References to Primary Literature
- Becker, RE Giacobini, E Mechanism of cholinesterase inhibition in senile dementia of the Alzheimer type: Clinical, pharmacological, and therapeutic aspects. Drug Dev. Res. 1988 12 163–195.
- Francis, PT Neurochemical studies on early-onset Alzheimer's disease. N. Engl. J. Med. 1985 313 7–11.
- Hardy, J Molecular classification of Alzheimer's disease Lancet 1991 337 1342–1343.
- Roberts, GW Gentleman, SM Lynch, A Graham, DI βA4 Amyloid protein deposition in brain after head trauma. Lancet 1991 338 1422–1423.
- Eagger, SA Levy, R Sahakian, BJ Tacrine in Alzheimer's disease. Lancet 1991 337 989–992.
- Growdon, JH Corkin, S Huff, FJ Rosen, TJ Piracetam combined with lecithin in the treatment of Alzheimer's disease. Neurobiol. Aging 1986 7 269–276.
- Bartus, RT Drugs to treat age-related neurodegenerative problems. JAGS 1990 38 680–695.
- Selkoe, DJ Amyloid protein and Alzheimer's disease. Sci. Amer. 1991 68–78.
- Sarter, M Taking stock of cognition enhancers. Trends Pharmacol. Sci. 1991 12 456–461.
- Royston, MC Rothwell, NJ Roberts, GW Alzheimer's disease: Pathology and potential treatments? TIPS 1992 13 131–133.
- Gandy, S Greengard, P Amyloidogenesis in Alzheimer's disease: Some possible therapeutic opportunities. TIPS 1992 13 108–113.
- Flood, JF Morley, JE Roberts, E Amnestic effects in mice of four synthetic homologous to amyloid βprotein from patients with Alzheimer disease. Proc. Natl. Acad. USA 1991 88 3363–3366.
- Wiseman, EJ Jarvik, LF Potassium channel blockers: Could they work in Alzheimer's disease? Alzheimer Disease and Associated Disorders 1991 5 25–30.
- Sherman, KA Effect of oral administration of reversible inhibitors of blood acetylcholinesterase in humans: E2020 and tacrine. Soc. Neurosci. 1991 17 11.
- Sherman, KA New methods to determine in vivo action of reversible acetylcholinesterase inhibitors: Tacrine and E2020. Soc. Neurosci. 1991 16.
- E2020. Drugs Future 1991 16 16.
- E2020. Drugs Future 1992 17 56.
- Sherman, KA Harms, KF Measuring the effects of reversible acetylcholine sterase inhibitors by ex vivo assay. Pharmacologist 1990 32 102.
- Brufani, M Maurizio, M Pomponi, M Acetylcholinesterase activity of a new carbamate, heptylphysostigmine, in view of its use in patients with Alzheimer-type disease. Eur. J. Biochem. 1986 157 115.
- Thai, LT Fuld, PA Memory ehancement with oral physostigmine in Alzheimer's disease. N. Engl. J. Med. 1983 308 720.
- Kozikowski, AP Delineating the pharmacophoric elements of huperzine-A: Importance of the unsaturated three-carbon bridge to its AChE inhibitory activity. J. Med. Chem. 1991 34 3399–3402.
- Paterson, IA Juorio, AV Berry, MD Zhu, MY Inhibition of monoamine oxidase-B by (–)-deprenyl potentiates neuronal responses to dopamine agonist but does not inhibit dopamine catabolism in rat stratum. J. Pharmacol. Exp. Ther. 1991 258 1019–1026.
- Chen, YL Synthesis, resolution, and structure-activity-relationships of potent acetylcholinesterase inhibitors: 8-Carbaphysostigmine analogues. J. Med. Chem. 1992 35 1429.
- Fink, DM Allen, RC Synthesis and carbamoylation of 1,2,3,4,5,6-hexahydro-1,3,-diemthyl-2,6-methano-1,3-benzodiazcin-8-ol: Bridged analogues of physostigmine. Tetrahedron Lett. 1992 33 2103.
- Sunderland, T Molchan, S Vitiello, B Martinez, R Martin, A Cholinergic Basis for Alzheimer Therapy Becker, R, Giacobini, E Birkhauser, Boston 1991 172–182.
- Giacobini, E Linville, D Messamore, E Ogane, N Cholinergic Basis for Alzheimer Therapy Becker, R, Giacobini, E Birkhauser, Boston 1991 477–490.
- Israel, M Manaranche, R Mastour-Frachon, P Morel, N Isolation of pure cholinergic nerve endings from the electric organ of Torpedo marmorata. Biochem. J. 1976 160 113–115.
- Saunders, J Synthesis and characterization of all four isomers of the muscarinic agonist 2′-methylspiro[1-azabicyclo[2.2.2] octane-3,4′-[1,3]dixolane]. J. Med. Chem. 1987 30 969–975.
- Tam, SW Rominger, D Nickolson, VJ Novel receptor site involved in enhancement of stimulus-induced acetylcholine, dopamine, and serotonin release. Mol. Pharmacol. 1991 40 16–21.
- Cook, L Nickolson, VJ Steinfels, GF Rohrbach, KW DeNoble, VJ Cognition enhancement by the acetylcholine releaser DuP996. Drug Dev. Res. 1990 19 301–324.
- Altman, HJ Normile, HJ Enhancement of the memory of a previously learned aversive habit following pre-test administration of a variety of serotonergic antagonists in mice. Psychopharmacol. 1986 90 24–27.
- DeNoble, VJ DeNoble, KF Spencer, KR Protection against hypoxla-induced passive avoidance deficits: Interaction between DuP996 and ketanserin. Brain Res. Bull. 1991 26 817–820.
- Rothman, SM Olney, JW TINS 1987 10 229.
- Maragos, W Greenamyre, J Penney, J Jr Young, A TINS 1987 10 65.
- Jones, RW Wesnes, KA Kirby, J Effects of NMDA modulation in scopolamine dementia. Ann. N.Y. Acad. Sci. (Aging Alzheimer's Dis.) 1991 241–244.
- Fischer, W Bjoerklund, A Chen, K Gage, FH NGF improves spacial memory in aged rodents as a function of age. Neurosci. Lett. 1991 131 135–139.
- Allen, SJ Normal beta-NGF content in Alzheimer's disease cerebral cortex and hippocampus. Neurosci. Lett. 1991 131 135–139.
- Geller, AI During, MJ Neve, RL Molecular analysis of neuronal physiology by gene transfer into neurons with herpes simplex virus vector. Neurosci. Lett. 1991 14 428–432.
- Richards, S-J The neuropathology of Alzheimer's disease investigated by transplantation of mouse Trisomy 16 hippocampal tissue. TINS 1991 14 334–338.
- Dunnett, S Cholinergic grafts, memory and aging. TINS 1991 14 371–376.
- Lindvall, O Prospects of transplantation in human neurodegenerative disease. TINS 1991 14 376–384.
- Advokat, C Pellegrin, AI Exctatory amino acids and memory: Evidence from research on Alzheimer's disease. Neurosci. Biobehav. Rev. 1992 16 13–24.
- Barker, R Substance P and neurodegenerative disorders. A speculative review. Neuropeptides (Edinburgh) 1991 20 73–78.
- Freeman, GB Mykytyn, V Gibson, GE Differential alteration of dopamine, acetylcholine, and glutamate release during anoxia and/or 3,4-diaminopyridine treatment. Neurochemical Res. 1987 12 1019–1027.
- Jucker, M Oettinger, R Improvement of radial maze patrolling in senescent rats by 3,4-diaminopyridine. Experientia 1986 42 700.
- Clipsin as a therapeutic aid to the treatment of Alzheimer's disease. Curr. Opin. Thera. Patents. 1992 2 4 500–501.
- Hardy, JA Higgins, GA Alzheimer's disease: The amyloid cascade hypothesis. Science 1992 256 184–185.
References to Patent literature
- Hoechst-Roussel EP -468104-A.
- Hoechst-Roussel EP -471296-A.
- Hoechst-Roussel EP -471298-A.
- Hoechst-Roussel EP -477903-A.
- Hoechst-Roussel EP -484573-A.
- Hoechst-Roussel US 5106856.
- Eisai Co EP -468187-A.
- Eisai Co US 4895841.
- Biorex-Kutato-Fejlesz WO 9200737.
- Pfizer Inc WO 9200961.
- SS Pharm Co EP -481429-A.
- Takeda EP -487071-A.
- Mediolanum Farm SpA EP -486958-A.
- Mayo Fnd for Med Ed & Res US 5104880.
- Sigma-Tau Ind Farm Riunite SpA EP -488965-A.
- Hoechst-Roussel WO 9200072.
- Hoechst-Roussel US 5100891.
- Boehringer Inhelheim Inst WO 9200297.
- Novo Nordisk AS WO 9203430.
- Novo Nordisk AS WO 9203433.
- Beecham Group Plc WO 9203435.
- Beecham Group Plc WO 9206959.
- Sumrtomo Pharm Co Ltd EP -476933-A.
- American Home Product Corp US 5099333.
- Nippon Shinyakau Co Ltd WO 9204333.
- Gyogyszerkutato Intezet KV WO 9207854.
- Adir & Co EP -485844-A.
- Merck Sharp & Dohme EP -473442-A.
- Beecham Group Inc WO 9204323.
- DuPont Merck Pharm Co WO 9200760.
- ER Squibb & Sons Inc EP -481207-A.
- Merck Sharp & Dohme GB -2245564-A.
- Warner-Lambert Co WO 9207855.
- Warner-Lambert Co US 5075305.
- Mitsui Petrochem Ind Ltd WO 9200970.
- Harvard College WO 9203474.
- New York University WO 9203374.
- Dana Farber Cancer Institute WO 9207945.
- University of California WO 9205272.
- University of California US 5064557.
- Children's Medical Center Corp WO 9202248.
- Kyowa Hakko Kogyo Co Ltd WO 9206976.
- Elan Corp plc EP -484186-A.
- Children's Medical Center Corp WO 9207562.
- Ludke, HW WO 9201455.
- Adir & Co EP -470317-A.
- Depha Team Srl WO 9206980.
- Adir & Co EP -486386-A.
- Biosources Genetics Corp WO 9207580.
- El DuPont de Nemours & Co WO 9200374.
- Boston University WO 9203542.
- Case Western Reserve University WO 9200521.
- Royal Institute for the Advancement of Learning US 5100645.
- Athena Neurosciences Inc WO 9207068.
- Upjohn Co WO 9206187.
- Hoechst-Roussel EP -489379-A.