18
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

Randomized Salvage Therapy with Saquinavir-Ritonavir versus Saquinavir-Nelfinavir for Highly Protease Inhibitor-Experienced HIV-Infected Patients

, , , , , , , , & show all
Pages 408-412 | Published online: 14 Jan 2015

REFERENCES

  • Deeks S, Hecht F, Swanson M. HIV RNA and CD4 cell count response to protease inhibitor therapy in an urban AIDS clinic. AIDS. 1999;13:F35–F43.
  • Girard P, Guiguet M, Bollens D, et al., and the Triest Cohort Investigators. Long-term outcome and treatment modifica-tions in a prospective cohort of human immunodeficiency virus type 1 infected patients on triple-drug antiretroviral regimens. Clin Infect Dis. 2000;31:987–994.
  • Mocroft A, Youle M, Moore A, et al. Reasons for modifica-tion and discontinuation of antiretrovirals: Results from a single treatment centre. AIDS. 200115: 185–194.
  • Carpenter C, Cooper D, Fischl M, et al. Antiretroviral therapy in adults. Updated recommendations of the Inter-national AIDS Society-USA panel. JAMA. 2000;283:381–390.
  • Deeks S, Hellman N, Grant R. Novel four-drug salvage treatment regimens after failure of a human immunodefi-ciency virus type 1 protease inhibitor-containing regimen. J Infect Dis. 1999;179:1375–1381.
  • Mocroft A, Phillips A, Miller V, et al., EuroSida Study Group. The use of and response to second-line protease inhibitor regimens: Results from the EuroSIDA study. AIDS. 2001;15:201–209.
  • Garaffo R, Durant J, Clevenbergh P. Relevance of protease inhibitor plasma levels in patients treated with genotypic adapted therapy [abstract]. Antiviral Ther. 1999;4\(Suppl 1):75. Abstract 109.
  • Havlir D, Hellmann N, Petropoulos C, et al. Drug suscepti-bility in HIV infection after viral rebound in patients receiv-ing indinavir-containing regimens. JAMA. 2000;283:229–234.
  • Hirsch M, Brun-Vezinet F, D'Aquila R, et al. Antiretroviral drug resistance testing in adult HIV-1 infection. Recom-mendation of an International AIDS Society-USA panel. JAMA. 2000;283:2417–2426.
  • Lorenzi P, Opravil M, Hirschel B. Impact of drug resistance mutations on virologic response to salvage therapy. AIDS. 1999;13:F17–F21.
  • Zolopa A, Schafer R, Warlord A. HIV-1 genotypic resis-tance patterns predict response to saquinavir-ritonavir therapy in patients in whom previous protease inhibitor therapy has failed. Ann Intern Med. 1999;131(11):813–821.
  • Yahi N, Tamalet C, Tourres C, et al. Mutation patterns of the reverse transcriptase and protease genes in human immunodeficiency virus type 1-infected patients undergo-ing combination therapy: Survey of 787 sequences. J Clin Microbiol. 1999;37:4099–4106.
  • Boden D, Hurley A, Zhang L, et al. HIV-1 drug resistance in newly infected individuals. JAMA. 1999;282:1135–1141.
  • Tremblay C, Merrill D, Chou T, Hirsch M. Interactions among combinations of two and three protease inhibitors against drug-susceptible and drug-resistant HIV-1 iso-lates. J Acquir Immune Defic Syndr. 1999;22:430–436.
  • Nascimbeni M, Lamotte C, Peytavin G, Farinotti R, Clavel F. Kinetics of antiviral activity and intracellular pharmacoki-netics of human immunodeficiency virus type 1 protease inhibitors in tissue culture. Antimicrob Agents Chemother. 1999;43:2629–2634.
  • Kempf D, Marsh K, Kumar G, et al. Pharmacokinetic en-hancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir. Antimicrob Agents Chemother. 1997;71:654–660.
  • Rockstroh J, Altfeld M, Kupfer B, et al. Failure of double protease inhibitor therapy as a salvage therapy for HIV-infected patients resistant to conventional triple therapy. Eur J Med Res. 1999;4:271–274.
  • Rodriguez-Rosado R, Soriano V, Barreiro P, Dona C, Gonzalez-Lahoz J. What dual protease inhibitor combina-tion for salvage therapies? AIDS. 1999;13:2180–2181.
  • Hoffmann F, Notheis G, Wintergerst U, Eberle J, Glitter L, Belohradsky B. Comparison of ritonavir plus saquinavir and nelfinavir plus saquinavir-containing regimens as sal-vage therapy in children with human immunodeficiency type 1 infection. Pediatr Infect Dis J. 2000;19:47–51.
  • Kirk O, Katzenstein T, Gerstoft J, et al. Combination therapy containing ritonavir plus saquinavir has superior short-term antiretroviral efficacy: A randomized trial. AIDS. 1999;13:F9–F16.
  • Tebas P, Patick A, Kane F, et al. Virologic responses to a ritonavir-saquinavir-containing regimen in patients who previously failed nelfinavir. AIDS. 1999;13:F23–F28.
  • Moyle G, Pozniak A, Opravil M, et al. The SPICE Study: 48-week activity of combinations of saquinavir soft gelatin and nelfinavir with and without nucleoside analogues. J Acquir Immune Defic Syndr. 2000;23:128–137.
  • Durant J, Clevenbergh P, Garraffo R, et al. Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: Pharmacological data from the Viradat Study. AIDS. 2000;14:1333–1339.
  • Cozzi Lepri A, Miller V, Phillips A, Rabenau H, Sabin C, Staszewski S. The virological response to highly active antiretroviral therapy over the first 24 weeks of therapy according to the pre-therapy viral load and the weeks 4-8 viral load. AIDS. 2001;15:47–54.
  • Montaner J, Harrigan P, Jahnke N, et al. Multiple drug rescue therapy for HIV-infected individuals with prior viro-logic failure to multiple regimens. AIDS. 200115: 61–69.
  • Paredes R, Puig Y, Arno A, et al. High-dose saquinavir plus ritonavir: Long term efficacy in HIV-positive protease in-hibitor-experienced patient(s) and predictors of virologic response. J Acquir Immune Defic Syndr. 1999;22:194–195.
  • Mocroft A, Devereux H, Kinloch-de-Loes S, et al., Royal Free Centre for HIV Medicine. Immunological, virological and clinical response to highly active antiretroviral therapy treatment regimens in a complete clinic population. AIDS. 2000;14:1545–1552.
  • Piroth L, Grappin M, Weidner A, et al. Discontinuation of protease inhibitors due to intolerance: A longitudinal study of 309 HIV-1 positive patients. La Presse Médicale. 1999;28:381–387.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.