Folate Intake and Supplement Use in Older Adults

References

• Adams , P. F. and Marano , M. A. 1995 . Current estimates from the National Health Interview Survey, 1994. National Center for Health Statistics . Vital Health Statistics , 10 ( 193 ) : 83 – 4 .
   Google Scholar
• Alaimo , K. , McDowell , M. A. , Briefel , R. R. , Bischof , A. M. , Caughman , C. R. , Loria , C. M. and Johnson , C. L. 1994 . Dietary intake of vitamins, minerals, and fiber of persons ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1, 1988–91 , No. 258 Hyattsville, Maryland : National Center for Health Statistics .
   Google Scholar
• American Heart Association . 1997 . Older Americans and cardiovascular diseases biostatistical fact sheets. ,
   Google Scholar
• Aronow , W. S. and Ahn , C. 1997a . Association between plasma homocysteine and coronary artery disease in older persons . American Journal of Cardiology , 80 : 1216 – 1218 .
   PubMed Web of Science ®Google Scholar
• Aronow , W. S. , Ahn , C. and Schoenfeld , M. R. 1997b . Association between plasma homocysteine and extracranial carotid arterial disease in older persons . American Journal of Cardiology , 79 : 1432 – 1433 .
   PubMed Web of Science ®Google Scholar
• Bailey , L. B. 1990 . Folate status assessment . Journal of Nutrition , 120 : 1508 – 1511 .
   PubMed Web of Science ®Google Scholar
• Bailey , L. B. 1992 . Evaluation of a new Recommended Dietary Allowance for folate . Journal of the American Dietetic Association , 92 : 463 – 468 . 471
   PubMedGoogle Scholar
• Blom , H. J. , Kleinveld , H. A. , Boers , G. H. , Demacker , P. N , Hak-Lemmers , H. L. , Te Poele-Pothoff , M. T. and Trijbels , J. M. 1995 . Lipid peroxidation and susceptibility of low density lipoprotein to in vitro oxidation in hyperhomocysteinemia . European Journal of Clinical Investigation , 25 : 149 – 154 .
   PubMed Web of Science ®Google Scholar
• Boushey , C. J. , Beresford , S. A. , Omenn , G. S. and Motulsky , A. G. 1995 . A quantitative assessment of plasma homocysteine as a risk factor for vascular disease . Journal of the American Medical Association , 274 : 1049 – 1057 .
   PubMed Web of Science ®Google Scholar
• Bowerman , S. J. A. and Harrill , I. 1983 . Nutrient consumptions of individuals taking or not taking nutrient supplements . Journal of the American Dietetic Association , 83 : 298 – 305 .
   PubMed Web of Science ®Google Scholar
• Brattstrom , L. , Israelsson , B. , Norrving , B. , Bergqvist , D. , Thorne , J. , Hultberg , B. and Hamfelt , A. 1990 . Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease . Atherosclerosis , 81 : 51 – 60 .
   PubMed Web of Science ®Google Scholar
• Brattstrom , L. E. , Israelsson , B. , Jeppson , J. O. and Hultberg , B. L. 1988 . Folic acid-an innocuous means to reduce plasma homocysteine . Scandinavian Journal of Clinical Laboratory , 48 : 215 – 221 .
   PubMed Web of Science ®Google Scholar
• Butterworth , C. E. and Tamura , T. 1989 . Folic acid safety and toxicity: A brief review . American Journal of Clinical Nutrition , 50 : 353 – 358 .
   PubMed Web of Science ®Google Scholar
• Celermajer , D. S. 1993 . Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not their heterozygous parents . Journal of the American College of Cardiology , 22 : 854 – 858 .
   PubMed Web of Science ®Google Scholar
• Clarke , R. , Daly , L. , Robinson , K. , Naughten , E. , Cahalane , S. , Fowler , B. and Graham , I. 1991 . Hyperhomocysteinemia . New England Journal of Medicine , 324 : 1149 – 1155 .
   PubMed Web of Science ®Google Scholar
• Cleveland , L. E. , Cook , A. C. , Krebs-Smith , S. and Friday , J. 1997 . Method for assessing food intakes in terms of servings based on food guidance . American Journal of Clinical Nutrition , 65 ( 4 ) : 1254S – 1263S .
   Web of Science ®Google Scholar
• Dalery , K. , Lussier-Cacan , S. , Selhub , J. , Davignon , J. , Latour , Y. and Genest , J. 1995 . Homocysteine and coronary artery disease in French Canadian subjects: Relation with vitamins B12, B6, pyridoxal phosphate, and folate . American Journal of Cardiology , 75 : 1107 – 1111 .
   PubMed Web of Science ®Google Scholar
• Davis , B. A. , Hofler , S. A. Bailey , L. B. 1994 . Homocysteine response to dietary folate modification in non-pregnant women ‘Abstract’ . FASEB Journal , 8 : A2248
   Web of Science ®Google Scholar
• de Bree , A. , van Dusseldorp , M. , Brouwer , I. A. , van het Hof , K. H. and Steegers-Theunissen , R. P. M. 1997 . Folate intake in Europe: Recommended, actual and desired intake . European Journal of Clinical Nutrition , 51 : 643 – 660 .
   PubMed Web of Science ®Google Scholar
• Dudman , N. P. B. , Hicks , C. , Lynch , J. F. , Wilcken , D. E. L. and Wang , J. 1991 . Homocysteine thiolacetone disposal by human arterial endothelial cells and serum in vitro . Arteriosclerosis Thrombosis , 11 : 663 – 670 .
   PubMedGoogle Scholar
• Dudman , N. P. , Wilcken , D. E. , Wang , J. , Lynch , J. F. , Macey , D. and Lundberg , P. 1993 . Disordered methionine/homocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy, and enzymology . Arteriosclerosis Thrombosis , 13 : 1253 – 60 .
   PubMedGoogle Scholar
• Duell , P. B. and Malinow , M. R. 1997 . Homocyst(e)ine: An important risk factor for atherosclerotic vascular disease . Current Opinions in Lipidology , 8 : 28 – 34 .
   PubMed Web of Science ®Google Scholar
• Fanelli-Kuczmarski , M. T. , Johnson , C. L. , Elias , L. and Najjar , M. F. 1990 . Folate status of Mexican American, Cuban, and Puerto Rican women . American Journal of Clinical Nutrition , 52 : 368 – 372 .
   PubMed Web of Science ®Google Scholar
• Food and Drug Administration. 1996a . Food standards: Amendment of the standards of identity for enriched grain products to require addition of folic acid . Federal Register , 61 : 8781 – 8797 .
   Google Scholar
• Food and Drug Administration. 1996b . Food additives permitted for direct addition to food for human consumption; folic acid (folacin) . Federal Register , 61 : 8797 – 8807 .
   Google Scholar
• Food and Nutrition Board. 1998 . Dietary Reference Intakes for Thiamin, Ribofla-vin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline , Washington, D.C. : National Academy Press .
   Google Scholar
• Genest , J. J. , McNamara , J. R. , Salem , D. N. , Wilson , P. W. , Schaefer , E. J. and Malinow , M. R. 1990 . Plasma homocysteine levels in men with premature coronary artery disease . Journal of the American College of Cardiology , 16 : 1114 – 1119 .
   PubMed Web of Science ®Google Scholar
• Gregory , J. F. 1997 . Bioavailability of folate . European Journal of Clinical Nutrition , 51 : S54 – S59 .
   Web of Science ®Google Scholar
• Harats , D. , Chevion , S. Nahir , M. 1998 . Citrus fruit supplementation reduces lipoprotein oxidation in young men ingesting a diet high in saturated fat . American Journal of Clinical Nutrition , 67 : 240 – 245 .
   PubMed Web of Science ®Google Scholar
• Hartz , S. C. , Otradovec , C. L. , McGandy , R. B. , Russell , R. M. , Jacob , R. A. , Sahyoun , N. , Peters , H. , Abrams , D. , Scura , L. A. and Whinston-Perry , R. A. 1988 . Nutrient supplement use by healthy elderly . Journal of the American College of Nutrition , 7 : 119 – 128 .
   PubMed Web of Science ®Google Scholar
• Herzlich , B. C. , Lichstein , E. , Schulhoff , N. , Weinstock , M. , Pagala , M. , Ravindran , K. , Namba , T. , Nieto , F. J. , Stabler , S. P. , Allen , R. H. and Malinow , M. R. 1996 . Relationship among homocyst(e)ine, vitamin B-12 and cardiac disease in the elderly . Journal of Nutrition , 126 : 1249S – 1253S .
   Web of Science ®Google Scholar
• Hirano , K. , Ogihara , T. , Miki , M. , Yasuda , H. , Tamai , H. , Kawamura , N. and Mino , M. 1994 . Homocysteine induces iron-catalyzed lipid peroxidation of low-density lipoproteins that is prevented by alpha-tocopherol . Free Radical Research , 21 : 267 – 276 .
   PubMed Web of Science ®Google Scholar
• Hopkins , P. N. , Wu , L. L. , Wu , J. , Hunt , S. C. , James , B. C. , Vincent , G. M. and Williams , R. R. 1995 . Higher plasma homocysteine and increased susceptibility to adverse effects of low folate in early familial coronary artery disease . Arteriosclerosis Thrombosis and Vascular Biology , 15 : 1314 – 1320 .
   PubMed Web of Science ®Google Scholar
• Jacob , R. A. , Mei-Miau , W. , Henning , S. and Swendseid , M. E. 1994 . Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction . Journal of Nutrition , 124 : 1072 – 1080 .
   PubMed Web of Science ®Google Scholar
• Joosten , E. , van den Berg , A. , Riezler , R. , Naurath , H. J. , Lindenbaum , J. , Stabler , S. P. and Allen , R. H. 1993 . Metabolic evidence that deficiencies of vitamin B-12 (cobalamin), folate, and vitamin B-6 occur commonly in elderly people . American Journal of Clinical Nutrition , 58 : 468 – 476 .
   PubMed Web of Science ®Google Scholar
• Kang , S. S. , Wong , P. W. and Norusis , M. 1987 . Homocysteinemia due to folate deficiency . Metabolism , 36 : 4458 – 4462 .
   Web of Science ®Google Scholar
• Keim , K. S. , Stewart , B. and Voichick , J. 1997 . Vegetable and fruit intake and perceptions of selected young adults . Journal of Nutrition Education , 29 : 80 – 85 .
   Google Scholar
• Koehler , K. M. , Pareo-Tubbeh , S. L. , Romero , L. J. , Baumgartner , R. N. and Garry , P. J. 1997 . Folate nutrition and older adults: Challenges and opportunities . Journal of the American Dietetic Association , 97 ( 2 ) : 167 – 173 .
   PubMed Web of Science ®Google Scholar
• Krebs-Smith , S. M , Cleveland , L. E. , Ballard-Barbash , R , Cook , D. A. and Kahle , L. L. 1997 . Characterizing food intake patterns of American adults . American Journal of Clinical Nutrition , 65 : 1264S – 1268S .
   PubMed Web of Science ®Google Scholar
• Krebs-Smith , S. M. , Cook , D. A. , Subar , A. , Cleveland , L. and Friday , J. 1995 . US adults' fruit and vegetable intakes, 1989 to 1991: A revised baseline for the Healthy People 2000 objective . American Journal of Public Health , 85 ( 12 ) : 1623 – 1629 .
   PubMed Web of Science ®Google Scholar
• Levine , G. N. 1995 . Medical Progress: Cholesterol reduction in cardiovascular disease-Clinical benefits and possible mechanisms . New England Journal of Medicine , 332 : 512 – 521 .
   PubMed Web of Science ®Google Scholar
• Lewis , C. A. , Pancharuniti , N. and Sauberlich , H. E. 1992 . Plasma folate adequacy as determined by homocysteine level . Annals of the New York Academy of Sciences , 669 : 360 – 362 .
   PubMed Web of Science ®Google Scholar
• Lindenbaum , J. and Allen , R. H. 1995 . “ Clinical spectrum and diagnosis of folate deficiency ” . In Folate in Health and Disease , Edited by: Bailey , L. B. 43 – 73 . New York : Marcel Dekker Inc. .
   Google Scholar
• Lindenbaum , J. , Rosenberg , I. H. , Wilson , P. W. F. , Stabler , S. P. and Allen , R. H. 1994 . Prevalence of cobalamin deficiency in the Framingham elderly population . American Journal of Clinical Nutrition , 60 : 2 – 11 .
   PubMed Web of Science ®Google Scholar
• Loehrer , F. M. , Tangst , C. P , Haefeli , W. E , Jordan , P. P , Ritz , R and Fowler , B. 1996 . Low whole-blood s-adenosylmethionine and correlation between 5-me-thyltetrahydrofolate and homocysteine in coronary artery disease . Arteriosclerosis Thrombosis and Vascular Biology , 16 : 727 – 733 .
   PubMed Web of Science ®Google Scholar
• Lussier-Cacan , S. , Xhignesse , M. , Piolot , A. , Selhub , J. , Davignon , J. and Genest , J. 1996 . Plasma total homocysteine in healthy subjects: Sex-specific relation with biological traits . American Journal of Clinical Nutrition , 64 : 587 – 593 .
   PubMed Web of Science ®Google Scholar
• Malinow , M. R. 1994 . Homocysteine and arterial occlusive disease . Journal of Internal Medicine , 236 : 603 – 617 .
   PubMed Web of Science ®Google Scholar
• Malinow , M. R. , Duell , P. B. , Hess , D. L. , Anderson , P. H. , Kruger , W. D. , Phillipson , B. E. , Gluckman , R. A. , Block , P. C. and Upson , B. M. 1998 . Reduction of plasma homocysteine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease . New England Journal of Medicine , 338 : 1009 – 1015 .
   PubMed Web of Science ®Google Scholar
• McDonald , L. 1964 . Homocystinuria, thrombosis, and the blood-platelets . Lancet , 1 : 745 – 746 .
   PubMed Web of Science ®Google Scholar
• Naurath , H. J. , Joosten , E. , Riezler , R. , Stabler , S. P. , Allen , R. H. and Lindenbaum , J. 1995 . Effects of vitamin B-12, folate, and vitamin B-6 supplements in elderly people with normal serum vitamin concentrations . Lancet , 346 : 85 – 89 .
   PubMed Web of Science ®Google Scholar
• Nygard , O. , Refsum , H. , Ueland , P. M. and Vollset , S. E. 1998 . Major lifestyle determinants of plasma total homocysteine distribution . American Journal of Clinical Nutrition , 67 : 263 – 270 .
   PubMed Web of Science ®Google Scholar
• Nygard , O. , Vollset , S. E. , Refsum , H. , Stensvold , I. , Tverdal , A. , Nordrehaug , J. E. , Ueland , M. and Kvale , G. 1995 . Total plasma homocysteine and cardiovascular risk profile: The Hordaland Homocysteine Study . Journal of the American Medical Association , 274 : 1526 – 1533 .
   PubMed Web of Science ®Google Scholar
• O'Keefe , C. A. , Bailey , L. B. , Thomas , E. A. , Hofler , S. A. , Davies , B. A. , Cerda , J. J. and Gregory , J. F. 1995 . Controlled dietary folate affects folate status in non-pregnant women . Journal of Nutrition , 125 : 2717 – 2725 .
   PubMed Web of Science ®Google Scholar
• Pancharuniti , N. , Lewis , C. A. , Sauberlich , H. E. , Perkins , L. L. , Go , R. C. , Alvarez , J. O. , Macaluso , M. , Acton , R. T. , Copeland , R. B. Cousins , A. L. 1994 . Plasma homocysteine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease . American Journal of Clinical Nutrition , 59 : 940 – 948 .
   PubMed Web of Science ®Google Scholar
• Patterson , B. H. , Block , G. , Rosenberger , W. F. , Pee , D. and Kahle , L. 1990 . Fruit and vegetables in the American diet: Data from the NHANES II survey . American Journal of Public Health , 80 ( 12 ) : 1443 – 1449 .
   PubMed Web of Science ®Google Scholar
• Pfeiffer , C. M. , Rogers , L. M. , Bailey , L. B. and Gregory , J. F. 1997 . Absorption of folate from fortified cereal-grain products and of supplemental folate consumed with or without food determined using a dual-label stable-isotope protocol . American Journal of Clinical Nutrition , 66 : 1388 – 1397 .
   PubMed Web of Science ®Google Scholar
• Romano , P. S. , Waitzman , N. J. , Scheffler , R. M. and Pi , R. D. 1995 . Folic acid fortification of grain: An economic analysis . American Journal of Public Health , 85 ( 5 ) : 667 – 673 .
   PubMed Web of Science ®Google Scholar
• Sauberlich , H. E. 1990 . “ Evaluation of folate nutrition in population groups ” . In Folic Acid Metabolism in Health and Disease , Edited by: Picciano , M. F. , Stokstad , E. L. R. and Gregory , J. F. 212 – 235 . New York, NY : Wiley-Liss .
   Google Scholar
• Sauberlich , H. E. , Kretsch , M. J. , Skala , J. H. , Johnson , H. L. and Taylor , P. C. 1987 . Folate requirement and metabolism in nonpregnant women . American Journal of Clinical Nutrition , 46 : 1016 – 1028 .
   PubMed Web of Science ®Google Scholar
• Schwartz , S. M. , Siscovick , D. S. , Malinow , M. R. , Rosendaal , F. R. , Beverly , R. K. , Hess , D. L. , Psaty , B. M. , Longstreth , W. T. , Koepsell , T. D. , Raghunathan , T. E. and Reitsma , P. H. 1997 . Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in methylenetetrahydro-folate reductase gene . Circulation , 96 : 412 – 417 .
   PubMed Web of Science ®Google Scholar
• Selhub , J. , Jacques , P. F. , Bostom , A. G. , D'Agostino , R. B. , Wilson , P. W. F. , Belanger , A. J. , O'Leary , D. H. , Wolf , P. A. , Schaefer , E. J. and Rosenberg , I. H. 1995 . Association between plasma homocysteine concentrations and extracra-nial carotid-artery stenosis . New England Journal of Medicine , 332 : 286 – 291 .
   PubMed Web of Science ®Google Scholar
• Selhub , J. , Jacques , P. F. , Wilson , P. W. F. , Rush , D. and Rosenberg , I. H. 1993 . Vitamin status and intake as primary determinants of homocysteinemia in an elderly population . Journal of the American Medical Association , 270 ( 22 ) : 2693 – 2698 .
   PubMed Web of Science ®Google Scholar
• Serdula , M. K. , Coates , R. J. , Byers , T. , Simones , E. , Mokdad , A. H. and Subar , A. 1995 . Fruit and vegetable intake among adults in 16 states: Results of a brief telephone survey . American Journal of Public Health , 85 ( 2 ) : 236 – 239 .
   PubMed Web of Science ®Google Scholar
• Shimakawa , T. , Nieto , F. J. , Malinow , M. R. , Chambless , L. E. , Schreiner , P. J. and Szklo , M. 1997 . Vitamin intake: A possible determinant of plasma homocys-teine among middle-aged adults . Annals of Epidemiology , 7 : 285 – 293 .
   PubMed Web of Science ®Google Scholar
• Singh , G. K. 1996 . Advance report of final mortality statistics, 1994 . Monthly Vital Statistics Report , 45 ( 3S ) : 1 – 13 .
   Google Scholar
• Slesinski , M. J. , Subar , A. F. and Kahle , L. L. 1995 . Trends in use of vitamin and mineral supplements in the United States . Journal of the American Dietetic Association , 95 : 921 – 923 .
   PubMed Web of Science ®Google Scholar
• Slesinski , M. J. , Subar , A. F. and Kahle , L. L. 1996 . Dietary intake of fat, fiber and other nutrients is related to the use of vitamin and mineral supplements in the United States: The 1992 National Health Interview Survey . Journal of Nutrition , 126 : 3001 – 3008 .
   PubMed Web of Science ®Google Scholar
• 1997 . SPSS for Windows , Version 7.5 Chicago, IL : SPSS, Inc. .
   Google Scholar
• Stamler , J. S. , Osborne , J. A. , Jaraki , O. , Rabbani , L. E. , Mullins , M. , Singel , D. and Loscalzo , J. 1993 . Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen . Journal of Clinical Investigation , 91 : 308 – 318 .
   PubMed Web of Science ®Google Scholar
• Stampfer , M. J. , Malinow , M. R. , Willett , W. C. , Newcomer , L. M. , Upson , B. , Ullmann , D. , Tishler , P. V. and Hennekens , C. H. 1992 . A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians . Journal of the American Medical Association , 268 : 877 – 881 .
   PubMed Web of Science ®Google Scholar
• Stewart , M. L. , McDonald , J. T. , Levy , A. S. , Schucker , R. E. and Henderson , D. P. 1985 . Vitamin/mineral supplement use: A telephone survey of adults in the United States . Journal of the American Dietetic Association , 85 : 1585 – 1590 .
   PubMed Web of Science ®Google Scholar
• Subar , A. F. and Block , G. 1990 . Use of vitamin and mineral supplements: Demographics and amounts of nutrients consumed. The 1987 Health Interview Survey . American Journal of Epidemiology , 132 : 1091 – 1101 .
   PubMed Web of Science ®Google Scholar
• Subar , A. F. , Block , G. and James , L. D. 1989 . Folate intake and food sources in the US population . American Journal of Clinical Nutrition , 50 : 508 – 516 .
   PubMed Web of Science ®Google Scholar
• Tippett , K. S. , Mickle , S. J. and Goldman , J. D. 1995 . “ Food and nutrient intake by individuals in the United States, 1 day, 1989–91 ” . In Continuing Survey of Food Intakes by Individuals, 1989–91 , Nationwide Food Surveys Rep. No. 91–2
   Google Scholar
• Tippett , K. S. and Cypel , Y. S. 1998 . Design and operation: The continuing survey of food intakes by individuals and the diet and health knowledge survey, 1994–96 , Nationwide Food Surveys Report No. 96–1 264 U.S. Department of Agriculture, Agricultural Research Service .
   Google Scholar
• Tonstad , S. 1997 . Correlates of plasma total homocysteine in patients with hyperli-pidemia . European Journal of Clinical Investigation , 27 : 1025 – 1029 .
   PubMed Web of Science ®Google Scholar
• Tsai , J. C. , Perella , M. A. , Yoshizumi , M. , Hsieh , C. M. , Haber , E. , Schlegel , R. and Lee , M. E. 1994 . Promotion of vascular smooth muscle cell growth by homo-cysteine: A link to atherosclerosis . Proceedings of the National Academy of Science USA , 91 : 6369 – 6373 .
   PubMed Web of Science ®Google Scholar
• Tucker , K. L. , Mahnken , B. , Wilson , P. W. F. , Jacques , P. and Selhub , J. 1996a . Folic acid fortification of the food supply: Potential benefits and risks for the elderly population . Journal of the American Medical Association , 276 : 1879 – 1885 .
   Web of Science ®Google Scholar
• Tucker , K. L. , Selhub , J. , Wilson , P. W. F. and Rosenberg , I. H. 1996b . Dietary intake pattern relates to plasma folate and homocysteine concentrations in the Framing-ham Heart Study . Journal of Nutrition , 126 : 3025 – 3031 .
   PubMed Web of Science ®Google Scholar
• Ubbink , J. B. 1997 . The role of vitamin in the pathogenesis and treatment of hyperhomocysteinemia . Journal of Inherited Metabolic Diseases , 20 : 316 – 325 .
   PubMed Web of Science ®Google Scholar
• Ubbink , J. B. , van der Merwe , A. , Delport , R. , Allen , R. H. , Stabler , S. P. , Riezler , R. and Vermaak , W. J. 1996 . The effects of a subnormal vitamin B-6 status on homocysteine metabolism . Journal of Clinical Investigation , 98 : 177 – 184 .
   PubMed Web of Science ®Google Scholar
• Ubbink , J. B. , van der Merwe , A. , Vermaak , W. J. and Delport , R. 1993 . Hyperho-mocysteinemia and the response to vitamin supplementation . Clinical Investigation , 71 : 993 – 998 .
   PubMedGoogle Scholar
• Ueland , P. M. and Refsum , H. 1989 . Plasma homocysteine, a risk factor for vascular disease . Journal of Laboratory Clinical Medicine , 114 : 473 – 501 .
   PubMed Web of Science ®Google Scholar
• Ueland , P. M. , Refsum , H. and Brattstrom , L. 1992 . “ Plasma homocysteine and cardiovascular disease ” . In Atherosclerotic cardiovascular disease, homeostasis, and endothelial function Edited by: Francis , B. R. 183 – 235 . Decker, NY
   Google Scholar
• US Dept. of Health and Human Services. 1991 . Healthy people 2000. National health promotion and disease prevention objectives , 91 – 50213 . Washington, DC : U.S. Government Printing Office. .
   Google Scholar
• Van der Berg , M. , Boers , G. H. J. , Franken , D. G. , Blom , H. J. , Van Kamp , G. J. , Jakobs , C. , Rauwerda , J. A. , Kluft , C. and Stehouwert , C. D. 1995 . Hyperhomo-cysteinemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease . European Journal of Clinical Investigation , 25 : 176 – 181 .
   PubMed Web of Science ®Google Scholar
• Verhoef , P. , Kok , F. J. , Kruyssen , D. A. , Schouten , E. G. , Witteman , J. C. , Grobbee , D. E. , Ueland , P. M. and Refsum , H. 1997 . Plasma total homocysteine, B vitamins, and risk of coronary atherosclerosis . Arteriosclerosis Thrombosis and Vascular Biology , 17 : 989 – 995 .
   PubMed Web of Science ®Google Scholar
• Verhoef , P. , Stampfer , M. J. , Buring , J. E. , Gaziano , J. M. , Allen , R. H. , Stabler , S. P. , Reynolds , R. D. , Kok , F. J. , Hennekens , C. H. and Willett , W. C. 1996 . Homocys-teine metabolism and risk of myocardial infarction: Relation with vitamins B6, B12, and folate . American Journal of Epidemiology , 143 : 845 – 859 .
   PubMed Web of Science ®Google Scholar
• VonEckardstein , A. , Malinow , M. R. , Upson , B. , Heinrich , J. , Schulte , H. , Schonfeld , R. , Kohler , E. and Assmann , G. 1994 . Effects of age, lipoproteins, and hemostatic parameters on the role of homocysteinemia as a cardiovascular risk factor in men . Arteriosclerosis Thrombosis , 14 : 460 – 464 .
   PubMedGoogle Scholar
• Weggemans , R. M. , deGroot , L. and Haller , J. 1997 . Factors related to plasma folate and vitamin B-12: The Seneca study . International Journal of Food Science and Nutrition , 48 : 141 – 150 .
   PubMed Web of Science ®Google Scholar
• 1997 . We s Va r P. C. , Version 2.1 Rockville, MD : Westat, Inc. .
   Google Scholar