- 1) Suttie, J. W., Synthesis of vitamin K-dependent proteins. FASEB J., 7, 445–452 (1993).
- 2) Wu, S. M., Stanley, T. B., Mutucumarana, V. P., and Stafford, D. W., Characterization of the γ-glutamyl carboxylase. Thromb. Haemost., 78, 599–604 (1997).
- 3) Suttie, J. W., The importance of menaquinone in human nutrition. Annu. Rev. Nutr., 15, 399–417 (1995).
- 4) Yamamoto, R., Komai, M., Kojima, K., Furukawa, Y., and Kimura, S., Menaquinone-4 accumulation in various tissues after an oral administration of phylloquinone in Wistar rats. J. Nutr. Sci. Vitaminol. (Tokyo), 43, 133–143 (1997).
- 5) Ronden, J. E., Thijssen, H. H., and Vermeer, C., Tissue distribution of K-vitamers under different nutritional regimens in the rat. Biochim. Biophys. Acta, 1379, 16–22 (1998).
- 6) Huber, A. M., Davidson, K. W., O’Brien-Morse, M. E., and Sadowski, J. A., Tissue phylloquinone and menaquinones in rats are affected by age and gender. J. Nutr., 129, 1039–1044 (1999).
- 7) Sambrook, J., Fritsch, E. F., and Maniatis, T., Molecular cloning: a laboratory manual, second ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor (1989).
- 8) Jukes, T. H., Vitamin K. In “The Vitamins: Fundamental Aspects in Nutrition and Health” 2nd ed., ed. Combs, Jr. G. F., Academic Press, San Diego, pp. 228–244 (1998).
- 9) Komai, M., Shirakawa, H., and Kimura, S., Newly developed model for vitamin K deficiency in germfree mice. Int. J. Vitam. Nutr. Res., 58, 55–59 (1988).
- 10) Schultz, D. R., and Arnold, P. I., Properties of four acute phase proteins: C-reactive protein, serum amyloid A protein, alpha 1-acid glycoprotein, and fibrinogen. Semin. Arthritis. Rheum., 20, 129–147 (1990).
- 11) Bacher, M., Meinhardt, A., Lan, H. Y., Mu, W., Metz, C. N., Chesney, J. A., Calandra, T., Gemsa, D., Donnelly, T., Atkins, R. C., and Bucala, R., Migration inhibitory factor expression in experimentally induced endotoxemia. Am. J. Pathol., 150, 235–246 (1997).
- 12) Macdonald, J., Galley, H. F., and Webster, N. R., Oxidative stress and gene expression in sepsis. Br. J. Anaesth., 90, 221–232 (2003).
- 13) Murakami, K., Okajima, K., Uchiba, M., Johno, M., Nakagaki, T., Okabe, H., and Takatsuki, K., Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production. Am. J. Physiol., 272, L197–202 (1997).
- 14) Grey, S. T., Tsuchida, A., Hau, H., Orthner, C. L., Salem, H. H., and Hancock, W. W., Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester. J. Immunol., 153, 3664–3672 (1994).
- 15) Yamaji, K., Wang, W., Liu, Y., Abeyama, K., Hashiguchi, T., Uchimura, T., Biswas, K. K., Iwamoto, H., and Maruyama, I., Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation. Thromb. Res., 115, 319–325 (2005).
- 16) Li, J., Lin, J. C., Wang, H., Peterson, J. W., Furie, B. C., Furie, B., Booth, S. L., Volpe, J. J., and Rosenberg, P. A., Novel role of vitamin K in preventing oxidative injury to developing oligodendrocytes and neurons. J. Neurosci., 23, 5816–5826 (2003).
- 17) Ollivier, V., Parry, G. C., Cobb, R. R., de Prost, D., and Mackman, N., Elevated cyclic AMP inhibits NF-κB-mediated transcription in human monocytic cells and endothelial cells. J. Biol. Chem., 271, 20828–20835 (1996).
- 18) Bshesh, K., Zhao, B., Spight, D., Biaggioni, I., Feokistov, I., Denenberg, A., Wong, H. R., and Shanley, T. P., The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cells. J. Leukoc. Biol., 72, 1027–1036 (2002).
- 19) Yoon, S. W., Goh, S. H., Chun, J. S., Cho, E. W., Lee, M. K., Kim, K. L., Kim, J. J., Kim, C. J., and Poo, H., α-Melanocyte-stimulating hormone inhibits lipopolysaccharide-induced tumor necrosis factor-α production in leukocytes by modulating protein kinase A, p38 kinase, and nuclear factor kappa B signaling pathways. J. Biol. Chem., 278, 32914–32920 (2003).
- 20) Otsuka, M., Kato, N., Shao, R. X., Hoshida, Y., Ijichi, H., Koike, Y., Taniguchi, H., Moriyama, M., Shiratori, Y., Kawabe, T., and Omata, M., Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation. Hepatology, 40, 243–251 (2004).
- 21) Nakashima, T., Kobayashi, Y., Yamasaki, S., Kawakami, A., Eguchi, K., Sasaki, H., and Sakai, H., Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-κB ligand: modulation of the expression by osteotropic factors and cytokines. Biochem. Biophys. Res. Commun., 275, 768–775 (2000).
- 22) Palmqvist, P., Persson, E., Conaway, H. H., and Lerner, U. H., IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-κB ligand, osteoprotegerin, and receptor activator of NF-κB in mouse calvariae. J. Immunol., 169, 3353–3362 (2002).
- 23) Akiyama, Y., Hara, K., Tajima, T., Murota, S., and Morita, I., Effect of vitamin K2 (menatetrenone) on osteoclast-like cell formation in mouse bone marrow cultures. Eur. J. Pharmacol., 263, 181–185 (1994).
- 24) Takeuchi, Y., Suzawa, M., Fukumoto, S., and Fujita, T., Vitamin K2 inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures. Bone, 27, 769–776 (2000).
- 25) Taira, H., Fujikawa, Y., Kudo, O., Itonaga, I., and Torisu, T., Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors. Calcif. Tissue Int., 73, 78–85 (2003).
- 26) Koshihara, Y., Hoshi, K., Okawara, R., Ishibashi, H., and Yamamoto, S., Vitamin K stimulates osteoblastogenesis and inhibits osteoclastogenesis in human bone marrow cell culture. J. Endocrinol., 176, 339–348 (2003).
- 27) Reddi, K., Henderson, B., Meghji, S., Wilson, M., Poole, S., Hopper, C., Harris, M., and Hodges, S. J., Interleukin 6 production by lipopolysaccharide-stimulated human fibroblasts is potently inhibited by naphthoquinone (vitamin K) compounds. Cytokine, 7, 287–290 (1995).
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Vitamin K Suppresses Lipopolysaccharide-Induced Inflammation in the Rat
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