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Original Articles

The Role of Magnesium in Immunity

Pages 107-126 | Published online: 20 Oct 2008

References

  • Leroy , J. 1926 . Necéssité du magnésium pour la croissance da la souris . C.R. Soc. Biol. , 94 : 431 – 433 .
  • Kruse , H. D. , Orent , E. R. and McCollum , E. V. 1932 . Studies on magnesium deficiency in animals. I. Symptomatology resulting from magnesium deprivation . J. Biol. Chem. , 96 : 519 – 539 .
  • Marier , J. R. 1986 . Magnesium content of the food supply in the modernday world . Magnesium , 5 : 1 – 8 .
  • Durlach , J. 1988 . Magnesium in Clinical Practice , London : John Libbey .
  • Kubena , K. S. and Durlach , J. 1990 . Historical review of the effects of marginal intake of magnesium in chronic experimental magnesium deficiency . Magnesium Res. , 3 : 219 – 226 .
  • Emelianov , A. V. , Fedoseev , G. B. , Emanuel , V. L. , Sinitsina , T. M. and Krunchak , L. F. 1990 . Effects of magnesium sulfate aerosol on indices of external respiration in patients with bronchial asthma . Klin. Med. , 68 : 31 – 34 .
  • Muresan , D. , Oana , A. , Nicolae , I. , Alecu , M. , Mosescu , L. , Benea , V. and Flueras , M. 1990 . Investigations of magnesium, histamine and immunoglobulin dynamics in acute urticaria . Arch. Roum. Pathol. Exp. Microbiol. , 49 : 31 – 35 .
  • Liu , G. H. and Morimoto , M. 1991 . Magnesium sulphate as a new desensitizing agent . J. Oral Rehabil. , 18 : 363 – 372 .
  • Kass , E. H. 1988 . Magnesium, Staphylococcus aureus and toxic shock syndrome . Magnesium , 7 : 315 – 319 .
  • Berman , A. C. and Boly , L. R. 1991 . Cisplatin therapy-associated recurrent toxic shock syndrome . West. J. Med. , 155 : 415 – 416 .
  • Sacco , N. A. and Filkins , J. P. 1988 . Phagocytes and monokines: Perspectives on metabolic regulation in sepsis . Magnesium , 7 : 281 – 289 .
  • Kashiwa , H. K. and Hungerford , G. F. 1958 . Blood leucocyte response in rats fed a magnesium deficient diet . Proc. Soc. Exp. Biol. Med. , 99 : 441 – 443 .
  • Hungerford , G. F. and Karson , E. F. 1960 . The eosinophilia of magnesium deficiency . Blood , 16 : 1642 – 1650 .
  • McCoy , J. H. and Kenney , M. A. 1975 . Depressed immune response in the magnesium-deficient rat . J. Nutr. , 105 : 791 – 797 .
  • Kenney , M. A. 1981 . Blood cells in the magnesium-deficient rat related to bone magnesium . Nutr. Rep. Int. , 23 : 455 – 463 .
  • Kenney , M. A. 1981 . Blood cells and bone in rats fed two levels of magnesium and of protein . Nutr. Rep. Int. , 23 : 1073 – 1076 .
  • Nishio , A. , Ishiguro , S. and Miyao , N. 1987 . Specific change of histamine metabolism in acute magnesium-deficient young rats . Drug Nutr. Interact. , 5 : 89 – 96 .
  • Hungerford , G. F. 1964 . Role of histamine in producing the eosinophilia of magnesium deficiency . Proc. Soc. Exp. Biol. Med. , 115 : 182 – 185 .
  • Itokawa , Y. , Panaka , C. and Kimura , M. 1972 . Effects of thiamine on serotonin levels in magnesium deficient animals . Metabol. , 21 : 375 – 379 .
  • McCreary , P. A. , Battifora , H. A. , Hahneman , B. M. , Laing , G. H. and Hass , G. M. 1967 . Leukocytosis, bone marrow hyperplasia and leukemia in chronic magnesium deficiency in the rat . Blood , 29 : 683 – 690 .
  • Belanger , L. F. 1977 . Variations in the mast cell population of skin and bone marrow in magnesium-deprived rats. The influence of sex hormones . J. Nutr. , 107 : 2164 – 2170 .
  • Kraeuter , S. L. and Schwartz , R. 1980 . Blood and mast cell histamine levels in magnesium-deficient rats . J. Nutr. , 110 : 851 – 858 .
  • Ishiguro , S. , Nishio , A. , Miyao , N. , Morikawa , Y. , Takeno , K. and Yanagiya , I. 1987 . Effects of magnesium deficiency on dermal mast cells in rats . Nippon-Yakurigaku-Zasshi , 89 : 121 – 127 .
  • Bertelsen , H. and Johansen , T. 1991 . Extracellular magnesium decreases the secretory response of rat peritoneal mast cells to compound 48/80 in vitro . Life Sci. , 49 : 1689 – 1697 .
  • Ponvert , C. , Galoppin , L. , Burtin , C. , Paupe , J. and Canu , P. 1984 . Noninvolvement of histamine and prostaglandins in the dermatosis of magnesium-deficient hairless rats . Pharmacology , 28 : 235 – 240 .
  • Winquist , I. , Olofsson , T. and Persson , E. 1985 . Effect of zinc and other cations on the release of eosinophil cationic protein . Scand. J. Clin. Lab. Invest. , 45 : 671 – 677 .
  • Brennan , J. K. , Seelig , C. B. and Lichtman , M. A. 1980 . “ The role of magnesium in neutrophil production and function ” . In Magnesium in Health and Disease , Edited by: Cantin , M. and Seelig , M. S. 169 – 193 . New York : SP Medical and Scientific Books .
  • Malter , J. S. , McCrory , W. A. , Wilson , M. and Gillis , P. 1990 . Adenosineuridine binding factor requires metals for binding to granulocyte-macrophage colony-stimulating factor mRNA . Enzyme , 44 : 203 – 213 .
  • Weglicki , W. B. , Phillips , T. M. , Freedman , A. M. , Cassidy , M. M. and Dickens , B. F. 1992 . Magnesium deficiency elevated circulating levels of inflammatory cytokines and endothelin . Mol. Cell Biochem. , 110 : 169 – 173 .
  • Stankiewicz , M. , Migdalska , A. , Bankowska , E. and Jeska , E. L. 1989 . Complement activation, phagocytosis, tumor growth and parasitic infection after magnesium supplementation in diet of mice . Magnesium , 8 : 87 – 93 .
  • Stankiewicz , M. 1975 . The participation of C3 and Mg in the mediation of cell adherence reactions (CAR) of Trichinella spiralis in normal non-immune sera . Bull. Acad. Pol. Sci. Cl. II , 23 : 87 – 92 .
  • Gallin , J. I. and Rosenthal , A. S. 1974 . The regulatory role of divalent cations in human granulocyte chemotaxis . J. Cell. Biol. , 62 : 594 – 609 .
  • Marasco , W. A. , Becker , E. L. and Oliver , J. M. 1980 . The ionic basis of chemotaxis . Am. J. Pathol. , 98 : 749 – 768 .
  • O'Flaherty , J. T. , Showell , H. J. and Ward , P. A. 1977 . Influence of extracellular Ca2+ and Mg2+ on chemotactic factor-induced neutrophil aggregation . Inflammation , 2 : 265 – 276 .
  • Pawlowski , N. A. , Abraham , E. L. , Pontier , S. , Scott , W. A. and Cohn , Z. A. 1985 . Human monocyte-endothelial cell interaction in vitro . Proc. Natl. Acad. Sci. , 82 : 8208 – 8212 .
  • Cai , J. P. , Harris , B. , Falanga , V. , Eaglstein , W. H. , Mertz , P. M. and Chin , Y. H. 1990 . Recruitment of mononuclear cells by endothelial cell binding into wounded skin is a selective, time-dependent process with defined molecular interactions . J. Invest. Dermatol. , 95 : 415 – 421 .
  • Alcock , N. W. and Shils , M. E. 1974 . Serum immunoglobulin G in the magnesium-depleted rat . Proc. Soc. Exp. Biol. Med. , 145 : 855 – 858 .
  • Elin , R. J. 1975 . The effect of magnesium deficiency in mice on serum immunoglobulin concentrations and antibody plaque-forming cells . Proc. Soc. Exp. Biol. Med. , 148 : 620 – 624 .
  • Battifora , H. A. , McCreary , P. A. , Hahneman , B. M. , Laing , G. H. and Hass , G. M. 1968 . Chronic magnesium deficiency in the rat. Studies of chronic myelogenous leukemia . Arch. Path. , 86 : 610 – 620 .
  • Kubena , K. S. , Cohill , D. T. and McMurray , D. N. 1989 . Effect of varying levels of magnesium during gestation and lactation on humoral immune response and tissue minerals in rats . Ann. Nutr. Metab. , 33 : 7 – 14 .
  • McCoy , J. H. 1981 . Physiological, dietary and environmental influences on serum immunoglobulin concentrations in nine-year-old girls . Nutr. Rep. Int. , 23 : 713 – 722 .
  • Prouvost-Danon , A. , Wyzolkowska , J. , Larvor , P. , Rayssiguier , Y. and Durlach , J. 1975 . Donneés sur le taux sérique d'anticorp réaginiques (IgE) chez le souris en carence magnésique . Rev. Franc. Allergol. , 15 : 147 – 150 .
  • Tada , T. and Okumura , K. 1971 . Regulation of homocytotropic antibody, formation in the rat. I. Feed-back regulation by passively administered antibody . J. Immunol. , 106 : 1002 – 1011 .
  • Pryzdial , E. L.G. and Isenman , D. E. 1986 . A reexamination of the role of magnesium in the human alternative pathway of complement . Molec. Immunol. , 23 : 87 – 96 .
  • Takada , A. , Takada , Y. , Makino , Y. , Sugawara , Y. and Shirahama , S. 1987 . Effects of lysine and glutamic acid on Mg++ on the conformations of C3 and B, and the activation of the alternative complement pathway . Complement , 4 : 110 – 119 .
  • Maeda , S. and Nagasawa , S. 1990 . Effect of sodium chloride concentration on fluid-phase assembly and stability of the C3 convertase of the classical pathway of the complement system . Biochem. J. , 271 : 749 – 754 .
  • McCoy , J. H. and Kenney , M. A. 1984 . “ Magnesium and immunocompetence ” . In Nutrition, Disease Resistance, and Immune Function , Edited by: Watson , R. R. 223 – 247 . New York : Marcel Dekker, Inc. .
  • Bois , P. 1964 . Tumour of the thymus in magnesium-deficient rats . Nature , 204 : 1316
  • Bois , P. , Sandborn , E. B. and Messier , P. E. 1969 . A study of thymic lymphosarcoma developing in magnesium-deficient rats . Cancer Res. , 29 : 763 – 775 .
  • Alcock , N. W. , Shils , M. E. , Lieberman , P. H. and Erlandson , R. A. 1973 . Thymic changes in the magnesium-depleted rat . Cancer Res. , 33 : 2196 – 2204 .
  • Flynn , A. and Yen , B. R. 1981 . Mineral deficiency effects on the generation of cytotoxic T-cells and T-helper cell factors in vitro . J. Nutr. , 111 : 907 – 913 .
  • Barbier , A. , Planchenault , C. , Vernhet , C. and Breliere , J. C. 1986 . Magnesium-deficient hairless rat: spleen cells mitogenic responses and variations in hormonal status . Agents Actions , 19 : 341 – 343 .
  • Flynn , A. 1984 . Control of in vitro lymphocyte proliferation by copper, magnesium and zinc deficiency . J. Nutr. , 114 : 2034 – 2042 .
  • Flynn , A. , Loftus , M. A. and Finke , J. H. 1984 . Production of interleukin-1 and interleukin-2 in allogeneic mixed lymphocyte cultures under copper, magnesium and zinc deficient conditions . Nutr. Res. , 4 : 673 – 679 .
  • Yiangou , M. and Hadjipetrou-Kourounakis , L. 1989 . Effect of magnesium deficiency on interleukin production by Fisher rats: Effect of interleukins on reduced in vitro lymphocyte responses to Concanavalin A and lipopolysaccharide . Int. Arch. Allergy Appl. Immunol. , 89 : 217 – 221 .
  • Flynn , A. 1985 . In vitro levels of copper, magnesium and zinc required for mitogen stimulated T lymphocyte proliferation . Nutr. Res. , 5 : 487 – 495 .
  • Ng , L. L. , Davies , J. E. and Garrido , M. C. 1991 . Intracellular free magnesium in human lymphocytes and the response to lectins . Clin. Sci. , 80 : 539 – 547 .
  • Carpentieri , U. , Myers , J. , Daeschner , C. W. and Haggard , M. E. 1988 . Effects of iron, copper, zinc, calcium, and magnesium on human lymphocytes in culture . Biol. Trace Elem. Res. , 16 : 165 – 176 .
  • Blanchard , D. , Aubry , J. P. , de Vries , J. E. and Spits , H. 1989 . The role of Ca2+ and Mg2+ in the cytotoxic T lymphocyte reaction and in the secretion of Nα-benzyloxycarbonyl-1-lysine thiobenzyl ester-serine esterase by human T cell clones . J. Immunol. , 142 : 2173 – 2180 .
  • Graziano , R. F. , Erbe , D. V. and Fanger , M. W. 1989 . The mechanisms of antibody-dependent killing mediated by lymphoid and myeloid cells are distinct based on different divalent cation requirements . J. Immunol. , 143 : 3894 – 3900 .
  • Chien , M. M. and Cambier , J. C. 1990 . Divalent cation regulation of phosphoinositide metabolism . J. Biol. Chem. , 265 : 9201 – 9207 .
  • Hiserodt , J. C. , Britvan , L. J. and Targan , S. R. 1982 . Characterization of the cytolytic reaction mechanism of the human natural killer (NK) lymphocyte: resolution into binding, programming, and killer cell-dependent steps . J. Immunol. , 129 : 1782 – 1787 .
  • Beck , K. W. , Schramel , P. , Hedl , A. , Jager , H. and Kaboth , W. 1989 . Trace element concentrations in HIV infected patients . Onkologie , 12 : 43 – 47 .
  • Laubach , H. E. 1989 . Effect of dietary magnesium on Ascaris suum infections of mice . Biochem. Med. Metab. Biol. , 42 : 95 – 104 .
  • Ashkenazy , Y. , Moshonov , S. , Fischer , G. , Feigel , D. , Caspi , A. , Kusniec , F. , Sela , B. and Zor , U. 1990 . Magnesium-deficient diet aggravates anaphylactic shock and promotes cardiac myolysis in guinea pigs . Magnesium Trace Elem. , 9 : 283 – 288 .
  • Durlach , J. 1975 . Rapports expérimentaux et cliniques entre magnésium et hypersensibilité . Rev. Franc. Allerg. , 15 : 133 – 146 .
  • Wei , W. and Franz , K. B. 1990 . A synergism of antigen challenge and severe magnesium deficiency on blood and urinary histamine levels in rats . J. Am. Coll. Nutr. , 9 : 616 – 622 .
  • Chyrek-Borowska , S. , Obrzut , D. and Hofman , J. 1978 . The relation between magnesium, blood histamine level and eosinophilia in the acute stage of the allergic reactions in humans . Arch. Immunol. Ther. Exp. , 26 : 709 – 712 .
  • Zieve , F. J. , Freude , K. A. and Zieve , L. 1977 . Effects of magnesium deficiency on protein and nucleic acid synthesis in vivo . J. Nutr. , 107 : 2178 – 2188 .
  • Günther , T. , Averdunk , R. , Wonigeit , K. and Vormann , J. 1988 . Characterization and growth-factor production of magnesium deficiency-induced malignant T-cell lymphomas . Magnesium Bull. , 10 : 22 – 26 .
  • Durlach , J. 1990 . “ Magnesium and its relationship to oncology ” . In Compendium on Magnesium and Its Role in Biology, Nutrition, and Physiology. Metal Ions in Biological Systems , Edited by: Sigel , H. and Sigel , A. Vol. 26 , 549 – 578 . New York : Marcel Dekker, Inc. .
  • Cittadini , A. , Wolf , F. I. , Bossi , D. and Calviello , G. 1991 . Magnesium in normal and neoplastic cell proliferation: state of the art on in vitro data . Magnesium Res. , 4 : 23 – 33 .
  • Young , G. A. and Parson , F. M. 1977 . The effects of dietary deficiencies of magnesium and potassium on the growth and chemistry of transplanted tumours and host tissues in the rat . Europ. J. Cancer , 13 : 103 – 113 .
  • Mills , B. J. , Broghamer , W. L. , Higgins , P. J. and Lindeman , R. D. 1984 . Inhibition of tumor growth by magnesium depletion of rats . J. Nutr. , 114 : 739 – 745 .
  • Mills , B. J. , Lindeman , R. D. and Lang , C. A. 1986 . Magnesium deficiency inhibits biosynthesis of blood glutathione and tumor growth in the rat . Proc. Soc. Exp. Biol. Med. , 181 : 326 – 332 .
  • Yan , L. , Boylan , L. M. and Spallholz , J. E. 1991 . Effect of dietary selenium and magnesium on human mammary tumor growth in athymic nude mice . Nutr. Cancer , 16 : 239 – 248 .
  • Kasprzak , K. S. , Ward , J. M. , Poirier , L. A. , Reichardt , D. A. , Denn , A. C. and Reynolds , C. W. 1987 . Nickel-magnesium interactions in carcinogenesis: dose effects and involvement of natural killer cells . Carcinogenesis , 8 : 1005 – 1011 .
  • Kasprzak , K. S. , Kiser , R. F. and Weislow , O. S. 1988 . Magnesium counteracts nickel-induced suppression of T lymphocyte response to Concanavalin A . Magnesium , 7 : 166 – 172 .
  • Chandra , S. and Chandra , R. K. 1986 . Nutrition, immune response, and outcome . Prog. Food Nutr. Sci. , 10 : 1 – 65 .
  • Chandra , R. K. and Puri , S. 1985 . Nutritional support improved antibody response to influenza virus vaccine in the elderly . Brit. Med. J. , 3 : 705 – 706 .
  • Costello , R. B. and Moser-Veillon , P. B. 1992 . A review of magnesium intake in the elderly. A cause for concern? . Magnesium Res. , 5 : 61 – 67 .
  • Lecos , C. W. 1984 . Diet and the elderly. Watch out for food drug mismatches . FDA Consumer , 18 : 7 85
  • Altura , B. M. and Altura , B. T. 1990 . “ Magnesium and the cardiovascular system: Experimental and clinical aspects updated ” . In Compendium on Magnesium and Its Role in Biology, Nutrition, and Physiology. Metal Ions in Biological Systems , Edited by: Sigel , H. and Sigel , A. 359 – 416 . New York : Marcel Dekker Inc. .
  • Abbasciano , V. , Mazzotta , D. , Vecchiatti , G. , Tassinari , D. , Nielsen , I. and Sartori , S. 1991 . Changes in serum, erythrocyte, and urinary magnesium after a single dose of cisplatin combination chemotherapy . Magnesium Res. , 4 : 123 – 125 .

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