1,798
Views
48
CrossRef citations to date
0
Altmetric
Original Articles

Effects of an Oral Administration of Glucosamine-Chondroitin-Quercetin Glucoside on the Synovial Fluid Properties in Patients with Osteoarthritis and Rheumatoid Arthritis

, , , , , & show all
Pages 288-292 | Received 23 Jun 2008, Accepted 07 Oct 2008, Published online: 22 May 2014

  • 1) Cohen, M., Wolfe, R., Mai, T., and Lewis, D., A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee. J. Rheumatol., 30, 523–528 (2003).
  • 2) Reginster, J. Y., Deroisy, R., Rovati, L. C., Lee, R. L., Lejeune, E., Bruyere, O., Giacovelli, G., Henrotin, Y., Dacre, J. E., and Gossett, C., Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet, 357, 251–256 (2001).
  • 3) Bruyere, O., Honore, A., Ethgen, O., Rovati, L. C., Giacovelli, G., Henrotin, Y. E., Seidel, L., and Reginster, J. Y., Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate. Osteoarthritis Cartilage, 11, 1–5 (2003).
  • 4) Richy, F., Bruyere, O., Ethgen, O., Cucherat, M., Henrotin, Y., and Reginster, J. Y., Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch. Intern. Med., 163, 1514–1522 (2003).
  • 5) Bassleer, C., Rovati, L., and Franchimont, P., Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro. Osteoarthritis Cartilage, 6, 427–434 (1998).
  • 6) Piperno, M., Reboul, P., Hellio Le Graverand, M. P., Peschard, M. J., Annefeld, M., Richard, M., and Vignon, E., Glucosamine sulfate modulates dysregulated activities of human osteoarthritic chondrocytes in vitro. Osteoarthritis Cartilage, 8, 207–212 (2000).
  • 7) Nakamura, H., Shibakawa, A., Tanaka, M., Kato, T., and Nishioka, K., Effects of glucosamine hydrochloride on the production of prostaglandin E2, nitric oxide and metalloproteases by chondrocytes and synoviocytes in osteoarthritis. Clin. Exp. Rheumatol., 22, 293–299 (2004).
  • 8) Lippiello, L., Woodward, J., Karpman, R., and Hammad, T. A., In vivo chondroprotection and metabolic synergy of glucosamine and chondroitin sulfate. Clin. Orthop., 381, 229–240 (2000).
  • 9) Beren, J., Hill, S. L., Diener-West, M., and Rose, N. R., Effect of pre-loading oral glucosamine HCl/chondroitin sulfate/manganese ascorbate combination on experimental arthritis in rats. Exp. Biol. Med., 226, 144–151 (2001).
  • 10) Wang, J. Y., and Roehrl, M. H., Glycosaminoglycans are a potential cause of rheumatoid arthritis. Proc. Natl. Acad. Sci. USA, 99, 14362–14367 (2002).
  • 11) Uebelhart, D., Malaise, M., Marcolongo, R., DeVathaire, F., Piperno, M., Mailleux, E., Fioravanti, A., Matoso, L., and Vignon, E., Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo. Osteoarthritis Cartilage, 12, 269–276 (2004).
  • 12) Uebelhart, D., Thonar, E. J., Zhang, J., and Williams, J. M., Protective effect of exogenous chondroitin 4,6-sulfate in the acute degradation of articular cartilage in the rabbit. Osteoarthritis Cartilage, 6 (Suppl. A), S6–S13 (1998).
  • 13) Verbruggen, G., Goemaere, S., and Veys, E. M., Chondroitin sulfate: S/DMOAD (structure/disease modifying anti-osteoarthritis drug) in the treatment of finger joint OA. Osteoarthritis Cartilage, 6 (Suppl. A), S37–S38 (1998).
  • 14) Campo, G. M., Avenoso, A., Campo, S., Ferlazzo, A. M., Altavilla, D., and Calatroni, A., Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats. Osteoarthritis Res. Ther., 5, 122–131 (2003).
  • 15) Arnett, F. C., Edworthy, S. M., Bloch, D. A., McShane, D. J., Fries, J. F., Cooper, N. S., Healey, L. A., Kaplan, S. R., Liang, M. H., Luthra, H. S., Medsger Jr., T. A., Mitchell, D. M., Neustadt, D. H., Pinals, R. S., Schaller, J. G., Sharp, J. T., Wilder, R. L., and Hunder, G. G., The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum., 31, 315–324 (1988).
  • 16) Matsuno, H., Kadowaki, K. M., and Tsuji, H., Generation II knee bracing for severe medial compartment osteoarthritis of the knee. Arch. Phys. Med. Rehabil., 78, 745–749 (1997).
  • 17) Mahoney, F. I., and Barthel, D. W., Functional evaluation: the barthel index. Md. State Med. J., 14, 61–65 (1965).
  • 18) Bergner, M., Bobbitt, R. A., Carter, W. B., and Gilson, B. S., The sickness impact profile: development and final revision of a health status measure. Med. Care, 19, 787–805 (1981).
  • 19) Matsuno, H., Yudoh, K., Kondo, M., Goto, M., and Kimura, T., Biochemical effect of intra-articular injections of high molecular weight hyaluronate in rheumatoid arthritis patients. Inflamm. Res., 48, 154–159 (1999).
  • 20) Goto, M., Hanyu, T., Yoshio, T., Matsuno, H., Shimizu, M., Murata, N., Shiozawa, S., Matsubara, T., Yamana, S., and Matsuda, T., Intra-articular injection of hyaluronate (SI-6601D) improves joint pain and synovial fluid prostaglandin E2 levels in rheumatoid arthritis: a multicenter clinical trial. Clin. Exp. Rheumatol., 19, 377–383 (2001).
  • 21) Shinmei, M., Miyauchi, S., Machida, A., and Miyazaki, K., Quantitation of chondroitin 4-sulfate and chondroitin 6-sulfate in pathologic synovial fluid. Arthritis Rheum., 35, 1304–1308 (1992).
  • 22) Reginster, J. Y., Bruyere, O., Lecart, M. P., and Henrotin, Y., Naturocetic (glucosamine and chondroitin sulfate) compounds as structure-modifying drugs in the treatment of osteoarthritis. Curr. Opin. Rheumatol., 15, 651–655 (2003).
  • 23) Houpt, J. B., McMillan, R., Wein, C., and Paget-Dellio, S. D., Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J. Rheumatol., 26, 2423–2430 (1999).
  • 24) Koizumi, F., Matsuno, H., Wakaki, K., Ishii, Y., Kurashige, Y., and Nakamura, H., Synovitis in rheumatoid arthritis: scoring of characteristic histopathological features. Pathol. Int., 49, 298–304 (1999).
  • 25) Hasselbacher, P., Synovial fluid analysis. In “Rheumatoid Arthritis” 1st ed., eds. Utsinger, P. D., Zvaifler, N. J., and Ehrich, G. E., St. Lippincott, Philadelphia, pp. 193–208 (1985).
  • 26) Dahl, L. B., Dahl, I. M., Engström-Laurent, A., and Granath, K., Concentration and molecular weight of sodium hyaluronate in synovial fluid from patients with rheumatoid arthritis and other arthropathies. Ann. Rheum. Dis., 44, 817–822 (1985).
  • 27) Moreland, L. W., Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action. Arthritis Res. Ther., 5, 54–67 (2003).
  • 28) Matsuno, H., Yudoh, K., Watanabe, Y., Nakazawa, F., Aono, H., and Kimura, T., Stromelysin-1 (MMP-3) in synovial fluid of patients with rheumatoid arthritis has potential to cleave membrane bound Fas ligand. J. Rheumatol., 28, 22–28 (2001).
  • 29) Das Jr., A., and Hammad, T. A., Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage, 8, 343–350 (2000).
  • 30) Hughes, R., and Carr, A., A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee. Rheumatology (Oxford), 41, 279–284 (2002).
  • 31) Bucsi, L., and Poor, G., Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage, 6 (Suppl. A), S31–S36 (1998).
  • 32) Leeb, B. F., Schweitzer, H., Montag, K., and Smolen, J. S., A metaanalysis of chondroitin sulfate in the treatment of osteoarthritis. J. Rheumatol., 27, 205–211 (2000).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.