432
Views
32
CrossRef citations to date
0
Altmetric
Reviews

Apoptosis-inducing agents: a patent review (2010 – 2013)

, &

Bibliography

  • Galluzzi L, Vitale I, Abrams JM, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012;19:107-20
  • Leist M, Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2001;2:589-98
  • Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-57
  • Meier P, Finch A, Evan G. Apoptosis in development. Nature 2000;407:796-801
  • Rathmell JC, Thompson CB. Pathways of apoptosis in lymphocyte development, homeostasis, and disease. Cell 2002;109:97-107
  • Reed JC. Apoptosis-based therapies. Nat Rev Drug Discov 2002;1:111-21
  • Hengartner MO. The biochemistry of apoptosis. Nature 2000;407:770-6
  • Degterev A, Boyce M, Yuan J. A decade of caspases. Oncogene 2003;2:8543-67
  • Gastman BR. Apoptosis and its clinical impact. Head Neck 2001;23:409-25
  • Chipuk JE, Green DR. How do Bcl-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol 2008;18:157-64
  • Thornberry NA. Caspases: key mediators of apoptosis. Chem Biol 1998;5:R97103
  • Available from: http://www.britannica.com/EBchecked/topic/264227/heterocyclic-compound/277878/Five-and-six-membered-rings-with-two-or-more-heteroatoms
  • Aberra F. Roll of pharmacologically active metabolites in drug discovery and development. Drug Discov Today 2006;11:133-42
  • Kunzer AR, Elmore SW, Hexamer A, et al. Preparation of heterocyclic apoptosis-inducing agents for treatment of cancer and immune disorders. WO083442; 2010
  • Wang Z. Preparation of heteroarylmethylenepyrrole derivatives for use as apoptosis inducers. WO053045; 2013
  • Ham SU. Preparation of 2-aminothiazole derivatives as antitumor agents. KR017196; 2012
  • Lee YH, Shin SY, Lim YH, et al. Preparation of bis(2-hydroxylbenzylamino)(pyridin-2-yl)methane as apoptosis inducer. KR139392; 2011
  • Bae IH, Jun MA, Song JY, et al. Preparation of pyrazinone derivatives having apoptosis-inducing activity. WO090316; 2011
  • Kamal A, Srikanth YVV, Khan MNA, et al. Benzothiazole derivatives as potential anticancer agents and apoptosis inducers and process for the preparation thereof. WO111016; 2012
  • Hergenrother PJ, Peterson QP, Hsu DC, et al. Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs. WO091382; 2010
  • Surolia A, Rai A, Panda D. Rhodanine compounds as tubulin binding anti-cancer agent and their application in treating cancers. IN2011DE01167; 2012
  • Ikeda T, Ono M, Ueno S, et al. Preparation of 2-azolylpyrrole compounds as tubulin polymerization inhibitors and antitumor agents. WO111831; 2013
  • Hitchcock M, Mengel A, Richter A, et al. Preparation of substituted benzylpyrazoles. WO092512; 2013
  • Lim YH, Lee YH, Ko DS, et al. Preparation of trimethoxyphenyl-4,5-dihydro-1H-pyrazol-3-yl-naphthalen-2-ol derivatives having apoptosis-inducing activity. KR049011; 2012
  • Li N, Cao X, Qiu J. {3-[2-(2-Hydroxy-5-nitrophenyl)-5-phenyl-1-H-imidazole-4-yl]phenyl} phenyl ketone as human PEBP4-targeting antitumor compound, its formulation and application. CN101810608; 2010
  • Kovach JS, Zhuang Z, Lu J. Methods for regulating cell mitosis by inhibiting serine/threonine phosphatase. WO014141; 2010
  • Wang L, Doherty G, Wang X, et al. Preparation of substituted benzothiazoles as apoptosis-inducing agents for the treatment of cancer, immune and autoimmune diseases. WO055895; 2013
  • Weinberg JB, Friedman DR, Cianciolo GJ, et al. Method of inducing apoptosis/cell death in leukemia cell using a purine nucleoside analogue. US0319360; 2011
  • Le DT, Casara P, Starck JB, et al. New indolizine derivatives, their preparation as pro-apoptotic and antitumor agents and their pharmaceutical compositions containing them. FR2986002; 2013
  • Brown D, Husband AJ, Mor G, et al. Methods using chroman compounds for inducing programmed cell death. CA2641541; 2010
  • Husband AJ, Brown D, Morn G, et al. Methods using chroman compounds for inducing programmed cell death. WO045674; 2010
  • Govindan SV, Goldenberg DM. Camptothecin conjugates with anti-CD22 antibodies for the treatment of B cell diseases. US0305631; 2011
  • Lu X, Zheng Z, Ma Y, et al. Xanthone compounds with antitumor activity, preparation and application thereof. CN101723952; 2010
  • Anderson MB, Willardsen JA, Weiner WS, et al. Preparation of 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis. US0069383; 2010
  • Yanagawa H, Hayakawa I, Shiheido H, et al. Antitumor agent containing thalidomide derivative as active ingredient. WO061862; 2010
  • Cai SX, Vaillancourt MT, Claassen G. Compounds and methods of inducing apoptosis via interaction with chaperonin CCT, use for the treatment of diseases responsive to induction of the caspase cascade, and screening methods. WO008558; 2010
  • Brugge J, Hung MC, Mills GB. A new mutational AKTivation in the PI3K pathway. Cancer Cell 2007;12:104-7
  • Vennemann MB, Thomas MT, Hoelder SB, et al. Preparation of fused pyrimidines as Akt inhibitors. WO091824; 2010
  • Reddy EP, Reddy MVT. Preparation of substituted pyrido[2,3-d]pyrimidin-7(8H)-ones as lk2 kinase inhibitors and anti-tumor agents. WO075616; 2011
  • Tanuma S, Fujiwara M. Glyoxalase I inhibitors as antitumor agents. JP2011219384; 2011
  • Zhang S, Gao Z, Cheng X, et al. Application of adenosine in preparing antitumor agent. CN102178689; 2011
  • Huang HS, Cha TC, Cha TL. Methods for inhibiting cancer cell proliferation and inducing cancer cell apoptosis using anthraquinone derivative, anthra[2,1-c][1,2,5]thiadiazole-6,11-dione (NSC745885). US0122937; 2012
  • Cotter FE. Preparation of isoquinolines and pyridopyrimidines for inducing cellular apoptosis. WO125343; 2010
  • Pechan P, Havlicek L. 5,7-Disubstituted 3-isopropylpyrazolo[4,3-d]pyrimidines, and their preparation and use for inhibiting proliferation and inducing apoptosis in mammalian cells, specifically in preventing, inhibiting or treating restenosis. WO139288; 2010
  • Kaminishi H, Kinjo J, Tsuchihashi R, et al. 3-(Aminocarbonyl)-1-[5-O-[[1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-ribofuranos-5-Oyl]phosphonyloxy(oxylato)phosphinyl]-beta-L-ribofuranosyl]pyridinium, its preparation, and axon elongation and neurite outgrowth promoter, antitumor agent, and food containing it. WO004917; 2012
  • Adra CN, Aldhfyan A. Use of thiazolobenzimidazole compounds for the treatment of tumors and proliferative disorders. WO077295; 2010
  • Casara P, Le Diguarher T, Durand D, et al. New tricyclic derivatives, their preparation as pro-apoptotic and antitumor agents and their pharmaceutical compositions containing them. WO007248; 2010
  • Bruncko M, Ding H, Doherty G, et al. Preparation of N-(phenylsulfonyl)benzamides and N-(3-pyridylsulfonyl)benzamides as apoptosis-inducing agents for the treatment of cancer and immune diseases and autoimmune diseases. WO138588; 2010
  • Bruncko M, Ding H, Doherty GA, et al. Preparation of N-acylsulfonamide Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases. US0298321; 2010
  • Bruncko M, Dai Y, Ding H, et al. Benzamide-sulfonamide derivatives as apoptosis-inducing agents and their preparation, pharmaceutical compositions and use in the treatment of cancer and immune and autoimmune diseases. US0298323; 2010
  • Hexamer L, Ding H, Elmore SW, et al. Preparation of cyclic sulfonamide compounds as apoptosis-inducing agents that act by inhibiting Bcl-2 proteins for the treatment of cancer and immune and autoimmune diseases. WO083441; 2010
  • Lawrence H, Ge Y, Sebti SM, et al. Preparation of 2-amino-1,4-naphthoquinones and N-aryl-aromatic sulfonamides as proteasome inhibitors for selectively inducing apoptosis in cancer cells. WO005534; 2010
  • Catron ND, Chen S, Gong Y, et al. Preparation of chlorophenyldimethyl cyclohexenylmethylpiperazinylnitrotetrahydropyranylmethylaminophenylsulfonylpyrrolopyridinyloxybenzamide salts and crystalline forms for use as apoptosis-inducing agents. WO071336; 2012
  • Birtalan E, Hoelig P, Lindley DJ, et al. Melt-extruded solid dispersions containing an apoptosis-inducing agent. US0108590; 2012
  • Tao ZF, Wang X, Souers AJ, et al. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases. WO150016; 2011
  • Yeaman MR, Yount NY. Peptides and methods for inducing programmed cell death and their use as antimicrobial, antitumor, antiinflammatory, and anti-proliferative agents. WO103567; 2011
  • Kim TH. An apoptosis-inducing peptide of Noxa protein and its use in cancer therapy. WO027980; 2011
  • Bae IH, Jun MA, Song JY, et al. Preparation of imidazopyrazinone peptide derivatives with apoptosis inducing activity on cells. WO090317; 2011
  • Condon SM, Deng Y, Laporte MG, et al. Preparation of dimeric Smac peptidomimetics for treating proliferative diseases, particularly cancers and autoimmune diseases. US0003877; 2011
  • Wang S, Sun H. Preparation of diazo bicyclic conformationally constrained Smac peptide mimetics as inhibitors of IAP proteins and inducers of apoptosis. WO050068; 2011
  • Bae IH, Byun EY, Ju HK, et al. Preparation of quinoline or quinazoline peptide derivatives with apoptosis inducing activity on cells. WO030160; 2012
  • Schmidt WI, Messmer D. Tumor targeting peptides, therapeutic and diagnostic compositions comprising the peptides. WO114539; 2010
  • Park GS, Cha Y. Pharmaceutical composition comprising Tcea3 protein and screening method of candidate materials inhibiting metastasis or inducing apoptosis of cancer cells using the same. KR122925; 2011
  • Zipkin RE, Adams JK, Spiegel S, et al. Novel sphingosine kinase type 1 inhibitors, compositions and processes for using same. US0035959; 2010
  • Salsbury FR, Scarpinato KD, King SB. Chemotherapeutic for inducing an MSH2-dependent apoptotic pathway. US0239522; 2010
  • Ahn JS, Kim BY, He L, et al. Acylamides inducing apoptosis of cancer cells. WO064745; 2010
  • Gao XM, Yu TL, Kathy Q, et al. Hela-cell apoptosis inducing natural compounds from Garcinia paucinervis and therapeutic uses thereof. US0301236; 2011
  • Wu YC, Lu MC, Chang FR, et al. Method of preparation of ethanol extract of Antrodia camphorata for inducing apoptosis. US0210869; 2010
  • Moreno O. Isoflavonoid compositions and methods for the treatment of cancer. WO061413; 2012
  • Kawai J, Simizu T. Apoptosis inducer containing ergosterol derivative for treatment of lung, tongue, or cervical cancer, and production thereof from agaricus. WO073085; 2013
  • Young MP, Mckeown P. Dexanabinol and derivatives thereof for inducing cancer cell apoptosis. WO030106; 2011
  • Kachlany SC. Combination therapy with leukotoxin to treat cancer. WO125942; 2012
  • Yu DS, Liying FB, Wang Y. Flavonoid glycoside of Camellia chrysantha, and preparation method and application thereof. CN102617672; 2012
  • Zhang L, Yu H, Bao J, et al. Application of curcumin in preparing antitumor agent for treating thyroid cancer. CN102319234; 2012
  • Zhang G, Wang Z, Wu J. Application of houttuynoid b in the medicine for treating leukemia. CN102861060; 2013
  • Fu J, Yang L, Qiu Y, et al. Application of celastrol in antitumor agent for treating glioma and preparation method thereof. CN102349917; 2012
  • Zhang Z, Xie F. (E, E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile and its derivatives as Bcl-2 family protein inhibitors for inducing cancer cell apoptosis. CN102212613; 2011
  • Sarkar FH, Mohammad RM. Thymoquinone analogs for the treatment of pancreatic cancer. WO126544; 2011
  • Lim YH, Lee YH, Ko DS, et al. Preparation of chalcone derivative having apoptosis-inducing activity. KR047503; 2012
  • Ukiya M. Antitumor steviol derivatives, and pharmaceuticals and apoptosis inducers containing the derivatives. JP074065; 2011
  • Sebti SM, Hamilton AD, Sill K, et al. Compounds and methods for inducing apoptosis in cancer cells using a bh3 alpha-helical mimetic. WO097133; 2012
  • Kamal A, Suresh P, Kumar BA, et al. Synthesis of new 4-beta-acrylamidopodophyllotoxin congeners as antitumour antibiotics and the process for preparation thereof. US0225672; 2013
  • Kamal A, Suresh P, Kumar BA, et al. Biological evaluation of 4-aza-2,3-didehydropodophyllotoxin analogues possessing potent antitumour activity. US522219; 2013
  • Kamal A, Shetti RVCRNC, Reddy KS, et al. Carbazole linked pyrrolo[2,1-c][1,4]benzodiazefine hybrids as potential anticancer agents and process for the preparation thereof. US0131336; 2013
  • Kamal A, Shetti RVCRNC, Ramaiah MJ, et al. Carbazole–pyrrolo[2,1-c][1,4]benzodiazepine conjugates: design, synthesis, and biological evaluation. Med Chem Commun 2011;2:780-8
  • Kamal A, Bharathi EV, Ramaiah MJ, et al. Quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates: design, synthesis and biological evaluation as potential anticancer agents. Bioorg Med Chem 2010;18:526-42
  • Kamal A, Bharathi EV, Dudekula D, et al. Quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) hybrids as potential anticancer agents and process for the preparation thereof. US0095214; 2012
  • Kamal A, Bharathi EV, Reddy JS, et al. Isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids a potential anticancer agents and process for the preparation thereof. WO058417A; 2010
  • Kamal A, Bharathi EV, Reddy JS, et al. Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2, 3-dihydroquinazolinone hybrids as anticancer agents. Eur J Med Chem 2011;46:691-703
  • Kamal A, Ramakrishna G, Raju P, et al. Design, synthesis and biological evaluation of imidazo[1,5-a]pyridine–PBD conjugates as potential DNA-directed alkylating agents. Med Chem Commun 2013;4:697-703
  • Kamal A, Ramakrishna G, Raju P, et al. Pyrrolo[2,1-c][1,4] benzodiazepine linked imidazo[1,5-a]pyridine conjugates as potential antitumour agents and process for the preparation thereof. US0253034; 2012
  • Kamal A, Reddy MA, Suresh P, et al. Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents. Bioorg Med Chem 2012;20:3480-92
  • Kamal A, Reddy MA, Suresh P, et al. Amidobenzothiazole analogues useful as potential anticancer agents and process for the preparation thereof. WO104857A1; 2012
  • Kamal A, Viswanath A, Murty JNSC, et al. Diaryl ether linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential anticancer agents and process for the preparation thereof. WO110840; 2012
  • Gesguiere A, Mathew M, Hu Z. Cancer therapy via selective uptake of specialized polymer/fullerene nanoparticles in cancer cells to induce apoptosis. US0129664; 2013
  • Biris A, Mahmood M. Compositions comprising nanoparticles and apoptotic agents and methods of use as cancer chemotherapeutics. WO129797; 2010
  • Naren M, Chen Z, Liu P, et al. Drug composition for inducing mitochondria apoptosis of multiple myeloma cells. CN103099816; 2013
  • Blander JM, Torchinsky M. Oral or mucosal vaccines comprising microbe-infected apoptotic cell expressing exogenous antigen for inducing TH17 helper cell response against cancer, autoimmune and TH17-associated diseases. WO068680; 2010
  • Nashimoto M. Heptamer-type small guide nucleic acid capable of inducing apoptosis of human hematologic cancer cells. WO022092; 2013
  • Masuko T, Tanba S, Shindo T, et al. Preparation of antibodies specific for LAT1 neutral amino acid transporter and their application as anticancer agents. JP024537; 2011
  • Foo HL. Tumor cytotoxic agent and methods thereof using probiotic lactic acid bacteria that produce metabolites. WO074351; 2012

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.