Dose Response in Radiation-Induced Human Carcinogenesis: Accumulated Data Do Not Yet Solve the Enigma

References

• BEIR III, Committee on the Biological Effects of Ionizing Radiations, National Research Council, The Effects on Populations of Exposure to Low Levels of Ionizing Radiation, National Academy Press, Washington, D.C. (1980).
   Google Scholar
• JOHN CAIRNS, “The Origin of Human Cancers,” Nature, 289, 353 (1981).
   Google Scholar
• “Two Views of the Causes of Cancers,” Nature, 289, 431 (1981).
   Google Scholar
• S. S. EPSTEIN and J. B. SWARTZ, “Fallacies of Lifestyle Cancer Theories,” Nature, 289, 127 (1981).
   PubMed Web of Science ®Google Scholar
• K. ILLMENSEE and L. C. STEVENS, “Teratomas and Chimeras,” Sci. Am., 240, 121 (1979).
   Google Scholar
• A. C. UPTON, “Radiobiological Effects of Low Doses. Implications for Radiological Protection,” Radiat. Res., 71, 51 (1977).
   PubMed Web of Science ®Google Scholar
• CHARLES E. LAND, “Estimating Cancer Risks from Low Doses of Ionizing Radiation,” Science, 209, 1197 (1980).
   PubMed Web of Science ®Google Scholar
• A. M. KELLERER and H. H. ROSSI, “The Theory of Dual Radiation Action,” Radiat. Res., Q.8, 85 (1972).
   Google Scholar
• A. M. KELLERER and H. H. ROSSI, “A Generalized Formulation of Dual Radiation Action,” Radiat. Res., 75, 471 (1978).
   Web of Science ®Google Scholar
• B. A. BRIDGES and D. G. HARNDEN, “Untangling Ataxia-telangiectasia,” Nature, 289, 222 (1981).
   Google Scholar
• A. F. COHEN and B. L. COHEN, “Tests of the Linearity Assumption in the Dose-Effect Relationship for Radiation Induced Cancer,” Health Phys., 38, 53 (1980).
   Google Scholar
• R. B. McPHERSON, “Environmental Radon and Radon Dosimetry in the Respiratory Tract,” Health Phys., 39, 929 (1980).
   Google Scholar
• V. E. ARCHER, E. P. RADFORD, O. AXELSON, and H. JORGENSEN, “Frequency of Different Histological Types of Bronchiogenic Carcinoma as Related to Radiation Exposure,” Cancer, 34, 2056 (1974).
   PubMedGoogle Scholar
• National Research Council, Advisory Committee on the Biological Effects of Ionizing Radiations, The Effects of Ionizing Radiation, National Academy of Sciences, Washington, D.C. (1972).
   Google Scholar
• R. D. EVANS, J. H. HARLEY, W. JACOBI, A. S. McLEAN, W. A. MILLS, and C. G. STEWART, “Estimate of Risk from Environmental Exposure to Radon-222 and Its Decay Products,” Nature, 290, 98 (1981).
   PubMed Web of Science ®Google Scholar
• United Nations Scientific Committee on the Effects of Atomic Radiation, “Ionizing Radiation: Sources and Biological Effects,” United Nations, New York (1982).
   Google Scholar
• C. D. HOLLOWELL, M. L. BOEGEL, J. G. INGERSOLL, and W. G. NAZAROFF, “Radon-222 in Energy Efficient Buildings,” Trans. Am. Nucl. Soc., 33, 148 (1979).
   Google Scholar
• BERNARD L. COHEN, “Health Effects of Radon from Insulation of Buildings,” Health Phys., 39, 937 (1980).
   PubMedGoogle Scholar
• S. FINCH and H. B. HAMILTON, “Atomic Bomb Radiation Studies in Japan,” Science, 192, 4242, 845 (1976).
   Google Scholar
• W. J. SCHULL, M. OTAKE, and J. V. NEAL, “Genetic Effects of the Atomic Bombs: A Reappraisal,” Science, 213, 1220 (1981).
   PubMed Web of Science ®Google Scholar
• S. OKADA, H. B. HAMILTON, N. EGAMI, S. OKAJIMA, W. J. RUSSELL, and K. TAKESHITA, “A Review of Thirty Years Study of Hiroshima and Nagasaki Atomic Bomb Survivors,” J. Radiat. Res. (Tokyo), 16 (Supplement), 1 (1975).
   Google Scholar
• E. MARSHALL, “New A-Bomb Studies Alter Radiation Estimates,” Science, 212, 900 (1981).
   Google Scholar
• E. MARSHALL, “New A-Bomb Data Shown to Radiation Experts,” Science, 212, 1364 (1981).
   Google Scholar
• W. LOEWE and E. MENDELSOHN, “Revised Dose Estimates at Hiroshima and Nagasaki,” Health Phys., 41, 663 (1981).
   PubMedGoogle Scholar
• T. STRAUME and R. L. DOBSON, “Implications of New Hiroshima and Nagasaki Dose Estimates: Cancer Risks and Neutron RBE,” Health Phys., 41, 666 (1981).
   Google Scholar
• W. E. LOEWE and E. MENDELSOHN, “Radiation Estimates,” Science, 213, 6 (1981).
   Google Scholar
• M. ICHIMARU, T. ISHIMARU, and J. L. BELSKY, “Incidence of Leukemia in Atomic Bomb Survivors Belonging to a Fixed Cohort in Hiroshima and Nagasaki, 1950–71. Radiation Dose, Years After Exposure, Age at Exposure, and Type of Leukemia,” J. Radiat. Res. (Tokyo), 19, 262 (1978).
   Google Scholar
• B. MacMAHON, “Prenatal X-Ray Exposure and Childhood Cancer,” J. Natl. Cancer Inst., 28, 1173 (1962).
   PubMed Web of Science ®Google Scholar
• A. STEWART and G. W. KNEALE, “Radiation Dose Effects in Relation to Obstetric X-Rays and Childhood Cancers,” Lancet, 1, 1185 (1970).
   PubMed Web of Science ®Google Scholar
• E. SHORE, L. H. HEMPELMANN, E. KOWALUK, P. S. MANSUR, B. S. PASTERNACK, R. E. ALBERT, and G. E. HAUGHIE, “Breast Neoplasma in Women Treated with X-Rays for Acute Postpartum Mastitis,” J. Natl. Cancer Inst., 59, 813 (1977).
   PubMed Web of Science ®Google Scholar
• P. G. SMITH and R. DOLL, “Age- and Time-Dependent Changes in the Rates of Radiation-Induced Cancers in Patients with Ankylosing Spondylitis Following a Single Course of X-Ray Treatment,” Late Biological Effects of Ionizing Radiation, p. 205, International Atomic Energy Agency, Vienna (1978).
   Google Scholar
• R. E. SHORE, R. E. ALBERT, and B. S. PASTERNACK, “Follow-Up Study of Patients Treated by X-Ray Epilation for Tinea Capitis,” Arch. Environ. Health, 31, 17 (1976).
   Google Scholar
• “Interagency Task Force on the Health Effects of Ionizing Radiation Report of the Work Group on Science,” U.S. Department of Health, Education, and Welfare, Washington, D.C. (1979).
   Google Scholar
• J. D. BOICE, Jr., C. E. LAND, R. E. SHORE, J. E. NORMAN, and M. TOKUNAGA, “Risk of Breast Cancer Following Low-Dose Exposure,” Radiology, 131, 589 (1979).
   PubMed Web of Science ®Google Scholar
• C. J. SHELLABARGER, R. D. BROWN, A. R. RAO, J. P. SHANLEY, V. P. BOND, A. M. KELLERER, H. H. ROSSI, L. J. GOODMAN, and R. E. MILLS, “Rat Mammary Carcinogenesis Following Neutron or X-Radiation,” Biological Effects of Neutron Irradiation, p. 391, International Atomic Energy Agency, Vienna (1974).
   Google Scholar
• L. J. DeGROOT, L. A. FROHMAN, E. L. KAPLAN, and S. R. REFETOFF, Eds., Radiation-Associated Thyroid Carcinoma, Grune & Stratton, New York (1977).
   Google Scholar
• R. E. SHORE, E. D. WOODARD, B. S. PASTERNACK, and L. H. HEMPELMANN, “Radiation and Host Factors in Human Thyroid Tumors Following Thymus Irradiation,” Health Phys., 38, 451 (1980).
   Google Scholar
• T. F. MANCUSO, A. STEWART, and G. KNEALE, “Radiation Exposures of Hanford Workers Dying from Cancer and Other Causes,” Health Phys., 33, 369 (1977).
   PubMed Web of Science ®Google Scholar
• National Research Council, Advisory Committee on the Biological Effects of Ionizing Radiations, The Effects on Populations of Exposure to Low Levels of Ionizing Radiation, National Academy of Sciences, Washington, D.C. (1972).
   Google Scholar
• E. S. GILBERT and S. MARKS, “Cancer Mortality in Hanford Workers,” Radiat. Res., 79, 122 (1979).
   PubMed Web of Science ®Google Scholar
• G. B. HUTCHINSON, B. MacMAHON, S. JABLON, and C. E. LAND, “Review of Report by Mancuso, Stewart, and Kneale of Radiation Exposure of Hanford Workers,” Health Phys., 37, 207 (1979).
   PubMed Web of Science ®Google Scholar
• T. NAJARIAN and T. COLTON, “Mortality from Leukemia and Cancer in Shipyard Nuclear Workers,” Lancet, 1, 1018 (1978).
   PubMed Web of Science ®Google Scholar
• J. L. LYON, M. R. KLAUBER, J. W. GARDNER, and K. S. UDALL, New England J. Med, 300, 397 (1979).
   PubMed Web of Science ®Google Scholar
• BERNARD L. COHEN, “The Cancer Risk from Low-Level Radiation,” Health Phys., 39, 659 (1980).
   Google Scholar
• DAVID DICKSON, “Melanoma Increase in Radiation Labs?,” Nature, 287, 475 (1980).
   Google Scholar
• UNSCEAR 77 United Nations Scientific Committee on Effects of Atomic Radiation, “Sources and Effects of Ionizing Radiation,” United Nations, New York (1977).
   Google Scholar
• M. W. CHARLES and PATRICIA J. LINDOP, “Risk Assessment Without the Bombs,” J. Soc. Radiolog. Protection, 1, 15 (1981).
   Google Scholar
• International Commission on Radiological Protection, Limits for Intake of Radionuclides by Workers, A Report by Committee 2, Pergamon Press, New York (1978).
   Google Scholar
• ARTHUR C. UPTON, “The Biological Effects of Low-Level Ionizing Radiation,” ScL Am., 246, 29 (1982).
   Google Scholar
• G. J. BRISCOE, “Futility of Epidemiological Studies of Radiation Effects,” Health Phys., 38, 863 (1980).
   Google Scholar
• KARL Z. MORGAN, “How Dangerous Is Low-Level Radiation?,” New Scientist, 82, 18 (1979).
   Google Scholar
• BERNARD L. COHEN, “Society’s Valuation of Life Saving in Radiation Protection and Other Contexts,” Health Phys., 38, 33 (1980).
   PubMedGoogle Scholar
• GIO BATTA GORI, “The Regulation of Carcinogenic Hazards,” Science, 208, 256 (1980).
   Google Scholar