- 1) Krämer, R., Production of amino acids: physiological and genetic approaches. Food Biotechnol., 18, 171–216 (2004).
- 2) Hermann, T., Industrial production of amino acids by coryneform bacteria. J. Biotechnol., 104, 155–172 (2003).
- 3) Nakayama, K., Kitada, S., and Kinoshita, S., L-valine production using microbial auxotroph. J. Gen. Appl. Microbiol., 7, 52–69 (1961).
- 4) Tsuchida, T., Yoshinaga, F., Kubota, K., and Momose, H., Production of L-valine by 2-thiazolealanine resistant mutants derived from glutamic acid producing bacteria. Agric. Biol. Chem., 39, 1319–1322 (1975).
- 5) Tsuchida, T., and Momose, H., Genetic changes of regulatory mechanisms occurred in leucine and valine producing mutants derived from Brevibacterium lactofermentum 2256. Agric. Biol. Chem., 39, 2193–2198 (1975).
- 6) Leyval, D., Uy, D., Delaunay, S., Goergen, J. L., and Engasser, J. M., Characterisation of the enzyme activities involved in the valine biosynthetic pathway in a valine-producing strain of Corynebacterium glutamicum. J. Biotechnol., 104, 241–252 (2003).
- 7) Elišáková, V., Pátek, M., Holátko, J., Nešvera, J., Leyval, D., Goergen, J. L., and Delaunay, S., Feedback-resistant acetohydroxy acid synthase increases valine production in Corynebacterium glutamicum. Appl. Environ. Microbiol., 71, 207–213 (2005).
- 8) Blombach, B., Schreiner, M. E., Holátko, J., Bartek, T., Oldiges, M., and Eikmanns, B. J., L-Valine production with pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum. Appl. Environ. Microbiol., 73, 2079–2084 (2007).
- 9) Blombach, B., Schreiner, M. E., Bartek, T., Oldiges, M., and Eikmanns, B. J., Corynebacterium glutamicum tailored for high-yield L-valine production. Appl. Microbiol. Biotechnol., 79, 471–479 (2008).
- 10) Lee, Y. T., and Duggleby, R. G., Mutagenesis studies on the sensitivity of Escherichia coli acetohydroxyacid synthase II to herbicides and valine. Biochem. J., 350, 69–73 (2000).
- 11) Mendel, S., Elkayam, T., Sella, C., Vinogradov, V., Vyazmensky, M., Chipman, D. M., and Barak, Z., Acetohydroxyacid synthase: a proposed structure for regulatory subunits supported by evidence from mutagenesis. J. Mol. Biol., 307, 465–477 (2001).
- 12) Mendel, S., Vinogradov, M., Vyazmensky, M., Chipman, D. M., and Barak, Z., The N-terminal domain of the regulatory subunit is sufficient for complete activation of acetohydroxyacid synthase III from Escherichia coli. J. Mol. Biol., 325, 275–284 (2003).
- 13) Aoki, R., Wada, M., Takesue, N., Tanaka, K., and Yokota, A., Enhanced glutamic acid production by a H+-ATPase-defective mutant of Corynebacterium glutamicum. Biosci. Biotechnol. Biochem., 69, 1466–1472 (2005).
- 14) Sekine, H., Shimada, T., Hayashi, C., Ishiguro, A., Tomita, F., and Yokota, A., H+-ATPase defect in Corynebacterium glutamicum abolishes glutamic acid production with enhancement of glucose consumption rate. Appl. Microbiol. Biotechnol., 57, 534–540 (2001).
- 15) Ikeda, M., and Nakagawa, S., The Corynebacterium glutamicum genome: features and impacts on biotechnological processes. Appl. Microbiol. Biotechnol., 62, 99–109 (2003).
- 16) Yokota, A., Terasawa, Y., Takaoka, N., Shimizu, H., and Tomita, F., Pyruvic acid production by an F1-ATPase-defective mutant of Escherichia coli W1485lip2. Biosci. Biotechnol. Biochem., 58, 2164–2167 (1994).
- 17) Causey, T. B., Shanmugam, K. T., Yomano, L. P., and Ingram, L. O., Engineering Escherichia coli for efficient conversion of glucose to pyruvate. Proc. Natl. Acad. Sci. USA, 101, 2235–2240 (2004).
- 18) Causey, T. B., Zhou, S., Shanmugam, K. T., and Ingram, L. O., Engineering the metabolism of Escherichia coli W3110 for the conversion of sugar to redox-neutral and oxidized products: homoacetate production. Proc. Natl. Acad. Sci. USA, 100, 825–832 (2003).
- 19) Wada, M., Narita, K., and Yokota, A., Alanine production in an H+-ATPase- and lactate dehydrogenase-defective mutant of Escherichia coli expressing alanine dehydrognase. Appl. Microbiol. Biotechnol., 76, 819–825 (2007).
- 20) Yokota, A., Henmi, M., Takaoka, N., Hayashi, C., Takezawa, Y., Fukumori, Y., and Tomita, F., Enhancement of glucose metabolism in a pyruvic acid-hyperproducing Escherichia coli mutant defective in F1-ATPase activity. J. Ferment. Bioeng., 83, 132–138 (1997).
- 21) Westerfeld, W. W., A colorimetric determination of blood acetoin. J. Biol. Chem., 161, 495–502 (1945).
- 22) Eddy, B. P., The Voges-Proskauer reaction and its significance: a review. J. Appl. Bacteriol., 24, 27–41 (1961).
- 23) Shäfer, A., Tauch, A., Jäger, W., Kalinowski, J., Thierbach, G., and Pühler, A., Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum. Gene, 145, 69–73 (1994).
- 24) Wada, M., Awano, N., Haisa, K., Takagi, H., and Nakamori, S., Purification, characterization and identification of cysteine desulfhydrase of Corynebacterium glutamicum, and its relationship to cysteine production. FEMS Microbiol. Lett., 217, 103–107 (2002).
- 25) Goudon, P., and Lindley, N. D., Metabolic analysis of glutamate production by Corynebacterium glutamicum. Metab. Eng., 1, 224–231 (1999).
- 26) Noda, S., Takezawa, Y., Mizutani, T., Asakura, T., Nishiumi, E., Onoe, K., Wada, M., Tomita, F., Matsushita, K., and Yokota, A., Alterations of cellular physiology in Escherichia coli in response to oxidative phosphorylation impaired by defective F1-ATPase. J. Bacteriol., 188, 6869–6876 (2006).
- 27) Merkamm, M., Chassagnole, C., Lindley, N. D., and Guyonvarch, A., Ketopantoate reductase activity is only encoded by ilvC in Corynebacterium glutamicum. J. Biotechnol., 104, 253–260 (2003).
- 28) Radmacher, E., Vaitsikova, A., Burger, U., Krumbach, K., Sahm, H., and Eggeling, L., Linking central metabolism with increased pathway flux: L-valine accumulation by Corynabacterium glutamicum. Appl. Environ. Microbiol., 68, 2246–2250 (2002).
- 29) Keilhauer, C., Eggeling, L., and Sahm, H., Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon. J. Bacteriol., 175, 5595–5603 (1993).
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Enhanced Valine Production in Corynebacterium glutamicum with Defective H+-ATPase and C-Terminal Truncated Acetohydroxyacid Synthase
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