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Bioscience, Biotechnology, and Biochemistry Volume 73, 2009 - Issue 2
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Original Articles

Missense Mutation in Abcg5 in SHRSP Rats Does Not Accelerate Intestinal Absorption of Plant Sterols: Comparison with Wistar Rats

Tadateru HAMADALaboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
,
Yoko KODAMALaboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
,
Hitomi GOTOLaboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
,
Takeshi YOSHIDALaboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
,
Katsumi IMAIZUMILaboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
&
Ikuo IKEDALaboratory of Food and Biomolecular Science, Department of Food Function and Health, Division of Bioscience and Biotechnology for Future Bioindustries, Graduate School of Agricultural Science, Tohoku University
Pages 361-365 | Received 28 Aug 2008, Accepted 24 Oct 2008, Published online: 22 May 2014

  • 1) Kidambi, S., and Patel, S. B., Sitosterolemia: pathophysiology, clinical presentation and laboratory diagnosis. J. Clin. Pathol., 61, 588–594 (2008).
  • 2) Berge, K. E., Tian, H., Graf, G. A., Yu, L., Grishin, N. V., Schultz, J., Kwiterovich, P., Shan, B., Barnes, R., and Hobbs, H. H., Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science, 290, 1771–1775 (2000).
  • 3) Lee, M. H., Lu, K., Hazard, S., Yu, H., Shulenin, S., Hidaka, H., Kojima, H., Allikmets, R., Sakuma, N., Pegoraro, R., Srivastava, A. K., Salen, G., Dean, M., and Patel, S. B., Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nat. Genet., 27, 79–83 (2001).
  • 4) Lu, K., Lee, M. H., and Patel, S. B., Dietary cholesterol absorption; more than just bile. Trends Endocrinol. Metab., 12, 314–320 (2001).
  • 5) Yu, L., Hammer, R. E., Li-Hawkins, J., Bergmann, K., Lütjohann, D., Cohen, J. C., and Hobbs, H. H., Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc. Natl. Acad. Sci. USA, 99, 16237–16242 (2002).
  • 6) Ikeda, I., Nakagiri, H., Sugano, M., Ohara, S., Hamada, T., Nonaka, M., and Imaizumi, K., Mechanisms of phytosterolemia in stroke-prone spontaneously hypertensive and WKY rats. Metabolism, 50, 1361–1368 (2001).
  • 7) Scoggan, K. A., Gruber, H., and Lariviere, K., A missense mutation in the Abcg5 gene causes phytosterolemia in SHR, stroke-prone SHR, and WKY rats. J. Lipid Res., 44, 911–916 (2003).
  • 8) Yu, H., Pandit, B., Klett, E., Lee, M. H., Lu, K., Helou, K., Ikeda, I., Egashira, N., Sato, M., Klein, R., Batta, A., Salen, G., and Patel, S. B., The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats. BMC Cardiovasc. Disord., 3, 4 (2003).
  • 9) Igel, M., Giesa, U., Lütjohann, D., and Bergmann, K., Comparison of the intestinal uptake of cholesterol, plant sterols, and stanols in mice. J. Lipid Res., 44, 533–538 (2003).
  • 10) Ikeda, I., Matsuoka, R., Hamada, T., Mitsui, K., Imabayashi, S., Uchino, A., Sato, M., Kuwano, E., Itamura, T., Yamada, K., Tanaka, K., and Imaizumi, K., Cholesterol esterase accelerates intestinal cholesterol absorption. Biochim. Biophys. Acta, 1571, 34–44 (2002).
  • 11) Reeves, P. G., Nielsen, F. H., and Fahey, G. C., AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc Writing Committee on the reformulation of the AIN-76A rodent diet. J. Nutr., 123, 1939–1951 (1993).
  • 12) Folch, J., Lees, M., and Sloane-Stanley, G. H., A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem., 226, 497–509 (1957).
  • 13) Ikeda, I., and Sugano, M., Some aspects of mechanism of inhibition of cholesterol absorption by β-sitosterol. Biochim. Biophys. Acta, 732, 651–658 (1983).
  • 14) Hamada, T., Egashira, N., Nishizono, S., Tomoyori, H., Nakagiri, H., Imaizumi, K., and Ikeda, I., Lymphatic absorption and deposition of various plant sterols in stroke-prone spontaneously hypertensive rats, a strain having a mutation in ATP binding cassette transporter G5. Lipids, 42, 241–248 (2007).
  • 15) Lütjohann, D., Björkhem, I., Beil, U. F., and von Bergmann, K., Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: effect of sitostanol treatment. J. Lipid Res., 36, 1763–1773 (1995).
  • 16) Yu, L., von Bergmann, K., Lutjohann, D., Hobbs, H. H., and Cohen, J. C., Selective sterol accumulation in ABCG5/ABCG8-deficient mice. J. Lipid Res., 45, 301–307 (2004).
  • 17) Batta, A. K., Xu, G., Bollineni, J. S., Shefer, S., and Salen, G., Effect of high plant sterol-enriched diet and cholesterol absorption inhibitor, SCH 58235, on plant sterol absorption and plasma concentrations in hypercholesterolemic wild-type Kyoto rats. Metabolism, 54, 38–48 (2005).
  • 18) Ikeda, I., Tanaka, K., Sugano, M., Vahouny, G. V., and Gallo, L. L., Discrimination between cholesterol and sitosterol for absorption in rats. J. Lipid Res., 29, 1583–1591 (1988).
  • 19) Katan, M. B., Grundy, S. M., Jones, P., Law, M., Miettinen, T., and Paoletti, R., Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin. Proc., 78, 965–978 (2003).
  • 20) Altmann, S. W., Davis H. R. Jr., Zhu, L.-J., Yao, X., Hoos, L. M., Tetzloff, G., Iyer, S. P. N., Maguire, M., Golovko, A., Zeng, M., Wang, L., Murgolo, N., and Graziano, M. P., Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption. Science, 303, 1201–1204 (2004).
  • 21) Hamada, T., Goto, H., Yamahira, T., Sugawara, T., Imaizumi, K., and Ikeda, I., Solubility in and affinity for the bile salt micelle of plant sterols are important determinants of their intestinal absorption in rats. Lipids, 41, 551–556 (2006).

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