610
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

Inhibition of 17α-Hydroxylase/C17,20-Lyase (CYP17) from Rat Testis by Green Tea Catechins and Black Tea Theaflavins

, , , , &
Pages 2325-2328 | Received 01 May 2007, Accepted 06 Jun 2007, Published online: 22 May 2014

  • 1) Giovannucci, E., Epidemiologic characteristics of prostate cancer. Cancer, 75 (Suppl), 1766–1777 (1995).
  • 2) Chung, B.-C., Picado-Leonard, J., Haniu, M., Bienkowski, M., Hall, P. F., Shively, J. E., and Miller, W. L., Cytochrome P450c17(steroid 17α-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues. Proc. Natl. Acad. Sci. USA, 84, 407–411 (1987).
  • 3) Jarman, M., Smith, H. J., Nicholls, P. J., and Simons, C., Inhibitors of enzymes of androgen biosynthesis: cytochrome P45017α and 5α-steroid reductase. Nat. Prod. Rep., 495–512 (1998).
  • 4) Njar, V. C. O., and Brodie, A. M. H., Inhibitors of 17α-Hydroxylase/17,20-Lyase (CYP17): potential agents for the treatment of prostate cancer. Curr. Pharm. Des., 5, 163–180 (1999).
  • 5) Hakki, T., and Bernhardt, R., CYP17- and CYP11B-dependent steroid hydroxylases as drug development targets. Pharmacol. Ther., 111, 27–52 (2006).
  • 6) Sergejew, T., and Hartmann, R. W., Pyridyl substituted benzocycloalkenes: new inhibitors of 17α-hydroxylase/17,20-lyase (P450 17α). J. Enzyme Inhib., 8, 113–122 (1994).
  • 7) Lee, B.-L., and Ong, C.-N., Comparative analysis of tea catechins and theaflavins by high-performance liquid chromatography and capillary electrophoresis. J. Chromatogr. A, 881, 439–447 (2000).
  • 8) Muto, S., Fujita, K., Yamazaki, Y., and Kamataki, T., Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450. Mutat. Res., 479, 197–206 (2001).
  • 9) Jankun, J., Selman, S. H., Swiercz, R., and Skrzypczak-Jankun, E., Why drinking green tea could prevent cancer. Nature, 387, 561 (1997).
  • 10) Chhabra, S. K., and Yang, C. S., Tea and prostate cancer. Epidemiol. Rev., 23, 106–109 (2001).
  • 11) Gupta, S., Hastak, K., Ahmad, N., Lewin, J. S., and Mukhtar, H., Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols. Proc. Natl. Acad. Sci. USA, 98, 10350–10355 (2001).
  • 12) Bettuzzi, S., Brausi, M., Rizzi, F., Castagnetti, G., Peracchia, G., and Corti, A., Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res., 66, 1234–1240 (2006).
  • 13) Zhou, J.-R., Yu, L., Zhong, Y., and Blackburn, G. L., Soy phytochemicals and tea bioactive components synergistically inhibit androgen-sensitive human prostate tumors in mice. J. Nutr., 133, 516–521 (2003).
  • 14) Lee, H.-H., Ho, C.-T., and Lin, J.-K., Theaflavin-3,3′-digallate and penta-O-galloyl-β-D-glucose inhibit rat liver microsomal 5α-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells. Carcinogenesis, 25, 1109–1118 (2004).
  • 15) Henning, S. M., Aronson, W., Niu, Y., Conde, F., Lee, N. H., Seeram, N. P., Lee, R.-P., Lu, J., Harris, D. M., Moro, A., Hong, J., Pak-Shan, L., Barnard, R. J., Ziaee, H. G., Csathy, G., Go, V. L. W., Wang, H., and Heber, D., Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption. J. Nutr., 136, 1839–1843 (2006).
  • 16) Liao, S., and Hiipakka, R. A., Selective inhibition of steroid 5α-reductase isozymes by tea epicatechin-3-gallate and epigallocatechin-3-gallate. Biochem. Biophys. Res. Commun., 214, 833–838 (1995).
  • 17) Bode, A. M., and Dong, Z., Signal transduction pathways: targets for green and black tea polyphenols. J. Biochem. Mol. Biol., 36, 66–77 (2003).
  • 18) Satoh, K., Sakamoto, Y., Ogata, A., Nagai, F., Mikuriya, H., Numazawa, M., Yamada, K., and Aoki, N., Inhibition of aromatase activity by green tea extract catechins and their endocrinological effects of oral administration in rats. Food Chem. Toxicol., 40, 925–933 (2002).
  • 19) Ideyama, Y., Kudoh, M., Tanimoto, K., Susaki, Y., Nanya, T., Nakahara, T., Ishikawa, H., Yoden, T., Okada, M., Fujikura, T., Akaza, H., and Shikama, H., Novel nonsteroidal inhibitor of cytochrome P45017α(17α-hydroxylase/C17-20 lyase), YM116, decreased prostatic weights by reducing serum concentrations of testosterone and adrenal androgens in rats. Prostate, 37, 10–18 (1998).
  • 20) Fujiki, H., Suganuma, M., Imai, K., and Nakachi, K., Green tea: cancer preventive beverage and/or drug. Cancer Lett., 188, 9–13 (2002).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.