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HIV Clinical Trials Volume 11, 2010 - Issue 1
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Brief reports

Memantine for AIDS Dementia Complex: Open-Label Report of ACTG 301

Yu ZhaoHarvard School of Public Health Boston, Massachusetts, USACorrespondence[email protected]
,
Bradford A. NaviaTufts University School of Medicine Boston, Massachusetts, USA
,
Christina M. MarraUniversity of Washington, Seattle, Washington, USA
,
Elyse J. SingerUCLA Medical Center Los Angeles, California, USA
,
Linda ChangJohn A. Burns School of Medicine University of Hawaii, Honolulu, Hawaii, USA
,
Joseph BergerUniversity of Kentucky Medical Center, Lexington, Kentucky, USA
,
Ronald J. EllisUniversity of California at San Diego, San Diego, California, USA
,
Dennis L. KolsonUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA
,
David SimpsonMount Sinai School of Medicine, New York, New York, USA
,
Eric N. MillerUCLA Semel Institute for Neuroscience, Los Angeles, California, USA
,
Stuart A. LiptonSanford-Burnham Medical Research Institute and University of California, San Diego, La Jolla, California, USA
,
Scott R. EvansHarvard School of Public Health Boston, Massachusetts, USA
,
Giovanni SchifittoUniversity of Rochester, Rochester, New York, USA
& Adult AIDS Clinical Trial Group (ACTG) 301 Team show all
Pages 59-67 | Published online: 06 Jan 2015

REFERENCES

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  • Dore GJ, Correll PK, Li Y, Kaldor JM, Cooper DA, Brew BJ. Changes to AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS. 1999;13:1249–1253.
  • Sacktor N, McDermott MP, Marder K, et al. HIV-associated cognitive impairment before and after the advent of com-bination therapy. J NeuroViroL 2002;8:136–142.
  • Neuenburg JK, Brodt HR, Herndier BG, et al. HIV-related neuropathology, 1985 to 1999: rising prevalence of HIV encephalopathy in the era of highly active antiretro-viral therapy. J Acquir Immune Defic Syndr. 2002;31: 171–177.
  • Simioni S, Cavassini M, Annoni JM, et al. Cognitive dys-function in HIV patients despite long-standing suppression of viremia. AIDS. 2009 Dec 7. [Epub ahead of print]. PMID: 19996937
  • Reisberg B, Doody R, Stoffler A, et al. Memantine in moderate-to-severe Alzheimer's disease. N Engl J Med. 2003;348:1333–1341.
  • Tariot PN, Farlow MR, Grossberg GT, Graham SM, McDonald S, Gergel I. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. JAMA. 2004;291: 317–324.
  • Toggas SM, Masliah E, Mucke L. Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antago-nist memantine. Brain Res. 1996;706:303–307.
  • Lipton SA. Memantine prevents HIV coat protein-induced neuronal injury in vitro. Neurology. 1992;42:1403–1405.
  • Nath A, Haughey NJ, Jones M, Anderson C, Bell JE, Geiger JD. Synergistic neurotoxicity by Human Immunodeficiency Virus proteins Tat and gp120: protection by memantine. Ann NeuroL 2000;47:186–194.
  • Anderson ER, Gendelman HE, Xiong H. Memantine pro-tects hippocampal neuronal function in murine human immunodeficiency virus type 1 encephalitis. J Neurosci. 2004;24:7194–7198.
  • Schifitto G, Navia BA, Yiannoutsos CT, et al. Memantine and HIV-associated cognitive impairment: a neuropsy-chological and proton magnetic resonance spectroscopy study. AIDS. 2007;21:1877–1886.
  • Price RW, Sidtis JJ. Evaluation of the AIDS dementia com-plex in clinical trials. J Acquir Immune Defic Syndr 1990; 3 (Suppl 2)

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