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Original Article

Patent Evaluation: Isoquinoline sulphonamide vasodilators

Pages 642-645 | Published online: 03 Mar 2008

References

  • ASANO T, HIDAKA H: Vasodilatory action of HA1004 [N-(2-guanidinoethyl)-5-isoquinoline-sulphonamide], a novel calcium antagonist with no effect on cardiac function. J. Pharmacol. Exp. Ther (1984) 231:141–145.
  • HIDAKA H, INAGAKI M, KAWAMOTO S, SASAKI Y: Isoquinolinesulphonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry (1984) 23:5036–5041.
  • DONATO DI PAOLA E, HICKS PE, LORRAIN J: Cardiovascular effects of FIA1004 in anaesthetised and pithed rats. Br. J. Pharmacol. (1986) 88:442P.
  • HARTENSTEIN H, ARANDA J, BARTH H, BETCHE HJ, KLEINSCHROTH J, RECK R, RUDOLPH C, TROSTMANN U, SCHACHTELE C: The design of protein kinase C inhibitors. In: Perspectives in Medicinal Chemistry. (1993) Fuhrer W, Giger R, Kyburz E, Testa B (Eds) pp99–118.

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