analysis: applications to representative chemical determinations. Clin. Chem., 24, 1343–1350 (1978).
  • 27) Takayama, M., Itoh, S., Nagasaki, T., and Tanimizu, I., A new enzymatic method for determination of serum choline-containing phospholipids. Clin. Chim. Acta, 79, 93–98 (1977).
  • 28) Folch, J., Lees, M., and Sloane-Stanley, G. H., A simple method for the isolation and purification of total lipides from animal tissue. J. Biol. Chem., 226, 497–509 (1957).
  • 29) Guermani-Nicolle, L., Villaume, C., Bau, H. M., Schwertz, A., Nicolas, J. P., and Mejean, L., The cholesterol-lowering property of soybeans fed to rats is related to the fasting duration. Plant Foods Hum. Nutr., 56, 239–249 (2001).
  • 30) Anderson, J. W., Davidson, M. H., Blonde, L., Brown, W. V., Howard, W. J., Ginsberg, H., Allgood, L. D., and Weingand, K. W., Long-term cholesterol-lowering effects of psyllium as an adjunct to diet therapy in the treatment of hypercholesterolemia. Am. J. Clin. Nutr., 71, 1433–1438 (2000).
  • 31) Bokura, H., and Kobayashi, S., Chitosan decreases total cholesterol in women: a randomized, double-blind, placebo-controlled trial. Eur. J. Clin. Nutr., 57, 721–725 (2003).
  • 32) Cerda, J. J., Robbins, F. L., Burgin, C. W., Baumgartner, T. G., and Rice, R. W., The effects of grapefruit pectin on patients at risk for coronary heart disease without altering diet or lifestyle. Clin. Cardiol., 11, 589–594 (1988).
  • 33) Terpstra, A. H., Lapre, J. A., de Vries, H. T., and Beynen, A. C., Hypocholesterolemic effect of dietary psyllium in female rats. Ann. Nutr. Metab., 44, 223–228 (2000).
  • 34) Sugano, M., Fujikawa, T., Hiratsuji, Y., Nakashima, K., Fukuda, N., and Hasegawa, Y., A novel use of chitosan as a hypocholesterolemic agent in rats. Am. J. Clin. Nutr., 33, 787–793 (1980).
  • 35) Judd, P. A., and Truswell, A. S., The hypocholesterolaemic effects of pectins in rats. Br. J. Nutr., 53, 409–425 (1985).
  • 36) Belem, M. A. F., and Lee, B. H., Production of bioingredients from Kluyveromyces marxianus grown on whey: an alternative. Crit. Rev. Food Sci. Nutr., 38, 565–598 (1998).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.