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Original Articles

High-Level Production of Astaxanthin by Xanthophyllomyces dendrorhous Mutant JH1 Using Statistical Experimental Designs

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Pages 1743-1748 | Received 27 Apr 2005, Accepted 16 Jun 2005, Published online: 22 May 2014

  • 1) Johnson, E. A., and Schroeder, W. A., Microbial carotenoids. Adv. Biochem. Eng., 53, 119–178 (1995).
  • 2) Johnson, E. A., Conklin, D. E., and Lewis, M. J., The yeast Phaffia rhodozyma as a dietary pigment source for salmonoids and crustaceans. J. Fish. Res. Bd. Canada, 34, 2417–2421 (1977).
  • 3) Johnson, E. A., and An, G. H., Astaxanthin from microbial sources. Crit. Rev. Biotechnol., 11, 297–326 (1991).
  • 4) Bendich, A., and Olson, J. A., Biological actions of carotenoides. FASEB J., 3, 1927–1932 (1989).
  • 5) Chew, B. P., Role of carotenoids in the immune response. J. Dairy Sci., 76, 2804–2811 (1993).
  • 6) Bertram, J. S., Cancer prevention of carotenoids: mechanistic studies in cultured cells. Ann. N.Y. Acad. Sci., 691, 177–191 (1993).
  • 7) Jyonouchi, H., Sun, S., Lijima, K., and Gross, M. D., Antitumor activity of astaxanthin and its mode of action. Nutr. Cancer, 36, 59–65 (2000).
  • 8) Kim, J. H., Choi, S. K., Lim, W. J., and Chang, H. I., Protective effect of astaxanthin produced by Xanthophyllomyces dendrorhous mutant on indomethacin-induced gastric mucosal injury in rats. J. Microbiol. Biotechnol., 14, 996–1003 (2004).
  • 9) Krinsky, N. I., Antioxidant function of carotenoids. Free Radic. Biol. Med., 7, 617–635 (1989).
  • 10) Mortensen, A., Skibsted, L. H., and Truscott, T., The interaction of dietary carotenoids with radical species. Arch. Biochem. Biophys., 385, 13–19 (2001).
  • 11) Naguib, Y. M., Antioxidant activities of astaxanthin and related carotenoids. J. Agric. Food Chem., 48, 1150–1154 (2000).
  • 12) Johnson, E. A., and Lewis, M. J., Astaxanthin formation by the yeast Phaffia rhodozyma. J. Gen. Microbiol., 115, 173–183 (1979).
  • 13) Margalith, P. Z., Production of ketocarotenoids by microalgae. Appl. Microbiol. Biotechnol., 51, 431–438 (1999).
  • 14) Park, E. K., and Lee, C. G., Astaxanthin production by Haematococcus pluvialis under various light intensities and wavelengths. J. Microbiol. Biotechnol., 11, 1024–1030 (2001).
  • 15) Harker, M., Tsavalos, A. J., and Young, A. J., Use of response surface methodology to optimize carotenogenesis in the microalga Haematococcus pluvialis. J. Appl. Phycol., 7, 399–406 (1995).
  • 16) Ramirez, J., Gutierrez, H., and Gschaedler, A., Optimization of astaxanthin production by Phaffia rhodozyma through factorial design and response surface methodology. J. Biotechnol., 88, 259–268 (2001).
  • 17) Vázquez, M., and Martin, A. M., Optimization of Phaffia rhodozyma continuous culture through response surface methodology. Biotechnol. Bioeng., 57, 314–320 (1998).
  • 18) Kim, J. H., Kim, C. W., and Chang, H. I., Screening and characterization of red yeast Xanthophyllomyces dendrorhous mutants. J. Microbiol. Biotechnol., 14, 570–575 (2004).
  • 19) Sedmak, J. J., Weerasinghe, D. K., and Jolly, S. O., Extraction and quantitation of astaxanthin from Phaffia rhodozyma. Biotech. Tech., 4, 107–112 (1990).
  • 20) An, G. H., Schuman, D. B., and Johnson, E. A., Isolation of Phaffia rhodozyma mutants with increased astaxanthin content. Appl. Environ. Microbiol., 55, 116–124 (1989).
  • 21) Simpson, K. I., Katayana, T., and Chichester, C. O., Carotenoids from microorganisms. In “Carotenoids as Colorants and Vitamin A Precursors”, ed. Bauernfeld, J. C., Academic Press, London (1981).
  • 22) Zhang, X. W., Gong, X. D., and Chen, F., Kinetic models for astaxanthin production by high cell density mixotrophic culture of the microalga Haematococcus pluvialis. J. Ind. Microbiol. Biotechnol., 23, 691–696 (1999).
  • 23) Reynders, M. B., Rawling, D. E., and Harrison, S. T. L., Studies on the growth, modeling and pigment production by the yeast Phaffia rhodozyma during fed-batch cultivation. Biotechnol. Lett., 18, 649–654 (1996).
  • 24) Kim, S. J., Kim, G. J., Park, D. H., and Ryu, Y. W., High-level production of astaxanthin by fed-batch culture of mutant strain Phaffia rhodozyma AJ-6-1. J. Microbiol. Biotechnol., 13, 175–181 (2003).
  • 25) Yu, S. S., and Ryu, Y. W., Selection of mutant Phaffia rhodozyma and determination of optimum culture conditions for astaxanthin production. Kor. J. Appl. Microbiol. Biotechnol., 29, 96–103 (2001).
  • 26) Parajó, J. C., Santos, V., and Vázquez, M., Optimization of carotenoid production by Phaffia rhodozyma cells grown on xylose. Process Chem., 33, 181–187 (1998).

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