Bibliography
- BOSS C, RICHARD-BILDSTEIN S, WELLER T, FISCHLI W, BINKERT C: Inhibitors of the Plasmodium falciparum parasite aspartic protease plasmepsin II as potential antimalarial agents. Curr. Med. Chem. (2003) 10:883-907.
- WATERS NC, DOW GS, KOZAR MP: Antimalarial compound identification and design: advances in the patent literature, 2000 – 2003. Expert Opin. Ther. Patents (2004) 14(8):1125-1138.
- BOSS C, RICHARD-BILDSTEIN S, FURNARI R et al.: Inhibitors of plasmepsin II – potential antimalarial agents. Chimia (2004) 58(9):634-639.
- RADDING JA: Development of anti-malarial inhibitors of haemoglobinases. Ann. Rep. Med. Chem. (1999) 34:159-168.
- WIRTH DF: Malaria: a third world disease in need of first world drug development. Ann. Rep. Med. Chem. (1999) 34:349-358.
- WIESNER J, ORTMANN R, JOMAA H, SCHLITZER M: Neue antimalaria-wirkstoffe. Angew. Chem. (2003) 115:5432-5451.
- MBAI M, RAJAMANI S, JANUARY CT: Blockade of HERG potassium channels by the antimalarial halofantrine. Circulation (2000) 102(18): Abs 1745.
- VENNERSTROM JL, ARBE-BARNES S, BRUN R et al.: Identification of an antimalarial synthetic trioxolane drug development candidate. Nature (2004) 430:900-904.
- ROSENTHAL PJ: Protease inhibitors. In: Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery. ROSENTHAL PJ (Ed.), Humana Press, Inc., New Jersey, USA (2001):325-345.
- JOMAA H, WIESNER J, SANDERBRAND S et al.: Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science (1999) 285:1573-1576.
- OMARA-OPYENE AL, MOURA PA, SULSONA CR et al.: Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy. J. Biol. Chem. (2004) 279(52):54088-54096.
- LIU J, GLUZMAN IY, DREW ME, GOLDBERG DE: The role of Plasmodium falciparum food vacuole plasmepsins. J. Biol Chem. (2005) 280(2):1432-1437.
- SENGE MO, HATSCHER S: The malaria pigment haemozoin – a focal point of action for antimalarial drugs. ChemBioChem. (2000) 1:247-249.
- ROBERT A, DECHY-CABARET O, CAZELLES J, MEUNIER B: From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs. Acc. Chem. Res. (2002) 35:167-174.
- EGAN TJ: Quinoline antimalarials. Expert Opin. Ther. Patents (2001) 11(2):185-209.
- ZIEGLER J, LINCK R, WRIGHT DW: Heme aggregation inhibitors: antimalarial drugs targeting an essential biomineralization process. Curr. Med. Chem. (2001) 8:171-189.
- BANERJEE R, LIU J, BEATTY W et al.: Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine. Proc. Natl. Acad. Sci. USA (2002) 99(2):990-995.
- ASOJO OA, AFONINA E, GULNIK SV et al.: Structures of Ser205 mutant plasmepsin II from Plasmodium falciparum at 1.8 Å in complex with the inhibitors rs367 and rs370. Acta Cryst. (2002) D58:2001-2008.
- PRADE L, JONES AF, BOSS C et al.: X-ray structure of plasmepsin II complexed with a potent achiral inhibitor. J. Biol. Chem. (2005) 280(25):23837-23843.
- COOMBS GH, GOLDBERG DE, KLEMBA M, BERRY C, KAY J, MOTTRAM JC: Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets. Trends Parasitol. (2001) 11:532-537.
- SILVA AM, LEE AY, ERICKSON JW, GOLDBERG DE: Structural analysis of plasmepsin II. In: Aspartic Proteinases. James MN (Ed.), Adv. Exp. Med. Biol. Plenum Press, New York, USA (1998) 436:363-373.
- MAIBAUM J, FELDMAN DL: Renin inhibitors as novel treatments for cardiovascular disease. Expert Opin. Ther. Patents (2003) 13(5):589-603.
- DEISS LP, GALINKA H, BERISSI H, COHEN O, KIMCHI A: Cathepsin D protease mediates programmed cell death induced by interferon-γ, Fas/APO-1 and TNF-α. EMBO J. (1996) 15:3861-3870.
- MUELLER R, HUERZELER M, BOSS C: Synthesis of plasmepsin II inhibitors – potential antimalarial agents. Molecules (2003) 8:556-564.
- DESJARDIN RE, CANFIELD CJ, HAYNES JD, CHULAY JD: Quantitative assessment of antimalarial activity in vitro by semiautomated microdilution technique. Antimicrob. Agents Chemother. (1979) 16:710-718.
- CARCACHE DA, HOERTNER SR, BERTOGG A et al.: De novo design, synthesis, and in vitro evaluation of a new class of nonpeptidic inhibitors of the malarial enzyme plasmepsin II. ChemBioChem (2002):1137-1141.
- CARCACHE DA, HOERTNER SR, BERTOGG A et al.: A new class of inhibitors for the malarial aspartic protease plasmepsin II based on a central 11-azatricyclo[6.2.1.027]undeca-2,4,6-triene scaffold. Helv. Chim. Acta (2003) 86:2192-2209.
- CARCACHE DA, HOERTNER SR, SEILER P: Development of a new class of inhibitors for the malarial aspartic protease plasmepsin II based on a central 7-azabicyclo[2.2.1]heptane scaffold. Helv. Chim. Acta (2003) 86:2173-2191.
- HOF F, DIEDERICH F: Medicinal chemistry in academia: molecular recognition with biological receptors. Chem. Comm. (2004) 5:484-487.
- OEFNER C, BINGGELI A, BREU V et al.: Renin inhibition by substituted piperidines: a novel paradigm for the inhibition of monomeric aspartic proteinases? Chem Biol. (1999) 6(3):127-31.
- HAQUE TS, SKILLMAN AG, LEE CE et al.: Potent low-molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II. J. Med. Chem. (1999) 42:1428-1440.
- MALY DJ, HUANG L, ELLMAN JA: Combinatorial strategies for targeting protein families: application to the proteases. ChemBioChem (2002):16-37.
- ASOJO OA, GULNIK SV, AFONINA E et al.: Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum. J. Mol. Biol. (2003) 327:173-181.
- BRINNER KM, KIM JM, HABASHITA H, GLUZMAN IY, GOLDBERG DE, ELLMAN JA: Novel and potent anti-malarial agents. Bioorg. Med. Chem. (2002) 10:3649-3661.
- CARROLL CD, PATEL H, JOHNSON O et al.: Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg. Med. Chem. Lett. (1998) 8:2315-2320.
- CARROLL CD, JOHNSON TO, TAO S et al.: Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D. Bioorg. Med. Chem. Lett. (1998) 8:3203-3206.
- KISO A, HIDAKA K, KIMURA T et al.: Substrate transition-state analogue inhibitors of plasmepsin II as antimalarial drugs. Peptide Science (2002):297-300.
- NEZAMI A: Structure-based design of novel inhibitors of plasmepsins: a family of antimalarial targets. PhD thesis, Johns Hopkins University (2003) UMI Number: 3107552.
- NEZAMI A, KIMURA T, HIDAKA K et al.: High-affinity inhibition of a family of Plasmodium falicparum proteases by a designed adaptive inhibitor. Biochemistry (2003) 42:8459-8464.
- ABDEL-RAHMAN HM, KIMURA T, HIDAKA K et al.: Design of inhibitors against HIV, HTLV-I, and Plasmodium falciparum aspartic proteases. Biol. Chem. (2004) 385:1035-1039.
- KISO A, HIDAKA K, KIMURA T et al.: Search for substrate-based inhibitors fitting the s2′ space of malarial aspartic protease plasmepsin II. J. Peptide Sci. (2004) 10:641-647.
- ERSMARK K, NERVALL M, HAMELINK E et al.: Synthesis of malarial plasmepsin inhibitors and predicition of binding modes by molecular dynamics simulations. J. Med. Chem. (2005) 48:6090-6106.
- ERSMARK K, FEIERBERG I, BJELIC S et al.: Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity. J. Med. Chem. (2004) 47:110-122.
- ERSMARK K, FEIERBERG I, BJELIC S et al.: C2-Symmetric inhibitors of Plasmodium falciparum plasmepsin II: synthesis and theoretical predicitions. Bioorg. Med. Chem. (2003) 11:3723-3733.
- OSCARSSON K, OSCARSON S, VRANG L, HAMELINK E, HALLBERG A, SAMUELSSON B: New potent C2-symmetric malaria plasmepsin I and II inhibitors. Bioorg. Med. Chem. (2003) 11:1235-1246.
- JOHANSSON PO, LINDBERG J, BLACKMAN MJ et al.: Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II. J. Med. Chem. (2005) 48:4400-4409.
- JOHANSSON PO, CHEN Y, BELFRAGE AK et al.: Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs. J. Med. Chem. (2004) 47:3353-3366.
Patents
- ACTELION PHARM. LTD: WO0224649 (2002).
- ACTELION PHARM. LTD: WO2005019176 (2005).
- ACTELION PHARM. LTD: WO2005058822 (2005).
- ACTELION PHARM. LTD: WO2004105738 (2004).
- ACTELION PHARM. LTD: WO2004002957 (2004).
- ACTELION PHARM. LTD: WO2004105762 (2004).
- ACTELION PHARM. LTD: WO03093267 (2003).
- F HOFFMANN-LA ROCHE AG: WO9912532 (1999).
- F HOFFMANN-LA ROCHE AG: WO9709311 (1997).
- ACTELION PHARM. LTD: WO0238534 (2002).
- REGENTS OF THE UNIV. CALIFORNIA: WO0056335 (2000).
- REGENTS OF THE UNIV. CALIFORNIA: WO0114331 (2001).
- PHARMACOPEIA, INC.: US5892038 (1999).
- PHARMACOPEIA, INC.: US5734054 (1998).
- PHARMACOPEIA, INC.: WO9955687 (1999).
- PHARMACOPEIA, INC.: US5986102 (1999).
- PHARMACOPEIA, INC.: US5872262 (1999).
- PHARMACOPEIA, INC.: US5962506 (1999).
- PHARMACOPEIA, INC.: US6150344 (2000).
- PHARMACOPEIA, INC.: US6326393 (2001).
- PHARMACOPEIA, INC.: US6191277 (2001).
- SCHERING CORP.; PHARMACOPEIA DRUG DISCOVERY, INC.: WO2005058311 (2005).
- ENANTA PHARM., INC.: WO01834433 (2001).
- ENANTA PHARM., INC.: WO03034989 (2003).
- THE JOHNS HOPKINS UNIV.: WO02074719 (2002).
- THE JOHNS HOPKINS UNIV.: US37953 (2005).
- MEDIVIR AB: WO9845330 (1998).
- MEDIVIR AB: WO3018537 (2003).
- VERTEX PHARM., INC.: WO9413629 (1994).
- GD SEARLE & CO.: WO9519958 (1995).
- GOVERNMENT OF THE USA REPRESENTED BY THE SECRETARY, DEPT. HEALTH & HUMAN SERVICES: WO0040558 (2000).
- GOVERNMENT OF THE USA REPRESENTED BY THE SECRETARY, DEPT. HEALTH & HUMAN SERVICES: WO9730072 (1997).
- USA AS REPRESENTED BY THE DEPT. OF HEALTH & HUMAN SERVICES: US5849691 (1998).
- F HOFFMANN-LA ROCHE AG: US5140011 (1992).
Websites
- http://www.rbm.who.int Roll Back Malaria initiative
- http://www.mmv.org Medicines for Malaria venture