Advanced search
Publication Cover
Bioscience, Biotechnology, and Biochemistry Volume 69, 2005 - Issue 9
Journal homepage
155
Views
8
CrossRef citations to date
0
Altmetric
Original Articles

Effect of Ascorbate on Acrolein Modification of Very Low Density Lipoprotein and Uptake of Oxidized Apolipoprotein E by Hepatocytes

Hirofumi ARAIDepartment of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine
,
Koji UCHIDALaboratory of Food and Biodynamics, Nagoya University School of Agricultural Science
&
Kazuyuki NAKAMURADepartment of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine
Pages 1760-1762 | Received 04 Oct 2004, Accepted 19 May 2005, Published online: 22 May 2014

  • 1) Steinbrecher, U. P., Zhang, H. F., and Lougheed, M., Role of oxidatively modified LDL in atherosclerosis. Free Radic. Biol. Med., 9, 155–168 (1990).
  • 2) Berliner, J. A., and Heinecke, J. W., The role of oxidized lipoproteins in atherogenesis. Free Radic. Biol. Med., 20, 707–727 (1996).
  • 3) Esterbauer, H., Schmidt, R., and Hayn, M., Relationships among oxidation of low-density lipoprotein, antioxidant protection, and atherosclerosis. Adv. Pharmacol., 38, 425–456 (1997).
  • 4) Steinberg, D., Low density lipoprotein oxidation and its pathobiological significance. J. Biol. Chem., 272, 20963–20966 (1997).
  • 5) Uchida, K., Kanematsu, M., Morimitsu, Y., Osawa, T., Noguchi, N., and Niki, E., Acrolein is a product of lipid peroxidation reaction: formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins. J. Biol. Chem., 273, 16058–16066 (1998).
  • 6) Uchida, K., Kanematsu, M., Sakai, K., Matsuda, T., Hattori, N., Mizuno, Y., Suzuki, D., Miyata, T., Noguchi, N., Niki, E., and Osawa, T., Protein-bound acrolein: potential markers for oxidative stress. Proc. Natl. Acad. Sci. U.S.A., 95, 4882–4887 (1998).
  • 7) Mahley, R. W., and Rall, S. C., Jr., Apolipoprotein E: far more than a lipid transport protein. Annu. Rev. Genomics Hum. Genet., 1, 507–537 (2000).
  • 8) Arai, H., Kashiwagi, S., Nagasaka, Y., Uchida, K., Hoshii, Y., and Nakamura, K., Oxidative modification of apolipoprotein E in human very-low-density lipoprotein and its inhibition by glycosaminoglycans. Arch. Biochem. Biophys., 367, 1–8 (1999).
  • 9) Arai, H., and Nakamura, K., Effect of L-ascorbic acid on the oxidative modification of apolipoprotein E in human very-low-density lipoprotein. J. Nutr. Sci. Vitaminol. (Tokyo), 50, 66–68 (2004).
  • 10) Hatch, F. T., Practical methods for plasma lipoprotein analysis. Adv. Lipid Res., 6, 1–68 (1968).
  • 11) Arai, H., Terao, J., Abdalla, D. S., Suzuki, T., and Takama, K., Coulometric detection in high-performance liquid chromatographic analysis of cholesteryl ester hydroperoxides. Free Radic. Biol. Med., 20, 365–371 (1996).
  • 12) Laemmli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680–685 (1970).
  • 13) Oswald, B., and Quarfordt, S., Effect of apoE on triglyceride emulsion interaction with hepatocyte and hepatoma G2 cells. J. Lipid Res., 28, 798–809 (1987).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.