Bibliography
- FLEGAL K, CARROLL MS, OGDEN CL, JOHNSON CL: Prevalence and trends in obesity among US adults, 1999-2000. JAMA (2002) 288: 1723-1727.
- KOPELMAN PG: Obesity as a medical problem. Nature (2000) 404:635–643.
- GURA T: Obesity drug pipeline not so fat. Science (2003) 299:849–852.
- BROWNING A: Recent developments in the discovery of melanin-concentrating hormone antagonists: novel antiobesity agents. Expert Opin. Ther. Patents (2004) 14:313–325.
- KOWALSKI TJ, McBRIAR MD: Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity. Expert Opin. Investig Drugs (2004) 13:1113–1122.
- CARPENTER AJ, HERTZOG DL: Melanin-concentrating hormone receptor antagonists as potential antiobesity agents. Expert Opin. Ther. Patents (2002) 12:1639–1646.
- BOUTIN JA, SUPLY T, AUDINOT V et al.: Melanin-concentrating hormone and its receptors: state of the art. Can. J. Physiol. Pharmacol. (2002) 80:388–385.
- HERVIEU G: Melanin-concentrating hormone functions in the nervous system: food intake and stress. Expert Opin. Ther. Targets (2003) 7:495-5n.
- QU D, LUDWIG DS, GAMMELTOFT S et al.: a role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature (1996) 380:243.
- SHIMADA M, TRITOS NA, LOWELL BB, FLIER JS, MARATOS-FLIER E: Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature (1998) 396:670–674.
- LUDWIG DS, TRITOS NA, MASTAITIS jw et al.: Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J. Clin. Investig (2001) 107:379–386.
- CHEN Y, HU C, HSU C-K et al.: Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Endocrinology (2002) 143:2469–2477.
- COLLINS AC, KYM PR: Prospects for obesity treatment: MCH receptor antagonists. Curr. Opin. Investig. Drugs (2003) 4:386.
- TAKEKAWA S, ASAMI A, ISHIHARA Y et al.: T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist. Eur. j Pharmacol (2002) 438:129.
- BOROWSKY B, DURKIN MM, OGOZALEK K et al.: Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nat. Med. (2002) 8:779–781.
- SOUERS AJ, GAO J, WODKA D et al: Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor-1 antagonists for the treatment of obesity. Bioorg. Med. Chem. Lett. (2005) 15:2752–2757.
- SOUERS AJ, GAO J, BRUNE M et al: Identification of 2-(4-benzyloxypheny1)-N-1 -(2-pyrrolidin-l-yl-ethyl)-1H-indazol-6-yllacetamide, an orally efficacious melanin-concentrating hormone receptor-1 antagonist for the treatment of obesity. J. Med. Chem. (2005) 48:1318–1321.
- MCBRIAR MD, GUZIK H, XU R et al: Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics. J. Med. Chem. (2005) 48:2274–2277.
- Thomson Current Drugs: drug report for AMG–076.
- Thomson Current Drugs: drug report for 856464.
- SOUERS AJ, WODKA D, GAO J et al: Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCH-1R antagonists. Part 1. Bioorg. Med. Chem. Lett. (2004) 14:4873–4877.
- VASUDEVAN A, WODKA D, VERZAL MK et al.: Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCH-1R antagonists. Part 2. Bioorg. Med. Chem. Lett. (2004) 14:4879–4882.
- SOUERS AJ, WODKA D, GAO Jet al.: Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCH-1R antagonists. Part 3. Bioorg. Med. Chem. Lett. (2004) 14:4883–4886.
- GREY J, DYCK B, ROWBOTTOM MW et al.: Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists. Bioorg. Med. Chem. Lett. (2005) 15:999–1004.