Fat Manipulation in the Treatment of Rheumatoid Arthritis

References

• Hilliquin , P. and Menkes , C. J. 1995 . “ Rheumatoid arthritis evaluation and management: Early and late disease ” . In Practical Rheumatology , Edited by: Dieppe , P M and Klippel . London : Mosby Year Book Limited .
   Google Scholar
• Semple , E. L. 1995 . Rheumatoid arthritis: New approaches for its evaluation and management . Arch Phys Med Rehab , 76 : 190 – 210 .
   PubMed Web of Science ®Google Scholar
• Darlington , L. G. , Jump , A. and Ramsey , N. W. 1990 . Dietary treatment of rheumatoid arthritis . The Practitioner , 234 : 456 – 60 .
   PubMedGoogle Scholar
• Ryan , S. 1995 . Nutrition and the rheumatoid patient . Br J Nursing , 4 : 132 – 6 .
   PubMedGoogle Scholar
• Kremer , J. M. and Bigaouette , J. 1996 . Nutrient intake of patients with rheumatoid arthritis is deficient in pyridoxine, zinc, copper and magnesium . J Rheumatol. , 23 : 990 – 4 .
   PubMed Web of Science ®Google Scholar
• Brooks , P. M. 1994 . “ Rheumatoid arthritis: Pharmacological approaches ” . In Rheu matology , Edited by: Dieppe , P M and Klippel . London : Mosby Year Book Limited .
   Google Scholar
• Garrett , S. , Kennedy , L. and Calen , A. Patient's perceptions of disease modulation by diet in inflammatory (rheumatoid arthritis/ankylosing spondylitis) and degenerative joint disease . Br J Rheum. , 33 ( S2 ) Abstract 43
   Google Scholar
• Volker , D. H. , Major , G. A. C. and Garg , M. L. 1998 . Fat, n-6 and n-3 fatty acid intake in rheumatoid and osteoarthritis patients . Aust J Nutr Diet. , 55 : 69 – 73 .
   Google Scholar
• Dong , C. H. and Banks , J. 1975 . New Hope for the Arthritic , New York : Balllantine Publishers .
   Google Scholar
• Haugen , M. , Kjeldsen-Kragh , J. , Nordvag , B. Y. and Forre , O. 1991 . Diet and disease symptoms in rheumatic diseases-results of a questionnaire based survey . Clin Rheu-matol. , 10 : 401 – 7 .
   PubMed Web of Science ®Google Scholar
• Cleland , L. G. , Hill , C. L. and James , M. J. 1995 . Diet and arthritis . Bailliere's Clin Rheu-matol. , 9 : 771 – 5 .
   PubMed Web of Science ®Google Scholar
• Martin , R. H. 1998 . The role of nutrition and diet in rheumatoid arthritis . Proc Nutr Soc. , 57 : 231 – 4 .
   PubMed Web of Science ®Google Scholar
• Volker , D. H. and Garg , M. L. 1996 . Dietary n-3 fatty acid supplementation in rheumatoid arthritis-mechanisms, clinical outcomes, controversies and future directions . J Clin Biochem Nutr. , 20 : 83 – 97 .
   Web of Science ®Google Scholar
• James , M. J. and Cleland , L. G. 1997 . Dietary n-3 fatty acids and therapy for rheumatoid arthritis . Sem Arthritis Rheum. , 27 : 85 – 97 .
   PubMed Web of Science ®Google Scholar
• Kremer , J. M. , Michalek , A. V. , Lininger , L. , Huych , C. , Bigaouette , J. , Timchalk , M. A. , Rynes , R. I. , Zieminski , J. and Bartholomew , M. 1985 . Effects of manipulating dietary fatty acids on clinical manifestations of rheumatoid arthritis . Lancet , I : 184 – 7 .
   Google Scholar
• Kremer , J. M. , Jubiz , W. , Mickalek , A. , Rynes , R. I. , Bartholomew , M. , Bigaouette , J. , Timchalk , M. A. , Beeler , D. and Linnger , L. 1987 . Fish-oil fatty acid supplementation in active rheumatoid arthritis . Ann Intern Med. , 106 : 497 – 503 .
   PubMed Web of Science ®Google Scholar
• Sperling , R. , Weinblatt , M. , Robin , J. , Ravalese , J. I. , Hoover , R. , House , F. , Coblyn , J. S. , Fraser , P. , Spur , B. W. , Robinson , D. R. , Lewis , R. A. and Austen , K. F. 1987 . Effects of dietary supplementation with marine fish oil on leucocyte lipid mediator generation and function in rheumatoid arthritis . Arthritis Rheum. , 30 : 988 – 97 .
   PubMed Web of Science ®Google Scholar
• Cleland , L. G. , French , J. , Betts , H. W. , Murphy , G. and Elliott , M. 1988 . Clinical and biochemical effects of dietary fish oil supplements in rheumatoid arthritis . J Rheuma-tol. , 15 : 471 – 5 .
   Google Scholar
• Kremer , J. M. , Lawrence , D. A. , Jubiz , W. , Di Giacomo , R. , Rynes , R. I. , Bartholomew , L. E. and Sherman , M. 1990 . Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis: clinical and immunological effects . Arthritis Rheum. , 33 : 810 – 20 .
   PubMed Web of Science ®Google Scholar
• Van der Tempel , H. , Tulleken , J. , Limburg , P. , Muskiet , F. A. J. and Van Rijswijk , M. H. 1990 . Effects of fish oil supplementation on rheumatoid arthritis . Ann Rheum Dis. , 49 : 76 – 80 .
   PubMed Web of Science ®Google Scholar
• Tulleken , J. E. , Limburg , P. C. , Muskiet , F. AJ. and van Rijswijk , M. H. 1990 . Vitamin E status during dietary fish oil supplementation in rheumatoid arthritis . Arthritis Rheum. , 33 : 1416 – 9 .
   PubMed Web of Science ®Google Scholar
• Skoldstam , L. , Borjesson , O. , Kjallman , A. , Seiving , A. and Akensson , B. 1992 . Effect of six months of fish oil supplementation in stable rheumatoid arthritis . Scan J Rheuma-tol. , 21 : 178 – 85 .
   PubMed Web of Science ®Google Scholar
• Neilsen , G. L. , Faarvang , K. L. , Thomsen , S. H. , Teglbjaerg , K. L. , Jensen , J. T. , Hansen , T. M. , Lervang , H. H. , Schmidt , E. B. , Dyerberg , J. and Ernest , E. 1992 . The effects of dietary supplementation with n-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: A randomised double blind trial . Eur J Clin Nutr , 22 : 982 – 9 .
   Google Scholar
• Espersen , G. T. , Grunnet , N. , Lervang , H. H. , Nielsen , G. L. , Thomsen , B. S. , Faarvang , K. L. , Dyerberg , J. and Ernst , E. 1992 . Decreased interleukin-1 beta levels in plasma from rheumatoid arthritis patients after dietary supplementation with n-3 polyunsaturated fatty acids . Clin Rheumatol. , 11 : 393 – 395 .
   PubMed Web of Science ®Google Scholar
• Kjeldsen-Kragh , J. , Lund , J. A. , Riise , T. , Finnanger , B. , Haaland , K. , Finstad , R. , Mikkelsen , K. and Forre , O. 1992 . Dietary omega-3 fatty acid supplementation and naproxen treatment in patients with rheumatoid arthritis . J Rheumatol. , 19 : 1531 – 6 .
   PubMed Web of Science ®Google Scholar
• Lau , C. S. , Morley , K. D. and Belch , J. J. 1993 . Effects of fish oil supplementation on non-steroidal anti-inflammatory drug requirement in patients with mild rheumatoid ar-thritis-a double blind placebo controlled study . Br J Rheumatol. , 32 : 982 – 9 .
   PubMedGoogle Scholar
• Guesens , P. , Wouters , C. , Nijs , J. , Jiang , Y. and Dequeker , J. 1994 . Long term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis . Arthritis Rheum. , 37 : 824 – 9 .
   PubMed Web of Science ®Google Scholar
• Kremer , J. M. , Lawrence , D. A. , Petrillo , G. F. , Litts , L. L. , Mullaly , P. M. , Rynes , R. I. , Stocker , R. P. , Parhami , N. , Greenstein , N. S. , Fuchs , B. R. , Mathur , A. , Robinson , D. R. , Sperling , R. I. and Bigaouette , J. 1995 . Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal anti-inflammatory drugs: Clinical and immune correlates . Arthritis and Rheum. , 38 : 1107 – 14 .
   PubMed Web of Science ®Google Scholar
• Volker , D. H. , FitzGerald , P. E. B. , Major , G. A. C. and Garg , M. L. 2000 . Efficacy of fish oil concentrate in the treatment of rheumatoid arthritis . J Rheumatol. , in press
   PubMed Web of Science ®Google Scholar
• Belch , J. J. , Ansell , D. , Madhok , R. , O'Dowd , A. and Sturrock , R. 1988 . Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: a soluble blind placebo controlled study . Ann Rheum Dis. , 47 : 96 – 105 .
   PubMed Web of Science ®Google Scholar
• Pullman-Mooar , S. , Laposata , M. , Lem , D. , Holman , R. T. , Leventhal , L. J. , DeMarco , D. and Zurier , R. B. 1990 . Alteration of the cellular fatty acid profile and the production of eicosanoids in human monocytes by gamma-linolenic acid . Arthritis Rheum. , 33 : 1526 – 33 .
   PubMed Web of Science ®Google Scholar
• Watson , J. , Bryars , M. L. , McGill , P. and Kelman , A. W. 1993 . Cytokine and prostaglandin production by monocytes of volunteers and rheumatoid arthritis patients treated with dietary supplements of blackcurrant seed oil . Br J Rheumatol. , 32 : 1055 – 8 .
   PubMedGoogle Scholar
• Leventhal , L. J. , Boyce , E. G. and Zurier , R. B. 1993 . Treatment of rheumatoid arthritis with blackcurrant seed oil . Br Soc Rheumatol. , 33 : 847 – 52 .
   Web of Science ®Google Scholar
• Zurier , R. B. , Rossetti , R. G. , Jacobson , E. W. , DeMarco , D. M. , Lui , N. Y. , Temming , J. E. , White , B. M. and Laposata , M. 1996 . Gamma-linolenic treatment of rheumatoid arthritis: A randomised, placebo-controlled trial . Arthritis Rheum. , 39 : 1808 – 17 .
   PubMed Web of Science ®Google Scholar
• Linos , A. , Kaklamanis , E. , Kontomerkos , A. , Koumantaki , Y. , Gasi , S. , Vaiopoulos , G. , Tsokos , G. C. and Kaklamanis , P. H. 1991 . The effect of olive oil and fish consumption on rheumatoid arthritis-a case control study . Scan J Rheumatol. , 20 : 419 – 26 .
   PubMed Web of Science ®Google Scholar
• Linos , A. , Kaklamani , V. G. , Kaklamani , E. , Koumantaki , Y. , Giziaki , E. and Papazo-glou , S. 1999 . Dietary factors in relation to rheumatoid arthritis: A role for olive oil and cooked vegetables . Amer J Clin Nutr. , 70 : 1077 – 82 .
   PubMed Web of Science ®Google Scholar
• James , M. L. , Gibson , R. A. , D'Angelo , M. , Neumann , M. A. and Cleland , L. G. 1993 . Simple relationships exist between dietary linolate and the n-6 fatty acids of human neutro-phils and plasma . Am J Clin Nutr. , 58 : 497 – 500 .
   PubMed Web of Science ®Google Scholar
• Cleland , L. G. , James , M. J. , Proudman , S. M. , Neumann , M. A. and Gibson , R. A. 1994 . Inhibition of human neutrophil leukotriene B4 synthesis in rats: A novel approach to inhibition to eicosanoid synthesis . Lipids , 29 : 151 – 5 .
   PubMed Web of Science ®Google Scholar
• Lands , W. E. M. 1995 . Long-term fat intake and biomarkers . Amer J Clin Nutr. , 61 : 721S – 25S .
   Web of Science ®Google Scholar
• Sprecher , H. , Devanand , L. , Luthrea , B. S. , Mohammed , B. S. and Baykousheva , S. P. 1995 . Reevaluation of pathways for the biosynthesis of polyunsaturated fatty acids . J Lipid Res. , 36 : 2471 – 7 .
   PubMed Web of Science ®Google Scholar
• Simopoulos , A. P. 1991 . Omega-3 fatty acids in health and disease and in growth and development . Amer J Clin Nutr. , 54 : 438 – 463 .
   PubMed Web of Science ®Google Scholar
• National Research Council Committee on Diet and Health . 1989 . Diet and Health: Implications for Reducing Chronic Disease Risk , Washington , DC : National Research Council, National Academy Press . Report on Diet and Health. (2nd edition)
   Google Scholar
• Whelan , J. 1996 . Antagonistic effects of dietary arachidonic acid and n-3 polyunsat-urated fatty acids . J Nutr. , 126 : 1086S – 91S .
   PubMed Web of Science ®Google Scholar
• Hwang , D. 1989 . Essential fatty acids and immune response . FASEB J , 3 : 2052 – 61 .
   PubMed Web of Science ®Google Scholar
• Lands , W. E. M. 1991 . Biosynthesis of Prostaglandins . Ann Rev Nutr. , 11 : 41 – 60 .
   PubMed Web of Science ®Google Scholar
• Zurier , R. B. 1993 . Essential fatty acids, inflammation and immune responses . Prosta-glandins, Leukotrienes and Essential Fatty Acids , 48 : 57 – 62 .
   PubMed Web of Science ®Google Scholar
• Blok , W. L. , Katan , M. B. and van der Meer , J. W. 1996 . Modulation of inflammation and cytokine production by dietary (n-3) fatty acids . Journal of Nutrition , 126 : 1515 – 33 . 1996
   PubMed Web of Science ®Google Scholar
• Shekelle , R. B. , Missell , L. V. , Oglesby , P. , MacMillan-Shyrock , A. and Stamer , J. 1985 . Fish consumption and mortality from coronary heart disease . N Eng J Med , 313 : 820 – 31 .
   PubMedGoogle Scholar
• Recht , L. , Helin , P. , Rasmussen , J. O. , Jacobsen , J. , Lithman , T. and Schersten , B. 1990 . Hand handicap and rheumatoid arthritis in a fish-eating society (the Faroe Islands) . J Intern Med. , 227 : 49 – 55 .
   PubMed Web of Science ®Google Scholar
• Shaperio , J. A. , Koepsell , T. D. , Voight , L. , Dugawson , C. E. , Kesten , M. and Nelson , J. L. 1996 . Diet in RA in women: possible preventative effect of fish consumption . Epidemiology , 7 : 256 – 63 .
   PubMed Web of Science ®Google Scholar
• Horrobin , D. F. 1987 . Low prevalence of coronary heart disease (CHD), psoriasis, asthma and rheumatoid arthritis in Eskimos: Are they caused by high dietary intake of eicosapentaenoic acid (EPA), a genetic variation of essential fatty acid (EFA) metabolism or a combination of both? . Med Hypotheses , 22 : 421 – 8 .
   PubMed Web of Science ®Google Scholar
• Shichikawa , K. , Takenaka , Y. , Maeda , A. , Yoshino , R. , Tsujimoto , M. , Ota , H. , Kashi-wade , T. and Hongo , I. 1981 . A longitudinal population survey of rheumatoid arthritis in a rural district in Wakayama . The Ryumachi , : 35 – 43 .
   PubMedGoogle Scholar
• Roberts-Thomson , R. A. and Roberts-Thomson , P. J. 1999 . Rheumatic disease and the Australian Aborigine . Ann Rheum Dis. , 58 : 266 – 70 .
   PubMed Web of Science ®Google Scholar
• James , M. J. , Gibson , R. A. , Neumann , M. A. and Cleland , L. G. 1993 . Effect of dietary supplementation with n-9 eicosatetraenoic acid on leukotriene B4 synthesis in rats: A novel approach to inhibition of eicosanoid synthesis . J Exp Med , 178 : 2261 – 5 .
   PubMed Web of Science ®Google Scholar
• Cleland , L. G. , Gibson , R. A. , Neumann , M. A. , Hamazaki , T. , Akimoto , K. and James , M. J. 1996 . Dietary (n-9) eicosatrienoic acid from cultured fungus inhibits leukotriene B4 synthesis in rats and the effect is modified by dietary linoleic acid . J Nutr. , 126 : 1534 – 40 .
   PubMed Web of Science ®Google Scholar
• James , M. J. , Cleland , L. G. , Gibson , R. A. and Hawkes , J. S. 1991 . Interaction between fish and vegetable oils in relation to rat leucocyte leukotriene production . J Nutr. , 121 : 631 – 7 .
   PubMed Web of Science ®Google Scholar
• Raederstorff , D. , Pantze , M. , Bachmann , H. and Moser , U. 1996 . Anti-inflammatory properties of docosahexaenoic and eicosapentaenoic acids in phorbol ester induced mouse ear inflammation . Int Arch Allergy Immunol. , 111 : 284 – 90 .
   PubMed Web of Science ®Google Scholar
• Henderson , B. , Pettipher , E. R. and Higgs , G. A. 1987 . Mediators of rheumatoid arthritis . Br M Bull. , 43 : 415 – 28 .
   PubMed Web of Science ®Google Scholar
• Arend , W. P. and Dayer , J.-M. 1995 . Inhibition of the production and effects of interleu-kin-1 and tumor necrosis factor [] in rheumatoid arthritis . Arthritis Rheum. , 38 : 151 – 60 .
   PubMed Web of Science ®Google Scholar
• Endres , S. , Ghorbani , R. , Kelly , V. , Georgilis , K. , Lonnemann , G. , van der Meer , J. M. W. , Cannon , J. G. , Rogers , T. S. , Klempner , M. S. , Weber , P. C. , Schaeffer , E. J. , Wolff , S. M. and Dinarello , C. A. 1989 . The effect of dietary supplements with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumour necrosis factor by mononuclear cells . N Eng J Med. , 320 : 265 – 71 .
   PubMed Web of Science ®Google Scholar
• Meydani , S. N. , Endres , S. , Woods , M. M. , Goldin , B. R. , Soo , C. , Morill-Labrode , A. , Dinarello , C. A. and Gorbach , S. L. 1991 . Oral n-3 fatty acid supplementation suppresses cyto-kine production and lymphocyte proliferation: Comparison between younger and older women . J Nutr , 121 : 547 – 55 .
   PubMed Web of Science ®Google Scholar
• Caughey , G. E. , Mantzioris , E. , Gibson , R. A. , Cleland , L. G. and James , M. J. 1996 . The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil . Amer J Clin Nutr. , 63 : 116 – 22 .
   PubMed Web of Science ®Google Scholar
• Calder , P. C. 1997 . N-3 polyunsaturated fatty acids and cytokine production in health and disease . Ann Nutr Metab. , 41 : 203 – 34 .
   PubMed Web of Science ®Google Scholar
• Galli , C. and Marangoni , F. 1997 . Recent advances in the biology of n-6 fatty acids . Nutr , 13 : 978 – 85 .
   PubMed Web of Science ®Google Scholar
• Hurd , E. R. and Gilliam , J. N. 1981 . Benificial effect of an essential fatty acid deficient diet in NZB/NZW F1 mice . J Invest Dermatol. , 77 : 381 – 4 .
   PubMed Web of Science ®Google Scholar
• Schreiner , G. F. , Rovin , B. and Lefkowith , J. B. 1989 . The antiinflammatory effects of essential fatty acid deficiency in experimental glomerulonephritis . J Immunol. , 143 : 3192 – 9 .
   PubMed Web of Science ®Google Scholar
• Denko , C. W. 1976 . Modification of adjuvant inflammation in rats deficient in essential fatty acids . Agents Actions , 6 : 636 – 41 .
   PubMedGoogle Scholar
• Volker , D. H. , Fitz , Gerald and Garg , M. L. 2000 . Diets differing in eicosapentaenoic to docosahexaenoic acid ratios alter the pathogenesis of arthritis in Lew/SSN rats . J Nutr , in press
   PubMed Web of Science ®Google Scholar
• Lerner , R. , Windstorm , P. , Berg , A. , Johansson , E. , Rosendahl , K. and Palmblad , J. 1995 . Development and characterisation of essential fatty acid deficiency in human endo-thelial cells . Pro Natl Acad Sci USA , 92 : 1147 – 51 .
   PubMed Web of Science ®Google Scholar
• English , R. , Cashel , K. , Bennett , S. , Berzins , J. , Waters , A. and Magnus , P. 1987 . National dietary survey of adults: 1983, No 2 nutrient intakes , 1 – 55 . Canberra : Australian Government Publishing Service .
   Google Scholar
• Lubeck , D. P. 1994 . “ The economic impact of rheumatoid arthritis ” . In Rheumatoid Arthritis: Pathogenesis, Assessment, Outcomes and Treatment , Edited by: Wolfe , F and Pincus , T. New York , NY : Marcel Dekker .
   Google Scholar
• Katan , M. B. , van Birgelen , A. , Deslypere , L. P. , Penders , M. and van Staveren , W. A. 1991 . Biological markers of dietary intake with emphasis on fatty acids . Ann Nutr Metab. , 35 : 249 – 52 .
   PubMed Web of Science ®Google Scholar
• Bauer , W. 1935 . What should a patient with arthritis eat? . J Amer Med Assoc. , 105 : 1 – 6 .
   Google Scholar
• Darlington , G. 1991 . Dietary therapy for arthritis . Rheum Dis Clin N Amer. , 17 : 273 – 85 .
   PubMed Web of Science ®Google Scholar
• Panush , R. D. 1991 . Does food cause or cure arthritis? . Rheum Dis Clin N Amer. , 17 : 259 – 72 .
   PubMed Web of Science ®Google Scholar
• Darlington , L. and Ramsey , N. 1993 . Review of dietary therapy for rheumatoid arthritis . Br J Rheumatol. , 32 : 507 – 40 .
   PubMedGoogle Scholar
• Panush , R. , Carter , R. , Katz , P. , Lowsari , S. and Finnie , S. 1983 . Diet therapy for rheumatoid arthritis . Arthritis Rheum. , 26 : 426 – 69 .
   Google Scholar
• Kremer , J. M. 1997 . “ Nutrition and Rheumatic Diseases ” . In Textbook of Rheumatology 5th Ed, Vol 1 , Edited by: Kelly , W , Harris , E , Ruddy , S and Sledge , C . Philadelphia : WB Saunders .
   Google Scholar
• Day , R. O. 1988 . Mode of action of nonsteroidal anti-inflammatory drugs . Med J Aust. , 148 : 195 – 9 .
   PubMed Web of Science ®Google Scholar
• Lugea , P. , Salas , A. , Rodriguez , R. and Malagalada , J. 1993 . Influence of dietary fat on duodenal resistance to acid . Gut , 34 : 1301 – 9 .
   Web of Science ®Google Scholar
• Felson , D. T. , Anderson , J. J. , Boers , M. , Bombardier , C. , Furst , D. and Goldsmith , C. 1995 . Katz, LM, Lightfoot RJ, Paulus H, Strand V, Tugwell P, Weinblatt M, Williams JH, Wolfe F, and Kieszak S. American College of Rheumatology Preliminary Definition of Improvement in Rheumatoid Arthritis . Arthritis Rheum. , 38 : 727 – 35 .
   PubMed Web of Science ®Google Scholar
• Fontana , A. , Hentgartner , H. , Fehr , K. , Grob , P. J. and Cohen , G. 1982 . IL-1 activity in syn-ovial fluid of patients with rheumatoid arthritis . Rheumatol Int. , 2 : 49 – 56 .
   PubMed Web of Science ®Google Scholar
• Di Govine , D. , Nuki , G. and Duff , G. W. 1988 . Tumor necrosis factor in synovial ex-udates . Ann Rheum Dis. , 47 : 768 – 72 .
   PubMed Web of Science ®Google Scholar
• Firestein , G. S. , Alvaro-Garcia , J. M. and Maki , R. 1990 . Quantitative analysis of cyto-kine gene expression in rheumatoid arthritis . J Immunol. , 144 : 3347 – 53 .
   PubMed Web of Science ®Google Scholar
• Brennan , F. M. , Zachariae , C. O. , Chantry , D. , Larsen , C. G. , Turner , M. , Maini , R. N. , Matsushima , K. and Feldmann , M. 1990 . Detection of IL-8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of IL-8 in RNA by isolated synovial cells . Eur J Immunol. , 20 : 2141 – 4 .
   PubMed Web of Science ®Google Scholar
• Katsikis , P. , Chu , C. Q. , Brennan , F. M. , Maini , R. N. and Feldmann , M. 1994 . Immunoregu-latory role of IL-10 in rheumatoid arthritis . J Exp Med. , 179 : 1517 – 27 .
   PubMed Web of Science ®Google Scholar
• Felson , D. T. , Anderson , J. J. , Boers , M. , Bombardier , C. , Chernoff , M. , Fried , B. , Furst , D. , Goldsmith , C. , Kieszak , S. , Lightfoot , R. , Paulus , H. , Tugwell , P. , Weinblatt , M. , Wid-mark , R. , Williams , H. J. and Wolfe , F. 1993 . The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials . Arthritis Rheum. , 36 : 729 – 40 .
   PubMed Web of Science ®Google Scholar
• Arnett , F. C. , Edworthy , S. M. and Bloch , D. A. 1988 . The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis . Arthritis Rheum. , 31 : 315 – 24 .
   PubMed Web of Science ®Google Scholar
• Helliwell , M. , Coombes , E. J. , Moody , B. J. , Batstone , G. F. and Robertson , J. C. 1984 . Nutritional status in patients with rheumatoid arthritis . Ann Rheum Dis. , 43 : 386 – 90 .
   PubMed Web of Science ®Google Scholar
• Roubenoff , R. , Roubenoff , R. A. and Cannon , J. G. 1994 . Rheumatoid cachexia: Cytokine driven hypermetabolism accompanying reduced body cell mass in chronic inflammation . J Clin Invest. , 93 : 2379 – 86 .
   PubMed Web of Science ®Google Scholar
• Dijkmans , B. C. 1995 . Folate supplementation and methotrexate . Br J Rheumatol. , 34 : 1172 – 4 .
   PubMedGoogle Scholar
• Kremer , J. M. 1997 . Is Methotrexate oncogenic in patients with rheumatoid arthritis? . Sem Arthritis Rheum. , 26 : 785 – 7 .
   PubMed Web of Science ®Google Scholar
• DiToro , R. and Polito , C. 1997 . Nutrition in juvenile rheumatoid arthritis . Nutr Res. , 17 : 741 – 58 .
   Web of Science ®Google Scholar
• Sahud , M. A. and Cohen , R. 1971 . Effect of aspirin ingestion on ascorbic acid levels in rheumatoid arthritis . Lancet , 1 : 937 – 41 .
   PubMed Web of Science ®Google Scholar
• Whitehouse , M. W. , Rainsford , K. D. , Taylor , R. M. and Vernon-Roberts , B. 1990 . Zinc monoglycerolate: A slow release source of zinc with anti-arthritic activity in rats . Agents Actions , 31 : 47 – 53 .
   PubMedGoogle Scholar
• Whitehouse , M. W. 1991 . “ Trace element supplements for inflammatory disease ” . In Second Line Agents in the Rheumatic Diseases , Edited by: Dixon , J and Furst , D . New York , NY : Marcel Dekker .
   Google Scholar
• Parke , A. L. , Parke , D. V. and Jones , F. A. 1996 . Diet and nutrition in rheumatoid arthritis and other chronic inflammatory diseases . J Clin Biochem Nutr. , 20 : 1 – 6 .
   Web of Science ®Google Scholar
• Hansen , G. V. , Neilsen , L. , Kluger , E. , Thysen , M. , Emmertsen , H. , Stengaard-Peder-sen , K. , Hansen , E. L. , Unger , B. and Andersen , P. W. 1996 . Nutritional status of Danish rheumatoid arthritis patients and effects of diet adjusted in energy intake, fish meal and anti-oxidants . Scand J Rheumatol. , 25 : 325 – 30 .
   PubMed Web of Science ®Google Scholar
• Morgan , S. L. , Anderson , A. M. , Hood , S. M. , Matthews , A. , Lee , J. Y. and Alarcon , G. S. 1997 . Nutrient intake patterns, body mass index and vitamin levels in patients with rheumatoid arthritis . Arthritis Care Res. , 10 : 9 – 19 .
   PubMed Web of Science ®Google Scholar
• Mera , S. L. 1994 . Diet and disease . Br J Biomed Sc. , 51 : 189 – 206 .
   PubMed Web of Science ®Google Scholar
• Mangge , H. , Hermann , J. and Schauenstein , K. 1999 . Diet and rheumatoid arthritis-a review . Scan J Rheumatol. , 28 : 201 – 9 .
   PubMed Web of Science ®Google Scholar
• Edmonds , S. E. , Winyard , P. G. , Guo , R. , Kidd , B. , Merry , P. , Langrish-Smith , A. , Han-sen , C. , Ramm , S. and Blake , D. R. 1997 . Putative analgesic activity of repeated oral doses of Vitamin E in the treatment of rheumatoid arthritis. Results of a prospective placebo controlled double blind trial . Ann Rheum Dis. , 56 : 649 – 55 .
   PubMed Web of Science ®Google Scholar
• Heliovaara , M. , Knekt , P. , Aho , K. , Aaran , R.-K. , Alfthan , G. and Aromaa , A. 1994 . Serum antioxidants and risk of rheumatoid arthritis . Ann Rheum Dis. , 53 : 51 – 3 .
   PubMed Web of Science ®Google Scholar
• James , M. J. , Cleland , L. G. and Gibson , R. A. 1992 . Inhibition of human neutrophil leuko-triene B4 synthesis by combination auranofin and eicosapentaenoic acid . Biochem Pharmacol. , 43 : 695 – 700 .
   PubMed Web of Science ®Google Scholar
• Prashker , K. J. and Meenan , R. F. 1995 . The total cost of drug therapy for rheumatoid arthritis: A model based on costs of drug monitoring and toxicity . Arthritis Rheum. , 38 : 318 – 25 .
   PubMed Web of Science ®Google Scholar