4
Views
0
CrossRef citations to date
0
Altmetric
Biology

Activation of EGFR, AKT and ERK1/2 by Exposure to Tritiated Water in Human Tumor Cells

, , &
Pages 1190-1192 | Published online: 07 Apr 2017

References

  • H. TAUCHI, M. ICHIMASA, Y. ICHIMASA, T. SHIRAISHI, K. MORISHIMA, S. MATSUURA, K. KOMATSU, Studies of mutagenesis caused by low dose rate tritium radiation using a novel hyper-sensitive detection system. Fusion Sci Technol, 41, 413 (2002).
  • T. UMATA, N. KUNUGITA, T. NORIMURA,A comparison of the mutagenic and apoptotic effects of tritiated water and acute or chronic caesium-137 gamma exposure on spleen T lymphocytes on normal and p53-deficient mice. Int J Radiat Biol, 85, 1082 (2009).
  • T. SHIMURA, S. KAKUDA, Y. OCHIAI, H. NAKAGAWA, Y. KUWAHARA, Y. TAKAI, J. KOBAYASHI, K. KOMATSU, M. FUKUMOTO, Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3beta-mediated cyclin D1 overexpression. Oncogene, 29, 4826–37 (2010).
  • L. BOZULIC, B. SURUCU, D. HYNX, B. A. HEMMINGS, PKB alpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol Cell, 30:203–13 (2008).
  • H. C. LEE, S. AN, H. LEE, S. H. WOO, H. O. JIN, S. K. SEO, T. B. CHOE, D. H. YOO, S. J. LEE, Y. J. HONG, M. J. PARK, C. H. RHEE, I. C. PARK and S. I. HONG, Activation of epidermal growth factor receptor and its downstream signaling pathway by nitric oxide in response to ionizing radiation. Molecular Cancer Res, 6, 996 (200).
  • Z. P. LI, Y. HOSOI, K. S. CAI, Y. TANNO, Y. MATSUMOTO, A. ENOMOTO, A. MORITA, K. NAKAGAWA, K. MIYAGAWA, Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation. Biochem Biophys Res Comm, 341, 363 (2006).
  • C. RETY, R. GILBIN, E. GOMEZ, Induction of reactive oxygen species and algal growth inhibition by tritiated water with or without copper. Environ Toxicol. n/a. doi: 10.1002/tox.20626
  • J. DONG, S. RAMACHANDIRAN, K. TIKOO, Z. JIA, S. S. LAU, T. J. MONKS, EGFR-independent activation of p38 MAPK and EGFR-dependent activation of ERK1/2 are required for ROS-induced renal cell death. American Journal of Physiology-Renal Physiology A. 2004;287:F1049–F58.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.