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Review

Epothilones and their analogues - a new class of promising microtubule inhibitors

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Pages 951-968 | Published online: 25 Feb 2005

Bibliography

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  • •This paper is the first to demonstrate that the cytotoxicity of epothilones is based on a paclitaxel-like mechanism of action.
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  • •A thoroughreviewofthebiologicalpropertiesofepothilonesA andB.
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  • ••The paper describes an ingenious methodfortheconversionofepothilonesA andB into the corresponding lactam analogs. In addition, it contains the first biological dataforBMS247550.
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  • •An important SAR paper,whichclarifiedthe significance of the epoxide oxygen for biological activity.
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