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Current Opinion on Therapeutic Patents Volume 2, 1992 - Issue 8
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Anti-Inflammatory, Anti-Allergic, Respiratory & GI Agents

Overview: Hydroxamate and Hydroxyurea Based Leukotriene Biosynthesis Inhibitors for the Treatment of Inflammatory Diseases

Rodney W Stevens Pfizer Pharmaceuticals Inc, Medicinal Chemistry Department, Central Research, Nagoya, Japan, 470-23
Pages 1151-1160 | Published online: 02 Mar 2011

References to Primary Literature

  • Jones, TR Letts, G Chan, C-C Daves, P Pharmacology and Pathophysiology of Leukotrienes Leukotrienes and Lipoxygenases: Chemical, Biological and Clinical Aspects. Rokach, J Elsevier Science 1989 309–403.
  • Ford-Hutchinson, AW Evidence for the Involvement of Leukotrienes and Other Lipoxygenase Products in Disease States Leukotrienes and Lipoxygenases: Chemical, Biological and Clinical Aspects. Rokach, J Elsevier Science 1989 405–420.
  • Masamune, H Melvin, LS Jr Novel Applications of Leucotriene Intervention. Annu. Rep. Med. Chem. 1989 24 71.
  • Corey, EJ Cashmin, JR Kanther, SS Wright, SW Rationally Designed, Potent Competitive Inhibitors of Leukotriene Biosynthesis. J. Am. Chem. Soc. 1984 106 1503.
  • Jackson, WP Islip, PJ Kneen, G Pugh, A Wates, PJ Acetohydroxamic Acids as Potent, Selective, Orally Active 5-Lipoxygenase Inhibitors. J. Med. Chem. 1988 31 499.
  • Kerdesky, FAJ Holms, JH Schmidt, SP Dyer, RD Carter, GW Eicosatetraenehydroxamates: Inhibitors of 5-lipoxygenase. Tetrahedron Lett. 1985 26 2143.
  • Summers, JB Mazdiyasni, H Holms, JH Ratajczak, JH Dyer, RD Carter, GW Hydroxamic Acid Inhibitors of 5-Lipoxygenase. J. Med. Chem. 1987 30 574.
  • Summers, JB Gunn, BP Masdiyasni, H Goetze, AM Young, PR Bouska, JB Dyer, RD Brooks, DW Carter, GW In Vivo Characterization of Hydroxamic Acid Inhibitors of 5-Lipoxygenase. J. Med Chem. 1987 30 2121.
  • Summers, JB Gunn, BP Martin, JG Mazdiyasni, H Stewart, AO Young, PR Goetze, AM Bouska, JB Dyer, RD Brooks, DW Carter, GW Orally Active Hydroxamic Acid Inhibitors of Leukotriene Biosynthesis. J. Med. Chem. 1988 31 3.
  • Summers, JB Gunn, BP Martin, JH Martin, MB Mazdiyasni, H Stewart, AO Young, PR Bouska, JB Goetze, AM Dyer, RD Brooks, DW Carter, GW Structure-activity Analysis of s Class of Orally Active Hydroxamic Acid Inhibitors of Leukotriene Biosynthesis. J. Med. Chem. 1988 31 1960.
  • Summers, JB Kim, KH Mazdiyasni, H Holms, JH Ratajczyk, JD Steward, AO Dyer, RD Carter, GW Hydroxamic Acid Inhibitors of 5-Lipoxygenase: Quantitative Structure-activity Relationships. J. Med. Chem. 1990 33 992.
  • Rask-Madsen, J Bukhave, K Lanrsen, LS Lauritsen, K 5-Lipoxygenase Inhibitors for the Treatment of Inflammatory Bowel Disease. Agents Action 1992 C37.
  • Israel, E Derkmarkarian, R Rosenberg, M Sperling, R Taylor, G Rubin, P Drazen, JM The Effects of a 5-Lipoxygenase Inhibitor on Asthma Induced by Cold, Dry Air. N. Engl. J. Med. 1990 333 1740.
  • Hui, KP Taylor, IK Taylor, GW Rubin, P Kesterson, J Barnes, NC Barnes, PJ Effects of a 5-Lipoxygenase Inhibitor on Leukotriene Generation and Airway Response after Allergen Challenge in Asthmatic Patients. Thorax 1991 46 184.
  • Knapp, HR Reduced Allergen-induced Nasal Congestion and Leukotriene Synthesis with an Orally Active 5-Lipoxygenase Inhibitor. N. Engl. J. Med. 1990 323 1745.
  • Weinblatt, M Kremer, J Helfgott, S Coblyn, J Maier, A Sperling, R Petrillo, G Kesterson, J Dube, L Henson, B Teoh, N Rubin, P A 5-Lipoxygenase Inhibitor in Rheumatoid Arthritis. Arthritis Rheum. 1990 33 S152.
  • Young, PR Bell, RL Bouska, J Lanni, C Summers, JB Brooks, DW Carter, GW A-69412: A New Soluble 5-Lipoxygenase Inhibitor with a Long Duration of Activity. FASEB J. 1991 5 A1273.
  • PharmaProjects Oct 1991.
  • Sweeny, DJ Bouska, J Machinist, J Bell, R Carter, G Cepa, S Nellans, HN Glucuronidation of Zileuton (A-64077) by Human Heptic Microsomes. Am. Soc. Pharmacol. Exp. Ther. 1992 20 328.
  • Braeckman, RA Granneman, GR Rubin, PR Kesterson, JW Pharmacokinetics and Metabolism of the New 5-Lipoxygenase Inhibitor A-64077 after Single Oral Administration in Man. J. Clin. Pharmacol. 1989 29 A22.
  • Musser, JH Kreft, AF Substituted-[2-Quinolinyl(Bridged)aryl] Compounds: Modulators of Eicosanoid Biosynthesis and Action. Drugs Fut. 1990 15 73.
  • Menard, L Pilote, S Naccade, PH Laviolette, M Borgeat, P Inhibitory Effects of MK-866 on Arachidonic Acid Metabolism in Human Phagocytes. Br. J. Pharmacol. 1990 100 15.
  • Garland, LG Salmon, JA Hydroxamic Acids and Hydroxyureas as Inhibitors of Arachidonate 5-Lipoxygenase. Drugs Fut. 1991 16 547.
  • Hsiao, C-N Kolasa, T Synthesis of Chiral Zileuton, a Potent and Selective Inhibitor of 5-Lipoxygenase. Tetrahedron Lett. 1992 33 2629.

References to Patent literature

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