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Miscellaneous

Water-soluble trioxanes as potent and safe antimalarial agents

Pages 1351-1354 | Published online: 25 Feb 2005

Bibliography

  • News from the WHO Division of Control of Tropical Diseases. TDR News (1994) 46:5.
  • FOLEY M, TILLEY L: Quinoline antimalarials: mechanisms of action and resistance. Int. j Parasite' (1997) 27:213–240.
  • UN AJ, LEE M, KLAYMAN, DL: Antimalarial activity of new water-soluble dihydroartemisinin derivatives 1. 1 Med. Chem. (1987) 30:2147–2150.
  • •An important paper detailing the first attempts at producing more stable analogues of artesunate.
  • UN AJ, ZIKRY, AB, KYLE, DE: Antimalarial activity of new dihydroartemisinin derivatives. 7. 4-(p-substituted phenyl)-4(R or .-[10a or 13- dihydroartemisinoxylbutyric Acids. j. Med. Chem. (1997) 40:1396–1400.
  • •An interesting paper which deals with the preparation of more stable analogues of artelinic acid (sodium artesuriate).
  • PETERS W, ROBINSON BL, TOVEY G et ai. The chemotherapy of rodent malaria 50. The activities of some synthetic 1,2,4-trioxanes against chloroquine-sensitive and chloroquine-resistant parasites 3. Observations on fenozan-50f, a difluorinated 3,3'-spirocyclopentane 1,2,4-trioxane. Ann. Trap. Med. Parasit. (1993) 87(2):111–123.
  • VENNERSTROM JL, DONG YX, ANDERSEN SL et al: Synthesis and antimalarial activity of sixteen dispiro-12,4,5-tetraoxanes: alkyl-substituted 7,8,15,16 tetraoxadispiro [5.2. 5. 21hexadecanes. j Med. Chem. (2000) 43(14):2753–2758.
  • MCCULLOUGH KJ, WOOD JK, BHATTACHARJEE AK et al.: Methyl-substituted dispiro-1,2,4,5-tetraoxanes: correlations of structural studies with antimalarial activity. I Med. Chem. (2000) 43(6):1246–1249.
  • JAQUET C, STOHLER HR, CHOLLET J, PETERS W: Antimalarial activity of the bicyclic peroxide ro-42-1611 (arteflene) in experimental-models. Trap. Med. Parasite" (1994) 45(3):266–271.
  • POSNER GH, CUMMING JN, WOO S-H, PLOYPRADITH P, XIE S, SHAPIRO TA: Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation. I Med. Chem. (1998) 41:940–951.
  • •Full chemical and biological details of the C-3-aryl class of trioxanes. The paper also discusses mechanisms of antimalarial activity.
  • CUMMING JN, PLOYPRADITH P, POSNER GH: Antimalarial activity of 1353 Expert Op/n. Ther. Patents (2001)11(8) artemisinin (quinghaosu) and related trioxanes: mechanism(s) of action. Adv. Pharmacol (1997) 37:2253–2297.
  • ••An excellent review from a chemicalperspective.
  • POSNER GH: Antimalarial peroxides in the qinghaosu (artemisinin) and yingzhaosu families. Expert Opin. Ther. Patents (1998) 8(11):1487–1493.
  • ••An excellent review that focuses on semi-synthetic and synthetic antimalarial peroxides worthy of further development.

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