- 1) Weintraub, S. J., Manson, S. R., and Deverman, B. E., Resistance to antineoplastic therapy: the oncogenic tyrosine kinase-Bcl-x(L) axis. Cancer Cell, 5, 3–4 (2004).
- 2) Wang, J. L., Zhang, Z. J., Choksi, S., Shan, S., Lu, Z., Croce, C. M., Alnemri, E. S., Korngold, R., and Huang, Z., Cell permeable Bcl-2 binding peptides: a chemical approach to apoptosis induction in tumor cells. Cancer Res., 60, 1498–1502 (2000).
- 3) Reed, J. C., Zha, H., Aime-Sempe, C., Takayama, S., and Wang, H. G., Structure-function analysis of Bcl-2 family proteins: regulators of programmed cell death. Adv. Exp. Med. Biol., 406, 99–112 (1996).
- 4) Liu, X., Dai, S., Zhu, Y., Marrack, P., and Kappler, J. W., The structure of a Bcl-xL/Bim fragment complex: implications for Bim function. Immunity, 19, 341–352 (2003).
- 5) Sattler, M., Liang, H., Nettesheim, D., Meadows, R. P., Harlan, J. E., Eberstadt, M., Yoon, H. S., Shuker, S. B., Chang, B. S., Minn, A. J., Thompson, C. B., and Fesik, S. W., Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science, 275, 983–986 (1997).
- 6) Oberstein, A., Jeffrey, P. D., and Shi, Y., Crystal structure of the Bcl-xL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J. Biol. Chem., 282, 13123–13132 (2007).
- 7) Petros, A. M., Nettesheim, D. G., Wang, Y., Olejniczak, E. T., Meadows, R. P., Mack, J., Swift, K., Matayoshi, E. D., Zhang, H., Thompson, C. B., and Fesik, S. W., Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci., 9, 2528–2534 (2000).
- 8) Degterev, A., Lugovskoy, A., Cardone, M., Mulley, B., Wagner, G., Mitchison, T., and Yuan, J., Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Nat. Cell Biol., 3, 173–182 (2001).
- 9) Oltersdorf, T., Elmore, S. W., Shoemaker, A. R., Armstrong, R. C., Augeri, D. J., Belli, B. A., Bruncko, M., Deckwerth, T. L., Dinges, J., Hajduk, P. J., Joseph, M. K., Kitada, S., Korsmeyer, S. J., Kunzer, A. R., Letai, A., Li, C., Mitten, M. J., Nettesheim, D. G., Ng, S., Nimmer, P. M., O’Connor, J. M., Oleksijew, A., Petros, A. M., Reed, J. C., Shen, W., Tahir, S. K., Thompson, C. B., Tomaselli, K. J., Wang, B., Wendt, M. D., Zhang, H., Fesik, S. W., and Rosenberg, S. H., An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature, 435, 677–681 (2005).
- 10) Weljie, A. M., Robertson, K. M., and Vogel, H. J., Conformational changes in the Ca2+-regulatory region from soybean calcium-dependent protein kinase-alpha: fluorescence resonance energy transfer studies. J. Biol. Chem., 278, 43764–43769 (2003).
- 11) Shi, Y., Stouten, P. F., Pillalamarri, N., Barile, L., Rosal, R. V., Teichberg, S., Bu, Z., and Callaway, D. J., Quantitative determination of the topological propensities of amyloidogenic peptides. Biophys. Chem., 120, 55–61 (2006).
- 12) Jeganathan, S., von Bergen, M., Brutlach, H., Steinhoff, H. J., and Mandelkow, E., Global hairpin folding of tau in solution. Biochemistry, 45, 2283–2293 (2006).
- 13) Wang, J. L., Liu, D., Zhang, Z. J., Shan, S., Han, X., Srinivasula, S. M., Croce, C. M., Alnemri, E. S., and Huang, Z., Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc. Natl. Acad. Sci. USA, 97, 7124–7129 (2000).
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A New Assay Based on Fluorescence Resonance Energy Transfer to Determine the Binding Affinity of Bcl-xL Inhibitors
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